CN101177433B - 左旋奥硝唑磷酸二钠五水合物及其制备方法和用途 - Google Patents
左旋奥硝唑磷酸二钠五水合物及其制备方法和用途 Download PDFInfo
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- CN101177433B CN101177433B CN2007101884870A CN200710188487A CN101177433B CN 101177433 B CN101177433 B CN 101177433B CN 2007101884870 A CN2007101884870 A CN 2007101884870A CN 200710188487 A CN200710188487 A CN 200710188487A CN 101177433 B CN101177433 B CN 101177433B
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- disodium phosphate
- ornidazole
- ornidazole disodium
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- pentahydrate
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- IPWKIXLWTCNBKN-ZCFIWIBFSA-N (2s)-1-chloro-3-(2-methyl-5-nitroimidazol-1-yl)propan-2-ol Chemical compound CC1=NC=C([N+]([O-])=O)N1C[C@H](O)CCl IPWKIXLWTCNBKN-ZCFIWIBFSA-N 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
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- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN2007101884870A CN101177433B (zh) | 2007-12-05 | 2007-12-05 | 左旋奥硝唑磷酸二钠五水合物及其制备方法和用途 |
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CN2007101884870A CN101177433B (zh) | 2007-12-05 | 2007-12-05 | 左旋奥硝唑磷酸二钠五水合物及其制备方法和用途 |
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CN101177433B true CN101177433B (zh) | 2010-10-06 |
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Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102516298A (zh) * | 2011-12-09 | 2012-06-27 | 陕西合成药业有限公司 | 左旋奥硝唑磷酸酯稳定的药用盐及其制备方法和用途 |
CN102516299A (zh) * | 2011-12-09 | 2012-06-27 | 陕西合成药业有限公司 | 左旋奥硝唑磷酸酯氨基酸盐及其制备方法和用途 |
CN102731571A (zh) * | 2012-02-14 | 2012-10-17 | 陕西合成药业有限公司 | 一种新的结晶性左旋奥硝唑磷酸酯二钠水合物及其用途 |
CN104610356A (zh) * | 2014-11-04 | 2015-05-13 | 扬子江药业集团南京海陵药业有限公司 | 一种稳定的磷酸酯结晶物及其制备方法 |
CN106467558A (zh) * | 2015-08-18 | 2017-03-01 | 陕西合成药业股份有限公司 | 一种磷酸左奥硝唑酯二钠晶型及其制备方法和药用组合物的用途 |
CN106667924A (zh) * | 2015-11-05 | 2017-05-17 | 陕西合成药业股份有限公司 | 一种稳定的磷酸左奥硝唑酯二钠冻干制剂及其制备方法 |
CN105646580A (zh) * | 2016-03-04 | 2016-06-08 | 中山福运生物科技有限公司 | 一种五水合左旋奥硝唑磷酸二钠的生产方法 |
CN107151257A (zh) * | 2016-03-04 | 2017-09-12 | 陕西合成药业股份有限公司 | 一种磷酸左奥硝唑酯二钠六水合物晶型及其制备方法 |
CN107235911A (zh) * | 2016-03-28 | 2017-10-10 | 陕西合成药业股份有限公司 | 一种2-甲基-4-硝基咪唑衍生物及其制备方法和药用组合物的用途 |
CN107857779A (zh) * | 2016-09-22 | 2018-03-30 | 天地人和生物科技有限公司 | 一种制备高纯度磷酸左奥硝唑酯二钠的方法 |
CN110538146A (zh) * | 2019-10-08 | 2019-12-06 | 四川太平洋药业有限责任公司 | 一种左奥硝唑氯化钠注射液及制备工艺 |
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CN1789250A (zh) * | 2005-12-16 | 2006-06-21 | 西安新安医药科技有限公司 | 一组硝基咪唑类衍生物的光学对映体、制备方法及其用途 |
CN1817868A (zh) * | 2005-12-15 | 2006-08-16 | 西安新安医药科技有限公司 | 一组抗厌氧菌感染的奥硝唑类衍生物及其制备方法 |
CN1887874A (zh) * | 2006-08-11 | 2007-01-03 | 西安新安医药科技有限公司 | 一种奥硝唑的衍生物、制备方法及用途 |
CN101007823A (zh) * | 2006-01-06 | 2007-08-01 | 西安新安医药科技有限公司 | 左旋奥硝唑磷酸酯及其制备方法和用途 |
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- 2007-12-05 CN CN2007101884870A patent/CN101177433B/zh active Active
Patent Citations (4)
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CN1817868A (zh) * | 2005-12-15 | 2006-08-16 | 西安新安医药科技有限公司 | 一组抗厌氧菌感染的奥硝唑类衍生物及其制备方法 |
CN1789250A (zh) * | 2005-12-16 | 2006-06-21 | 西安新安医药科技有限公司 | 一组硝基咪唑类衍生物的光学对映体、制备方法及其用途 |
CN101007823A (zh) * | 2006-01-06 | 2007-08-01 | 西安新安医药科技有限公司 | 左旋奥硝唑磷酸酯及其制备方法和用途 |
CN1887874A (zh) * | 2006-08-11 | 2007-01-03 | 西安新安医药科技有限公司 | 一种奥硝唑的衍生物、制备方法及用途 |
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CN 1887874 A,全文. |
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Owner name: SHAANXI SYNTHETIC PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: SHANXI XIN'AN MEDICAL SCIENCE AND TECHNOLOGY CO., LTD. Effective date: 20130929 |
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Effective date of registration: 20130929 Address after: 710075 Shaanxi city of Xi'an province high three road No. 2 room 30803 Genting Haijia Patentee after: Shaanxi Synthetic Pharmaceutical Co, Ltd. Address before: 710075 Shaanxi city of Xi'an province high tech Zone Three New Road No. 2 Haijia Genting 30803 Patentee before: Shanxi Xin'an Medical Science and Technology Co., Ltd. |
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Owner name: SHAANXI HECHENG PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: SHAANXI SYNTHETIC PHARMACEUTICAL CO., LTD. |
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Address after: Xi'an high tech Zone high three road No. 2 building 30803 commercial sea cloud chamber Patentee after: SHAANXI SYNTHETIC PHARMACEUTICAL Co.,Ltd. Address before: 710075 Shaanxi city of Xi'an province high three road No. 2 room 30803 Genting Haijia Patentee before: Shaanxi Synthetic Pharmaceutical Co, Ltd. |
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Address after: Room 30803, Haijia Yunding commercial and residential building, No.2, Gaoxin Third Road, high tech Zone, Xi'an City, Shaanxi Province Patentee after: Huachuang Synthetic Pharmaceutical Co.,Ltd. Address before: Xi'an high tech Zone high three road No. 2 building 30803 commercial sea cloud chamber Patentee before: SHAANXI SYNTHETIC PHARMACEUTICAL Co.,Ltd. |
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