ZA200705130B - Process for the synthesis of azetidinones - Google Patents

Process for the synthesis of azetidinones

Info

Publication number
ZA200705130B
ZA200705130B ZA200705130A ZA200705130A ZA200705130B ZA 200705130 B ZA200705130 B ZA 200705130B ZA 200705130 A ZA200705130 A ZA 200705130A ZA 200705130 A ZA200705130 A ZA 200705130A ZA 200705130 B ZA200705130 B ZA 200705130B
Authority
ZA
South Africa
Prior art keywords
azetidinones
synthesis
Prior art date
Application number
ZA200705130A
Other languages
English (en)
Inventor
Thiruvengadam Thiruvettipuram
Fu Xiaoyong
John S Chiu
Timothy L Mcallister
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of ZA200705130B publication Critical patent/ZA200705130B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA200705130A 2004-12-20 2007-06-20 Process for the synthesis of azetidinones ZA200705130B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63759404P 2004-12-20 2004-12-20

Publications (1)

Publication Number Publication Date
ZA200705130B true ZA200705130B (en) 2008-09-25

Family

ID=36218762

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200705130A ZA200705130B (en) 2004-12-20 2007-06-20 Process for the synthesis of azetidinones

Country Status (13)

Country Link
US (3) US20060135755A1 (fr)
EP (1) EP1831162B1 (fr)
JP (2) JP4890466B2 (fr)
CN (1) CN101119966B (fr)
AR (1) AR052067A1 (fr)
CA (1) CA2591564A1 (fr)
HK (1) HK1102030A1 (fr)
HR (1) HRP20121007T1 (fr)
MX (1) MX2007007473A (fr)
SG (1) SG158132A1 (fr)
SI (1) SI1831162T1 (fr)
WO (1) WO2006068990A1 (fr)
ZA (1) ZA200705130B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
DE602004029715D1 (de) 2003-12-23 2010-12-02 Astrazeneca Ab Diphenylazetidinonderivate mit die cholesterinabsorption hemmender wirkung
CA2550373C (fr) * 2003-12-23 2012-01-31 Merck & Co., Inc. Composes anti-hypercholesterolemie
UY29607A1 (es) 2005-06-20 2007-01-31 Astrazeneca Ab Compuestos quimicos
AR057072A1 (es) 2005-06-22 2007-11-14 Astrazeneca Ab Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
BRPI0605934A2 (pt) * 2005-09-08 2009-05-26 Teva Pharma processos para a preparação de ( 3r, 4s) - 4 - ( (4-benziloxi ) fenil ) - 1 - ( 4 - fluorofenil ) - 3 - ( (s) - 3 - ( 4 - fluorofenil ) - 3 - hidroxipropil) - 2 - azetidinona, um intermediário para a sìntese da ezetimiba
AR060623A1 (es) 2006-04-27 2008-07-02 Astrazeneca Ab Compuestos derivados de 2-azetidinona y un metodo de preparacion
JP2010529148A (ja) * 2007-06-07 2010-08-26 テバ ファーマシューティカル インダストリーズ リミティド エゼチミブ製造のための還元方法
CZ2008317A3 (cs) * 2008-05-21 2009-12-02 Zentiva, A. S. Zpusob výroby (3R,4S)-1-(4-fluorfenyl)-3-[(3S)-3-(4-fluorfenyl)-3-hydroxypropyl)]-4-(4-hydroxyfenyl)-2-azetidinonu
EP2414529A2 (fr) 2009-04-01 2012-02-08 Matrix Laboratories Ltd Procédé enzymatique pour la préparation de la (s)-5-(4-fluorophényl)-5-hydroxy-1-morpholin-4-yl-pentan-1-one, un intermédiaire de l'ézétimibe et la conversion ultérieure en ézétimibe
WO2010141494A2 (fr) * 2009-06-02 2010-12-09 Codexis, Inc. Synthèse d'ézétimibe
CN102234246A (zh) * 2010-04-23 2011-11-09 浙江华海药业股份有限公司 一种合成依替米贝的新方法
CN106397292A (zh) * 2016-09-20 2017-02-15 苏州普罗达生物科技有限公司 依替米贝的中间体及其合成方法与依替米贝的合成方法
CN112939835A (zh) * 2021-02-09 2021-06-11 中国科学技术大学 一种β-内酰胺类化合物的合成方法
CN115160179A (zh) * 2022-08-04 2022-10-11 湖南方盛堂制药有限公司 依折麦布中间体的制备工艺

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ14294A3 (en) 1991-07-23 1994-07-13 Schering Corp Substituted beta-lactam compounds usable as hypocholesterol pharmaceutical preparations and process for preparing thereof
CN1071745C (zh) 1993-07-09 2001-09-26 先灵公司 合成氮杂环丁酮类化合物的方法
AU7472896A (en) 1995-11-02 1997-05-22 Schering Corporation Process for preparing 1-(4-fluorophenyl)-3(r)-(3(s)-hydroxy-3-({phenyl or 4-fluorophenyl})-propyl)-4(s)-(4-hydroxyphenyl)-2-azetidinon
US6207822B1 (en) * 1998-12-07 2001-03-27 Schering Corporation Process for the synthesis of azetidinones
WO2000034240A1 (fr) * 1998-12-07 2000-06-15 Schering Corporation Procede relatif a la synthese d'azetidinones
KR100833089B1 (ko) 2000-12-21 2008-05-29 사노피-아벤티스 도이칠란트 게엠베하 신규한 1,2-디페닐아제티딘온 및 당해 화합물을 함유하는 지질 대사 장애를 치료하기 위한 약제학적 조성물
US20080194494A1 (en) 2005-04-26 2008-08-14 Microbia, Inc. 4-Biarylyl-1-Phenylazetidin-2-One Glucuronide Derivatives for Hypercholesterolemia
US20090099355A1 (en) 2005-05-25 2009-04-16 Microbia, Inc. Processes for Production of 4-(Biphenylyl)Azetidin-2-One Phosphonic Acids
EP1893570A4 (fr) 2005-06-22 2009-12-23 Reddy Manne Satynarayana Procédé amélioré pour la préparation d'ézétimibe
US20070049748A1 (en) 2005-08-26 2007-03-01 Uppala Venkata Bhaskara R Preparation of ezetimibe
HUP0501164A2 (en) 2005-12-20 2007-07-30 Richter Gedeon Nyrt New industrial process for the production of ezetimibe
WO2007120824A2 (fr) 2006-04-10 2007-10-25 Teva Pharmaceutical Industries Ltd. Procédés de synthèse de l'azétidinone

Also Published As

Publication number Publication date
US20110144327A1 (en) 2011-06-16
CA2591564A1 (fr) 2006-06-29
EP1831162A1 (fr) 2007-09-12
MX2007007473A (es) 2007-09-04
US8383810B2 (en) 2013-02-26
US20120083601A1 (en) 2012-04-05
CN101119966A (zh) 2008-02-06
JP2012036224A (ja) 2012-02-23
SG158132A1 (en) 2010-01-29
HRP20121007T1 (hr) 2013-01-31
SI1831162T1 (sl) 2013-03-29
JP2008524251A (ja) 2008-07-10
EP1831162B1 (fr) 2012-10-31
CN101119966B (zh) 2014-08-13
HK1102030A1 (en) 2007-11-02
AR052067A1 (es) 2007-02-28
WO2006068990A1 (fr) 2006-06-29
US20060135755A1 (en) 2006-06-22
JP4890466B2 (ja) 2012-03-07

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