CN101095701B - 一种含有蝙蝠蛾被毛孢-发酵虫草菌粉的片状药品及其制备方法 - Google Patents
一种含有蝙蝠蛾被毛孢-发酵虫草菌粉的片状药品及其制备方法 Download PDFInfo
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Abstract
本发明属于一种含有蝙蝠蛾被毛孢-发酵虫草菌粉的片状药品及其制备方法。所要解决的问题就是背景技术存在的：服用此种药物胶囊制剂胃部不适；不适合老人等人群服用；胶囊中药物的粒度相对较大，不利于功效成份的吸收。解决该技术问题所采用的技术方案要点是：其含有主料：蝙蝠蛾被毛孢-发酵虫草菌粉；辅料：湿润剂和/或粘合剂、崩解剂、润滑剂。取蝙蝠蛾被毛孢菌丝，粉碎成极细粉，取极细粉333g，加入湿润剂和/或粘合剂30-40g、崩解剂20-30g，混合均匀，加入浓度10-15％的粘合剂溶液进行调和，制粒，80℃以下干燥，整粒，加入崩解剂25-35g，润滑剂10-20g、混匀，压制成1000片，包装，即得。本发明具有性状稳定、剂量准确，成本低，无不良刺激、对药物的吸收更易等优点。
Description
技术领域：本发明属于“冬虫夏草”类的药品及其制备方法，特别是一种含有蝙蝠蛾被毛孢-发酵虫草菌粉的片状药品及其制备方法。
背景技术：蝙蝠蛾被毛孢菌粉，是从青海新鲜“冬虫夏草”中分离得到的麦角菌科真菌冬虫夏草的无性世代——蝙蝠蛾被毛孢菌种，经液体发酵培养所得菌丝体的干燥粉末。是天然“冬虫夏草”人工替代品。具有“补肺益肾，止血化痰功能。用于久咳虚喘，劳嗽咯血，阳痿遗精，腰膝酸痛”。现代医学发现，还具有镇静、抗惊厥、降压、改善心肌缺血、抗衰老、提高免疫力、双向调节人体内分泌、抗排异和抗肺癌、淋巴癌、肝癌的作用，其药用价值越来越引起国内外药学界的重视。目前市场上含有蝙蝠蛾被毛孢菌粉的药品仅有一种胶囊制剂，制剂法定名“百令胶囊”，是将蝙蝠蛾被毛孢菌丝经一般方法粉碎后直接填充至胶囊壳中，其对蝙蝠蛾被毛孢菌丝粉碎的粒度无特殊要求。其主要缺陷是：1、服用此种药物在发挥蝙蝠蛾被毛孢菌粉治疗作用的同时又服用了胶囊壳，而胶囊壳主要是由明胶加填充剂和色素制成，由于胶囊壳的存在有些患者在服用后会感到胃部不适；2、胶囊药物不适合老人、儿童及吞咽动作不协调的人群服用；3、由于胶囊制剂的内容物蝙蝠蛾被毛孢菌粉是用一般方法粉碎的，胶囊中药物的粒度相对较大，一般为60-80目，在人体中不利于功效成份的吸收与利用，不利于充分发挥其应有的治疗作用。
发明内容：本发明的目的就是提出一种含有蝙蝠蛾被毛孢-发酵虫草菌粉的片状药品及其制备方法的技术方案，以解决背景技术存在的：服用此种药物在发挥蝙蝠蛾被毛孢菌粉治疗作用的同时又服用了胶囊壳，存在有些患者在服用后会感到胃部不适；胶囊药物不适合老人、儿童及吞咽动作不协调的人群服用；胶囊中药物的粒度相对较大，在人体中不利于功效成份的吸收与利用，不利于充分发挥其应有的治疗作用。解决该技术问题所采用的技术方案是：一种含有蝙蝠蛾被毛孢-发酵虫草菌粉的片状药品，其特征在于其含有主料：蝙蝠蛾被毛孢-发酵虫草菌粉；辅料：湿润剂和/或粘合剂、崩解剂、润滑剂；其中，按照每333g蝙蝠蛾被毛孢-发酵虫草菌粉，配合30-40g湿润剂和/或粘合剂，45-65g崩解剂，10-20g润滑剂。其中，辅料中的湿润剂和/或粘合剂为：交联聚维酮、羟丙基甲基纤维素、糊精、微晶纤维素、蒸馏水、乙醇、淀粉浆、羧甲基纤维素钠、羟丙基纤维素、甲基纤维素、乙基纤维素、明胶、蔗糖、聚乙烯吡咯烷酮；崩解剂为：羧甲基淀粉钠、干淀粉、低取代羟丙基纤维素、交联聚乙烯吡咯烷酮、交联羧甲基纤维素钠；润滑剂为：微粉硅胶、硬脂酸镁、滑石粉、氢化植物油、聚乙二醇类、月桂醇硫酸镁。一种含有蝙蝠蛾被毛孢-发酵虫草菌粉的片状药品(如前所述)的制备方法，其特征在于取蝙蝠蛾被毛孢菌丝，粉碎成极细粉，取极细粉333g，加入湿润剂和/或粘合剂30-40g、崩解剂20-30g，混合均匀，加入浓度10-15％的粘合剂溶液进行调和，制粒，80℃以下干燥，整粒，加入崩解剂25-35g，润滑剂10-20g、混匀，压制成1000片，包装，即得。
本发明与现有技术比较所具有的有益效果是：由于采用上述技术方案，1、本药品生产的机械化、自动化程度较高，性状稳定、剂量准确，成本及售价都较低，其运输、贮存、携带及应用也都比较方便。2、本药品无胶囊壳对胃造成的不良刺激。3、本药品中对主料蝙蝠蛾被毛孢菌丝粉碎成极细粉，粒度在150目以上，使蝙蝠蛾被毛孢菌丝的细胞破壁率大大提高，服用时在人体内的生物利用度较高，使人体对药物的吸收更易、更充分。
具体实施方式：。
实施例1、一种含有蝙蝠蛾被毛孢-发酵虫草菌粉的片状药品，其含有主料：蝙蝠蛾被毛孢-发酵虫草菌粉333g；辅料：交联聚维酮、羟丙基甲基纤维素、糊精、微晶纤维素的混合物40g、55g羧甲基淀粉钠、20g微粉硅胶。
一种含有蝙蝠蛾被毛孢-发酵虫草菌粉的片状药品(如上所述)的制备方法，其特征在于取蝙蝠蛾被毛孢菌丝，粉碎成极细粉，取极细粉333g，加入交联聚维酮、羟丙基甲基纤维素、糊精、微晶纤维素的混合物40g、羧甲基淀粉钠20g，混合均匀，加入浓度15％的粘合剂溶液进行调和，制粒，80℃以下干燥，整粒，加入羧甲基淀粉钠35g，微粉硅胶20g、混匀，压制成1000片，包装，即得。
实施例2、一种含有蝙蝠蛾被毛孢-发酵虫草菌粉的片状药品，其含有主料：蝙蝠蛾被毛孢-发酵虫草菌粉333g；辅料：交联聚维酮、羟丙基甲基纤维素、糊精、微晶纤维素的混合物35g、60g羧甲基淀粉钠、15g微粉硅胶。
一种含有蝙蝠蛾被毛孢-发酵虫草菌粉的片状药品(如上所述)的制备方法，其特征在于取蝙蝠蛾被毛孢菌丝，粉碎成极细粉，取极细粉333g，加入交联聚维酮、羟丙基甲基纤维素、糊精、微晶纤维素的混合物35g、羧甲基淀粉钠30g，混合均匀，加入浓度12％的粘合剂溶液进行调和，制粒，80℃以下干燥，整粒，加入羧甲基淀粉钠30g，微粉硅胶15g、混匀，压制成1000片，包装，即得。
Claims (1)
1.一种含有蝙蝠蛾被毛孢-发酵虫草菌粉的片状药品的制备方法，其特征在于取蝙蝠蛾被毛孢菌丝，粉碎成极细粉，取极细粉333g，加入湿润剂和/或粘合剂30-40g、崩解剂20-30g，混合均匀，加入浓度10-15％的粘合剂溶液进行调和，制粒，80℃以下干燥，整粒，加入崩解剂25-35g，润滑剂10-20g、混匀，压制成1000片，包装，即得。
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| CN102240365A (zh) * | 2010-05-14 | 2011-11-16 | 湖南瑞丹科技有限公司 | 增强机体免疫力的药物组合物及其制备方法 |
| CN103127182B (zh) * | 2013-03-11 | 2014-05-28 | 王永铨 | 冬虫夏草真菌蝙蝠蛾被毛孢菌丝超细粉片剂的制备方法 |
| CN103432172A (zh) * | 2013-08-23 | 2013-12-11 | 周秋火 | 虫草片剂 |
| CN108065369A (zh) * | 2017-12-27 | 2018-05-25 | 青海珠峰冬虫夏草保健品有限公司 | 一种蝙蝠蛾被毛孢菌粉保健品 |
| CN109172617A (zh) * | 2018-11-29 | 2019-01-11 | 江西济民可信金水宝制药有限公司 | 一种口腔崩解片 |
| CN110496141B (zh) * | 2019-09-10 | 2022-02-25 | 杭州华东医药集团新药研究院有限公司 | 一种含冬虫夏草的药物组合物 |
| CN110575442B (zh) * | 2019-10-16 | 2022-03-18 | 青海珠峰冬虫夏草药业有限公司 | 一种发酵冬虫夏草菌粉片剂 |
| CN110772545A (zh) * | 2019-11-08 | 2020-02-11 | 西藏藏草宜生生物科技有限公司 | 一种蝙蝠蛾被毛孢菌丝超细粉的片剂的制备方法 |
| CN112617187A (zh) * | 2020-12-30 | 2021-04-09 | 广东粤微食用菌技术有限公司 | 一种具有增强免疫力功能的破壁蝙蝠蛾被毛孢菌丝体胶囊及其制备方法和用途 |
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| 中华人民共和国药典 2005年版一部.2005,434. |
| 中华人民共和国药典 2005年版一部.2005,434. * |
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