AU2006239548B8 - Imidazo [1, 2-A] pyridine derivatives useful as peptide deformylase (PDF) inhibitors - Google Patents

Imidazo [1, 2-A] pyridine derivatives useful as peptide deformylase (PDF) inhibitors Download PDF

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Publication number
AU2006239548B8
AU2006239548B8 AU2006239548A AU2006239548A AU2006239548B8 AU 2006239548 B8 AU2006239548 B8 AU 2006239548B8 AU 2006239548 A AU2006239548 A AU 2006239548A AU 2006239548 A AU2006239548 A AU 2006239548A AU 2006239548 B8 AU2006239548 B8 AU 2006239548B8
Authority
AU
Australia
Prior art keywords
hydroxy
imidazo
ylamino
acetamide
pyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006239548A
Other languages
English (en)
Other versions
AU2006239548A1 (en
AU2006239548B2 (en
Inventor
Michael Thormann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU2006239548A1 publication Critical patent/AU2006239548A1/en
Application granted granted Critical
Publication of AU2006239548B2 publication Critical patent/AU2006239548B2/en
Publication of AU2006239548B8 publication Critical patent/AU2006239548B8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2006239548A 2005-04-25 2006-04-24 Imidazo [1, 2-A] pyridine derivatives useful as peptide deformylase (PDF) inhibitors Ceased AU2006239548B8 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005019181A DE102005019181A1 (de) 2005-04-25 2005-04-25 Peptid-Deformylase (PDF) Inhibitoren 1
DE102005019181.9 2005-04-25
PCT/EP2006/003767 WO2006114263A1 (en) 2005-04-25 2006-04-24 Imidazo [1, 2-a] pyridine derivatives useful as peptide deformylase (pdf) inhibitors

Publications (3)

Publication Number Publication Date
AU2006239548A1 AU2006239548A1 (en) 2006-11-02
AU2006239548B2 AU2006239548B2 (en) 2010-04-29
AU2006239548B8 true AU2006239548B8 (en) 2010-08-26

Family

ID=36692610

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006239548A Ceased AU2006239548B8 (en) 2005-04-25 2006-04-24 Imidazo [1, 2-A] pyridine derivatives useful as peptide deformylase (PDF) inhibitors

Country Status (12)

Country Link
US (2) US7662833B2 (https=)
EP (1) EP1877408A1 (https=)
JP (1) JP2008538778A (https=)
KR (1) KR20080002867A (https=)
CN (1) CN101163703B (https=)
AU (1) AU2006239548B8 (https=)
BR (1) BRPI0609946A2 (https=)
CA (1) CA2605925A1 (https=)
DE (1) DE102005019181A1 (https=)
MX (1) MX2007013225A (https=)
RU (1) RU2420526C2 (https=)
WO (1) WO2006114263A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008068392A1 (fr) * 2006-12-07 2008-06-12 Commissariat A L'energie Atomique Nouveaux derives fluorophores imidazo [1,2-a] pyridin-3-yl-amine et leur procede de preparation
CN101855222A (zh) * 2007-05-10 2010-10-06 通用电气健康护理有限公司 对大麻素cb2受体具有活性的咪唑并(1,2-a)吡啶和相关化合物
DE102007040336A1 (de) 2007-08-27 2009-03-05 Johann Wolfgang Goethe-Universität Frankfurt am Main Neue Inhibitoren der 5-Lipoxygenase und deren Verwendungen
FR2925903B1 (fr) * 2008-01-02 2011-01-21 Sanofi Aventis DERIVES 6-HETEROCYCLIQUE-IMIDAZO°1,2-a!PYRIDINE-2- CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
WO2010032195A1 (en) 2008-09-16 2010-03-25 Csir Imidazopyridines and imidazopyrimidines as hiv-i reverse transcriptase inhibitors
CN101729939B (zh) * 2008-10-31 2012-12-05 中兴通讯股份有限公司 无源光网络带宽分配方法及系统
WO2011041713A2 (en) * 2009-10-02 2011-04-07 Glaxosmithkline Llc Piperazinyl antiviral agents
EP2601194B1 (en) 2010-08-03 2016-05-25 Merck Sharp & Dohme Corp. Fused-imidazoyl compounds useful as antimicrobial agents
CA2822357A1 (en) 2010-12-22 2012-06-28 Abbvie Inc. Hepatitis c inhibitors and uses thereof
CN103957910A (zh) * 2011-10-21 2014-07-30 葛兰素史克有限责任公司 增加先天免疫反应的化合物和方法
KR101650539B1 (ko) 2014-10-15 2016-08-26 장준구 다각도로 발광하는 led패키지
CN107245050B (zh) * 2016-12-05 2019-10-25 徐州医科大学 香草醛异羟肟酸类衍生物及其应用
EP3750878B1 (en) * 2019-06-14 2025-05-14 Vivoryon Therapeutics N.V. Heteroaromatic inhibitors of astacin proteinases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040127719A1 (en) * 2002-03-08 2004-07-01 Kexin Yang Alpha-isocyanocarboxylate solid support templates, method of preparation and for using the same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU176214B (en) * 1977-05-18 1981-01-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new 5,6-dihydro-imidazo-square bracket-5,1-a-square bracket closed-isoquinolin derivatives
CA1164459A (en) * 1980-11-11 1984-03-27 Yung-Hsiung Yang Process for preparing (imidazo¬1,2-a|pyridine- 2-yl)-carbostyril or -3,4-dihydrocarbostyryl derivatives
JPS61218589A (ja) * 1985-03-26 1986-09-29 Eisai Co Ltd ５―（６―イミダゾ〔１，２―ａ〕ピリジニル）ピリジン誘導体
JPH0717971A (ja) * 1993-07-02 1995-01-20 Takeda Chem Ind Ltd イミダゾール誘導体、その製造法及び用途
DE69729007T2 (de) * 1996-08-07 2005-04-07 Darwin Discovery Ltd., Slough Hydroxamsäure- und carbonsäure-derivate mit mmp und tnf hemmender wirkung
AR029916A1 (es) * 2000-05-05 2003-07-23 Smithkline Beecham Corp N-formil-n-hidroxi-ariloxi alquilaminas y metodos para tratar infecciones bacterianas
DE10050663A1 (de) * 2000-10-13 2002-04-18 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung
TWI312347B (en) * 2001-02-08 2009-07-21 Eisai R&D Man Co Ltd Bicyclic nitrogen-containing condensed ring compounds
DE10150172A1 (de) * 2001-10-11 2003-04-30 Morphochem Ag Neue Verbindungen, die Protein Tyrosin Phosphatase 1B (PTP-1B) inhibieren
UY27813A1 (es) * 2002-05-31 2003-12-31 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
AU2003296960A1 (en) * 2002-12-11 2004-06-30 Smithkline Beecham Corporation Peptide deformylase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040127719A1 (en) * 2002-03-08 2004-07-01 Kexin Yang Alpha-isocyanocarboxylate solid support templates, method of preparation and for using the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEN, J. J. et al., Synlett, 2001, 8, 1263-1265 *

Also Published As

Publication number Publication date
US7662833B2 (en) 2010-02-16
RU2007143512A (ru) 2009-06-10
JP2008538778A (ja) 2008-11-06
KR20080002867A (ko) 2008-01-04
CA2605925A1 (en) 2006-11-02
BRPI0609946A2 (pt) 2010-05-11
EP1877408A1 (en) 2008-01-16
US20080188515A1 (en) 2008-08-07
RU2420526C2 (ru) 2011-06-10
AU2006239548A1 (en) 2006-11-02
CN101163703A (zh) 2008-04-16
WO2006114263A1 (en) 2006-11-02
MX2007013225A (es) 2007-12-12
AU2006239548B2 (en) 2010-04-29
CN101163703B (zh) 2010-12-15
US20090215816A1 (en) 2009-08-27
DE102005019181A1 (de) 2006-10-26

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
TH Corrigenda

Free format text: IN VOL 24, NO 17, PAGE(S) 1953 UNDER THE HEADING APPLICATIONS ACCEPTED - NAME INDEX UNDER THE NAME NOVARTIS AG, APPLICATION NO. 2006239548, UNDER INID (54) CORRECT THE TITLE TO READ IMIDAZO [1, 2-A] PYRIDINE DERIVATIVES USEFUL AS PEPTIDE DEFORMYLASE (PDF) INHIBITORS

MK14 Patent ceased section 143(a) (annual fees not paid) or expired