CN101031555A - 具有vap－1抑制活性的噻唑衍生物 - Google Patents
具有vap－1抑制活性的噻唑衍生物 Download PDFInfo
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- CN101031555A CN101031555A CNA200580031703XA CN200580031703A CN101031555A CN 101031555 A CN101031555 A CN 101031555A CN A200580031703X A CNA200580031703X A CN A200580031703XA CN 200580031703 A CN200580031703 A CN 200580031703A CN 101031555 A CN101031555 A CN 101031555A
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- Prior art keywords
- amino
- methyl
- thiazoles
- phenyl
- ethyl
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- 238000002360 preparation method Methods 0.000 claims description 141
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 141
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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| AU2004904196 | 2004-07-27 | ||
| AU2004904196A AU2004904196A0 (en) | 2004-07-27 | Thiazole Derivatives Having VAP-1 Inhibitory Activity |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103459369A (zh) * | 2011-03-15 | 2013-12-18 | 安斯泰来制药株式会社 | 胍化合物 |
| CN107661500A (zh) * | 2009-09-08 | 2018-02-06 | 生物结治疗公司 | Vap‑1抑制剂用于治疗纤维变性疾病的用途 |
| CN107922379A (zh) * | 2015-08-06 | 2018-04-17 | 宇部兴产株式会社 | 取代胍衍生物 |
| CN110114350A (zh) * | 2016-12-28 | 2019-08-09 | 宇部兴产株式会社 | 取代胍化合物 |
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| EP1999119A2 (en) | 2006-02-15 | 2008-12-10 | Abbott Laboratories | Novel acetyl-coa carboxylase (acc) inhibitors and their use in diabetes, obesity and metabolic syndrome |
| CN101384568B (zh) * | 2006-02-15 | 2012-12-12 | 雅培制药有限公司 | 乙酰辅酶a羧化酶(acc)抑制剂及其在糖尿病、肥胖症和代谢综合征中的应用 |
| KR20100034024A (ko) * | 2007-06-25 | 2010-03-31 | 가부시키가이샤 아루떼꾸 우에노 | 저산소 또는 허혈에 따른 안질환용 조성물 |
| EP2213303A4 (en) * | 2007-10-19 | 2011-12-28 | R Tech Ueno Ltd | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CATARACT |
| WO2009061830A1 (en) * | 2007-11-06 | 2009-05-14 | Massachusetts Eye & Ear Infirmary | Methods and compositions for treating conditions associated with angiogenesis using a vascular adhesion protein-1 (vap-1) inhibitor |
| US8362022B2 (en) * | 2008-01-18 | 2013-01-29 | Allergan, Inc. | Selective subtype alpha 2 adrenergic agents and methods for use thereof |
| TWI437986B (zh) | 2008-01-31 | 2014-05-21 | R Tech Ueno Ltd | 噻唑衍生物及使用該衍生物作為ｖａｐ－１抑制劑之用途 |
| TWI490214B (zh) | 2008-05-30 | 2015-07-01 | 艾德克 上野股份有限公司 | 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途 |
| KR20110082145A (ko) * | 2008-10-21 | 2011-07-18 | 메타볼렉스, 인코포레이티드 | 아릴 ｇｐｒ１２０ 수용체 작동약 및 이의 용도 |
| FI20115234A0 (fi) | 2011-03-08 | 2011-03-08 | Biotie Therapies Corp | Uusia pyridatsinoni- ja pyridoniyhdisteitä |
| WO2013057944A1 (ja) | 2011-10-19 | 2013-04-25 | 興和株式会社 | 新規なスピロインドリン化合物、及びそれを含有する医薬 |
| US20160113893A1 (en) | 2013-06-12 | 2016-04-28 | Proximagen Limited | New therapeutic uses of enzyme inhibitors |
| ES2714125T3 (es) | 2014-04-15 | 2019-05-27 | Pecsi Tudomanyegyetem | Inhibidores de la amino oxidasa sensible a la semicarbazida para uso como analgésicos en una neuropatía traumática y una inflamación neurogénica |
| WO2015189534A1 (en) | 2014-06-12 | 2015-12-17 | Proximagen Limited | Vap-1 inhibitors for treating muscular dystrophy |
| CN104478828B (zh) * | 2014-12-10 | 2016-07-06 | 漳州片仔癀药业股份有限公司 | 2-氨基-7-取代苯并噻唑类化合物及其制备方法与用途 |
| JOP20200093A1 (ar) * | 2015-01-09 | 2017-06-16 | Kyowa Kirin Co Ltd | طريقة لإنتاج مشتق ثيازول |
| JP2018076236A (ja) | 2015-06-05 | 2018-05-17 | 株式会社アールテック・ウエノ | がんを処置するための医薬組成物 |
| CA3007768A1 (en) | 2015-12-07 | 2017-06-15 | Benevolentai Cambridge Limited | Vap-1 inhibitors for treating pain |
| KR20190003995A (ko) * | 2016-05-12 | 2019-01-10 | 베링거 인겔하임 인터내셔날 게엠베하 | 피리디닐 유도체, 약제학적 조성물 및 이의 aoc3 저해제로서의 용도 |
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| EP0068033B1 (en) * | 1981-01-08 | 1985-07-10 | Mitsui Toatsu Kagaku Kabushiki Kaisha | N-(4-phenyl-2-thiazolyl)carbamate derivatives, process for their preparation, and medicinal composition containing same |
| US4699928A (en) * | 1984-07-13 | 1987-10-13 | Merrell Dow Pharmaceuticals Inc. | Fluoroallylamine derivatives |
| IT1181871B (it) * | 1985-04-01 | 1987-09-30 | Consiglio Nazionale Ricerche | Inibitori selettivi delle benzilamminossidasi rispetto ad altre amminossidasi |
| US4916151A (en) * | 1985-12-05 | 1990-04-10 | Merrell Dow Pharmaceuticals Inc. | Method of treating parkinson's syndrome |
| US4650907A (en) * | 1985-12-05 | 1987-03-17 | Merrell Dow Pharmaceuticals Inc. | Nonaromatic fluoroallylamine MAO inhibitors |
| US5021456A (en) * | 1988-02-25 | 1991-06-04 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4943593A (en) * | 1988-02-25 | 1990-07-24 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4965288A (en) * | 1988-02-25 | 1990-10-23 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5059814A (en) * | 1988-11-30 | 1991-10-22 | The California Institute Of Technology | Winner-take-all circuits for neural computing systems |
| JPH0848664A (ja) * | 1994-08-05 | 1996-02-20 | Hisamitsu Pharmaceut Co Inc | 新規なグアニジノ安息香酸エステル誘導体 |
| GB9506188D0 (en) * | 1995-03-27 | 1995-05-17 | Fujisawa Pharmaceutical Co | Amidine derivatives |
| PL360374A1 (en) * | 2000-07-05 | 2004-09-06 | Biotie Therapies Corporation | Inhibitors of copper-containing amine oxidases |
| WO2002038153A1 (en) * | 2000-11-09 | 2002-05-16 | Biovitrum Ab | New use of 4, 5, 6, 7-tetrahydroimidazo-[4,5-c]pyridine derivatives |
| WO2004067521A1 (en) * | 2003-01-27 | 2004-08-12 | Astellas Pharma Inc. | Thiazole derivatives and their use as vap-1 inhibitors |
| WO2004087138A1 (en) * | 2003-03-31 | 2004-10-14 | Sucampo Ag | Method for treating vascular hyperpermeable disease |
| US20070208068A1 (en) * | 2004-03-18 | 2007-09-06 | R-Tech Ueno, Ltd. & Astellas Pharma Inc. | Aqueous Composition Comprising Thiazole Derivative |
-
2005
- 2005-07-27 DE DE602005013793T patent/DE602005013793D1/de active Active
- 2005-07-27 JP JP2007504792A patent/JP4978464B2/ja not_active Expired - Fee Related
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- 2005-07-27 ES ES05768525T patent/ES2324922T3/es active Active
- 2005-07-27 EP EP05768525A patent/EP1786792B1/en not_active Not-in-force
- 2005-07-27 AT AT05768525T patent/ATE427941T1/de not_active IP Right Cessation
- 2005-07-27 US US11/572,772 patent/US20070254931A1/en not_active Abandoned
- 2005-07-27 KR KR1020077004487A patent/KR20070050932A/ko not_active Application Discontinuation
- 2005-07-27 CN CNA200580031703XA patent/CN101031555A/zh active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107661500A (zh) * | 2009-09-08 | 2018-02-06 | 生物结治疗公司 | Vap‑1抑制剂用于治疗纤维变性疾病的用途 |
| CN103459369A (zh) * | 2011-03-15 | 2013-12-18 | 安斯泰来制药株式会社 | 胍化合物 |
| CN103459369B (zh) * | 2011-03-15 | 2015-05-27 | 安斯泰来制药株式会社 | 胍化合物 |
| US9051283B2 (en) | 2011-03-15 | 2015-06-09 | Astellas Pharma Inc. | Guanidine compound |
| US9556160B2 (en) | 2011-03-15 | 2017-01-31 | Astellas Pharma Inc. | Guanidine compound |
| CN107922379A (zh) * | 2015-08-06 | 2018-04-17 | 宇部兴产株式会社 | 取代胍衍生物 |
| US10759781B2 (en) | 2015-08-06 | 2020-09-01 | Ube Industries, Ltd. | Substituted guanidine derivatives |
| CN107922379B (zh) * | 2015-08-06 | 2020-11-06 | 宇部兴产株式会社 | 取代胍衍生物 |
| CN110114350A (zh) * | 2016-12-28 | 2019-08-09 | 宇部兴产株式会社 | 取代胍化合物 |
| CN110114350B (zh) * | 2016-12-28 | 2022-03-04 | 宇部兴产株式会社 | 取代胍化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE427941T1 (de) | 2009-04-15 |
| JP2008508188A (ja) | 2008-03-21 |
| EP1786792B1 (en) | 2009-04-08 |
| WO2006011631A3 (en) | 2006-04-20 |
| DE602005013793D1 (de) | 2009-05-20 |
| ES2324922T3 (es) | 2009-08-19 |
| WO2006011631A2 (en) | 2006-02-02 |
| KR20070050932A (ko) | 2007-05-16 |
| US20070254931A1 (en) | 2007-11-01 |
| EP1786792A2 (en) | 2007-05-23 |
| CA2575411A1 (en) | 2006-02-02 |
| JP4978464B2 (ja) | 2012-07-18 |
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