CN100360520C - 4-(哌啶基)(2-吡啶基)亚甲基-(e)-o-甲基肟及其盐的合成 - Google Patents

4-(哌啶基)(2-吡啶基)亚甲基-(e)-o-甲基肟及其盐的合成 Download PDF

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Publication number
CN100360520C
CN100360520C CNB028204271A CN02820427A CN100360520C CN 100360520 C CN100360520 C CN 100360520C CN B028204271 A CNB028204271 A CN B028204271A CN 02820427 A CN02820427 A CN 02820427A CN 100360520 C CN100360520 C CN 100360520C
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CN
China
Prior art keywords
formula
compound
acid
solvent
toluene
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB028204271A
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English (en)
Chinese (zh)
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CN1678605A (zh
Inventor
吴文学
廖宏标
蔡介士
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
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Publication of CN1678605A publication Critical patent/CN1678605A/zh
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Publication of CN100360520C publication Critical patent/CN100360520C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CNB028204271A 2001-10-15 2002-10-15 4-(哌啶基)(2-吡啶基)亚甲基-(e)-o-甲基肟及其盐的合成 Expired - Fee Related CN100360520C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32956101P 2001-10-15 2001-10-15
US60/329,561 2001-10-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2007101863662A Division CN101157685A (zh) 2001-10-15 2002-10-15 4-(哌啶基)(2-吡啶基)亚甲基-(e)-o-甲基肟及其盐的合成

Publications (2)

Publication Number Publication Date
CN1678605A CN1678605A (zh) 2005-10-05
CN100360520C true CN100360520C (zh) 2008-01-09

Family

ID=23285979

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB028204271A Expired - Fee Related CN100360520C (zh) 2001-10-15 2002-10-15 4-(哌啶基)(2-吡啶基)亚甲基-(e)-o-甲基肟及其盐的合成
CNA2007101863662A Pending CN101157685A (zh) 2001-10-15 2002-10-15 4-(哌啶基)(2-吡啶基)亚甲基-(e)-o-甲基肟及其盐的合成

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2007101863662A Pending CN101157685A (zh) 2001-10-15 2002-10-15 4-(哌啶基)(2-吡啶基)亚甲基-(e)-o-甲基肟及其盐的合成

Country Status (13)

Country Link
EP (1) EP1436282B1 (enExample)
JP (1) JP4425632B2 (enExample)
CN (2) CN100360520C (enExample)
AR (1) AR036881A1 (enExample)
AT (1) ATE298333T1 (enExample)
CA (1) CA2463510A1 (enExample)
DE (1) DE60204791T2 (enExample)
DK (1) DK1436282T3 (enExample)
ES (1) ES2240839T3 (enExample)
MX (1) MXPA04003477A (enExample)
PT (1) PT1436282E (enExample)
WO (1) WO2003033488A1 (enExample)
ZA (1) ZA200402070B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007075702A2 (en) * 2005-12-21 2007-07-05 Schering Corporation Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and h3 receptor antagonist/inverse agonist
FR2938534B1 (fr) 2008-11-14 2012-10-26 Sanofi Aventis Procede de preparation de l'hemifumarate d'eplivanserine
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
JP7021643B2 (ja) * 2017-02-08 2022-02-17 日産化学株式会社 オキシイミノ化合物の幾何異性体の製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20020507A1 (es) * 2000-10-17 2002-06-25 Schering Corp Compuestos no-imidazoles como antagonistas del receptor histamina h3

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Discovery of 4-[(Z)-(4-Bromophenyl)-(ethoxyimino)methyl]-1'-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4'-methyl-1,4'-bipiperidineN-Oxide (SCH 351125): An Orally Bioavailable Human CCR5Antagonist for the Treatment of HIV Infection. Palani A et al.Journal of Medicinal Chemistry, American Chemical Society. Washington, US,Vol.44 No.21. 2001 *
Dual Antagonists of Platelet Activating Factor and Histamine.Identification of Structural Requirements for Dual Activity ofN-Acyl-4-(5,6-dihydro-11H-benzo[5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidines. Piwinski J J et al.Journal of Medicinal Chemistry, American Chemistry Society.Washington, US,Vol.34 No.1. 1991 *

Also Published As

Publication number Publication date
MXPA04003477A (es) 2004-07-30
ZA200402070B (en) 2005-04-29
ES2240839T3 (es) 2005-10-16
AR036881A1 (es) 2004-10-13
JP2005506357A (ja) 2005-03-03
EP1436282B1 (en) 2005-06-22
DE60204791D1 (de) 2005-07-28
PT1436282E (pt) 2005-10-31
ATE298333T1 (de) 2005-07-15
CN101157685A (zh) 2008-04-09
HK1062683A1 (en) 2004-11-19
WO2003033488A1 (en) 2003-04-24
JP4425632B2 (ja) 2010-03-03
DK1436282T3 (da) 2005-07-11
CA2463510A1 (en) 2003-04-24
DE60204791T2 (de) 2006-05-18
CN1678605A (zh) 2005-10-05
EP1436282A1 (en) 2004-07-14

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Granted publication date: 20080109

Termination date: 20111015