CN101209255B - 连翘酯苷注射制剂及其制备方法 - Google Patents

连翘酯苷注射制剂及其制备方法 Download PDF

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Publication number
CN101209255B
CN101209255B CN2007101932272A CN200710193227A CN101209255B CN 101209255 B CN101209255 B CN 101209255B CN 2007101932272 A CN2007101932272 A CN 2007101932272A CN 200710193227 A CN200710193227 A CN 200710193227A CN 101209255 B CN101209255 B CN 101209255B
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forsythiaside
injection
freeze
add
stir
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CN101209255A (zh
Inventor
玄振玉
王勇
黄孝春
陆宏国
孙田江
陈国俊
唐秋玲
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Lunan New Time Bio Tech Co ltd
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Shandong New Time Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2007101932272A 2006-12-28 2007-11-27 连翘酯苷注射制剂及其制备方法 Active CN101209255B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2007101932272A CN101209255B (zh) 2006-12-28 2007-11-27 连翘酯苷注射制剂及其制备方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN200610148180.3 2006-12-28
CN200610148180 2006-12-28
CN2007101932272A CN101209255B (zh) 2006-12-28 2007-11-27 连翘酯苷注射制剂及其制备方法

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CN101209255A CN101209255A (zh) 2008-07-02
CN101209255B true CN101209255B (zh) 2013-04-03

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Country Status (7)

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US (1) US20100317604A1 (enExample)
EP (1) EP2113252A4 (enExample)
JP (1) JP5546867B2 (enExample)
KR (1) KR101117861B1 (enExample)
CN (1) CN101209255B (enExample)
AU (1) AU2007344604A1 (enExample)
WO (1) WO2008086698A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101919869B (zh) * 2009-06-16 2013-06-05 上海医药工业研究院 一种连翘酯苷a药物组合物
CN103054885A (zh) * 2011-10-18 2013-04-24 鲁南制药集团股份有限公司 连翘酯苷在制备抗甲型h1n1病毒药物中的用途及其制剂
CN103054884B (zh) * 2011-10-18 2015-11-04 鲁南制药集团股份有限公司 连翘酯苷在制备抗副流感病毒药物中的用途及其制剂
CN102512371A (zh) * 2012-01-09 2012-06-27 北京农学院 一种连翘酯苷脂质体的制备方法
KR102248956B1 (ko) * 2013-11-18 2021-05-07 주식회사 엘지생활건강 항염증 또는 피부 미백용 조성물
CN108354940A (zh) * 2015-10-16 2018-08-03 山西大学 连翘酯苷a在制备减肥药物中的应用
CN112946113B (zh) * 2021-02-01 2022-09-30 湖北医药学院 一种鉴别道地药材十堰连翘基源的方法
CN114990054B (zh) * 2022-07-22 2023-07-21 成都艾伟孚生物科技有限公司 一种辅助生殖用洗精受精液

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1032876C (zh) * 1991-08-12 1996-09-25 兖州矿务局科研所 高潜水塌陷区抗变形可搬迁房屋
US6083921A (en) * 1998-01-12 2000-07-04 Xu; Kai Jian Pharmaceutical compositions and method of using same
JP3882106B2 (ja) * 2000-12-06 2007-02-14 三栄源エフ・エフ・アイ株式会社 退色抑制剤
US6953786B2 (en) * 2002-10-01 2005-10-11 The Regents Of The University Of California Compositions comprising plant-derived polyphenolic compounds and inhibitors of reactive oxygen species and methods of using thereof
JP2006188436A (ja) * 2004-12-28 2006-07-20 Japan Science & Technology Agency 医用ポリフェノール溶液

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
万旭英等.连翘酯苷冻干粉的遗传毒性试验.《毒理学杂志》.2007,第21卷(第4期), *
孙耀华.注射用冷冻干燥制品.《药剂学》.人民卫生出版社,2003,132. *
张立伟等.连翘酯苷稳定性研究.《中成药》.2003,第25卷(第5期),353-356. *

Also Published As

Publication number Publication date
JP2010514706A (ja) 2010-05-06
KR101117861B1 (ko) 2012-03-14
KR20090095668A (ko) 2009-09-09
AU2007344604A1 (en) 2008-07-24
JP5546867B2 (ja) 2014-07-09
WO2008086698A1 (en) 2008-07-24
US20100317604A1 (en) 2010-12-16
EP2113252A4 (en) 2012-10-31
EP2113252A1 (en) 2009-11-04
CN101209255A (zh) 2008-07-02

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