CN101048375B - 视黄酸的氨基、氨基酸或肽共轭物 - Google Patents

视黄酸的氨基、氨基酸或肽共轭物 Download PDF

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Publication number
CN101048375B
CN101048375B CN200580022901XA CN200580022901A CN101048375B CN 101048375 B CN101048375 B CN 101048375B CN 200580022901X A CN200580022901X A CN 200580022901XA CN 200580022901 A CN200580022901 A CN 200580022901A CN 101048375 B CN101048375 B CN 101048375B
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China
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residue
alkynyl
amino acid
alkyl
peptide
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Expired - Fee Related
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CN200580022901XA
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Chinese (zh)
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CN101048375A (zh
Inventor
拉斐尔·布玛
约亨·克洛克
于尔根·H·沃勒哈特
菲利普·以马利·迈兰
思得凡·斯多克利
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DSM IP Assets BV
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DSM IP Assets BV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Birds (AREA)
  • Cosmetics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200580022901XA 2004-07-09 2005-07-01 视黄酸的氨基、氨基酸或肽共轭物 Expired - Fee Related CN101048375B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04016239.8 2004-07-09
EP04016239 2004-07-09
PCT/EP2005/007134 WO2006005455A2 (en) 2004-07-09 2005-07-01 Amino, amino acid or peptide conjugates of retinoic acid

Publications (2)

Publication Number Publication Date
CN101048375A CN101048375A (zh) 2007-10-03
CN101048375B true CN101048375B (zh) 2012-12-05

Family

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Family Applications (1)

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CN200580022901XA Expired - Fee Related CN101048375B (zh) 2004-07-09 2005-07-01 视黄酸的氨基、氨基酸或肽共轭物

Country Status (7)

Country Link
US (1) US20070270472A1 (cg-RX-API-DMAC7.html)
EP (1) EP1765773A2 (cg-RX-API-DMAC7.html)
JP (1) JP2008515770A (cg-RX-API-DMAC7.html)
KR (1) KR20070038509A (cg-RX-API-DMAC7.html)
CN (1) CN101048375B (cg-RX-API-DMAC7.html)
BR (1) BRPI0513145A (cg-RX-API-DMAC7.html)
WO (1) WO2006005455A2 (cg-RX-API-DMAC7.html)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10959933B1 (en) 2020-06-01 2021-03-30 The Procter & Gamble Company Low pH skin care composition and methods of using the same
US11110049B2 (en) 2017-06-23 2021-09-07 The Procter & Gamble Company Composition and method for improving the appearance of skin
US11583488B2 (en) 2020-06-01 2023-02-21 The Procter & Gamble Company Method of improving penetration of a vitamin B3 compound into skin
US11622963B2 (en) 2018-07-03 2023-04-11 The Procter & Gamble Company Method of treating a skin condition

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8628756B2 (en) * 2005-12-30 2014-01-14 Revance Therapeutics, Inc. Arginine heteromers for topical administration
EP2491928A2 (en) * 2007-10-19 2012-08-29 The University of Tokyo Therapeutic agent for vitiligo and method of accelerating pigmentation
JP6018752B2 (ja) * 2009-09-29 2016-11-02 株式会社 資生堂 抗酸化組成物
EP2667853A4 (en) * 2011-01-25 2014-08-20 Procter & Gamble LIPOSOME AND BODY CARE COMPOSITION THEREWITH
KR101224809B1 (ko) * 2012-04-24 2013-01-21 주식회사 아이피어리스 레티노산 유도체, 이의 제조 방법 및 이를 포함하는 화장품 조성물
EP2745904B1 (en) 2012-12-21 2015-12-16 Dionex Corporation HILIC/Anion-Exchange/Cation-Exchange Multimodal Media
US9511144B2 (en) 2013-03-14 2016-12-06 The Proctor & Gamble Company Cosmetic compositions and methods providing enhanced penetration of skin care actives
KR102157407B1 (ko) * 2013-08-15 2020-09-17 마리 케이 인코포레이티드 주름 치료를 위한 국소 피부 조성물
FR3054130B1 (fr) * 2016-07-22 2019-04-26 Syntivia Procede de traitement cosmetique de la peau
KR102093209B1 (ko) * 2017-05-11 2020-03-25 (주)케어젠 이소트레티노인과 펩타이드의 결합체
CN110831586B (zh) * 2017-05-23 2023-06-13 密执安大学评议会 二甲基-壬四烯基-三甲基-环己基化合物及其用途
KR102076178B1 (ko) * 2018-07-18 2020-02-11 주식회사 코리아나화장품 초유 및 오르니틴을 유효성분으로 함유하는 피부 주름 개선용 화장료 조성물
KR20210092483A (ko) 2020-01-16 2021-07-26 맹창남 모발 및 두피상태 개선용 화장료 조성물
CN117384073A (zh) * 2022-07-11 2024-01-12 南京毓浠医药技术有限公司 一种维a酸醇胺类复合物及其制备方法和应用
CN118121574A (zh) * 2022-12-02 2024-06-04 南京毓浠医药技术有限公司 一种含维a酸组合物及其制备方法和用途
KR20250136628A (ko) 2024-03-08 2025-09-16 주식회사 에이치엔컴퍼니 모발 개선용 화장료 조성물
CN118126119B (zh) * 2024-05-10 2024-08-06 荷本世新(北京)生物科技有限公司 维a酸多肽衍生物及其制备方法和用途

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GB1449027A (en) * 1973-01-03 1976-09-08 Basf Ag Vitamin a acid amides
US4108880A (en) * 1975-11-03 1978-08-22 Johnson & Johnson Esters of retinoic acid
CN1429815A (zh) * 2002-09-02 2003-07-16 复旦大学 化合物n－全反式维甲酰胺衍生物及其制备方法和应用

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US3950418A (en) * 1970-02-02 1976-04-13 Hoffmann-La Roche Inc. Vitamin A acid amides
CH529742A (de) * 1970-02-02 1972-10-31 Hoffmann La Roche Verfahren zur Herstellung von Vitamin-A-Säureamiden
CH661516A5 (de) * 1983-12-08 1987-07-31 Hoffmann La Roche Phenylnonatetraenoylzuckerderivate.
US5559149A (en) * 1990-01-29 1996-09-24 Johnson & Johnson Consumer Products, Inc. Skin care compositions containing retinoids
DE4032187C2 (de) * 1990-10-10 1995-03-30 Gradinger F Hermes Pharma N-Retinoyl-L-aminomercapto-Verbindungen und Zwischenprodukte, Verfahren zu ihrer Herstellung und ihre Verwendung
DE19523079A1 (de) * 1995-06-26 1997-01-02 Basf Ag Ester und Amide der 9(Z)-Retinsäure
JP3510591B2 (ja) * 1998-03-30 2004-03-29 エルジ ケミカル リミテッド ポリエトキシル化レチンアミド誘導体およびその製造方法
JP4646408B2 (ja) * 1999-03-02 2011-03-09 協和発酵バイオ株式会社 化粧料
JP2001039997A (ja) * 1999-07-29 2001-02-13 Lion Corp 安定化されたレチノイン酸類の誘導体、ならびにそれらを含有する外用剤組成物
JP4221547B2 (ja) * 2001-01-26 2009-02-12 ライオン株式会社 レチノイン酸類またはその誘導体を含有する組成物
KR100439627B1 (ko) * 2001-06-18 2004-07-12 주식회사 엘지생활건강 피부주름 예방 및 치료용 조성물
EP1543821B1 (en) * 2002-07-25 2008-02-13 Lion Corporation External preparation
JP4256389B2 (ja) * 2003-11-17 2009-04-22 セダーマ テトラペプチドとトリペプチドの混合物を含む組成物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1449027A (en) * 1973-01-03 1976-09-08 Basf Ag Vitamin a acid amides
US4108880A (en) * 1975-11-03 1978-08-22 Johnson & Johnson Esters of retinoic acid
CN1429815A (zh) * 2002-09-02 2003-07-16 复旦大学 化合物n－全反式维甲酰胺衍生物及其制备方法和应用

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11110049B2 (en) 2017-06-23 2021-09-07 The Procter & Gamble Company Composition and method for improving the appearance of skin
US11622963B2 (en) 2018-07-03 2023-04-11 The Procter & Gamble Company Method of treating a skin condition
US10959933B1 (en) 2020-06-01 2021-03-30 The Procter & Gamble Company Low pH skin care composition and methods of using the same
US11583488B2 (en) 2020-06-01 2023-02-21 The Procter & Gamble Company Method of improving penetration of a vitamin B3 compound into skin
US11911498B2 (en) 2020-06-01 2024-02-27 The Procter & Gamble Company Low pH skin care composition and methods of using the same

Also Published As

Publication number Publication date
KR20070038509A (ko) 2007-04-10
BRPI0513145A (pt) 2008-04-29
WO2006005455A2 (en) 2006-01-19
US20070270472A1 (en) 2007-11-22
CN101048375A (zh) 2007-10-03
EP1765773A2 (en) 2007-03-28
JP2008515770A (ja) 2008-05-15
WO2006005455A3 (en) 2008-02-07

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