CN101171236A - 抗肿瘤的四氢嘧啶 - Google Patents

抗肿瘤的四氢嘧啶 Download PDF

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Publication number
CN101171236A
CN101171236A CNA2006800149611A CN200680014961A CN101171236A CN 101171236 A CN101171236 A CN 101171236A CN A2006800149611 A CNA2006800149611 A CN A2006800149611A CN 200680014961 A CN200680014961 A CN 200680014961A CN 101171236 A CN101171236 A CN 101171236A
Authority
CN
China
Prior art keywords
unsubstituted
replacement
compound
alkyl
optional
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800149611A
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English (en)
Chinese (zh)
Inventor
约瑟·费尔南多·雷耶斯贝尼特斯
玛丽亚·德尔·卡门·奎瓦斯马昌特
戴维·蒙塔尔沃洛沃
玛·赫苏斯·马丁洛佩斯
玛丽亚·克里斯蒂娜·马特奥乌尔瓦诺
安德烈斯·弗兰切斯基索洛索
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmamar SA
Original Assignee
Pharmamar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmamar SA filed Critical Pharmamar SA
Publication of CN101171236A publication Critical patent/CN101171236A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CNA2006800149611A 2005-05-03 2006-05-03 抗肿瘤的四氢嘧啶 Pending CN101171236A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05076037 2005-05-03
EP05076037.0 2005-05-03

Publications (1)

Publication Number Publication Date
CN101171236A true CN101171236A (zh) 2008-04-30

Family

ID=36649783

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800149611A Pending CN101171236A (zh) 2005-05-03 2006-05-03 抗肿瘤的四氢嘧啶

Country Status (13)

Country Link
US (1) US20100216817A1 (https=)
EP (1) EP1879870A1 (https=)
JP (1) JP2008540362A (https=)
KR (1) KR20080007640A (https=)
CN (1) CN101171236A (https=)
AU (1) AU2006243407A1 (https=)
CA (1) CA2605784A1 (https=)
EA (1) EA013160B1 (https=)
IL (1) IL186781A0 (https=)
MX (1) MX2007013683A (https=)
NO (1) NO20076162L (https=)
NZ (1) NZ563054A (https=)
WO (1) WO2006117197A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102210868A (zh) * 2011-04-29 2011-10-12 济南环肽医药科技有限公司 四氢嘧啶及其衍生物在制备口服吸收促进剂中的应用
CN108120792A (zh) * 2017-12-14 2018-06-05 青海出入境检验检疫局检验检疫综合技术中心 一种四氢嘧啶的高效液相检测及含量测定方法
CN110156697A (zh) * 2019-05-30 2019-08-23 常州沃腾化工科技有限公司 一种1,2-二甲基-1,4,5,6-四氢嘧啶的经济合成方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20231233T1 (hr) 2017-04-27 2024-01-19 Pharma Mar, S.A. Antitumorski spojevi

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2743255A (en) * 1952-12-19 1956-04-24 Petrolite Corp Amine-modified thermoplastic phenolaldehyde resins and method of making same
US4292429A (en) * 1978-03-08 1981-09-29 Ciba-Geigy Corporation Imidazole urea and amido compounds

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102210868A (zh) * 2011-04-29 2011-10-12 济南环肽医药科技有限公司 四氢嘧啶及其衍生物在制备口服吸收促进剂中的应用
CN108120792A (zh) * 2017-12-14 2018-06-05 青海出入境检验检疫局检验检疫综合技术中心 一种四氢嘧啶的高效液相检测及含量测定方法
CN110156697A (zh) * 2019-05-30 2019-08-23 常州沃腾化工科技有限公司 一种1,2-二甲基-1,4,5,6-四氢嘧啶的经济合成方法
CN110156697B (zh) * 2019-05-30 2022-05-06 常州沃腾化工科技有限公司 一种1,2-二甲基-1,4,5,6-四氢嘧啶的合成方法

Also Published As

Publication number Publication date
NZ563054A (en) 2010-09-30
MX2007013683A (es) 2007-12-03
EA013160B1 (ru) 2010-02-26
CA2605784A1 (en) 2006-11-09
EP1879870A1 (en) 2008-01-23
US20100216817A1 (en) 2010-08-26
IL186781A0 (en) 2008-02-09
NO20076162L (no) 2007-11-29
JP2008540362A (ja) 2008-11-20
WO2006117197A1 (en) 2006-11-09
AU2006243407A1 (en) 2006-11-09
EA200702397A1 (ru) 2008-02-28
KR20080007640A (ko) 2008-01-22

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SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20080430