CN101028253A - 含有表没食子儿茶素没食子酸酯的组合物 - Google Patents
含有表没食子儿茶素没食子酸酯的组合物 Download PDFInfo
- Publication number
- CN101028253A CN101028253A CNA2007100964346A CN200710096434A CN101028253A CN 101028253 A CN101028253 A CN 101028253A CN A2007100964346 A CNA2007100964346 A CN A2007100964346A CN 200710096434 A CN200710096434 A CN 200710096434A CN 101028253 A CN101028253 A CN 101028253A
- Authority
- CN
- China
- Prior art keywords
- compositions
- polysaccharide
- egcg
- powder
- alginate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 title claims abstract description 35
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 title claims abstract description 32
- 239000000203 mixture Substances 0.000 title claims description 30
- 229940030275 epigallocatechin gallate Drugs 0.000 title abstract description 29
- 239000000843 powder Substances 0.000 claims abstract description 23
- 150000004676 glycans Chemical class 0.000 claims abstract description 20
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 20
- 239000005017 polysaccharide Substances 0.000 claims abstract description 20
- 239000008187 granular material Substances 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 6
- 229940072056 alginate Drugs 0.000 claims description 6
- 235000010443 alginic acid Nutrition 0.000 claims description 6
- 229920000615 alginic acid Polymers 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
- 239000012530 fluid Substances 0.000 claims description 5
- 229930014124 (-)-epigallocatechin gallate Natural products 0.000 claims description 4
- 235000004911 (-)-epigallocatechin gallate Nutrition 0.000 claims description 4
- VFSWRBJYBQXUTE-UHFFFAOYSA-N epi-Gallocatechin 3-O-gallate Natural products Oc1ccc2C(=O)C(OC(=O)c3cc(O)c(O)c(O)c3)C(Oc2c1)c4cc(O)c(O)c(O)c4 VFSWRBJYBQXUTE-UHFFFAOYSA-N 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 238000001694 spray drying Methods 0.000 claims description 4
- 238000005243 fluidization Methods 0.000 claims description 3
- 229910052756 noble gas Inorganic materials 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 229920001817 Agar Polymers 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- 229920002907 Guar gum Polymers 0.000 claims description 2
- -1 Hydroxypropyl Chemical group 0.000 claims description 2
- 239000008272 agar Substances 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 235000010418 carrageenan Nutrition 0.000 claims description 2
- 229920001525 carrageenan Polymers 0.000 claims description 2
- 239000000665 guar gum Substances 0.000 claims description 2
- 235000010417 guar gum Nutrition 0.000 claims description 2
- 229960002154 guar gum Drugs 0.000 claims description 2
- 239000002002 slurry Substances 0.000 claims description 2
- 238000005507 spraying Methods 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 239000000230 xanthan gum Substances 0.000 claims description 2
- 235000010493 xanthan gum Nutrition 0.000 claims description 2
- 229940082509 xanthan gum Drugs 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 abstract description 22
- 239000001814 pectin Substances 0.000 abstract description 22
- 229920001277 pectin Polymers 0.000 abstract description 22
- 150000001875 compounds Chemical class 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract 1
- 238000005469 granulation Methods 0.000 description 10
- 230000003179 granulation Effects 0.000 description 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 238000009477 fluid bed granulation Methods 0.000 description 4
- 239000000314 lubricant Substances 0.000 description 4
- 229920002472 Starch Chemical class 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000008107 starch Chemical class 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- HOWGUJZVBDQJKV-UHFFFAOYSA-N docosane Chemical compound CCCCCCCCCCCCCCCCCCCCCC HOWGUJZVBDQJKV-UHFFFAOYSA-N 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000003595 mist Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- DMBUODUULYCPAK-UHFFFAOYSA-N 1,3-bis(docosanoyloxy)propan-2-yl docosanoate Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCCCCCC DMBUODUULYCPAK-UHFFFAOYSA-N 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N 2,3,4,5-tetrahydroxypentanal Chemical compound OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 1
- 241001093152 Mangifera Species 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 235000021536 Sugar beet Nutrition 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002790 anti-mutagenic effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000001913 cellulose Chemical class 0.000 description 1
- 229920002678 cellulose Chemical class 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 229940040387 citrus pectin Drugs 0.000 description 1
- 239000009194 citrus pectin Substances 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 238000009478 high shear granulation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 125000000185 sucrose group Chemical group 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Jellies, Jams, And Syrups (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Fertilizers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01118246 | 2001-07-30 | ||
| EP01118246.6 | 2001-07-30 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028097823A Division CN1325049C (zh) | 2001-07-30 | 2002-07-22 | 含有表没食子儿茶素没食子酸酯的组合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101028253A true CN101028253A (zh) | 2007-09-05 |
Family
ID=8178165
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007100964346A Pending CN101028253A (zh) | 2001-07-30 | 2002-07-22 | 含有表没食子儿茶素没食子酸酯的组合物 |
| CNB028097823A Expired - Fee Related CN1325049C (zh) | 2001-07-30 | 2002-07-22 | 含有表没食子儿茶素没食子酸酯的组合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028097823A Expired - Fee Related CN1325049C (zh) | 2001-07-30 | 2002-07-22 | 含有表没食子儿茶素没食子酸酯的组合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20040198673A1 (enExample) |
| EP (1) | EP1411986B1 (enExample) |
| JP (1) | JP2005501833A (enExample) |
| KR (1) | KR100611855B1 (enExample) |
| CN (2) | CN101028253A (enExample) |
| AT (1) | ATE388723T1 (enExample) |
| AU (1) | AU2002327893B8 (enExample) |
| BR (1) | BR0209864A (enExample) |
| CA (1) | CA2450772C (enExample) |
| DE (1) | DE60225560T2 (enExample) |
| ES (1) | ES2301670T3 (enExample) |
| MX (1) | MXPA04000618A (enExample) |
| WO (1) | WO2003011339A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104719910A (zh) * | 2015-04-19 | 2015-06-24 | 福州乾正药业有限公司 | 具有热稳定性的egcg固体分散体组合物及其制备方法和应用 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006087164A1 (en) | 2005-02-15 | 2006-08-24 | Dsm Ip Assets B.V. | Compositions containing polysaccharides |
| CN100446762C (zh) * | 2005-09-05 | 2008-12-31 | 中山大学 | （-）-表没食子儿茶素没食子酸酯固体分散体及其制备方法与应用 |
| KR20100075960A (ko) * | 2007-10-29 | 2010-07-05 | 디에스엠 아이피 어셋츠 비.브이. | 레스베라트롤 및 펙틴을 함유하는 조성물 |
| CA2885388C (en) | 2012-10-04 | 2018-01-02 | Abbott Laboratories | Methods for enhancing the effect of egcg on mitigating skeletal muscle loss |
| WO2015136551A2 (en) * | 2014-03-12 | 2015-09-17 | Tata Chemicals Limited | A molecular complex of epigallocatechin-3-gallate and a process for production thereof |
| CN113384781B (zh) * | 2020-03-11 | 2024-03-29 | 李彤 | 一种egcg雾化系统 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3666484A (en) * | 1969-11-12 | 1972-05-30 | Lipton Inc Thomas J | Process for making a spray-dried instant tea of desired bulk density |
| US4268533A (en) * | 1979-11-21 | 1981-05-19 | General Foods Corporation | Quick-set low methoxyl pectin composition |
| JPS5759803A (en) * | 1980-09-30 | 1982-04-10 | Takeda Chem Ind Ltd | Granule of l-sodium ascorbate, its preparation, and tablet comprising it |
| AU587863B2 (en) * | 1985-10-07 | 1989-08-31 | Basf Aktiengesellschaft | Vitamin-containing granules and production thereof |
| US4800096A (en) * | 1987-05-29 | 1989-01-24 | General Foods Corporation | Pectin gelling composition |
| JP2812682B2 (ja) * | 1988-05-24 | 1998-10-22 | 株式会社伊藤園 | コレステロール排泄促進剤及びコレステロール排泄促進飲食物 |
| DE3903217A1 (de) * | 1989-02-03 | 1990-08-09 | Boehringer Ingelheim Vetmed | Verfahren zur herstellung fester pharmazeutischer zubereitungen |
| JPH03141220A (ja) * | 1989-10-26 | 1991-06-17 | Tsumura & Co | 抗レトロウイルス剤 |
| US4935256A (en) * | 1989-10-31 | 1990-06-19 | Procter & Gamble Company | Process for making green tea solids |
| PT96229B (pt) * | 1989-12-22 | 1998-06-30 | Syntex Pharma Int | Processo para a preparacao de composicoes farmaceuticas em po, secas por pulverizacao, directamente compressiveis em comprimidos, contendo naproxeno ou naproxeno sodico |
| JPH0595988A (ja) * | 1990-10-22 | 1993-04-20 | Kanebo Ltd | 漢方エキス造粒物および漢方エキス含有固形製剤の製造方法 |
| JPH04253918A (ja) * | 1991-02-05 | 1992-09-09 | Mitsui Norin Kk | 血糖上昇抑制剤 |
| JP3469258B2 (ja) * | 1992-10-09 | 2003-11-25 | 太陽化学株式会社 | 腎機能改善用剤 |
| US5486507A (en) * | 1994-01-14 | 1996-01-23 | Fuisz Technologies Ltd. | Porous particle aggregate and method therefor |
| JPH07223941A (ja) * | 1994-02-14 | 1995-08-22 | Nippon Ham Kk | 抗補体作用物質 |
| JP4127864B2 (ja) * | 1994-09-29 | 2008-07-30 | 太陽化学株式会社 | グラム陰性菌増殖抑制剤 |
| JPH08253423A (ja) * | 1995-01-19 | 1996-10-01 | Tokushu Meneki Kenkyusho:Kk | ラクトフェリン含有食品・医薬品顆粒およびその製造 方法 |
| AU689036B2 (en) * | 1995-05-10 | 1998-03-19 | Kureha Chemical Industry Co., Ltd. | Pharmaceutical composition containing substance inhibiting HSP47 production |
| US5997937A (en) * | 1996-05-06 | 1999-12-07 | Kraft Foods, Inc. | Quick-setting gel mix |
| DE19627344A1 (de) * | 1996-07-01 | 1998-01-08 | Vitasyn Gmbh Entwicklung & Ver | Therapeutisch wirksame bzw. gesundheitsfördernde Zubereitung aus definierten Polyphenolverbindungen |
| JP4098376B2 (ja) * | 1996-09-05 | 2008-06-11 | ビーエーエスエフ ソシエタス・ヨーロピア | 錠剤特性の優れた水溶性ビタミン組成物およびその製造法 |
| WO1998029098A1 (en) * | 1996-12-31 | 1998-07-09 | Inhale Therapeutic Systems, Inc. | Processes for spray drying aqueous suspensions of hydrophobic drugs with hydrophilic excipients and compositions prepared by such processes |
| JPH10279486A (ja) * | 1997-04-02 | 1998-10-20 | Taiyo Kagaku Co Ltd | 免疫賦活組成物 |
| JPH11116475A (ja) * | 1997-10-07 | 1999-04-27 | Snow Brand Milk Prod Co Ltd | 炎症性腸疾患予防及び／又は治療剤 |
| US5904924A (en) * | 1997-11-04 | 1999-05-18 | Oncologics, Inc. | Green nutritional powder composition |
| US6093715A (en) * | 1999-03-24 | 2000-07-25 | Basf Aktiengesellschaft | Process for producing riboflavin-containing granules |
| US6410052B1 (en) * | 1999-03-30 | 2002-06-25 | Purdue Research Foundation | Tea catechins in sustained release formulations as cancer specific proliferation inhibitors |
| AU4043900A (en) * | 1999-03-30 | 2000-10-16 | Purdue Research Foundation | Compositions containing tea catechins as cancer specific proliferation inhibitors |
| JP4082823B2 (ja) * | 1999-05-06 | 2008-04-30 | 日本メナード化粧品株式会社 | 光毒性抑制剤 |
| JP4731777B2 (ja) * | 1999-10-12 | 2011-07-27 | マルホ株式会社 | 経口医薬組成物 |
| US20040202714A1 (en) * | 1999-10-12 | 2004-10-14 | Daiichi Suntory Pharma Co., Ltd. | Oral pharmaceutical composition |
| FI20000004A0 (fi) * | 2000-01-03 | 2000-01-03 | Slk Foundation | Flavonoidilääke... |
| JP3694733B2 (ja) * | 2000-06-29 | 2005-09-14 | 独立行政法人農業・生物系特定産業技術研究機構 | 抗アレルギー剤 |
| US6358526B1 (en) * | 2000-08-16 | 2002-03-19 | Rexall Sundown | Method of making tablets and tablet compositions produced therefrom |
-
2002
- 2002-07-22 DE DE60225560T patent/DE60225560T2/de not_active Revoked
- 2002-07-22 CA CA002450772A patent/CA2450772C/en not_active Expired - Fee Related
- 2002-07-22 KR KR1020047001329A patent/KR100611855B1/ko not_active Expired - Fee Related
- 2002-07-22 ES ES02762383T patent/ES2301670T3/es not_active Expired - Lifetime
- 2002-07-22 CN CNA2007100964346A patent/CN101028253A/zh active Pending
- 2002-07-22 JP JP2003516569A patent/JP2005501833A/ja active Pending
- 2002-07-22 CN CNB028097823A patent/CN1325049C/zh not_active Expired - Fee Related
- 2002-07-22 EP EP02762383A patent/EP1411986B1/en not_active Revoked
- 2002-07-22 BR BR0209864-4A patent/BR0209864A/pt not_active Application Discontinuation
- 2002-07-22 US US10/485,248 patent/US20040198673A1/en not_active Abandoned
- 2002-07-22 MX MXPA04000618A patent/MXPA04000618A/es active IP Right Grant
- 2002-07-22 AU AU2002327893A patent/AU2002327893B8/en not_active Ceased
- 2002-07-22 AT AT02762383T patent/ATE388723T1/de not_active IP Right Cessation
- 2002-07-22 WO PCT/EP2002/008127 patent/WO2003011339A1/en not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104719910A (zh) * | 2015-04-19 | 2015-06-24 | 福州乾正药业有限公司 | 具有热稳定性的egcg固体分散体组合物及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60225560D1 (de) | 2008-04-24 |
| CA2450772A1 (en) | 2003-02-13 |
| MXPA04000618A (es) | 2005-06-17 |
| EP1411986A1 (en) | 2004-04-28 |
| AU2002327893A1 (en) | 2003-02-17 |
| KR100611855B1 (ko) | 2006-08-11 |
| ES2301670T3 (es) | 2008-07-01 |
| DE60225560T2 (de) | 2009-04-02 |
| AU2002327893B2 (en) | 2006-12-21 |
| WO2003011339A1 (en) | 2003-02-13 |
| CA2450772C (en) | 2008-09-30 |
| EP1411986B1 (en) | 2008-03-12 |
| JP2005501833A (ja) | 2005-01-20 |
| AU2002327893B8 (en) | 2007-01-18 |
| BR0209864A (pt) | 2004-06-08 |
| US20040198673A1 (en) | 2004-10-07 |
| ATE388723T1 (de) | 2008-03-15 |
| CN1325049C (zh) | 2007-07-11 |
| CN1509186A (zh) | 2004-06-30 |
| KR20040032872A (ko) | 2004-04-17 |
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