JP4425632B2 - ４−（ピペリジル）（２−ピリジル）メタノン−（ｅ）−ｏ−メチルオキシムおよびその塩の合成 - Google Patents

４−（ピペリジル）（２−ピリジル）メタノン−（ｅ）−ｏ−メチルオキシムおよびその塩の合成 Download PDF

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Publication number
JP4425632B2
JP4425632B2 JP2003536228A JP2003536228A JP4425632B2 JP 4425632 B2 JP4425632 B2 JP 4425632B2 JP 2003536228 A JP2003536228 A JP 2003536228A JP 2003536228 A JP2003536228 A JP 2003536228A JP 4425632 B2 JP4425632 B2 JP 4425632B2
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JP
Japan
Prior art keywords
formula
compound
solvent
acid
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2003536228A
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English (en)
Japanese (ja)
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JP2005506357A (ja
JP2005506357A5 (enExample
Inventor
ウェンシュ ウ，
ホンビアオ リアオ，
デビット ジェイ． エス． ツァイ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
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Schering Corp
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Application filed by Schering Corp filed Critical Schering Corp
Publication of JP2005506357A publication Critical patent/JP2005506357A/ja
Publication of JP2005506357A5 publication Critical patent/JP2005506357A5/ja
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Publication of JP4425632B2 publication Critical patent/JP4425632B2/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2003536228A 2001-10-15 2002-10-15 ４−（ピペリジル）（２−ピリジル）メタノン−（ｅ）−ｏ−メチルオキシムおよびその塩の合成 Expired - Fee Related JP4425632B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32956101P 2001-10-15 2001-10-15
PCT/US2002/033118 WO2003033488A1 (en) 2001-10-15 2002-10-15 Synthesis of 4-(piperidyl) (2-pyridyl)methanone-(e)-o-methyloxime and its salts

Publications (3)

Publication Number Publication Date
JP2005506357A JP2005506357A (ja) 2005-03-03
JP2005506357A5 JP2005506357A5 (enExample) 2009-08-20
JP4425632B2 true JP4425632B2 (ja) 2010-03-03

Family

ID=23285979

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003536228A Expired - Fee Related JP4425632B2 (ja) 2001-10-15 2002-10-15 ４−（ピペリジル）（２−ピリジル）メタノン−（ｅ）−ｏ−メチルオキシムおよびその塩の合成

Country Status (13)

Country Link
EP (1) EP1436282B1 (enExample)
JP (1) JP4425632B2 (enExample)
CN (2) CN100360520C (enExample)
AR (1) AR036881A1 (enExample)
AT (1) ATE298333T1 (enExample)
CA (1) CA2463510A1 (enExample)
DE (1) DE60204791T2 (enExample)
DK (1) DK1436282T3 (enExample)
ES (1) ES2240839T3 (enExample)
MX (1) MXPA04003477A (enExample)
PT (1) PT1436282E (enExample)
WO (1) WO2003033488A1 (enExample)
ZA (1) ZA200402070B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007075702A2 (en) * 2005-12-21 2007-07-05 Schering Corporation Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and h3 receptor antagonist/inverse agonist
FR2938534B1 (fr) 2008-11-14 2012-10-26 Sanofi Aventis Procede de preparation de l'hemifumarate d'eplivanserine
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
JP7021643B2 (ja) * 2017-02-08 2022-02-17 日産化学株式会社 オキシイミノ化合物の幾何異性体の製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20020507A1 (es) * 2000-10-17 2002-06-25 Schering Corp Compuestos no-imidazoles como antagonistas del receptor histamina h3

Also Published As

Publication number Publication date
MXPA04003477A (es) 2004-07-30
ZA200402070B (en) 2005-04-29
ES2240839T3 (es) 2005-10-16
AR036881A1 (es) 2004-10-13
JP2005506357A (ja) 2005-03-03
EP1436282B1 (en) 2005-06-22
DE60204791D1 (de) 2005-07-28
PT1436282E (pt) 2005-10-31
ATE298333T1 (de) 2005-07-15
CN101157685A (zh) 2008-04-09
HK1062683A1 (en) 2004-11-19
WO2003033488A1 (en) 2003-04-24
DK1436282T3 (da) 2005-07-11
CA2463510A1 (en) 2003-04-24
DE60204791T2 (de) 2006-05-18
CN1678605A (zh) 2005-10-05
CN100360520C (zh) 2008-01-09
EP1436282A1 (en) 2004-07-14

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