CN101007027A - 神经调节蛋白用于心血管疾病治疗的方法和组合物 - Google Patents

神经调节蛋白用于心血管疾病治疗的方法和组合物 Download PDF

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CN101007027A
CN101007027A CNA200610139361XA CN200610139361A CN101007027A CN 101007027 A CN101007027 A CN 101007027A CN A200610139361X A CNA200610139361X A CN A200610139361XA CN 200610139361 A CN200610139361 A CN 200610139361A CN 101007027 A CN101007027 A CN 101007027A
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neuregulin
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recombinant human
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周明东
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ZESHENG SCIENCE AND TECHNOLOGY DEVELOPMENT Co Ltd SHANGHAI
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ZESHENG SCIENCE AND TECHNOLOGY DEVELOPMENT Co Ltd SHANGHAI
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CNA200610139361XA 2002-05-24 2003-05-15 神经调节蛋白用于心血管疾病治疗的方法和组合物 Pending CN101007027A (zh)

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CNA200610139361XA CN101007027A (zh) 2002-05-24 2003-05-15 神经调节蛋白用于心血管疾病治疗的方法和组合物

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PCT/CN2002/000349 WO2003099320A1 (en) 2002-05-24 2002-05-24 Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy
CNPCT/CN02/00349 2002-05-24
CNA200610139361XA CN101007027A (zh) 2002-05-24 2003-05-15 神经调节蛋白用于心血管疾病治疗的方法和组合物

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CNA200610139361XA Pending CN101007027A (zh) 2002-05-24 2003-05-15 神经调节蛋白用于心血管疾病治疗的方法和组合物
CNB038118661A Expired - Lifetime CN100522997C (zh) 2002-05-24 2003-05-15 神经调节蛋白用于心血管疾病治疗的方法和组合物
CN2006101543547A Expired - Lifetime CN1935254B (zh) 2002-05-24 2003-05-15 神经调节蛋白用于心血管疾病治疗的方法和组合物
CN2009101185220A Expired - Lifetime CN101491670B (zh) 2002-05-24 2003-05-15 神经调节蛋白用于心血管疾病治疗的方法和组合物

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CNB038118661A Expired - Lifetime CN100522997C (zh) 2002-05-24 2003-05-15 神经调节蛋白用于心血管疾病治疗的方法和组合物
CN2006101543547A Expired - Lifetime CN1935254B (zh) 2002-05-24 2003-05-15 神经调节蛋白用于心血管疾病治疗的方法和组合物
CN2009101185220A Expired - Lifetime CN101491670B (zh) 2002-05-24 2003-05-15 神经调节蛋白用于心血管疾病治疗的方法和组合物

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US (4) US7795212B2 (enExample)
EP (2) EP2606901A1 (enExample)
JP (5) JP2005532332A (enExample)
CN (4) CN101007027A (enExample)
AU (3) AU2002304965A1 (enExample)
CA (1) CA2487112C (enExample)
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WO (3) WO2003099320A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011091723A1 (en) * 2010-01-29 2011-08-04 Zensun (Shanghai) Science & Technology Limited Neuregulin based compositions and uses thereof for preventing, treating or delaying the myocardial ischemia-reperfusion injury
CN104399062A (zh) * 2011-01-11 2015-03-11 上海泽生科技开发有限公司 神经调节蛋白用于预防、治疗或延迟心脏缺血再灌注损伤的方法和组合物
US11253573B2 (en) 2011-10-10 2022-02-22 Zensun (Shanghai) Science & Technology, Co., Ltd. Compositions and methods for treating heart failure
TWI787596B (zh) * 2019-04-01 2022-12-21 美商美國禮來大藥廠 神經調節蛋白-4(neuregulin-4)化合物及使用方法

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPP785098A0 (en) 1998-12-21 1999-01-21 Victor Chang Cardiac Research Institute, The Treatment of heart disease
US9694121B2 (en) 1999-08-09 2017-07-04 Cardiokinetix, Inc. Systems and methods for improving cardiac function
US8500795B2 (en) 1999-08-09 2013-08-06 Cardiokinetix, Inc. Retrievable devices for improving cardiac function
US8257428B2 (en) 1999-08-09 2012-09-04 Cardiokinetix, Inc. System for improving cardiac function
US8377114B2 (en) 1999-08-09 2013-02-19 Cardiokinetix, Inc. Sealing and filling ventricular partitioning devices to improve cardiac function
US7674222B2 (en) 1999-08-09 2010-03-09 Cardiokinetix, Inc. Cardiac device and methods of use thereof
US10307147B2 (en) 1999-08-09 2019-06-04 Edwards Lifesciences Corporation System for improving cardiac function by sealing a partitioning membrane within a ventricle
US8529430B2 (en) 2002-08-01 2013-09-10 Cardiokinetix, Inc. Therapeutic methods and devices following myocardial infarction
US9078660B2 (en) 2000-08-09 2015-07-14 Cardiokinetix, Inc. Devices and methods for delivering an endocardial device
US10064696B2 (en) 2000-08-09 2018-09-04 Edwards Lifesciences Corporation Devices and methods for delivering an endocardial device
US9332993B2 (en) 2004-08-05 2016-05-10 Cardiokinetix, Inc. Devices and methods for delivering an endocardial device
US9332992B2 (en) 2004-08-05 2016-05-10 Cardiokinetix, Inc. Method for making a laminar ventricular partitioning device
WO2003099320A1 (en) 2002-05-24 2003-12-04 Zensun (Shanghai) Sci-Tech.Ltd Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy
US7198899B2 (en) * 2002-06-03 2007-04-03 Chiron Corporation Use of NRG4, or inhibitors thereof, in the treatment of colon and pancreatic cancers
WO2007019232A2 (en) * 2005-08-03 2007-02-15 Immunogen, Inc. Immunoconjugate formulations
CA2658326C (en) * 2005-09-02 2013-04-23 Morehouse School Of Medicine Neuregulins for prevention and treatment of damage from acute assault on vascular and neuronal tissue
US20070213264A1 (en) 2005-12-02 2007-09-13 Mingdong Zhou Neuregulin variants and methods of screening and using thereof
US20070190127A1 (en) * 2005-12-30 2007-08-16 Mingdong Zhou Extended release of neuregulin for improved cardiac function
EP1986735A4 (en) 2006-02-06 2011-06-29 Northwind Ventures SYSTEMS AND METHODS FOR VOLUME REDUCTION
AU2008251822B2 (en) * 2007-05-10 2014-02-06 Acorda Therapeutics, Inc. Methods for detecting cardiac damage
CN101310765A (zh) * 2007-05-25 2008-11-26 上海泽生科技开发有限公司 神经调节蛋白应用于人的安全剂量
CN101310766B (zh) * 2007-05-25 2014-04-16 上海泽生科技开发有限公司 神经调节蛋白的新用途
CN103432681A (zh) * 2007-05-25 2013-12-11 上海泽生科技开发有限公司 包含神经调节蛋白的药物制剂及装置
US20090156488A1 (en) * 2007-09-12 2009-06-18 Zensun (Shanghai) Science & Technology Limited Use of neuregulin for organ preservation
EP3632459A1 (en) * 2008-07-17 2020-04-08 Acorda Therapeutics, Inc. Therapeutic dosing of a neuregulin or a subsequence thereof for treatment or prophylaxis of heart failure
EP3777878A1 (en) 2008-08-15 2021-02-17 Acorda Therapeutics, Inc. Compositions and methods for treatment during non-acute periods following cns neurological injury
US9198952B2 (en) 2008-09-22 2015-12-01 The Brigham And Women's Hospital, Inc. Compositions of and methods of using ligand dimers
CN102231987A (zh) * 2008-11-28 2011-11-02 上海泽生科技开发有限公司 纽兰格林和心脏干细胞
EP2808339B1 (en) 2008-11-28 2017-02-15 Zensun (Shanghai) Science & Technology, Co., Ltd. Neuregulin peptides and their use
WO2010142141A1 (en) * 2009-06-09 2010-12-16 Zensun (Shanghai) Science & Technology Limited Neuregulin based methods for treating heart failure
ES2748886T3 (es) * 2009-06-09 2020-03-18 Zensun Shanghai Science & Tech Co Ltd Métodos basados en Neuregulina para el tratamiento de la insuficiencia cardíaca
US8889625B2 (en) 2009-07-10 2014-11-18 Northwestern University Cardioprotective role of hepatic cells and hepatocyte secretory factors in myocardial ischemia
US20120121557A1 (en) * 2009-07-22 2012-05-17 Children's Medical Center Corporation Neuregulin induced proliferation of cardiomyocytes
JP6096262B2 (ja) * 2009-08-25 2017-03-15 ゼンサン (シャンハイ) サイエンス アンド テクノロジー,シーオー.,エルティーディー. ニューレグリンに基づく心不全の治療方法
ES2610241T3 (es) * 2009-10-23 2017-04-26 Amorcyte, Inc. Composiciones y usos para el tratamiento de lesiones miocárdicas progresivas debidas a una insuficiencia vascular
EP2493417B1 (en) 2009-10-26 2017-06-21 Cardiokinetix, Inc. Ventricular volume reduction
CN103772498B (zh) * 2009-11-09 2015-07-15 上海泽生科技开发有限公司 纽兰格林及其用途
US9029328B2 (en) 2010-03-24 2015-05-12 The Brigham And Women's Hospital, Inc. Methods for cardioprotection and cardioregeneration with dimers of EGF family ligands
BR112013022208A2 (pt) 2011-03-02 2022-03-08 Berg Llc Ensaios baseados em investigação celular e usos destes
WO2012151349A1 (en) 2011-05-03 2012-11-08 Liu Shu Q Neuroprotection by hepatic cells and hepatocyte secretory factors
MX357392B (es) 2012-04-02 2018-07-06 Berg Llc Ensayos basados en interrogatorios celulares y uso de los mismos.
JP6219934B2 (ja) 2012-05-22 2017-10-25 バーグ エルエルシー 薬物誘発毒性マーカーを同定するための照合による細胞に基づくアッセイ
EP2895861A4 (en) 2012-09-12 2016-06-22 Berg Llc USE OF MARKERS FOR THE IDENTIFICATION OF CARDIOTOXIC AGENTS
WO2014051567A1 (en) * 2012-09-26 2014-04-03 Morehouse School Of Medicine Chimeric neuregulins and method of making and use thereof
RU2650635C2 (ru) 2012-10-08 2018-04-16 Цзэньсунь (Шанхай) Сайенс Энд Текнолоджи, Ко., Лтд. Композиции и способы лечения сердечной недостаточности у пациентов с диабетом
BR112015029293A2 (pt) 2013-05-22 2018-04-24 Zensun Shanghai Science & Tech Ltd método e kit para prevenir, tratar ou retardar uma doença ou distúrbio cardiovascular em um mamífero
WO2015049517A2 (en) * 2013-10-01 2015-04-09 Kymab Limited Animal models and therapeutic molecules
WO2015055825A1 (en) * 2013-10-18 2015-04-23 Attoquant Diagnostics Gmbh Method for diagnosis of primary hyperaldosteronism
CN104758922A (zh) 2014-01-03 2015-07-08 上海泽生科技开发有限公司 纽兰格林制剂的配方
WO2015158743A1 (en) 2014-04-15 2015-10-22 Universiteit Antwerpen Treatment of nephropathy
KR102662004B1 (ko) 2014-09-11 2024-04-29 버그 엘엘씨 환자 데이터에 기반한 헬스케어 진단 및 치료를 위한 베이지안 인과 관계 네트워크 모델
CN105497876B (zh) 2014-09-24 2021-01-15 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延迟心脏室性心律失常的方法和组合物
CN106852115A (zh) 2014-09-28 2017-06-13 卡迪欧凯尼迪克斯公司 用于治疗心功能不全的装置
CN105561298A (zh) * 2014-10-17 2016-05-11 上海泽生科技开发有限公司 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物
WO2016116477A1 (en) * 2015-01-20 2016-07-28 Universiteit Antwerpen Neuregulin in the treatment of fibrotic disorders
CN104922153A (zh) * 2015-04-02 2015-09-23 连祺周 Nrg1-erbb4复合体在制备治疗心肌缺血的药物中的应用
US10017574B2 (en) * 2015-05-07 2018-07-10 Yeda Research And Development Co. Ltd. Methods, kits and devices for promoting cardiac regeneration
US10758560B2 (en) 2015-12-22 2020-09-01 Societe Des Produits Nestle S.A. Methods for treating sarcopenia and frailty
US10898330B2 (en) 2017-03-28 2021-01-26 Edwards Lifesciences Corporation Positioning, deploying, and retrieving implantable devices
BR112020020646A2 (pt) * 2018-04-11 2021-02-23 Salubris Biotherapeutics, Inc. composições de proteína de fusão recombinante de neuregulina-1 (nrg-1) humana e métodos de uso destas
CN111407881A (zh) * 2019-01-07 2020-07-14 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延迟心肌损伤的方法和组合物
CN109999015A (zh) * 2019-04-24 2019-07-12 江苏省中医药研究院 紫草素在制备预防或治疗房颤药物中的用途
KR20220066116A (ko) 2019-09-16 2022-05-23 젠순 (상하이) 사이언스 앤드 테크놀로지 캄파니 리미티드 재조합 인간 뉴레귤린 유도체 및 그의 용도
CN110714068A (zh) * 2019-11-14 2020-01-21 南通大学 膜蛋白分子ErbB4在制备治疗脑缺血损伤药物中的应用
CN113289002A (zh) 2020-02-24 2021-08-24 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延缓心力衰竭的方法和组合物
CN113238060B (zh) * 2021-05-08 2022-10-11 迈克生物股份有限公司 用于预测或诊断心肌炎的试剂盒
US20250241989A1 (en) * 2021-10-22 2025-07-31 The Research Institute At Nationwide Children's Hospital Neuregulin for Protection Against Respiratory Viral Infection and Post-Viral Disease

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
EP0052322B1 (de) 1980-11-10 1985-03-27 Gersonde, Klaus, Prof. Dr. Verfahren zur Herstellung von Lipid-Vesikeln durch Ultraschallbehandlung, Anwendung des Verfahrens und Vorrichtung zur Durchführung des Verfahrens
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
DE3374837D1 (en) 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
DE3377363D1 (en) 1982-03-31 1988-08-18 Ajinomoto Kk Gene coding for interleukin-2 polypeptide, recombinant dna carrying said gene, cell lines possessing the recombinant dna,and method for producing interleukin-2 using said cells
DE3218121A1 (de) 1982-05-14 1983-11-17 Leskovar, Peter, Dr.-Ing., 8000 München Arzneimittel zur tumorbehandlung
DE3220116A1 (de) 1982-05-28 1983-12-01 Dr. Karl Thomae Gmbh, 7950 Biberach Mikrobiologisch hergestellte (alpha)- und ss-interferone, dna-sequenzen, die fuer diese interferone codieren, mikroorganismen, die diese genetische information enthalten, und verfahren zu ihrer herstellung
EP0102324A3 (de) 1982-07-29 1984-11-07 Ciba-Geigy Ag Lipide und Tenside in wässriger Phase
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
JPS607934A (ja) 1983-06-29 1985-01-16 Dai Ichi Seiyaku Co Ltd リポソ−ムの製造方法
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
DE3483949D1 (de) 1983-09-26 1991-02-21 Udo Dr Med Ehrenfeld Mittel und erzeugnis fuer die diagnose und therapie von tumoren sowie zur behandlung von schwaechen der zelligen und humoralen immunabwehr.
EP0143949B1 (en) 1983-11-01 1988-10-12 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Pharmaceutical composition containing urokinase
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US4569790A (en) 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
EP0206448B1 (en) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
WO1989001489A1 (en) 1987-08-10 1989-02-23 Commonwealth Scientific And Industrial Research Or Control of angiogenesis and compositions and methods therefor
SE463851B (sv) 1988-09-02 1991-02-04 Amsu Ltd Komposition foer behandling av erektil dysfunktion via uretra
JPH02226533A (ja) 1989-02-27 1990-09-10 Mitsubishi Electric Corp 情報記録媒体
US5716930A (en) 1991-04-10 1998-02-10 Ludwig Institute For Cancer Research Glial growth factors
US7115554B1 (en) 1993-05-06 2006-10-03 Acorda Therapeutics, Inc. Methods of increasing myotube formation or survival or muscle cell mitogenesis differentiation or survival using neuregulin GGF III
GB9107566D0 (en) 1991-04-10 1991-05-29 Ludwig Inst Cancer Res Glial mitogenic factors,their preparation and use
US5530109A (en) 1991-04-10 1996-06-25 Ludwig Institute For Cancer Research DNA encoding glial mitogenic factors
US5367060A (en) 1991-05-24 1994-11-22 Genentech, Inc. Structure, production and use of heregulin
US5834229A (en) 1991-05-24 1998-11-10 Genentech, Inc. Nucleic acids vectors and host cells encoding and expressing heregulin 2-α
IL101943A0 (en) 1991-05-24 1992-12-30 Genentech Inc Structure,production and use of heregulin
KR100223255B1 (ko) 1992-02-10 1999-10-15 더글라스 테스타 개량된 알파 인터페론 조성물 및 인간 말초혈 백혈구로 부터의 제조 방법
US6087323A (en) 1992-04-03 2000-07-11 Cambridge Neuroscience, Inc. Use of neuregulins as modulators of cellular communication
DE4221256C2 (de) 1992-06-26 1997-07-10 Lancaster Group Ag Galenische Zusammensetzung für die topische Anwendung
US5869305A (en) 1992-12-04 1999-02-09 The University Of Pittsburgh Recombinant viral vector system
FI943071A7 (fi) 1993-06-24 1994-12-25 Takeda Chemical Industries Ltd Anti-endoteliiniainetta pysyvästi vapauttava valmiste
US5834441A (en) 1993-09-13 1998-11-10 Rhone-Poulenc Rorer Pharmaceuticals Inc. Adeno-associated viral (AAV) liposomes and methods related thereto
US5399699A (en) 1994-01-24 1995-03-21 Abbott Laboratories Indole iminooxy derivatives which inhibit leukotriene biosynthesis
EP1104809A1 (en) 1994-04-09 2001-06-06 F. Hoffmann-La Roche Ag Process for producing alpha-interferon
US5770567A (en) 1994-11-14 1998-06-23 Genentech, Inc. Sensory and motor neuron derived factor (SMDF)
JP3342873B2 (ja) 1995-03-10 2002-11-11 ジェネンテク・インコーポレイテッド gas6による受容体活性化
US6750196B1 (en) * 1995-03-27 2004-06-15 Acorda Therapeutics Methods of treating disorders of the eye
US5741511A (en) 1995-04-12 1998-04-21 Sam Yang Co., Ltd. Transdermal drug delivery device for treating erectile dysfunction
US5714385A (en) 1995-05-10 1998-02-03 Genentech, Inc. Media for culturing schwann cells
US5721139A (en) 1995-05-10 1998-02-24 Genentech, Inc. Isolating and culturing schwann cells
US6033660A (en) 1995-05-10 2000-03-07 Genentech, Inc. Method of treating a nervous system injury with cultured schwann cells
US5912326A (en) 1995-09-08 1999-06-15 President And Fellows Of Harvard College Cerebellum-derived growth factors
US5888767A (en) 1996-11-27 1999-03-30 The Johns Hopkins University School Of Medicine Method of using a conditionally replicating viral vector to express a gene
US5941868A (en) 1995-12-22 1999-08-24 Localmed, Inc. Localized intravascular delivery of growth factors for promotion of angiogenesis
US5736154A (en) 1996-03-11 1998-04-07 Fuisz Technologies Ltd. Transdermal delivery system
US5968511A (en) 1996-03-27 1999-10-19 Genentech, Inc. ErbB3 antibodies
US5834235A (en) 1996-06-21 1998-11-10 Health Research, Incorporated Inferferon-α-induced protein
IL127892A0 (en) 1996-07-12 1999-10-28 Genentech Inc Gamma-heregulin
DE69740038D1 (enExample) 1996-07-12 2010-12-16 Genentech Inc
US6156728A (en) 1996-11-01 2000-12-05 Genentech, Inc. Treatment of inner ear hair cells
US6593290B1 (en) 1996-11-01 2003-07-15 Genentech, Inc. Treatment of inner ear hair cells
US6136558A (en) * 1997-02-10 2000-10-24 Genentech, Inc. Heregulin variants
JP4515542B2 (ja) 1997-02-10 2010-08-04 ジェネンテック, インコーポレイテッド ヒレグリン変異体
US20020002276A1 (en) 1997-02-10 2002-01-03 Genentech, Inc. Chimeric heteromultimer adhesins
US6162641A (en) 1997-06-06 2000-12-19 The Regents Of The University Of Michigan Neuregulin response element and uses therefor
US6121415A (en) 1997-07-09 2000-09-19 Genentech, Inc. ErbB4 receptor-specific neuregolin related ligands and uses therefor
SE9703226D0 (sv) 1997-09-08 1997-09-08 Astra Ab New pharmaceutical composition
CA2306228A1 (en) * 1997-10-14 1999-04-22 Cambridge Neuroscience, Inc. Therapeutic methods comprising use of a neuregulin
US6197801B1 (en) 1998-01-14 2001-03-06 Usa Doctors Products, Inc. Injectable pharmaceutical composition for treatment and reversal of erectile dysfunction
US5962274A (en) 1998-03-13 1999-10-05 Wake Forest University Viral vector directed to predetermined target cells
AUPP785098A0 (en) * 1998-12-21 1999-01-21 Victor Chang Cardiac Research Institute, The Treatment of heart disease
US6446242B1 (en) 1999-04-02 2002-09-03 Actel Corporation Method and apparatus for storing a validation number in a field-programmable gate array
US6635249B1 (en) 1999-04-23 2003-10-21 Cenes Pharmaceuticals, Inc. Methods for treating congestive heart failure
US6933122B1 (en) 1999-05-14 2005-08-23 The Trustees Of Columbia University In The City Of New York A-form of cytoplasmic domain of nARIA (CRD-neuregulin) and uses thereof
CN1138785C (zh) * 1999-06-04 2004-02-18 周明东 生长因子神经调节蛋白及其类似物的新应用
US6602851B1 (en) 1999-10-08 2003-08-05 Uab Research Foundation SMDF and GGF neuregulin splice variant isoforms and uses thereof
US6811788B2 (en) 2000-01-19 2004-11-02 Baofa Yu Combinations and methods for treating neoplasms
ES2252216T3 (es) 2000-02-11 2006-05-16 Proteosys Ag Utilizacion de neorregulina-beta como indicador y/o diana.
EP1265999A2 (en) * 2000-02-28 2002-12-18 Decode Genetics EHF. Human schizophrenia gene
JP2004527203A (ja) 2000-02-28 2004-09-09 デコード ジェネティクス イーエッチエフ. ヒト精神分裂病遺伝子
US6544759B1 (en) 2000-04-21 2003-04-08 Yeda Research And Development Co. Ltd Polynucleotides encoding a novel growth factor which acts through ErbB-4 kinase receptor tyrosine
WO2003099320A1 (en) 2002-05-24 2003-12-04 Zensun (Shanghai) Sci-Tech.Ltd Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy
CN1498656A (zh) 2002-11-08 2004-05-26 上海泽生科技开发有限公司 神经调节蛋白用于心肌梗死治疗的方法和组合物
JP2004348674A (ja) * 2003-05-26 2004-12-09 Noritsu Koki Co Ltd 領域検出方法及びその装置
CN1715926B (zh) 2004-07-02 2011-08-17 上海泽生科技开发有限公司 神经调节蛋白突变体的应用
CN1743005A (zh) 2004-09-02 2006-03-08 上海泽生科技开发有限公司 Pi3-k抑制剂的新用途及组合物
CN1743006A (zh) 2004-09-02 2006-03-08 上海泽生科技开发有限公司 Mapk抑制剂的新用途及组合物
US20070213264A1 (en) * 2005-12-02 2007-09-13 Mingdong Zhou Neuregulin variants and methods of screening and using thereof
US20070190127A1 (en) * 2005-12-30 2007-08-16 Mingdong Zhou Extended release of neuregulin for improved cardiac function
US9580515B2 (en) * 2006-08-21 2017-02-28 Zensun (Shanghai) Science & Technology, Co., Ltd. Neukinase, a downstream protein of neuregulin
US20090156488A1 (en) * 2007-09-12 2009-06-18 Zensun (Shanghai) Science & Technology Limited Use of neuregulin for organ preservation

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011091723A1 (en) * 2010-01-29 2011-08-04 Zensun (Shanghai) Science & Technology Limited Neuregulin based compositions and uses thereof for preventing, treating or delaying the myocardial ischemia-reperfusion injury
CN102869370A (zh) * 2010-01-29 2013-01-09 上海泽生科技开发有限公司 神经调节蛋白用于预防、治疗或延迟心脏缺血再灌注损伤的方法和组合物
US11826400B2 (en) 2010-01-29 2023-11-28 Zensun (Shanghai) Science & Technology Limited Neuregulin based compositions and uses thereof for preventing, treating or delaying the myocardial ischemia-reperfusion injury
CN104399062A (zh) * 2011-01-11 2015-03-11 上海泽生科技开发有限公司 神经调节蛋白用于预防、治疗或延迟心脏缺血再灌注损伤的方法和组合物
US11253573B2 (en) 2011-10-10 2022-02-22 Zensun (Shanghai) Science & Technology, Co., Ltd. Compositions and methods for treating heart failure
US12076370B2 (en) 2011-10-10 2024-09-03 Zensun (Shanghai) Science & Technology, Co., Ltd. Compositions and methods for treating heart failure
TWI787596B (zh) * 2019-04-01 2022-12-21 美商美國禮來大藥廠 神經調節蛋白-4(neuregulin-4)化合物及使用方法

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