CN101209255B - 连翘酯苷注射制剂及其制备方法 - Google Patents
连翘酯苷注射制剂及其制备方法 Download PDFInfo
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- CN101209255B CN101209255B CN2007101932272A CN200710193227A CN101209255B CN 101209255 B CN101209255 B CN 101209255B CN 2007101932272 A CN2007101932272 A CN 2007101932272A CN 200710193227 A CN200710193227 A CN 200710193227A CN 101209255 B CN101209255 B CN 101209255B
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- Prior art keywords
- fructus forsythiae
- ester glycoside
- forsythiae ester
- injection
- add
- Prior art date
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101932272A CN101209255B (zh) | 2006-12-28 | 2007-11-27 | 连翘酯苷注射制剂及其制备方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610148180 | 2006-12-28 | ||
| CN200610148180.3 | 2006-12-28 | ||
| CN2007101932272A CN101209255B (zh) | 2006-12-28 | 2007-11-27 | 连翘酯苷注射制剂及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101209255A CN101209255A (zh) | 2008-07-02 |
| CN101209255B true CN101209255B (zh) | 2013-04-03 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007101932272A Active CN101209255B (zh) | 2006-12-28 | 2007-11-27 | 连翘酯苷注射制剂及其制备方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100317604A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2113252A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5546867B2 (cg-RX-API-DMAC7.html) |
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| CN (1) | CN101209255B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007344604A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008086698A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101919869B (zh) * | 2009-06-16 | 2013-06-05 | 上海医药工业研究院 | 一种连翘酯苷a药物组合物 |
| CN103054884B (zh) * | 2011-10-18 | 2015-11-04 | 鲁南制药集团股份有限公司 | 连翘酯苷在制备抗副流感病毒药物中的用途及其制剂 |
| CN103054885A (zh) * | 2011-10-18 | 2013-04-24 | 鲁南制药集团股份有限公司 | 连翘酯苷在制备抗甲型h1n1病毒药物中的用途及其制剂 |
| CN102512371A (zh) * | 2012-01-09 | 2012-06-27 | 北京农学院 | 一种连翘酯苷脂质体的制备方法 |
| KR102201194B1 (ko) * | 2013-11-18 | 2021-01-12 | 주식회사 엘지생활건강 | 피부 재생, 주름 개선, 항염증 또는 피부 미백용 조성물 |
| CN105168372A (zh) * | 2015-10-16 | 2015-12-23 | 山西大学 | 连翘叶或其组分在制备减肥制品中的应用 |
| CN112946113B (zh) * | 2021-02-01 | 2022-09-30 | 湖北医药学院 | 一种鉴别道地药材十堰连翘基源的方法 |
| CN114990054B (zh) * | 2022-07-22 | 2023-07-21 | 成都艾伟孚生物科技有限公司 | 一种辅助生殖用洗精受精液 |
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| CN1032876C (zh) * | 1991-08-12 | 1996-09-25 | 兖州矿务局科研所 | 高潜水塌陷区抗变形可搬迁房屋 |
| US6083921A (en) * | 1998-01-12 | 2000-07-04 | Xu; Kai Jian | Pharmaceutical compositions and method of using same |
| JP3882106B2 (ja) * | 2000-12-06 | 2007-02-14 | 三栄源エフ・エフ・アイ株式会社 | 退色抑制剤 |
| US6953786B2 (en) * | 2002-10-01 | 2005-10-11 | The Regents Of The University Of California | Compositions comprising plant-derived polyphenolic compounds and inhibitors of reactive oxygen species and methods of using thereof |
| JP2006188436A (ja) * | 2004-12-28 | 2006-07-20 | Japan Science & Technology Agency | 医用ポリフェノール溶液 |
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2007
- 2007-11-27 CN CN2007101932272A patent/CN101209255B/zh active Active
- 2007-12-24 EP EP07846011A patent/EP2113252A4/en not_active Withdrawn
- 2007-12-24 US US12/521,494 patent/US20100317604A1/en not_active Abandoned
- 2007-12-24 WO PCT/CN2007/003757 patent/WO2008086698A1/zh not_active Ceased
- 2007-12-24 KR KR1020097015858A patent/KR101117861B1/ko not_active Expired - Fee Related
- 2007-12-24 JP JP2009543329A patent/JP5546867B2/ja not_active Expired - Fee Related
- 2007-12-24 AU AU2007344604A patent/AU2007344604A1/en not_active Abandoned
Non-Patent Citations (3)
| Title |
|---|
| 万旭英等.连翘酯苷冻干粉的遗传毒性试验.《毒理学杂志》.2007,第21卷(第4期), * |
| 孙耀华.注射用冷冻干燥制品.《药剂学》.人民卫生出版社,2003,132. * |
| 张立伟等.连翘酯苷稳定性研究.《中成药》.2003,第25卷(第5期),353-356. * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010514706A (ja) | 2010-05-06 |
| EP2113252A4 (en) | 2012-10-31 |
| WO2008086698A1 (en) | 2008-07-24 |
| CN101209255A (zh) | 2008-07-02 |
| US20100317604A1 (en) | 2010-12-16 |
| KR101117861B1 (ko) | 2012-03-14 |
| KR20090095668A (ko) | 2009-09-09 |
| EP2113252A1 (en) | 2009-11-04 |
| AU2007344604A1 (en) | 2008-07-24 |
| JP5546867B2 (ja) | 2014-07-09 |
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