CN101157685A - 4-(哌啶基)(2-吡啶基)亚甲基-(e)-o-甲基肟及其盐的合成 - Google Patents

4-(哌啶基)(2-吡啶基)亚甲基-(e)-o-甲基肟及其盐的合成 Download PDF

Info

Publication number
CN101157685A
CN101157685A CNA2007101863662A CN200710186366A CN101157685A CN 101157685 A CN101157685 A CN 101157685A CN A2007101863662 A CNA2007101863662 A CN A2007101863662A CN 200710186366 A CN200710186366 A CN 200710186366A CN 101157685 A CN101157685 A CN 101157685A
Authority
CN
China
Prior art keywords
formula
compound
acid
compounds
isomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2007101863662A
Other languages
English (en)
Chinese (zh)
Inventor
吴文学
廖宏标
蔡介士
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CN101157685A publication Critical patent/CN101157685A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CNA2007101863662A 2001-10-15 2002-10-15 4-(哌啶基)(2-吡啶基)亚甲基-(e)-o-甲基肟及其盐的合成 Pending CN101157685A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32956101P 2001-10-15 2001-10-15
US60/329561 2001-10-15

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB028204271A Division CN100360520C (zh) 2001-10-15 2002-10-15 4-(哌啶基)(2-吡啶基)亚甲基-(e)-o-甲基肟及其盐的合成

Publications (1)

Publication Number Publication Date
CN101157685A true CN101157685A (zh) 2008-04-09

Family

ID=23285979

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2007101863662A Pending CN101157685A (zh) 2001-10-15 2002-10-15 4-(哌啶基)(2-吡啶基)亚甲基-(e)-o-甲基肟及其盐的合成
CNB028204271A Expired - Fee Related CN100360520C (zh) 2001-10-15 2002-10-15 4-(哌啶基)(2-吡啶基)亚甲基-(e)-o-甲基肟及其盐的合成

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB028204271A Expired - Fee Related CN100360520C (zh) 2001-10-15 2002-10-15 4-(哌啶基)(2-吡啶基)亚甲基-(e)-o-甲基肟及其盐的合成

Country Status (13)

Country Link
EP (1) EP1436282B1 (enExample)
JP (1) JP4425632B2 (enExample)
CN (2) CN101157685A (enExample)
AR (1) AR036881A1 (enExample)
AT (1) ATE298333T1 (enExample)
CA (1) CA2463510A1 (enExample)
DE (1) DE60204791T2 (enExample)
DK (1) DK1436282T3 (enExample)
ES (1) ES2240839T3 (enExample)
MX (1) MXPA04003477A (enExample)
PT (1) PT1436282E (enExample)
WO (1) WO2003033488A1 (enExample)
ZA (1) ZA200402070B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2634940A1 (en) * 2005-12-21 2007-07-05 Schering Corporation Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and h3 receptor antagonist/inverse agonist
FR2938534B1 (fr) 2008-11-14 2012-10-26 Sanofi Aventis Procede de preparation de l'hemifumarate d'eplivanserine
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
US10710977B2 (en) * 2017-02-08 2020-07-14 Nissan Chemical Corporation Method for producing geometrical isomer of oximino compound

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20020507A1 (es) * 2000-10-17 2002-06-25 Schering Corp Compuestos no-imidazoles como antagonistas del receptor histamina h3

Also Published As

Publication number Publication date
CN100360520C (zh) 2008-01-09
DE60204791T2 (de) 2006-05-18
ATE298333T1 (de) 2005-07-15
PT1436282E (pt) 2005-10-31
JP4425632B2 (ja) 2010-03-03
CN1678605A (zh) 2005-10-05
ZA200402070B (en) 2005-04-29
CA2463510A1 (en) 2003-04-24
JP2005506357A (ja) 2005-03-03
EP1436282A1 (en) 2004-07-14
DE60204791D1 (de) 2005-07-28
WO2003033488A1 (en) 2003-04-24
HK1062683A1 (en) 2004-11-19
ES2240839T3 (es) 2005-10-16
EP1436282B1 (en) 2005-06-22
AR036881A1 (es) 2004-10-13
DK1436282T3 (da) 2005-07-11
MXPA04003477A (es) 2004-07-30

Similar Documents

Publication Publication Date Title
WO2008005423A1 (en) Improved method of making sufentanil
CN101711232A (zh) 邻-氯甲基苯基乙醛酸酯、(e)-2-(2-氯甲基苯基)-2-烷氧亚胺基乙酸酯的改进制备方法以及用于这些制备方法的新型中间体
CN100360520C (zh) 4-(哌啶基)(2-吡啶基)亚甲基-(e)-o-甲基肟及其盐的合成
US10934251B2 (en) Process for the preparation of lomitapide
JP2001510174A (ja) アミノアリールアセチレンを調製するためのプロセス
JP2003500479A (ja) カテコールヒドラゾン誘導体、製造方法及びこれを含む医薬組成物
JP2005506357A5 (enExample)
US6881845B2 (en) Process for preparing (±)trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidine
JPH07116116B2 (ja) ３−アミノアクリル酸エステルの製造法
US6642385B2 (en) Synthesis of 4-(piperidyl)(2-pyridyl)methanone-(E)-O-methyloxime and salts
US7166729B2 (en) Process for the preparation of 5-substituted isobenzofurans
CN102746327A (zh) 肼化合物的制造方法、以及肼化合物的制造中间体及其制造方法
JP2003515600A (ja) ｛２−［４−（α−フェニル−ｐ−クロロベンジル）ピペラジン−１−イル］エトキシ｝酢酸の製法及びそのための新規な中間体
JPH11322643A (ja) クロロアルキン類およびアルキニルアミン類の製造方法
HK1062683B (en) Synthesis of 4-(piperidyl) (2-pyridyl)methanone-(e)-o-methyloxime and its salts
US9908858B2 (en) Method for the synthesis of a hydrazine that can be used in the treatment of the papilloma virus
JP4441260B2 (ja) ４−アミノ−４−フェニルピペリジン類の製造方法
JPH0665163A (ja) 置換エチルアミン類、その製造法、薬剤としての使用ならびに合成中間体
JP3873796B2 (ja) ３−ヒドラゾノ−２−ヒドロキシイミノプロピオニトリル誘導体及びその製法
JP2009510017A (ja) （３−クロロ−４−フルオロフェニル）−（４−フルオロ−４−｛［（５−メチル−ピリミジン−２−イルメチル）−アミノ］−メチル｝−ピペリジン−１−イル）−メタノンの製造方法および新規な中間体ピリミジン誘導体
JPH07242614A (ja) 光学活性なオキシム誘導体およびその製造方法
JP2002513012A (ja) 活性医薬化合物製造のためのテトラロンイミンの製造方法
JPS6338981B2 (enExample)
JP2000327674A (ja) ４−ハロベンゾフラン誘導体及びその製造方法
JPH0912546A (ja) アザビシクロ環化合物および製造方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
AD01 Patent right deemed abandoned

Effective date of abandoning: 20080409

C20 Patent right or utility model deemed to be abandoned or is abandoned