CN101119966B - 合成2-吖丁啶酮的方法 - Google Patents

合成2-吖丁啶酮的方法 Download PDF

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Publication number
CN101119966B
CN101119966B CN200580048205.6A CN200580048205A CN101119966B CN 101119966 B CN101119966 B CN 101119966B CN 200580048205 A CN200580048205 A CN 200580048205A CN 101119966 B CN101119966 B CN 101119966B
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China
Prior art keywords
quaternary ammonium
alkyl
group
formula
agent
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CN200580048205.6A
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English (en)
Chinese (zh)
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CN101119966A (zh
Inventor
T·K·思卢弗蒂普拉姆
J·S·赵
X·傅
T·L·姆卡利斯特
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Merck Sharp and Dohme BV
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN200580048205.6A 2004-12-20 2005-12-19 合成2-吖丁啶酮的方法 Active CN101119966B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63759404P 2004-12-20 2004-12-20
US60/637,594 2004-12-20
PCT/US2005/045901 WO2006068990A1 (fr) 2004-12-20 2005-12-19 Procede de synthese d'azetidinones

Publications (2)

Publication Number Publication Date
CN101119966A CN101119966A (zh) 2008-02-06
CN101119966B true CN101119966B (zh) 2014-08-13

Family

ID=36218762

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200580048205.6A Active CN101119966B (zh) 2004-12-20 2005-12-19 合成2-吖丁啶酮的方法

Country Status (13)

Country Link
US (3) US20060135755A1 (fr)
EP (1) EP1831162B1 (fr)
JP (2) JP4890466B2 (fr)
CN (1) CN101119966B (fr)
AR (1) AR052067A1 (fr)
CA (1) CA2591564A1 (fr)
HK (1) HK1102030A1 (fr)
HR (1) HRP20121007T1 (fr)
MX (1) MX2007007473A (fr)
SG (1) SG158132A1 (fr)
SI (1) SI1831162T1 (fr)
WO (1) WO2006068990A1 (fr)
ZA (1) ZA200705130B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
WO2005061452A1 (fr) 2003-12-23 2005-07-07 Astrazeneca Ab Derives diphenylazetidinone a activite inhibitrice de l'absorption du cholesterol
WO2005062824A2 (fr) * 2003-12-23 2005-07-14 Merck & Co., Inc. Composes anti-hypercholesterolemie
UY29607A1 (es) 2005-06-20 2007-01-31 Astrazeneca Ab Compuestos quimicos
AR057072A1 (es) 2005-06-22 2007-11-14 Astrazeneca Ab Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
WO2007030721A2 (fr) * 2005-09-08 2007-03-15 Teva Pharmaceutical Industries Ltd. Procedes pour preparer (3r,4s)-4-((4-benzyloxy)phenyle)-1-(4-fluorophenyle)-3-((s)-3-(4-fluorophenyle)-3-hydroxypropyle)-2-azetidinone, un intermediaire pour la synthese de l'ezetimibe
TW200811098A (en) 2006-04-27 2008-03-01 Astrazeneca Ab Chemical compounds
JP2010529148A (ja) * 2007-06-07 2010-08-26 テバ ファーマシューティカル インダストリーズ リミティド エゼチミブ製造のための還元方法
CZ2008317A3 (cs) * 2008-05-21 2009-12-02 Zentiva, A. S. Zpusob výroby (3R,4S)-1-(4-fluorfenyl)-3-[(3S)-3-(4-fluorfenyl)-3-hydroxypropyl)]-4-(4-hydroxyfenyl)-2-azetidinonu
EP2414529A2 (fr) 2009-04-01 2012-02-08 Matrix Laboratories Ltd Procédé enzymatique pour la préparation de la (s)-5-(4-fluorophényl)-5-hydroxy-1-morpholin-4-yl-pentan-1-one, un intermédiaire de l'ézétimibe et la conversion ultérieure en ézétimibe
WO2010141494A2 (fr) * 2009-06-02 2010-12-09 Codexis, Inc. Synthèse d'ézétimibe
CN102234246A (zh) * 2010-04-23 2011-11-09 浙江华海药业股份有限公司 一种合成依替米贝的新方法
CN106397292A (zh) * 2016-09-20 2017-02-15 苏州普罗达生物科技有限公司 依替米贝的中间体及其合成方法与依替米贝的合成方法
CN112939835A (zh) * 2021-02-09 2021-06-11 中国科学技术大学 一种β-内酰胺类化合物的合成方法
CN115160179A (zh) * 2022-08-04 2022-10-11 湖南方盛堂制药有限公司 依折麦布中间体的制备工艺

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6093812A (en) * 1991-07-23 2000-07-25 Schering Corporation Process for the stereospecific synthesis of azetidinones
US6207822B1 (en) * 1998-12-07 2001-03-27 Schering Corporation Process for the synthesis of azetidinones

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU681419B2 (en) * 1993-07-09 1997-08-28 Schering Corporation Process for the synthesis of azetidinones
AU7472896A (en) 1995-11-02 1997-05-22 Schering Corporation Process for preparing 1-(4-fluorophenyl)-3(r)-(3(s)-hydroxy-3-({phenyl or 4-fluorophenyl})-propyl)-4(s)-(4-hydroxyphenyl)-2-azetidinon
JP3640888B2 (ja) * 1998-12-07 2005-04-20 シェーリング コーポレイション アゼチジノンの合成プロセス
BR0116325A (pt) 2000-12-21 2003-10-14 Aventis Pharma Gmbh 1,2-difenilazetidinonas, processos para a sua preparação, medicamentos contendo estes compostos e sua aplicação para o tratamento de distúrbios do metabolismo de lipìdios
JP2008539255A (ja) 2005-04-26 2008-11-13 マイクロビア インコーポレーテッド 高コレステロール血症のための４−ビアリーリル−１−フェニルアゼチジン−２−オングルクロニド誘導体
EA200702614A1 (ru) 2005-05-25 2008-04-28 Майкробиа, Инк. Способы получения 4-(бифенилил)азетидин-2-оналкилфосфиновых кислот
RU2008102236A (ru) 2005-06-22 2009-07-27 РЕДДИ Манне САТЬЯНАРАЯНА (IN) Улучшенный способ получения эзетимиб
US20070049748A1 (en) 2005-08-26 2007-03-01 Uppala Venkata Bhaskara R Preparation of ezetimibe
HU0501164D0 (en) 2005-12-20 2006-02-28 Richter Gedeon Vegyeszet New industrial process for the production of ezetimibe
US20080032964A1 (en) 2006-04-10 2008-02-07 Kansal Vinod K Process for the synthesis of azetidinone

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6093812A (en) * 1991-07-23 2000-07-25 Schering Corporation Process for the stereospecific synthesis of azetidinones
US6207822B1 (en) * 1998-12-07 2001-03-27 Schering Corporation Process for the synthesis of azetidinones

Also Published As

Publication number Publication date
US20060135755A1 (en) 2006-06-22
US20120083601A1 (en) 2012-04-05
EP1831162B1 (fr) 2012-10-31
JP4890466B2 (ja) 2012-03-07
EP1831162A1 (fr) 2007-09-12
ZA200705130B (en) 2008-09-25
MX2007007473A (es) 2007-09-04
SI1831162T1 (sl) 2013-03-29
US8383810B2 (en) 2013-02-26
HK1102030A1 (en) 2007-11-02
HRP20121007T1 (hr) 2013-01-31
CA2591564A1 (fr) 2006-06-29
JP2008524251A (ja) 2008-07-10
WO2006068990A1 (fr) 2006-06-29
CN101119966A (zh) 2008-02-06
SG158132A1 (en) 2010-01-29
US20110144327A1 (en) 2011-06-16
JP2012036224A (ja) 2012-02-23
AR052067A1 (es) 2007-02-28

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Address after: New jersey, USA

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Applicant before: SCHERING Corp.

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Free format text: CORRECT: APPLICANT; FROM: SCHERING CORP (US) TO: MSD CORP.

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Patentee before: MERCK SHARP & DOHME Corp.