CN101203214B - 用于治疗皮肤结缔组织疾病的β2-肾上腺素受体激动剂 - Google Patents

用于治疗皮肤结缔组织疾病的β2-肾上腺素受体激动剂 Download PDF

Info

Publication number
CN101203214B
CN101203214B CN2006800165347A CN200680016534A CN101203214B CN 101203214 B CN101203214 B CN 101203214B CN 2006800165347 A CN2006800165347 A CN 2006800165347A CN 200680016534 A CN200680016534 A CN 200680016534A CN 101203214 B CN101203214 B CN 101203214B
Authority
CN
China
Prior art keywords
skin
weight
lupus erythematosus
agonist
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2006800165347A
Other languages
English (en)
Chinese (zh)
Other versions
CN101203214A (zh
Inventor
莫滕·斯洛斯·韦德纳
汉斯·克里斯蒂安·武尔夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astion Pharma AS
Original Assignee
Astion Development AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astion Development AS filed Critical Astion Development AS
Publication of CN101203214A publication Critical patent/CN101203214A/zh
Application granted granted Critical
Publication of CN101203214B publication Critical patent/CN101203214B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2006800165347A 2005-04-13 2006-04-12 用于治疗皮肤结缔组织疾病的β2-肾上腺素受体激动剂 Expired - Fee Related CN101203214B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200500529 2005-04-13
DKPA200500529 2005-04-13
PCT/DK2006/050013 WO2006108424A2 (en) 2005-04-13 2006-04-12 Beta-2 adrenoceptor agonists for treating connective tissue diseases of the skin

Publications (2)

Publication Number Publication Date
CN101203214A CN101203214A (zh) 2008-06-18
CN101203214B true CN101203214B (zh) 2012-11-21

Family

ID=36703472

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800165347A Expired - Fee Related CN101203214B (zh) 2005-04-13 2006-04-12 用于治疗皮肤结缔组织疾病的β2-肾上腺素受体激动剂

Country Status (28)

Country Link
US (4) US8426475B2 (https=)
EP (1) EP1719507B1 (https=)
JP (1) JP5021621B2 (https=)
KR (1) KR101355422B1 (https=)
CN (1) CN101203214B (https=)
AR (1) AR054249A1 (https=)
AT (1) ATE473735T1 (https=)
AU (1) AU2006233502B2 (https=)
BR (1) BRPI0609361A2 (https=)
CA (1) CA2604758C (https=)
CY (1) CY1111541T1 (https=)
DE (1) DE602006015387D1 (https=)
DK (1) DK1719507T3 (https=)
EA (1) EA016082B1 (https=)
ES (1) ES2348920T3 (https=)
HR (1) HRP20100552T1 (https=)
IL (1) IL186491A (https=)
MX (1) MX2007012794A (https=)
MY (1) MY147864A (https=)
NO (1) NO331211B1 (https=)
NZ (1) NZ562940A (https=)
PL (1) PL1719507T3 (https=)
PT (1) PT1719507E (https=)
RS (1) RS51464B (https=)
SI (1) SI1719507T1 (https=)
TW (1) TWI366457B (https=)
WO (1) WO2006108424A2 (https=)
ZA (1) ZA200708748B (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0604826D0 (en) * 2006-03-09 2006-04-19 Arakis Ltd The treatment of inflammatory disorders and pain
US8268813B2 (en) 2006-07-10 2012-09-18 Intervet International B.V. Zilpaterol enantiomer compositions and methods of making and using such compositions
GB0624757D0 (en) * 2006-12-12 2007-01-17 Sosei R & D Ltd Novel compounds
GB0805535D0 (en) 2008-03-27 2008-04-30 Univ Leicester Scar prevention
US20120252831A1 (en) * 2011-03-31 2012-10-04 Mustafa Nevzat Ilac Sanayii A.S. Compositions of opioid antagonists and methods for treating scleroderma therewith
CN102267917B (zh) * 2011-06-15 2013-07-31 浙江工业大学 一种盐酸甲氧那明的合成方法
WO2013171330A1 (en) * 2012-05-18 2013-11-21 Intervet International B.V. A method of enhancing performance in broiler chickens
GB2513297A (en) 2013-03-08 2014-10-29 Univ Leicester Methods
CN104606177B (zh) * 2014-11-21 2018-02-02 苏州君宁新药开发中心有限公司 左旋(r)沙丁胺醇制剂在治疗皮肤及粘膜创伤溃疡的药物应用
WO2018000098A1 (en) * 2016-06-30 2018-01-04 Cipher Pharmaceuticals Inc. Treatment of inflammatory myopathies
CN106580978A (zh) * 2016-11-30 2017-04-26 郑州仁宏医药科技有限公司 一种治疗皮炎的西药组合物及其应用
WO2019032147A1 (en) * 2017-08-10 2019-02-14 Avro Life Sciences, Inc. TRANSDERMAL DRUG DELIVERY SYSTEM
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714745D0 (en) * 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201903832D0 (en) 2019-03-20 2019-05-01 Atrogi Ab New compounds and methods
WO2020198466A1 (en) * 2019-03-27 2020-10-01 Curasen Therapeutics, Inc. Beta adrenergic agonist and methods of using the same
EP4076422A4 (en) 2019-12-18 2024-01-24 Curasen Therapeutics, Inc. Methods for improving neurological diseases and disorders
CN112300237A (zh) * 2020-04-13 2021-02-02 苏州恩泰新材料科技有限公司 海豹胆酸的制备方法及其应用
WO2022074228A1 (en) * 2020-10-09 2022-04-14 Mc2 Therapeutics Ltd Treatment of dermatological conditions
CN116236467B (zh) * 2023-02-07 2023-10-27 中国人民解放军总医院 西马特罗或其衍生物的新用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2255503A (en) * 1991-04-05 1992-11-11 Sandoz Ltd Bronchodilator enantiomers
WO2004073614A2 (en) * 2003-02-14 2004-09-02 Combinatorx, Incorporated Combination therapy for the treatment of immunoinflammatory disorders

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA7464B (en) 1973-01-16 1974-11-27 J Voorhees Treatment of proliferating skin diseases with papavine alkaloids
US4284623A (en) * 1979-11-09 1981-08-18 Beck Lee R Method of treating inflammation using bovine milk
SU895445A1 (ru) * 1980-05-15 1982-01-07 Военно-Медицинская Краснознаменная Академия Им. С.М.Кирова Способ лечени кожных форм красной волчанки
US4574129A (en) 1984-01-31 1986-03-04 Bristol-Myers Company Topical nonsteroidal anti-inflammatory methods
JPS61154201A (ja) 1984-12-26 1986-07-12 Matsushita Electric Ind Co Ltd 誘電体フイルタ
US4699777A (en) 1985-08-21 1987-10-13 Schering Corporation Compositions and method for enhancement of the transdermal flux of albuterol with a combination of 1-dodecyl-azacyclopheptan-2-one and urea
PH25150A (en) 1986-06-05 1991-03-13 Ciba Geigy Ag Novel pharmaceutical preparation for topical application
US4980159A (en) 1989-05-23 1990-12-25 Bristol-Myers Squibb Company Processes and compositions for the topical application of β-adrenergic agonists for pilomotor effects
RU2092105C1 (ru) * 1989-11-20 1997-10-10 Нижегородский научно-исследовательский кожно-венерологический институт Способ определения терапевтической тактики у больных очаговой склеродермией и дискоидной красной волчанкой
DE4014252A1 (de) 1990-05-04 1991-11-07 Boehringer Ingelheim Vetmed Enantiomerentrennung von cimaterol, (-)-cimaterol und dessen verwendung als arzneimittel oder als leistungsfoerderer
US5919827A (en) * 1990-07-11 1999-07-06 Sepracor Inc. Method for treating asthma using optically pure R(-) salmeterol
ES2053333T3 (es) 1990-07-26 1994-07-16 Searle & Co Sistema polimerico para la administracion de farmacos.
US5795564A (en) 1991-04-05 1998-08-18 Sepracor, Inc. Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol
JP3294876B2 (ja) 1992-07-20 2002-06-24 トキコ株式会社 給油装置
AU1533495A (en) 1994-01-12 1995-08-01 Byk Nederland Bv Phenyl ethanol amine ethers and uses thereof as beta-adreno-receptor agonists
JPH07304647A (ja) 1994-05-09 1995-11-21 Kao Corp マッサージ用組成物
GB9422306D0 (en) * 1994-11-04 1994-12-21 Sandoz Ltd Organic compounds
GB9510162D0 (en) * 1995-05-19 1995-07-12 Bouras Elias Compositions for the treatment of skin conditions
JPH09110674A (ja) 1995-10-16 1997-04-28 Kao Corp 浴用剤組成物
FR2740040B1 (fr) 1995-10-23 1997-12-05 Oreal Utilisation d'au moins un agoniste beta-adrenergique en tant qu'antagoniste de substance p
CA2286913C (en) 1997-04-30 2008-12-09 Bridge Pharma, Inc. Composition and methods using an eutomer
US6254882B1 (en) 1997-09-16 2001-07-03 Sepracor Inc. Methods and compositions for treating pulmonary disorders using optically pure (S)—salmeterol
WO2002018395A1 (en) * 2000-08-31 2002-03-07 Merck & Co., Inc. Phosphate derivatives as immunoregulatory agents
WO2002040021A2 (en) 2000-11-17 2002-05-23 Idenix (Cayman) Limited Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
JP4657605B2 (ja) 2001-12-03 2011-03-23 ワイス・エルエルシー 細胞質内ホスホリパーゼａ２の阻害剤
KR20050007460A (ko) 2002-04-19 2005-01-18 아스션 디벨롭먼트 에이/에스 베타-2 아드레날린 수용체 아고니스트 및 아미노당의배합물 및 면역조정 장애의 치료에 있어서의 이들의 용도
WO2003088997A2 (en) 2002-04-22 2003-10-30 Universiteit Utrecht Holding B.V. Reduction of unwanted immune reactions
US20060100181A1 (en) * 2002-05-03 2006-05-11 Jost-Price Edward R Combinations for the treatment of inflammatory skin disorders
DE10224888A1 (de) 2002-06-05 2003-12-24 Merck Patent Gmbh Pyridazinderivate
BR0314713A (pt) * 2002-09-24 2005-07-26 Combinatorx Inc Processos e reagentes para o tratamento de doenças e distúrbios associados com nìveis aumentados de citocinas pró-inflamatórias
US20040229849A1 (en) 2002-09-24 2004-11-18 Jost-Price Edward Roydon Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
US20040220153A1 (en) * 2002-09-24 2004-11-04 Jost-Price Edward Roydon Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
ZA200505523B (en) 2002-12-20 2006-09-27 Amgen Inc Asthma and allergic inflammation modulators
EP1613266A4 (en) * 2003-04-15 2009-05-06 Theraquest Biosciences Llc METHOD FOR TREATING PAIN AND COMPOSITIONS FOR USE THEREOF
JP2009514779A (ja) 2003-07-11 2009-04-09 グラクソ グループ リミテッド 医薬製剤
US20050192261A1 (en) 2003-09-15 2005-09-01 Jost-Price Edward R. Methods and reagents for the treatment of immunoinflammatory disorders
SG148198A1 (en) * 2003-11-21 2008-12-31 Combinatorx Inc Methods and reagents for the treatment of inflammatory disorders
EP1725226A2 (en) * 2004-03-17 2006-11-29 Sosei R&D Ltd. The treatment of inflammatory disorders and pain using beta-aminoalcohols
WO2005102296A2 (en) 2004-04-23 2005-11-03 Heptagen Limited Combinations for the treatment of immunoproliferative skin disorders such as psoriasis
WO2006027579A2 (en) 2004-09-07 2006-03-16 Sosei R & D Ltd. The treatment of inflammatory disorders and pain

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2255503A (en) * 1991-04-05 1992-11-11 Sandoz Ltd Bronchodilator enantiomers
WO2004073614A2 (en) * 2003-02-14 2004-09-02 Combinatorx, Incorporated Combination therapy for the treatment of immunoinflammatory disorders

Also Published As

Publication number Publication date
TW200719882A (en) 2007-06-01
ES2348920T3 (es) 2010-12-17
SI1719507T1 (sl) 2010-11-30
AU2006233502A1 (en) 2006-10-19
HRP20100552T1 (hr) 2010-11-30
MX2007012794A (es) 2008-02-22
PL1719507T3 (pl) 2010-12-31
EA016082B1 (ru) 2012-02-28
IL186491A (en) 2011-12-29
IL186491A0 (en) 2008-08-07
CA2604758C (en) 2014-11-25
BRPI0609361A2 (pt) 2010-03-30
NO331211B1 (no) 2011-10-31
US20190125699A1 (en) 2019-05-02
JP5021621B2 (ja) 2012-09-12
WO2006108424A2 (en) 2006-10-19
CN101203214A (zh) 2008-06-18
WO2006108424A3 (en) 2006-12-14
WO2006108424A9 (en) 2007-08-09
DE602006015387D1 (de) 2010-08-26
US20130237607A1 (en) 2013-09-12
PT1719507E (pt) 2010-10-21
EA200702204A1 (ru) 2008-04-28
JP2008535873A (ja) 2008-09-04
AU2006233502B2 (en) 2011-07-28
CY1111541T1 (el) 2015-08-05
US9907765B2 (en) 2018-03-06
TWI366457B (en) 2012-06-21
RS51464B (sr) 2011-04-30
DK1719507T3 (da) 2010-11-01
KR101355422B1 (ko) 2014-02-06
KR20080005957A (ko) 2008-01-15
ATE473735T1 (de) 2010-07-15
EP1719507B1 (en) 2010-07-14
US20170157068A1 (en) 2017-06-08
NO20075527L (no) 2008-01-14
NZ562940A (en) 2010-02-26
AR054249A1 (es) 2007-06-13
EP1719507A1 (en) 2006-11-08
ZA200708748B (en) 2010-03-31
HK1091739A1 (en) 2007-01-26
US8426475B2 (en) 2013-04-23
US20060235048A1 (en) 2006-10-19
MY147864A (en) 2013-01-31
CA2604758A1 (en) 2006-10-19

Similar Documents

Publication Publication Date Title
US9907765B2 (en) Treatment of connective tissue diseases of the skin
RU2538729C2 (ru) Применение агонистов альфа 2 адренергических рецепторов для лечения или предотвращения псориаза
JP2022543703A (ja) Ｃｂｄ製剤およびその使用
EP2958549A1 (en) Combinations of indigo naturalis and berberine and uses thereof
WO2017111069A1 (ja) 止痒剤
RU2630978C2 (ru) Фармацевтические составы для лечения заболеваний и состояний кожи, содержащие 7-(1н-имидазол-4-илметил)-5,6,7,8-тетрагидрохинолин
WO2019113519A1 (en) Topical ointment formulations of pde-4 inhibitor and their use in treating skin conditions
US9283217B2 (en) Pharmaceutical compositions comprising 7-(1 H-imidazol-4-ylmethyl)-5,6,7,8-tetrahydro-quinoline for treating skin diseases and conditions
US8513309B2 (en) Perfluorocarbons for use in treating pruritus
HK1091739B (en) Beta-2 adrenoceptor agonists for treating connective tissue diseases of the skin
WO2018000098A1 (en) Treatment of inflammatory myopathies
US20080255238A1 (en) Composition containing a thiourea derivative for preventing or treating pruritic or irritant skin diseases
JP5376481B1 (ja) 経皮吸収用医薬組成物
HK1175698B (en) Use of alpha 2 adrenergic receptor agonists for treating or preventing psoriasis

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: AP NEWCO, INC.

Free format text: FORMER OWNER: ASTION DEV AS

Effective date: 20150401

Owner name: CIPHER PHARMACEUTICALS INC.

Free format text: FORMER OWNER: ASTION DEV AS

Effective date: 20150401

C56 Change in the name or address of the patentee

Owner name: ASTION DEV AS

Free format text: FORMER NAME: AP NEWCO, INC.

CP03 Change of name, title or address

Address after: Dan Mays Kopf Lund

Patentee after: ASTION PHARMA A/S

Address before: Copenhagen

Patentee before: AP new Cool Co.

TR01 Transfer of patent right

Effective date of registration: 20150401

Address after: Ontario, Canada

Patentee after: Cipher Pharmaceutical Co.

Address before: Dan Mays Kopf Lund

Patentee before: ASTION PHARMA A/S

Effective date of registration: 20150401

Address after: Copenhagen

Patentee after: AP new Cool Co.

Address before: Copenhagen

Patentee before: ASTION PHARMA A/S

TR01 Transfer of patent right

Effective date of registration: 20200803

Address after: Tamba banmori

Patentee after: ASTION PHARMA A/S

Address before: Ontario, Canada

Patentee before: Cipher Pharmaceutical Co.

TR01 Transfer of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20121121

Termination date: 20210412

CF01 Termination of patent right due to non-payment of annual fee