CN101213196B - 吡啶并[2,3-d]嘧啶衍生物，它们的制备，在治疗中的用途 - Google Patents

吡啶并[2,3-d]嘧啶衍生物，它们的制备，在治疗中的用途 Download PDF

Info

Publication number
CN101213196B
CN101213196B CN2006800237082A CN200680023708A CN101213196B CN 101213196 B CN101213196 B CN 101213196B CN 2006800237082 A CN2006800237082 A CN 2006800237082A CN 200680023708 A CN200680023708 A CN 200680023708A CN 101213196 B CN101213196 B CN 101213196B
Authority
CN
China
Prior art keywords
compound
butyl
formula
preparation
tert
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2006800237082A
Other languages
English (en)
Chinese (zh)
Other versions
CN101213196A (zh
Inventor
B·鲍里
P·卡塞拉斯
S·杰加姆
C·穆诺克斯
P·佩劳特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Publication of CN101213196A publication Critical patent/CN101213196A/zh
Application granted granted Critical
Publication of CN101213196B publication Critical patent/CN101213196B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2006800237082A 2005-07-01 2006-06-29 吡啶并[2,3-d]嘧啶衍生物，它们的制备，在治疗中的用途 Expired - Fee Related CN101213196B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0507032A FR2887882B1 (fr) 2005-07-01 2005-07-01 Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
FR0507032 2005-07-01
PCT/FR2006/001518 WO2007003765A1 (fr) 2005-07-01 2006-06-29 DERIVES DE PYRIDO[2,3-d]PYRIMIDINE, LEUR PREPARATION, LEUR APPLICATION EN THERAPEUTIQUE

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201110187994.9A Division CN102260258B (zh) 2005-07-01 2006-06-29 吡啶并[2,3-d]嘧啶衍生物,它们的制备,在治疗中的用途

Publications (2)

Publication Number Publication Date
CN101213196A CN101213196A (zh) 2008-07-02
CN101213196B true CN101213196B (zh) 2011-09-07

Family

ID=36096420

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2006800237082A Expired - Fee Related CN101213196B (zh) 2005-07-01 2006-06-29 吡啶并[2,3-d]嘧啶衍生物，它们的制备，在治疗中的用途
CN201110187994.9A Expired - Fee Related CN102260258B (zh) 2005-07-01 2006-06-29 吡啶并[2,3-d]嘧啶衍生物,它们的制备,在治疗中的用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201110187994.9A Expired - Fee Related CN102260258B (zh) 2005-07-01 2006-06-29 吡啶并[2,3-d]嘧啶衍生物,它们的制备,在治疗中的用途

Country Status (40)

Country Link
US (2) US7504406B2 (enExample)
EP (2) EP2020410B1 (enExample)
JP (1) JP4472009B2 (enExample)
KR (1) KR101298344B1 (enExample)
CN (2) CN101213196B (enExample)
AR (1) AR054812A1 (enExample)
AT (1) ATE423119T1 (enExample)
AU (1) AU2006264801B2 (enExample)
BR (1) BRPI0613020A2 (enExample)
CA (1) CA2610794C (enExample)
CR (1) CR9568A (enExample)
CY (2) CY1110457T1 (enExample)
DE (1) DE602006005246D1 (enExample)
DK (2) DK2020410T3 (enExample)
DO (1) DOP2006000145A (enExample)
EA (1) EA014312B1 (enExample)
EC (1) ECSP078011A (enExample)
ES (2) ES2450067T3 (enExample)
FR (1) FR2887882B1 (enExample)
HR (2) HRP20090236T1 (enExample)
IL (1) IL187900A0 (enExample)
JO (1) JO2550B1 (enExample)
MA (1) MA29561B1 (enExample)
ME (1) ME01813B (enExample)
MX (1) MX2007016239A (enExample)
MY (1) MY143089A (enExample)
NO (1) NO20080418L (enExample)
NZ (1) NZ564072A (enExample)
PA (1) PA8684801A1 (enExample)
PE (1) PE20070139A1 (enExample)
PL (2) PL1902054T3 (enExample)
PT (2) PT2020410E (enExample)
RS (2) RS50781B (enExample)
SI (2) SI1902054T1 (enExample)
TN (1) TNSN07440A1 (enExample)
TW (1) TWI321566B (enExample)
UA (1) UA92021C2 (enExample)
UY (1) UY29645A1 (enExample)
WO (1) WO2007003765A1 (enExample)
ZA (1) ZA200711032B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102260258A (zh) * 2005-07-01 2011-11-30 赛诺菲-安万特 吡啶并[2，3-d]嘧啶衍生物，它们的制备，在治疗中的用途

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2873118B1 (fr) 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
FR2910813B1 (fr) * 2006-12-28 2009-02-06 Sanofi Aventis Sa Nouvelle utilisation therapeutique pour le traitement des leucemies
EP2344484B1 (en) * 2008-10-17 2016-06-08 Akaal Pharma Pty Ltd S1p receptors modulators and use thereof
WO2010042998A1 (en) 2008-10-17 2010-04-22 Akaal Pharma Pty Ltd S1p receptors modulators
FR2948568B1 (fr) * 2009-07-30 2012-08-24 Sanofi Aventis Formulation pharmaceutique
CN103204825B (zh) * 2012-01-17 2015-03-04 上海科州药物研发有限公司 作为蛋白激酶抑制剂的苯并噻唑化合物及其制备方法和用途
EP2638911A1 (en) 2012-03-14 2013-09-18 Sanofi Novel combinations for treating acute myeloid leukaemia or chronic myeloid leukaemia
CN103833771A (zh) * 2012-11-22 2014-06-04 天津滨江药物研发有限公司 作为蛋白激酶Mek抑制剂的苯并五元杂环化合物及其制备方法和用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996015128A2 (en) * 1994-11-14 1996-05-23 Warner-Lambert Company 6-ARYL PYRIDO[2,3-d]PYRIMIDINES AND NAPHTHYRIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION
WO2001055147A1 (en) * 2000-01-25 2001-08-02 Warner-Lambert Company PYRIDO[2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS
WO2001070741A1 (en) * 2000-03-06 2001-09-27 Warner-Lambert Company 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors
WO2004085436A2 (en) * 2003-03-28 2004-10-07 F. Hoffmann-La Roche Ag Pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1171218A (en) 1967-11-09 1969-11-19 Parke Davis & Co New Heterocyclic Amine Compounds and Methods for their Production
JPH04128276A (ja) 1990-09-19 1992-04-28 Pfizer Pharmaceut Co Ltd アミノベンゾサルタム誘導体およびその用途
IL115256A0 (en) 1994-11-14 1995-12-31 Warner Lambert Co 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
IL117923A (en) 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
US5620981A (en) 1995-05-03 1997-04-15 Warner-Lambert Company Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
MXPA02011263A (es) 2000-08-04 2003-03-10 Warner Lambert Co 2-(4-piridil)amino-6-dialcoxifenil- pirido(2,3-d) pirimidin-7-onas.
AU2002324450A1 (en) * 2001-06-21 2003-01-08 Ariad Pharmaceuticals, Inc. Novel pyridopyrimidines and uses thereof
AU2002952453A0 (en) * 2002-11-01 2002-11-21 Novogen Research Pty Ltd Aminated isoflavonoid derivatives and uses thereof
US20050009849A1 (en) 2003-01-03 2005-01-13 Veach Darren R. Pyridopyrimidine kinase inhibitors
WO2005105097A2 (en) 2004-04-28 2005-11-10 Gpc Biotech Ag Pyridopyrimidines for treating inflammatory and other diseases
FR2873118B1 (fr) 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
FR2887882B1 (fr) * 2005-07-01 2007-09-07 Sanofi Aventis Sa Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
US8338435B2 (en) * 2006-07-20 2012-12-25 Gilead Sciences, Inc. Substituted pyrido(3,2-D) pyrimidines and pharmaceutical compositions for treating viral infections

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996015128A2 (en) * 1994-11-14 1996-05-23 Warner-Lambert Company 6-ARYL PYRIDO[2,3-d]PYRIMIDINES AND NAPHTHYRIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION
WO2001055147A1 (en) * 2000-01-25 2001-08-02 Warner-Lambert Company PYRIDO[2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS
WO2001070741A1 (en) * 2000-03-06 2001-09-27 Warner-Lambert Company 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors
WO2004085436A2 (en) * 2003-03-28 2004-10-07 F. Hoffmann-La Roche Ag Pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Andrew M.Thompson, et al..Synthesis and Structure-Activity Relationships of Soluble 7-Substituted 3-(3,5-Dimethoxyphenyl)-1,6-naphthyridin-2-amines and Related Ureas as Dual Endothelial Growth FactorReceptor-2 Tyrosine Kinases.Journal of Medicinal Chemistry48 14.2005,48(14),4628-4653. *
AndrewM.Thompson et al..Synthesis and Structure-Activity Relationships of Soluble 7-Substituted 3-(3
Mel C. Schroeder, et al..Soluble 2-Substituted Aminopyrido[2,3-d]pyrimidin-7-ylUreas.Structure-Activity Relationships against SelectedTyrosineKinases and Exploration of in Vitro and in VivoAnticancerActivity.Journal of Medicinal Chemistry44 12.2001,44(12),1915-1926. *
MelC.Schroeder et al..Soluble 2-Substituted Aminopyrido[2

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102260258A (zh) * 2005-07-01 2011-11-30 赛诺菲-安万特 吡啶并[2，3-d]嘧啶衍生物，它们的制备，在治疗中的用途

Also Published As

Publication number Publication date
TNSN07440A1 (en) 2009-03-17
DK1902054T3 (da) 2009-06-15
ES2450067T3 (es) 2014-03-21
JP2008544975A (ja) 2008-12-11
EP2020410B1 (fr) 2013-12-18
PL2020410T3 (pl) 2014-05-30
EP1902054A1 (fr) 2008-03-26
NZ564072A (en) 2012-02-24
EA200800223A1 (ru) 2008-06-30
ATE423119T1 (de) 2009-03-15
UY29645A1 (es) 2007-01-31
EP2020410A1 (fr) 2009-02-04
RS50781B (sr) 2010-08-31
MX2007016239A (es) 2008-03-06
PT1902054E (pt) 2009-04-22
SI2020410T1 (sl) 2014-04-30
CN102260258B (zh) 2015-01-07
JO2550B1 (en) 2010-09-05
IL187900A0 (en) 2008-03-20
HRP20140246T1 (hr) 2014-06-20
KR20080021714A (ko) 2008-03-07
PL1902054T3 (pl) 2009-07-31
AU2006264801B2 (en) 2012-05-10
WO2007003765A1 (fr) 2007-01-11
BRPI0613020A2 (pt) 2010-12-14
PA8684801A1 (es) 2007-01-17
CA2610794A1 (fr) 2007-01-11
NO20080418L (no) 2008-03-28
AR054812A1 (es) 2007-07-18
JP4472009B2 (ja) 2010-06-02
ECSP078011A (es) 2008-01-23
HK1122797A1 (en) 2009-05-29
US20090163522A1 (en) 2009-06-25
DOP2006000145A (es) 2008-01-31
AU2006264801A1 (en) 2007-01-11
PT2020410E (pt) 2014-03-20
KR101298344B1 (ko) 2013-08-20
DK2020410T3 (en) 2014-03-24
CR9568A (es) 2008-02-20
ZA200711032B (en) 2009-04-29
DE602006005246D1 (de) 2009-04-02
FR2887882A1 (fr) 2007-01-05
CY1114989T1 (el) 2016-12-14
US20080176874A1 (en) 2008-07-24
EP1902054B1 (fr) 2009-02-18
MA29561B1 (fr) 2008-06-02
US7504406B2 (en) 2009-03-17
CN101213196A (zh) 2008-07-02
TWI321566B (en) 2010-03-11
CA2610794C (fr) 2012-02-21
MY143089A (en) 2011-03-15
ES2322101T3 (es) 2009-06-16
PE20070139A1 (es) 2007-03-07
HRP20090236T1 (hr) 2009-05-31
SI1902054T1 (sl) 2009-06-30
FR2887882B1 (fr) 2007-09-07
EA014312B1 (ru) 2010-10-29
TW200745102A (en) 2007-12-16
CY1110457T1 (el) 2015-04-29
RS53211B (sr) 2014-08-29
UA92021C2 (ru) 2010-09-27
ME01813B (me) 2014-09-20
US8008310B2 (en) 2011-08-30
CN102260258A (zh) 2011-11-30

Similar Documents

Publication Publication Date Title
EP3173412B1 (en) 2,4-disubstituted 7h-pyrrolo[2,3-d]pyrimidine derivative, preparation method and medicinal use thereof
CN103588792B (zh) 吡啶并嘧啶或嘧啶并嘧啶类化合物、其制备方法、药物组合物及其用途
CN102399220A (zh) 三并环类PI3K和mTOR双重抑制剂
CN101679426A (zh) 9-(吡唑-3-基)-9H-嘌呤-2-胺和3-(吡唑-3-基)-3H-咪唑并[4,5-b]吡啶-5-胺衍生物和它们治疗癌症的用途
US8008310B2 (en) Derivatives of pyrido[2,3-d]pyrimidine, the preparation thereof, and the therapeutic application of the same
CN108191837A (zh) PI3Kα/mTOR双激酶抑制剂及其药物组合物和应用
RS67253B1 (sr) Azahinolini kao inhibitori cd38
CN111153891B (zh) 一种取代苯并咪唑类PI3Kα/mTOR双靶点抑制剂及其药物组合物和应用
JP7149854B2 (ja) Ｐｉ３ｋ ｂｅｔａ阻害薬としての二環式ピリジン、ピラジンおよびピリミジン誘導体
JP2022523351A (ja) ヘテロアリール誘導体およびこれを有効成分として含む薬学的組成物
US10301325B2 (en) Quinoline derivative, and pharmaceutical composition, preparation method and use thereof
WO2022116943A1 (zh) 取代的稠合双环化合物作为激酶抑制剂及其应用
CN108117551B (zh) 取代(1H-吡唑[3,4-b]吡啶)脲类化合物及其抗肿瘤用途
HK1122797B (en) Derivatives of pyrido[2,3-d]pyrimidine, the preparation thereof, and the therapeutic application of the same
CA3100095C (en) Indoline-1-carboxamide compound, preparation method therefor and medical use thereof
HK1163102A (en) Derivatives of pyrido[2,3-d]pyrimidine, the preparation thereof, and the therapeutic application of the same
WO2025234404A1 (ja) ピリミジン含有縮合環化合物及びその用途
WO2023033742A1 (en) Compounds useful in modulation of ahr signalling
CN117720532A (zh) 作为rsk抑制剂的吡咯并嘧啶衍生物及其应用
KR20220062003A (ko) 치환된 이미다조퀴녹살린 화합물 및 이의 용도

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1122797

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1122797

Country of ref document: HK

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20110907

Termination date: 20170629

CF01 Termination of patent right due to non-payment of annual fee