CN101163716A - 白细胞介素-6聚乙二醇结合物及其制备方法和应用 - Google Patents

白细胞介素-6聚乙二醇结合物及其制备方法和应用 Download PDF

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Publication number
CN101163716A
CN101163716A CNA2006800133365A CN200680013336A CN101163716A CN 101163716 A CN101163716 A CN 101163716A CN A2006800133365 A CNA2006800133365 A CN A2006800133365A CN 200680013336 A CN200680013336 A CN 200680013336A CN 101163716 A CN101163716 A CN 101163716A
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China
Prior art keywords
interleukin
polyethylene glycol
peg
glycol conjugate
conjugate
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CNA2006800133365A
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CN101163716B (zh
Inventor
张雪梅
袁涛
张珂
饶海林
邓杰
王智杰
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Chengdu Institute of Biological Products Co Ltd
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Chengdu Institute of Biological Products Co Ltd
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Priority to CN2006800133365A priority Critical patent/CN101163716B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6

Abstract

本发明提供了一种白细胞介素－6聚乙二醇结合物，和由白细胞介素－6聚乙二醇结合物添加药学上可接受的辅料制备而成的药物组合物，以及白细胞介素－6聚乙二醇结合物在制备治疗血小板减少症的药物、放化疗辅助用药物、免疫增强药物的应用。经PEG单修饰后的白细胞介素－6的稳定性大大提高，它的体内半衰期长，血清清除率低，使用剂量和频率大能为减少，副作用也大为降低。既能方便患者使用，降低使用成本，也能提高使用安全性，大大减轻患者的痛苦。同时，本发明的单修饰的人白细胞介素－6聚乙二醇结合物的均一性好，能达到临床用药安全、有效、质量可控的要求。

Description

PCT国内申请，说明书已公开。

Claims (1)

1.PCT国内申请，权利要求书已公开。
CN2006800133365A 2005-04-30 2006-04-30 白细胞介素-6聚乙二醇结合物及其制备方法和应用 Expired - Fee Related CN101163716B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2006800133365A CN101163716B (zh) 2005-04-30 2006-04-30 白细胞介素-6聚乙二醇结合物及其制备方法和应用

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN200510020835 2005-04-30
CN200510020835.4 2005-04-30
PCT/CN2006/000891 WO2006116948A1 (fr) 2005-04-30 2006-04-30 Conjugue de polyethylene glycol et d’interleukine-6 et son procede de preparation et son utilisation
CN2006800133365A CN101163716B (zh) 2005-04-30 2006-04-30 白细胞介素-6聚乙二醇结合物及其制备方法和应用

Publications (2)

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CN101163716A true CN101163716A (zh) 2008-04-16
CN101163716B CN101163716B (zh) 2011-09-07

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CN2006800133365A Expired - Fee Related CN101163716B (zh) 2005-04-30 2006-04-30 白细胞介素-6聚乙二醇结合物及其制备方法和应用

Country Status (2)

Country Link
CN (1) CN101163716B (zh)
WO (1) WO2006116948A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112110982A (zh) * 2020-09-24 2020-12-22 科兴生物制药股份有限公司 一种蛋白质定点聚乙二醇化修饰的制备方法
CN114392348A (zh) * 2021-03-11 2022-04-26 河北菲尼斯生物技术有限公司 聚乙二醇定点修饰的白介素-2及其制备方法和用途

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009069133A2 (en) * 2007-11-28 2009-06-04 Hadasit Medical Research Services And Development Ltd. Methods for the treatment of radiation or chemotherapy-induced tissue damage
CN101602801A (zh) * 2008-06-13 2009-12-16 杭州九源基因工程有限公司 聚乙二醇单修饰的重组人粒细胞集落刺激因子突变体
CN114668852A (zh) * 2017-09-30 2022-06-28 天津键凯科技有限公司 一种聚乙二醇-多肽和蛋白类药物的结合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04218000A (ja) * 1990-02-13 1992-08-07 Kirin Amgen Inc 修飾ポリペプチド
WO2002026265A2 (en) * 2000-09-29 2002-04-04 Schering Corporation Pegylated interleukin-10
KR100480430B1 (ko) * 2001-12-04 2005-04-06 선바이오(주) 인터페론-베타와 폴리에틸렌글리콜 유도체의 배합체
CA2536643C (en) * 2003-08-25 2013-11-12 Toray Industries, Inc. Interferon-.beta. complex
CN1651461A (zh) * 2004-11-29 2005-08-10 华东理工大学 聚乙二醇修饰重组人白介素及其制备方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112110982A (zh) * 2020-09-24 2020-12-22 科兴生物制药股份有限公司 一种蛋白质定点聚乙二醇化修饰的制备方法
CN112110982B (zh) * 2020-09-24 2021-12-07 科兴生物制药股份有限公司 一种蛋白质定点聚乙二醇化修饰的制备方法
CN114392348A (zh) * 2021-03-11 2022-04-26 河北菲尼斯生物技术有限公司 聚乙二醇定点修饰的白介素-2及其制备方法和用途

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CN101163716B (zh) 2011-09-07
WO2006116948A1 (fr) 2006-11-09

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Address after: Jinjiang District Jinhua Road Chengdu City, Sichuan province 610023 Chinese No. 379

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