CN101091789B - 海洋胶原肽在制备免疫调节药物或食品中的用途 - Google Patents
海洋胶原肽在制备免疫调节药物或食品中的用途 Download PDFInfo
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Abstract
本发明涉及海洋胶原肽在制备免疫调节药物或食品中的用途，所述海洋胶原肽是由大马哈鱼或罗非鱼的鱼皮经水解产生的一组分子量在200～1000D的小分子肽，具有容易吸收、吸收快、低粘度、水溶性好等特点。实验证实，给予小鼠海洋胶原肽可明显增强小鼠迟发性变态反应(DTH)能力和ConA刺激的T淋巴细胞增殖；同时可明显增加抗体生成细胞数量，并对巨噬细胞碳粒廓清能力和对鸡红细胞的吞噬能力具有明显促进作用。上述结果表明海洋胶原肽对细胞免疫功能、体液免疫功能及巨噬细胞的吞噬功能均具有调节作用。
Description
技术领域
本发明涉及海洋胶原肽的新用途，具体来说是海洋胶原肽在制备免疫调节药物或食品中的用途。属食品保健和医药领域。
背景技术
近年来，免疫功能低下，包括原发性及继发性免疫功能缺陷、缺乏或受损，受到国内外医学家们的广泛关注，因为它们本身及所诱发的各种并发症，特别是感染，常使病人的病情严重，难以治疗，并可引起严重的后果，甚至危及生命。如果通过开发保健食品，来改善机体免疫功能，经济实用，将对我国的卫生保健行业带来很大的前景。
植物和动物蛋白质水解产生的某些肽具有免疫活性作用。Meisel等(1996)证实酪蛋白序列中存在不同的生物活性成份，经酶解后可得到下列四种活性肽：①opioid agonists阿片类激动剂。②opiiod anregonists阿片类拮抗剂。③immunostinulants(immunopeptides)免疫刺激剂。④mineral Carriers(Caseinphosphopeptided)金属载体。β-酪蛋白水解生成的三肽Leu-Leu-Tyr以及α-酪蛋白的N末端Thr-Thy-Met-Pro-Leu-Phe在试验中可以促进人和绵羊腹膜内巨噬细胞的吞噬作用。Berthoa等(1981)，Parker等从人乳酪蛋白酶解中分离得到的二种活性肽，Val-Gln-Pro-Ile-Pro-tyr和Gly-Leu-Phe这二种肽浓度在0.1umol/L时就能激活腹膜巨噬细胞对绵羊红细胞的吞噬作用。Cosre等(1992)报道β-酪蛋白胃蛋白酶-糜蛋白酶消化产物中的多肽可促进大鼠成熟的淋巴细胞的未成熟的脾细胞的增殖。Azuma等(1989)从卵清蛋白中提取的肽能促进细胞的生长和DNA的合成。陈栋梁等学者应用同位素示踪动物实验也证实了白蛋白多肽与核酸共同食用，可促进核苷酸的吸收及利用促进免疫器官核酸的分布量，有益于免疫细胞内核酸代谢的补救合成，提高机体的细胞免疫功能。
海洋胶原肽是由大马哈鱼或罗非鱼的鱼皮经水解产生的一组分子量在200～1000D的小分子肽。具有容易吸收、吸收快、低粘度、水溶性好等特点。已有研究表明，海洋胶原肽具有调节血脂作用、增加骨密度的作用。
发明内容
本发明旨在通过进一步研究，提供海洋胶原肽在制备免疫调节药物或食品中的用途，为通过饮食改善机体免疫功能提供一种新途径。
其中所述的药物为粉剂、颗粒剂、胶囊、片剂、丸剂。
其中所述的食品为淀粉制品、乳及乳制品、豆制品、烘焙制品。
具体实施方案
以下通过动物实验来阐明本发明所述海洋胶原肽在免疫调节方面的作用效果。
1.材料和方法
1.1受试样品：海洋胶原肽，由北京中食海氏生物技术有限公司制备。
1.2实验动物：清洁级雌性ICR小鼠192只，6～8周龄，18～22克，由北京大学医学部实验动物中心提供，批准号为SCXK11-00-0004，清洁级动物房饲养，饲养环境温度25℃，湿度60％RH。
1.3检验指标：小鼠脾脏和胸腺重；抗体形成细胞(IgM-PFC/脾)测定，采用Jerne改良玻片法；血清抗体滴度，采用血清半数溶血值HC50；迟发型变态反应(DTH)，采用足跖肿胀法测定；ConA刺激的小鼠脾淋巴细胞增殖功能，采用MTT法；巨噬细胞吞噬功能的检测，采用碳粒廓清法及腹腔巨噬细胞吞噬鸡红细胞(半体内法)测定；NK细胞活性测定，采用乳酸脱氢酶(LDH)测定法。
1.4实验方法：动物分成溶剂对照组、低剂量组、中剂量组和高剂量组，每组48只，每组再分为4个亚组，每个亚组12只。将海洋胶原肽配成低、中、高三个浓度，即0.22gl/kg、0.45g/kg和1.35g/kg体重，分别相当于人每天用量(2.7g/d)的5、10和30倍，各实验组小鼠每天灌胃一次，灌胃量按0.1ml/10g体重计，连续灌胃30天，实验结束时按照卫生部《保健食品功能学评价程序和检验方法》进行上述指标检测。
2.结果
2.1海洋胶原肽对小鼠免疫器官重量的影响：结果显示，给予海洋胶原肽30天，未对小鼠脾脏和胸腺的绝对重量和相对重量产生明显影响。
2.2海洋胶原肽对小鼠细胞免疫功能的影响：由表1中可见，与对照组比较，0.45和1.35g/kgbw组小鼠足跖肿胀程度显著增高(P＜0.05)；表2显示各剂量组小鼠淋巴细胞增殖显著高于对照组(P＜0.05)。上述结果表明海洋胶原肽对小鼠细胞免疫功能中的迟发性变态反应(DTH)和ConA刺激的T淋巴细胞增殖有明显的增强作用。
表1.海洋胶原肽对小鼠迟发性变态反应(DTH)的影响
*：与对照组(0g/kgBW)比较差异有显著性，P＜0.05
表2.海洋胶原肽对ConA刺激的小鼠T淋巴细胞增殖(DTH)的影响
*：与对照组(0g/kgBW)比较差异有显著性，P＜0.05
2.3海洋胶原肽对小鼠体液免疫功能的影响：由表3中可见，与对照组比较，0.45和1.35g/kgbw组小鼠抗体生成细胞数量显著增高(P＜0.05)；表4显示各剂量组小鼠半数溶血值与对照组相比未见明显变化(P＞0.05)。上述结果表明海洋胶原肽可明显提高小鼠抗体生成细胞的数量，对小鼠血清抗体滴度没有明显影响；结果提示海洋胶原肽对小鼠体液免疫功能有增强的作用。
表3.海洋胶原肽对小鼠抗体生成细胞(IgM-PFC)的影响
*：与对照组(0g/kgBW)比较差异有显著性，P＜0.05
表4.海洋胶原肽对小鼠半数溶血值(HC50)的影响
2.4海洋胶原肽对小鼠巨噬细胞吞噬功能的影响：由表5中可见，与对照组比较，0.45和1.35g/kgbw组小鼠碳粒廓清指数显著增高(P＜0.05)；表6显示各剂量组小鼠腹腔巨噬细胞吞噬鸡红细胞的吞噬率(PP)和吞噬指数(PI)与对照组相比均显著升高(P＜0.05)。上述结果表明海洋胶原肽可明显提高小鼠抗体生成细胞的数量，对小鼠血清抗体滴度没有明显影响；结果提示海洋胶原肽对小鼠体液免疫功能有增强的作用。
表5.海洋胶原肽对小鼠碳粒廓清能力的影响
*：与对照组(0g/kgBw)比较差异有显著性，P＜0.05
表6.海洋胶原肽对小鼠巨噬细胞吞噬率(PP)和吞噬指数(PI)的影响
*：与对照组(0g/kg/BW)比较差异有显著性，P＜0.05
2.5海洋胶原肽对小鼠自然杀伤(NK)细胞活性的影响：结果显示，与对照组比较，给予海洋胶原肽30天未对小鼠NK细胞活性产生明显影响。
3.结论
小鼠经口给予海洋胶原肽30天后，其检测结果表明，海洋胶原肽对细胞免疫功能中迟发性变态反应(DTH)和ConA刺激的T淋巴细胞增殖有明显的增强作用；对体液免疫功能中的抗体生成细胞数量具有明显的升高作用；对巨噬细胞碳粒廓清能力和对鸡红细胞的吞噬能力具有明显促进作用；综上结果显示海洋胶原肽具有免疫调节作用。
Claims (3)
1.海洋胶原肽在制备免疫调节药物或食品中的用途，所述海洋胶原肽是以大马哈鱼或罗非鱼的鱼皮经水解产生的一组分子量在200-1000D的小分子肽。
2.按权利要求1所述的用途，其中所述的药物为粉剂、颗粒剂、胶囊、片剂、丸剂。
3.按权利要求1所述的用途，其中所述的食品为淀粉制品、乳及乳制品、豆制品、烘焙制品。
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| CN102077942B (zh) * | 2010-09-20 | 2013-04-24 | 王强 | 一种骨病患者专用的海洋特膳食品 |
| CN102140467B (zh) * | 2010-12-30 | 2013-05-15 | 苏州吉玛基因股份有限公司 | 人miR-365反义核酸及其应用 |
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