CN101111154B - 联合免疫基因疗法和化学疗法用于治疗癌症和过度增生性疾病 - Google Patents
联合免疫基因疗法和化学疗法用于治疗癌症和过度增生性疾病 Download PDFInfo
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- CN101111154B CN101111154B CN2005800475870A CN200580047587A CN101111154B CN 101111154 B CN101111154 B CN 101111154B CN 2005800475870 A CN2005800475870 A CN 2005800475870A CN 200580047587 A CN200580047587 A CN 200580047587A CN 101111154 B CN101111154 B CN 101111154B
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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- Pharmacology & Pharmacy (AREA)
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- General Chemical & Material Sciences (AREA)
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- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63504204P | 2004-12-09 | 2004-12-09 | |
| US60/635,042 | 2004-12-09 | ||
| US11/261,931 US7964571B2 (en) | 2004-12-09 | 2005-10-28 | Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases |
| US11/261,931 | 2005-10-28 | ||
| PCT/US2005/041935 WO2006062723A2 (en) | 2004-12-09 | 2005-11-17 | Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101111154A CN101111154A (zh) | 2008-01-23 |
| CN101111154B true CN101111154B (zh) | 2013-03-27 |
Family
ID=36578384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2005800475870A Expired - Lifetime CN101111154B (zh) | 2004-12-09 | 2005-11-17 | 联合免疫基因疗法和化学疗法用于治疗癌症和过度增生性疾病 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7964571B2 (enExample) |
| EP (2) | EP2444498A1 (enExample) |
| JP (3) | JP5704788B2 (enExample) |
| CN (1) | CN101111154B (enExample) |
| AT (1) | ATE540121T1 (enExample) |
| AU (1) | AU2005314468B2 (enExample) |
| CA (1) | CA2590160C (enExample) |
| ES (1) | ES2380107T3 (enExample) |
| WO (1) | WO2006062723A2 (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090123468A1 (en) | 2003-10-24 | 2009-05-14 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
| US8062891B2 (en) | 2003-10-24 | 2011-11-22 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to plants |
| US8507277B2 (en) | 2003-10-24 | 2013-08-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides |
| US8133733B2 (en) | 2003-10-24 | 2012-03-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to target tissues |
| JP4838722B2 (ja) | 2003-10-24 | 2011-12-14 | ゲンシア コーポレーション | ポリヌクレオチドを送達する方法、及び送達用組成物 |
| US7964571B2 (en) | 2004-12-09 | 2011-06-21 | Egen, Inc. | Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases |
| US20120269886A1 (en) | 2004-12-22 | 2012-10-25 | Nitto Denko Corporation | Therapeutic agent for pulmonary fibrosis |
| PT2730277T (pt) | 2004-12-22 | 2020-04-21 | Nitto Denko Corp | Veículo de fármaco e kit de veículo de fármaco para a inibição da fibrose |
| US9572886B2 (en) | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
| US8871247B2 (en) | 2007-02-19 | 2014-10-28 | Marine Polymer Technologies, Inc. | Hemostatic compositions and therapeutic regimens |
| TWI407971B (zh) | 2007-03-30 | 2013-09-11 | Nitto Denko Corp | Cancer cells and tumor-related fibroblasts |
| US20090011040A1 (en) * | 2007-05-02 | 2009-01-08 | Naash Muna I | Use of compacted nucleic acid nanoparticles in non-viral treatments of ocular diseases |
| US20080312174A1 (en) * | 2007-06-05 | 2008-12-18 | Nitto Denko Corporation | Water soluble crosslinked polymers |
| US9144546B2 (en) | 2007-08-06 | 2015-09-29 | Clsn Laboratories, Inc. | Nucleic acid-lipopolymer compositions |
| CA2698812A1 (en) | 2007-09-14 | 2009-03-19 | Nitto Denko Corporation | Drug carriers |
| JP5279235B2 (ja) * | 2007-11-05 | 2013-09-04 | 国立大学法人 岡山大学 | 抗癌剤耐性癌において抗癌剤増強作用を有する癌細胞死誘導剤 |
| US20100056475A1 (en) * | 2008-08-06 | 2010-03-04 | Alexander Chucholowski | Cyclodextrin conjugates |
| CA2759098A1 (en) * | 2009-04-14 | 2010-10-21 | Smith Holdings, Llc | Methods and compositions for the treatment of medical conditions involving cellular programming |
| JP2013522375A (ja) * | 2010-03-24 | 2013-06-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | フラビウイルス感染を処置または予防するためのアナログ |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP3431485B2 (en) | 2010-10-01 | 2024-09-04 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| CN102784398B (zh) * | 2011-05-16 | 2014-06-18 | 南京大学 | 内皮抑素作为递送系统和化学合成的rna干扰分子组成的组合物及应用 |
| WO2012155328A1 (zh) * | 2011-05-16 | 2012-11-22 | 南京大学 | 包含内皮抑素和rna干扰分子的组合物及其应用 |
| JP6049712B2 (ja) | 2011-07-08 | 2016-12-21 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルThe University Of North Carolina At Chapel Hill | 抗癌治療及び画像化並びに骨障害治療のための金属ビスホスホネートナノ粒子 |
| JP5904483B2 (ja) * | 2011-09-06 | 2016-04-13 | 国立大学法人 長崎大学 | 研磨剤を含有する核酸導入剤 |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2763701B1 (en) | 2011-10-03 | 2018-12-19 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| WO2014063128A1 (en) * | 2012-10-20 | 2014-04-24 | Board Of Regents, The University Of Texas System | Cancer cell trap |
| CA2892529C (en) | 2012-11-26 | 2023-04-25 | Moderna Therapeutics, Inc. | Terminally modified rna |
| ITMI20122270A1 (it) * | 2012-12-31 | 2014-07-01 | Giovanni Mogna | Terapia di supporto ai trattamenti di chemioterapia per i tumori, per la sindrome da immunodeficienza acquisita e per le leucemie. |
| HK1217215A1 (zh) | 2013-01-17 | 2016-12-30 | Modernatx, Inc. | 用於改变细胞表型的信号传感器多核苷酸 |
| US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US9784730B2 (en) | 2013-03-21 | 2017-10-10 | University Of Washington Through Its Center For Commercialization | Nanoparticle for targeting brain tumors and delivery of O6-benzylguanine |
| DK3019619T3 (da) | 2013-07-11 | 2021-10-11 | Modernatx Inc | Sammensætninger, der omfatter syntetiske polynukleotider, som koder for crispr-beslægtede proteiner, og syntetiske sgrna'er, og anvendelsesfremgangsmåder |
| EP3041934A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EA201690675A1 (ru) | 2013-10-03 | 2016-08-31 | Модерна Терапьютикс, Инк. | Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности |
| CN105705143A (zh) * | 2013-11-08 | 2016-06-22 | 达娜-法勃肿瘤研究所公司 | 用于体内试剂递送的核酸纳米结构 |
| GB201322626D0 (en) * | 2013-12-19 | 2014-02-05 | Immutep S A | Combined preparations for the treatment of cancer |
| WO2016011226A1 (en) | 2014-07-16 | 2016-01-21 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| EP3206987B2 (en) | 2014-10-14 | 2024-07-24 | The University of Chicago | Nanoparticles for photodynamic therapy, x-ray induced photodynamic therapy, radiotherapy, chemotherapy, immunotherapy, and any combination thereof |
| US10806694B2 (en) | 2014-10-14 | 2020-10-20 | The University Of Chicago | Nanoparticles for photodynamic therapy, X-ray induced photodynamic therapy, radiotherapy, radiodynamic therapy, chemotherapy, immunotherapy, and any combination thereof |
| AU2016251687C1 (en) | 2015-04-22 | 2023-07-27 | CureVac SE | RNA containing composition for treatment of tumor diseases |
| EP3426598B1 (en) | 2016-03-11 | 2021-07-28 | Children's Medical Center Corporation | Nucleic acid nanoswitch catenanes |
| EP3439666A4 (en) | 2016-05-20 | 2019-12-11 | The University of Chicago | NANOPARTICLES FOR CHEMOTHERAPY, TARGETED THERAPY, PHOTODYNAMIC THERAPY, IMMUNOTHERAPY AND ALL COMBINATIONS THEREOF |
| CN109561691A (zh) * | 2016-06-07 | 2019-04-02 | 太平洋心肺血研究所 | 用于治疗癌症的组合物和方法 |
| CA3029813A1 (en) | 2016-06-13 | 2017-12-21 | Torque Therapeutics, Inc. | Methods and compositions for promoting immune cell function |
| CN115948505B (zh) | 2016-08-02 | 2025-07-25 | 哈佛学院院长及董事 | 交叉协同自组装体 |
| WO2018048792A1 (en) | 2016-09-08 | 2018-03-15 | North Carolina State University | Methods for diagnosis of pseudoperonospora cubensis infection and selection of plant resistance genes to the same |
| JP6850870B2 (ja) * | 2017-03-31 | 2021-03-31 | 富士フイルム株式会社 | 圧電体膜、圧電素子、及び、圧電素子の製造方法 |
| WO2018232502A1 (en) * | 2017-06-20 | 2018-12-27 | Rjh Biosciences Inc. | Transfection reagents for delivery of nucleic acids |
| CN111194232B (zh) | 2017-08-02 | 2023-01-31 | 芝加哥大学 | 纳米级金属有机层和金属有机纳米片 |
| KR20210032924A (ko) | 2017-09-05 | 2021-03-25 | 토크 테라퓨틱스, 인코포레이티드 | 치료용 단백질 조성물 및 그의 제조 및 사용 방법 |
| CA3111100A1 (en) * | 2018-08-31 | 2020-03-05 | Cormedix Inc. | Taurolidine treatment for myc-expressing tumors in mammalian bodies |
| US12268748B2 (en) | 2019-04-10 | 2025-04-08 | President And Fellows Of Harvard College | Nucleic acid nanostructures crosslinked with oligolysine |
| TWI870475B (zh) * | 2019-10-02 | 2025-01-21 | 美商卡凡恩公司 | 用於治療神經毒性之方法及材料 |
| US20240180849A1 (en) * | 2021-04-20 | 2024-06-06 | Purdue Research Foundation | Immunofunctional carrier, methods of uses, and composition matters as an antitumor immunotherapy |
| CN116621965A (zh) * | 2022-05-06 | 2023-08-22 | 珠海丽凡达生物技术有限公司 | 治疗性核酸分子、混合物、药物及在治疗实体瘤中的应用 |
| JP2025532514A (ja) * | 2022-09-07 | 2025-10-01 | イムノン、インコーポレイテッド | 癌を治療するためのil-12遺伝子治療と抗vegfとの併用 |
| CN117144509A (zh) * | 2023-02-21 | 2023-12-01 | 山东第一医科大学(山东省医学科学院) | 一种乳腺癌联合治疗的Bcl-2 siRNA@DOX核/壳纤维材料及其制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002022174A1 (en) * | 2000-09-14 | 2002-03-21 | Expression Genetics, Inc. | A novel cationic lipopolymer as biocompatible gene delivery agent |
| WO2003008555A2 (en) * | 2001-07-19 | 2003-01-30 | Expression Genetics, Inc. | Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4121982A (en) | 1978-02-03 | 1978-10-24 | American Chemical & Refining Company Incorporated | Gold alloy plating bath and method |
| US5283185A (en) | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
| WO1994022468A1 (en) | 1993-04-02 | 1994-10-13 | Anticancer, Inc. | Method for delivering beneficial compositions to hair follicles |
| JP3078107B2 (ja) | 1992-04-07 | 2000-08-21 | 日本原子力研究所 | 放射性廃棄物の減容処理方法 |
| JP3347381B2 (ja) | 1993-01-27 | 2002-11-20 | 協和醗酵工業株式会社 | ペットフード |
| US5393335A (en) | 1993-04-23 | 1995-02-28 | Ppg Industries, Inc. | Starch-oil sizing for glass fibers |
| AU4690596A (en) | 1994-12-30 | 1996-07-24 | Chiron Viagene, Inc. | Nucleic acid condensing agents with reduced immunogenicity |
| FR2730637B1 (fr) | 1995-02-17 | 1997-03-28 | Rhone Poulenc Rorer Sa | Composition pharmaceutique contenant des acides nucleiques, et ses utilisations |
| US6410046B1 (en) | 1996-11-19 | 2002-06-25 | Intrabrain International Nv | Administering pharmaceuticals to the mammalian central nervous system |
| US5955415A (en) | 1997-08-04 | 1999-09-21 | Lever Brothers Company, Division Of Conopco, Inc. | Detergent compositions containing polyethyleneimines for enhanced peroxygen bleach stability |
| IL139761A0 (en) | 1998-05-20 | 2002-02-10 | Expression Genetics Inc | A hepatocyte targeting polyethylene glyco-grafted poly-l-lysine polymeric gene carrier |
| CN101041079A (zh) | 1999-12-30 | 2007-09-26 | 诺瓦提斯公司 | 用于基因治疗的新的胶体合成载体 |
| AU6814601A (en) * | 2000-06-01 | 2001-12-11 | Sloan Kettering Inst Cancer | Use of mutant herpes viruses and anticancer agents in the treatment of cancer |
| US20040142474A1 (en) * | 2000-09-14 | 2004-07-22 | Expression Genetics, Inc. | Novel cationic lipopolymer as a biocompatible gene delivery agent |
| JP2004510829A (ja) | 2000-10-09 | 2004-04-08 | バイエル アクチェンゲゼルシャフト | 核酸を細胞内に転移させるための複合体 |
| JP2006517790A (ja) | 2003-01-09 | 2006-08-03 | インヴィトロジェン コーポレーション | ポリペプチド−核酸複合体の細胞の送達および活性化 |
| US8057821B2 (en) | 2004-11-03 | 2011-11-15 | Egen, Inc. | Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof |
| US7964571B2 (en) | 2004-12-09 | 2011-06-21 | Egen, Inc. | Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases |
| US7740880B2 (en) | 2006-03-03 | 2010-06-22 | University Of Utah Research Foundation | Polymeric carrier for delivery of small interfering RNA |
-
2005
- 2005-10-28 US US11/261,931 patent/US7964571B2/en active Active
- 2005-11-17 CA CA2590160A patent/CA2590160C/en not_active Expired - Lifetime
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002022174A1 (en) * | 2000-09-14 | 2002-03-21 | Expression Genetics, Inc. | A novel cationic lipopolymer as biocompatible gene delivery agent |
| WO2003008555A2 (en) * | 2001-07-19 | 2003-01-30 | Expression Genetics, Inc. | Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier |
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| EP2444498A1 (en) | 2012-04-25 |
| JP5704788B2 (ja) | 2015-04-22 |
| EP1827101B1 (en) | 2012-01-04 |
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| EP1827101A4 (en) | 2009-04-29 |
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| AU2005314468A1 (en) | 2006-06-15 |
| US9468687B2 (en) | 2016-10-18 |
| US7964571B2 (en) | 2011-06-21 |
| JP2012188430A (ja) | 2012-10-04 |
| CA2590160C (en) | 2018-05-22 |
| ATE540121T1 (de) | 2012-01-15 |
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| US8623837B2 (en) | 2014-01-07 |
| US20140186375A1 (en) | 2014-07-03 |
| ES2380107T3 (es) | 2012-05-08 |
| AU2005314468B2 (en) | 2011-03-17 |
| WO2006062723A2 (en) | 2006-06-15 |
| CN101111154A (zh) | 2008-01-23 |
| JP2008523061A (ja) | 2008-07-03 |
| HK1117345A1 (en) | 2009-01-16 |
| EP1827101A2 (en) | 2007-09-05 |
| US20110218231A1 (en) | 2011-09-08 |
| JP2014169305A (ja) | 2014-09-18 |
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