CN101128467B - 喜树碱亚单元的新合成 - Google Patents

喜树碱亚单元的新合成 Download PDF

Info

Publication number
CN101128467B
CN101128467B CN2006800056195A CN200680005619A CN101128467B CN 101128467 B CN101128467 B CN 101128467B CN 2006800056195 A CN2006800056195 A CN 2006800056195A CN 200680005619 A CN200680005619 A CN 200680005619A CN 101128467 B CN101128467 B CN 101128467B
Authority
CN
China
Prior art keywords
formula
compound
reaction
alkyl
further reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2006800056195A
Other languages
English (en)
Chinese (zh)
Other versions
CN101128467A (zh
Inventor
勒内·彼得斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN101128467A publication Critical patent/CN101128467A/zh
Application granted granted Critical
Publication of CN101128467B publication Critical patent/CN101128467B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2006800056195A 2005-02-22 2006-02-14 喜树碱亚单元的新合成 Expired - Fee Related CN101128467B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05101338.1 2005-02-22
EP05101338 2005-02-22
PCT/EP2006/001306 WO2006089657A1 (en) 2005-02-22 2006-02-14 New synthesis of a camptothecin subunit

Publications (2)

Publication Number Publication Date
CN101128467A CN101128467A (zh) 2008-02-20
CN101128467B true CN101128467B (zh) 2010-12-22

Family

ID=36177738

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800056195A Expired - Fee Related CN101128467B (zh) 2005-02-22 2006-02-14 喜树碱亚单元的新合成

Country Status (11)

Country Link
US (1) US7423152B2 (enExample)
EP (1) EP1856124B1 (enExample)
JP (1) JP4861340B2 (enExample)
KR (1) KR100916175B1 (enExample)
CN (1) CN101128467B (enExample)
AT (1) ATE531719T1 (enExample)
CA (1) CA2597388A1 (enExample)
IL (1) IL185015A (enExample)
MX (1) MX2007010033A (enExample)
TW (1) TWI314932B (enExample)
WO (1) WO2006089657A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7632540B2 (en) * 2003-07-01 2009-12-15 Transitions Optical, Inc. Alignment facilities for optical dyes
CN104277144A (zh) * 2008-07-31 2015-01-14 卢布里佐尔公司 共聚物及其润滑组合物
CN101544651B (zh) * 2009-04-24 2011-11-02 华东师范大学 多取代吡啶酮化合物的合成方法
CN101591342B (zh) * 2009-07-03 2011-07-27 华东师范大学 用于喜树碱类化合物制备的关键中间体合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162532A (en) * 1990-12-20 1992-11-10 North Carolina State University Intermediates and method of making camptothecin and camptothecin analogs
US5491237A (en) * 1994-05-03 1996-02-13 Glaxo Wellcome Inc. Intermediates in pharmaceutical camptothecin preparation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Daniel L. Comins等.A Six-Step Synthesis of Camptothecin.Journal of organic chemistry59 (18).1994,59((18)),全文.
Daniel L. Comins等.A Six-Step Synthesis of Camptothecin.Journal of organic chemistry59 (18).1994,59((18)),全文. *

Also Published As

Publication number Publication date
CN101128467A (zh) 2008-02-20
EP1856124B1 (en) 2011-11-02
US20060189807A1 (en) 2006-08-24
WO2006089657A1 (en) 2006-08-31
JP2008531487A (ja) 2008-08-14
TW200640935A (en) 2006-12-01
IL185015A (en) 2012-07-31
KR20070104424A (ko) 2007-10-25
ATE531719T1 (de) 2011-11-15
JP4861340B2 (ja) 2012-01-25
MX2007010033A (es) 2007-10-04
TWI314932B (en) 2009-09-21
KR100916175B1 (ko) 2009-09-08
CA2597388A1 (en) 2006-08-31
EP1856124A1 (en) 2007-11-21
IL185015A0 (en) 2007-12-03
US7423152B2 (en) 2008-09-09

Similar Documents

Publication Publication Date Title
US5468859A (en) Process for asymmetric total synthesis of camptothecin analogues
CN101128467B (zh) 喜树碱亚单元的新合成
CN103304478B (zh) 一类合成renieramycins型生物碱的中间体及其制备方法
KURIHARA et al. Synthetic studies of (±)-lysergic acid and related compounds
Reding et al. Synthesis of 2, 3-disubstituted indoles by radical cyclization with hypophosphorous acid and its application to total synthesis of (±)-catharanthine
EP1791539B1 (en) Process to prepare camptothecin derivatives
Buron et al. Towards a biomimetic synthesis of barrenazine A
CN118546160A (zh) 一种螺氧吲哚-1,2-噁嗪并吲哚衍生物及其制备方法和应用
WO2002022618A1 (fr) Preparation de la camptothecine et de ses derives
CN108530241B (zh) 一种具有苄位季碳中心的苯并环衍生物的制备方法
Yamada et al. Synthetic studies of psilocin analogs having either a formyl group or bromine atom at the 5-or 7-position
CN110650735A (zh) 通过钯-催化的分子内链烯基化的4,5-螺环的高度非对映选择性结构
US6486320B2 (en) Preparation of camptothecin and of its derivatives
Henegar et al. Synthesis of (+/‐) mappicine and mappicine ketone
US6426417B1 (en) Processes and intermediates useful to make antifolates
CN106674222B (zh) 一种手性三环酮胺化合物及其合成方法和应用
JP2022545102A (ja) Ｌ－エリトロ－ビオプテリン類化合物の製造方法
CN106554307B (zh) 一种海洋真菌来源的抗病毒喹啉酮生物碱类衍生物的制备方法
AU2003284116A1 (en) Process for making spirolactone compounds
MXPA00007824A (enExample)
JP2000044566A (ja) ピリジン誘導体の製造方法
JP2003501355A (ja) カンプトテシンおよびノタポジチン誘導体の製造法
WO2007066512A1 (ja) トリアザスマネン類、及び、その製造方法
JPH11255744A (ja) ２，４−二置換および２，３，５−三置換ピロール誘導体およびその製造中間体

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20101222

Termination date: 20140214