CN101163703B - 用作肽脱甲酰基酶（pdf）抑制剂的咪唑并[1,2-a]吡啶衍生物 - Google Patents

用作肽脱甲酰基酶（pdf）抑制剂的咪唑并[1,2-a]吡啶衍生物 Download PDF

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Publication number
CN101163703B
CN101163703B CN2006800139164A CN200680013916A CN101163703B CN 101163703 B CN101163703 B CN 101163703B CN 2006800139164 A CN2006800139164 A CN 2006800139164A CN 200680013916 A CN200680013916 A CN 200680013916A CN 101163703 B CN101163703 B CN 101163703B
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CN
China
Prior art keywords
imidazo
hydroxy
ylamino
acetamide
pyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN2006800139164A
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English (en)
Chinese (zh)
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CN101163703A (zh
Inventor
M·托尔曼
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Novartis AG
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2006800139164A 2005-04-25 2006-04-24 用作肽脱甲酰基酶（pdf）抑制剂的咪唑并[1,2-a]吡啶衍生物 Expired - Fee Related CN101163703B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005019181A DE102005019181A1 (de) 2005-04-25 2005-04-25 Peptid-Deformylase (PDF) Inhibitoren 1
DE102005019181.9 2005-04-25
PCT/EP2006/003767 WO2006114263A1 (en) 2005-04-25 2006-04-24 Imidazo [1, 2-a] pyridine derivatives useful as peptide deformylase (pdf) inhibitors

Publications (2)

Publication Number Publication Date
CN101163703A CN101163703A (zh) 2008-04-16
CN101163703B true CN101163703B (zh) 2010-12-15

Family

ID=36692610

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800139164A Expired - Fee Related CN101163703B (zh) 2005-04-25 2006-04-24 用作肽脱甲酰基酶（pdf）抑制剂的咪唑并[1,2-a]吡啶衍生物

Country Status (12)

Country Link
US (2) US7662833B2 (https=)
EP (1) EP1877408A1 (https=)
JP (1) JP2008538778A (https=)
KR (1) KR20080002867A (https=)
CN (1) CN101163703B (https=)
AU (1) AU2006239548B8 (https=)
BR (1) BRPI0609946A2 (https=)
CA (1) CA2605925A1 (https=)
DE (1) DE102005019181A1 (https=)
MX (1) MX2007013225A (https=)
RU (1) RU2420526C2 (https=)
WO (1) WO2006114263A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008068392A1 (fr) * 2006-12-07 2008-06-12 Commissariat A L'energie Atomique Nouveaux derives fluorophores imidazo [1,2-a] pyridin-3-yl-amine et leur procede de preparation
CN101855222A (zh) * 2007-05-10 2010-10-06 通用电气健康护理有限公司 对大麻素cb2受体具有活性的咪唑并(1,2-a)吡啶和相关化合物
DE102007040336A1 (de) 2007-08-27 2009-03-05 Johann Wolfgang Goethe-Universität Frankfurt am Main Neue Inhibitoren der 5-Lipoxygenase und deren Verwendungen
FR2925903B1 (fr) * 2008-01-02 2011-01-21 Sanofi Aventis DERIVES 6-HETEROCYCLIQUE-IMIDAZO°1,2-a!PYRIDINE-2- CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
WO2010032195A1 (en) 2008-09-16 2010-03-25 Csir Imidazopyridines and imidazopyrimidines as hiv-i reverse transcriptase inhibitors
CN101729939B (zh) * 2008-10-31 2012-12-05 中兴通讯股份有限公司 无源光网络带宽分配方法及系统
WO2011041713A2 (en) * 2009-10-02 2011-04-07 Glaxosmithkline Llc Piperazinyl antiviral agents
EP2601194B1 (en) 2010-08-03 2016-05-25 Merck Sharp & Dohme Corp. Fused-imidazoyl compounds useful as antimicrobial agents
CA2822357A1 (en) 2010-12-22 2012-06-28 Abbvie Inc. Hepatitis c inhibitors and uses thereof
CN103957910A (zh) * 2011-10-21 2014-07-30 葛兰素史克有限责任公司 增加先天免疫反应的化合物和方法
KR101650539B1 (ko) 2014-10-15 2016-08-26 장준구 다각도로 발광하는 led패키지
CN107245050B (zh) * 2016-12-05 2019-10-25 徐州医科大学 香草醛异羟肟酸类衍生物及其应用
EP3750878B1 (en) * 2019-06-14 2025-05-14 Vivoryon Therapeutics N.V. Heteroaromatic inhibitors of astacin proteinases

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0632040A1 (en) * 1993-07-02 1995-01-04 Takeda Chemical Industries, Ltd. Antibacterial imidazole derivatives
WO2001085170A1 (en) * 2000-05-05 2001-11-15 Smithkline Beecham Corporation Peptide deformylase inhibitors
WO2003101442A1 (en) * 2002-05-31 2003-12-11 Smithkline Beecham Corporation Peptide deformylase inhibitors
WO2004052919A2 (en) * 2002-12-11 2004-06-24 Smithkline Beecham Corporation Peptide deformylase inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU176214B (en) * 1977-05-18 1981-01-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new 5,6-dihydro-imidazo-square bracket-5,1-a-square bracket closed-isoquinolin derivatives
CA1164459A (en) * 1980-11-11 1984-03-27 Yung-Hsiung Yang Process for preparing (imidazo¬1,2-a|pyridine- 2-yl)-carbostyril or -3,4-dihydrocarbostyryl derivatives
JPS61218589A (ja) * 1985-03-26 1986-09-29 Eisai Co Ltd ５―（６―イミダゾ〔１，２―ａ〕ピリジニル）ピリジン誘導体
DE69729007T2 (de) * 1996-08-07 2005-04-07 Darwin Discovery Ltd., Slough Hydroxamsäure- und carbonsäure-derivate mit mmp und tnf hemmender wirkung
DE10050663A1 (de) * 2000-10-13 2002-04-18 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung
TWI312347B (en) * 2001-02-08 2009-07-21 Eisai R&D Man Co Ltd Bicyclic nitrogen-containing condensed ring compounds
DE10150172A1 (de) * 2001-10-11 2003-04-30 Morphochem Ag Neue Verbindungen, die Protein Tyrosin Phosphatase 1B (PTP-1B) inhibieren
US20040127719A1 (en) * 2002-03-08 2004-07-01 Kexin Yang Alpha-isocyanocarboxylate solid support templates, method of preparation and for using the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0632040A1 (en) * 1993-07-02 1995-01-04 Takeda Chemical Industries, Ltd. Antibacterial imidazole derivatives
WO2001085170A1 (en) * 2000-05-05 2001-11-15 Smithkline Beecham Corporation Peptide deformylase inhibitors
WO2003101442A1 (en) * 2002-05-31 2003-12-11 Smithkline Beecham Corporation Peptide deformylase inhibitors
WO2004052919A2 (en) * 2002-12-11 2004-06-24 Smithkline Beecham Corporation Peptide deformylase inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Chen, Jack J. et al..Multi-Component Synthesis of Imidazo[1,2-a] AnnulatedHeterocycles on α-Isocyano Resin Esters.Synlett 8.2001,(8),1263-1265.
Chen, Jack J. et al..Multi-Component Synthesis of Imidazo[1,2-a] AnnulatedHeterocycles on α-Isocyano Resin Esters.Synlett 8.2001,(8),1263-1265. *
EP 0632040 A1,全文.

Also Published As

Publication number Publication date
US7662833B2 (en) 2010-02-16
RU2007143512A (ru) 2009-06-10
AU2006239548B8 (en) 2010-08-26
JP2008538778A (ja) 2008-11-06
KR20080002867A (ko) 2008-01-04
CA2605925A1 (en) 2006-11-02
BRPI0609946A2 (pt) 2010-05-11
EP1877408A1 (en) 2008-01-16
US20080188515A1 (en) 2008-08-07
RU2420526C2 (ru) 2011-06-10
AU2006239548A1 (en) 2006-11-02
CN101163703A (zh) 2008-04-16
WO2006114263A1 (en) 2006-11-02
MX2007013225A (es) 2007-12-12
AU2006239548B2 (en) 2010-04-29
US20090215816A1 (en) 2009-08-27
DE102005019181A1 (de) 2006-10-26

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Granted publication date: 20101215

Termination date: 20120424