TW200502219A - Pharmaceutically active isoindoline derivatives - Google Patents

Pharmaceutically active isoindoline derivatives

Info

Publication number
TW200502219A
TW200502219A TW093100952A TW93100952A TW200502219A TW 200502219 A TW200502219 A TW 200502219A TW 093100952 A TW093100952 A TW 093100952A TW 93100952 A TW93100952 A TW 93100952A TW 200502219 A TW200502219 A TW 200502219A
Authority
TW
Taiwan
Prior art keywords
pharmaceutically active
isoindoline derivatives
active isoindoline
dione
derivatives
Prior art date
Application number
TW093100952A
Other languages
Chinese (zh)
Other versions
TWI276628B (en
Inventor
George W Muller
Hon-Wah Man
Shen-Chu Roger Chen
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of TW200502219A publication Critical patent/TW200502219A/en
Application granted granted Critical
Publication of TWI276628B publication Critical patent/TWI276628B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Isoindolin-1-one and lsoindoline-1,3-dione substituted in the 2-position with an α-(3,4-disubstituted phenyl)alkyl group and in the 4- and/or 5-position with a nitrogen-containing group are inhibitors of, and thus useful in the treatment of disease states mediated by, TNF α and phosphodiesterase. A typical embodiment is 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methyl sulfonylethyl]-4,5-diamionisoindoline-1,3-dione.
TW93100952A 1999-11-12 2000-12-07 Pharmaceutically active isoindoline derivatives TWI276628B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16516899P 1999-11-12 1999-11-12
US59034400A 2000-06-08 2000-06-08

Publications (2)

Publication Number Publication Date
TW200502219A true TW200502219A (en) 2005-01-16
TWI276628B TWI276628B (en) 2007-03-21

Family

ID=29738942

Family Applications (2)

Application Number Title Priority Date Filing Date
TW93100952A TWI276628B (en) 1999-11-12 2000-12-07 Pharmaceutically active isoindoline derivatives
TW89123732A TWI261592B (en) 1999-11-12 2000-12-07 Pharmaceutically active isoindoline derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW89123732A TWI261592B (en) 1999-11-12 2000-12-07 Pharmaceutically active isoindoline derivatives

Country Status (3)

Country Link
CN (1) CN101074210A (en)
DE (1) DE60045878D1 (en)
TW (2) TWI276628B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105294533A (en) * 2015-12-02 2016-02-03 宋彤云 Pharmaceutical composition for treating bone diseases
CN107698484B (en) * 2017-11-13 2020-05-19 广东中科药物研究有限公司 Preparation method and application of lenalidomide derivative
CN111170925B (en) * 2020-01-09 2023-01-17 常州大学 Phthalimide compound as PDE2/4 dual inhibitor and preparation method thereof
CN114436935B (en) * 2022-02-14 2024-05-28 河南师范大学 Method for synthesizing optically active beta-amino ketone derivative by asymmetric conjugate addition

Also Published As

Publication number Publication date
TWI276628B (en) 2007-03-21
DE60045878D1 (en) 2011-06-01
TWI261592B (en) 2006-09-11
CN101074210A (en) 2007-11-21

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees