CN101014581A - 用于治疗抑郁的新哌啶衍生物 - Google Patents
用于治疗抑郁的新哌啶衍生物 Download PDFInfo
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- CN101014581A CN101014581A CNA2005800262910A CN200580026291A CN101014581A CN 101014581 A CN101014581 A CN 101014581A CN A2005800262910 A CNA2005800262910 A CN A2005800262910A CN 200580026291 A CN200580026291 A CN 200580026291A CN 101014581 A CN101014581 A CN 101014581A
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- base
- compound
- benzo
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- phenyl
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Classifications
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- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
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- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/64—Oxygen atoms
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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SE04019691 | 2004-08-02 | ||
SE0401969A SE0401969D0 (sv) | 2004-08-02 | 2004-08-02 | Piperidine derivatives |
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CN101014581A true CN101014581A (zh) | 2007-08-08 |
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CNA2005800262910A Pending CN101014581A (zh) | 2004-08-02 | 2005-07-27 | 用于治疗抑郁的新哌啶衍生物 |
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Cited By (1)
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CN103254127A (zh) * | 2013-05-28 | 2013-08-21 | 北京哈三联科技有限责任公司 | 甘氨酸重摄取抑制剂及其应用 |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2008129622A (ru) * | 2005-12-20 | 2010-01-27 | Новартис АГ (CH) | Производные никотиновой кислоты в качестве модуляторов метаботропных глутаматных рецепторов |
DE102006060598A1 (de) * | 2006-12-21 | 2008-06-26 | Merck Patent Gmbh | Tetrahydrobenzoisoxazole |
SK542007A3 (sk) | 2007-04-20 | 2008-11-06 | Unimed Pharma, Spol. S R. O. | Substituované sulfónamidy, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie |
HUP0900281A2 (hu) * | 2009-05-05 | 2011-01-28 | Univ Szegedi | Kinurénsav-származékok, eljárás a vegyületek elõállítására, a vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk fejfájás kezelésére |
RU2584986C2 (ru) * | 2011-08-03 | 2016-05-27 | Нэшнл Тайвань Юниверсити | Агонисты протеинтирозинфосфатазы-1, содержащей домен гомологии-2 src, и способы лечения с применением указанных агонистов |
EP3116501A1 (en) | 2014-03-13 | 2017-01-18 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing cftr activity |
EP3116870A1 (en) | 2014-03-13 | 2017-01-18 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing cftr activity |
WO2015161011A1 (en) * | 2014-04-17 | 2015-10-22 | Merck Sharp & Dohme Corp. | Benzamide cgrp receptor antagonists |
CA2952862A1 (en) | 2014-06-19 | 2015-12-23 | Proteostasis Therapeutics, Inc. | Compounds, compositions and methods of increasing cftr activity |
MA41253A (fr) | 2014-12-23 | 2017-10-31 | Proteostasis Therapeutics Inc | Composés, compositions et procédés pour augmenter l'activité du cftr |
US10392378B2 (en) | 2014-12-23 | 2019-08-27 | Proteostasis Therapeutics, Inc. | Derivatives of 5-phenyl- or 5-heteroarylathiazol-2-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
CA2971855A1 (en) | 2014-12-23 | 2016-06-30 | Proteostasis Therapeutics, Inc. | Derivatives of 5-(hetero)arylpyrazol-3-carboxylic amide or 1-(hetero)aryltriazol-4-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
CA2971835A1 (en) | 2014-12-23 | 2016-06-30 | Proteostasis Therapeutics, Inc. | Derivatives of 3-heteroarylisoxazol-5-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
AU2016297886B2 (en) | 2015-07-24 | 2020-12-10 | Proteostasis Therapeutics, Inc. | Compounds, compositions and methods of increasing CFTR activity |
JP6929276B2 (ja) | 2015-10-06 | 2021-09-01 | プロテオステイシス セラピューティクス,インコーポレイテッド | 化合物、医薬的に許容される塩又はその立体異性体及び医薬組成物 |
MA43775A (fr) | 2016-04-07 | 2021-05-05 | Proteostasis Therapeutics Inc | Analogues du ivacaftor conentant des atomes de silicium |
WO2017223188A1 (en) | 2016-06-21 | 2017-12-28 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing cftr activity |
KR20220090492A (ko) * | 2019-07-23 | 2022-06-29 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 바이시클릭 cx3cr1 수용체 작용제 |
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FR2396757A2 (fr) * | 1977-07-08 | 1979-02-02 | Ile De France | Nouveaux 2,3-alkylene bis (oxy) benzamides substitues, leurs derives et leurs procedes de preparation |
IL117438A (en) * | 1995-03-16 | 2001-12-23 | Lilly Co Eli | Indazolecarboxamides, their preparation and pharmaceutical compositions containing them |
ES2109190B1 (es) * | 1996-03-22 | 1998-07-01 | Univ Madrid Complutense | Nuevos derivados de bencimidazol con afinidad por los receptores serotoninergicos 5-ht /5-ht |
AU756586C (en) * | 1997-07-01 | 2004-01-29 | Warner-Lambert Company | 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors |
JP2002534381A (ja) * | 1999-01-07 | 2002-10-15 | ワーナー−ランバート・カンパニー | Mek阻害剤を用いた抗ウィルス法 |
CA2482341A1 (en) * | 2002-04-09 | 2003-10-23 | 7Tm Pharma A/S | Novel methoxybenzamide compounds for use in mch receptor related disorders |
AU2003226929A1 (en) * | 2002-11-25 | 2004-06-18 | 7Tm Pharma A/S | Novel benzamide compounds for use in mch receptor related disorders |
RU2229475C1 (ru) * | 2003-03-06 | 2004-05-27 | ООО "Исследовательский институт химического разнообразия | 6-сульфамоилхинолин-4-карбоновые кислоты, их производные и комбинаторная библиотека |
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2004
- 2004-08-02 SE SE0401969A patent/SE0401969D0/xx unknown
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2005
- 2005-07-27 CN CNA2005800262910A patent/CN101014581A/zh active Pending
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- 2005-07-27 RU RU2007105968/04A patent/RU2007105968A/ru not_active Application Discontinuation
- 2005-07-27 CA CA002576073A patent/CA2576073A1/en not_active Abandoned
- 2005-07-27 JP JP2007524766A patent/JP2008508351A/ja not_active Abandoned
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- 2005-07-27 US US11/572,965 patent/US20070191358A1/en not_active Abandoned
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2007
- 2007-01-04 IL IL180546A patent/IL180546A0/en unknown
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103254127A (zh) * | 2013-05-28 | 2013-08-21 | 北京哈三联科技有限责任公司 | 甘氨酸重摄取抑制剂及其应用 |
CN103254127B (zh) * | 2013-05-28 | 2015-08-19 | 北京哈三联科技有限责任公司 | 甘氨酸重摄取抑制剂及其应用 |
Also Published As
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JP2008508351A (ja) | 2008-03-21 |
IL180546A0 (en) | 2007-06-03 |
KR20070038136A (ko) | 2007-04-09 |
EP1781630A1 (en) | 2007-05-09 |
AU2005267930A1 (en) | 2006-02-09 |
WO2006014134A1 (en) | 2006-02-09 |
CA2576073A1 (en) | 2006-02-09 |
SE0401969D0 (sv) | 2004-08-02 |
RU2007105968A (ru) | 2008-09-10 |
ZA200700685B (en) | 2008-09-25 |
BRPI0514036A (pt) | 2008-05-27 |
MX2007001225A (es) | 2007-03-23 |
NO20071137L (no) | 2007-04-19 |
US20070191358A1 (en) | 2007-08-16 |
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