CN101074210A - 具有药物活性的二氢异吲哚衍生物 - Google Patents

具有药物活性的二氢异吲哚衍生物 Download PDF

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Publication number
CN101074210A
CN101074210A CNA200710104109XA CN200710104109A CN101074210A CN 101074210 A CN101074210 A CN 101074210A CN A200710104109X A CNA200710104109X A CN A200710104109XA CN 200710104109 A CN200710104109 A CN 200710104109A CN 101074210 A CN101074210 A CN 101074210A
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CN
China
Prior art keywords
carbon atom
phenyl
compound
alkyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA200710104109XA
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English (en)
Chinese (zh)
Inventor
文汉华
乔治·马勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celgene Corp
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of CN101074210A publication Critical patent/CN101074210A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA200710104109XA 1999-11-12 2000-11-09 具有药物活性的二氢异吲哚衍生物 Pending CN101074210A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16516899P 1999-11-12 1999-11-12
US60/165,168 1999-11-12
US59034400A 2000-06-08 2000-06-08
US09/590,344 2000-06-08
US09/708,199 2000-11-08

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB00818254XA Division CN1325497C (zh) 1999-11-12 2000-11-09 具有药物活性的二氢异吲哚衍生物

Publications (1)

Publication Number Publication Date
CN101074210A true CN101074210A (zh) 2007-11-21

Family

ID=29738942

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA200710104109XA Pending CN101074210A (zh) 1999-11-12 2000-11-09 具有药物活性的二氢异吲哚衍生物

Country Status (3)

Country Link
CN (1) CN101074210A (de)
DE (1) DE60045878D1 (de)
TW (2) TWI261592B (de)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105294533A (zh) * 2015-12-02 2016-02-03 宋彤云 一种治疗骨病的药物组合物
WO2019091046A1 (zh) * 2017-11-13 2019-05-16 广东中科药物研究有限公司 一种来那度胺的衍生物的制备方法与应用
CN111170925A (zh) * 2020-01-09 2020-05-19 常州大学 作为pde2/4双重抑制剂的邻苯二甲酰亚胺类化合物及其制备方法
CN114436935A (zh) * 2022-02-14 2022-05-06 河南师范大学 不对称共轭加成合成光学活性β-氨基酮衍生物的方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105294533A (zh) * 2015-12-02 2016-02-03 宋彤云 一种治疗骨病的药物组合物
WO2019091046A1 (zh) * 2017-11-13 2019-05-16 广东中科药物研究有限公司 一种来那度胺的衍生物的制备方法与应用
CN111170925A (zh) * 2020-01-09 2020-05-19 常州大学 作为pde2/4双重抑制剂的邻苯二甲酰亚胺类化合物及其制备方法
CN114436935A (zh) * 2022-02-14 2022-05-06 河南师范大学 不对称共轭加成合成光学活性β-氨基酮衍生物的方法

Also Published As

Publication number Publication date
TWI276628B (en) 2007-03-21
DE60045878D1 (de) 2011-06-01
TWI261592B (en) 2006-09-11
TW200502219A (en) 2005-01-16

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C06 Publication
PB01 Publication
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SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20071121