BR112013022208A2 - Ensaios baseados em investigação celular e usos destes - Google Patents

Ensaios baseados em investigação celular e usos destes

Info

Publication number
BR112013022208A2
BR112013022208A2 BR112013022208A BR112013022208A BR112013022208A2 BR 112013022208 A2 BR112013022208 A2 BR 112013022208A2 BR 112013022208 A BR112013022208 A BR 112013022208A BR 112013022208 A BR112013022208 A BR 112013022208A BR 112013022208 A2 BR112013022208 A2 BR 112013022208A2
Authority
BR
Brazil
Prior art keywords
biological system
data
based assays
cellular
model
Prior art date
Application number
BR112013022208A
Other languages
English (en)
Inventor
Rajin Narain Niven
Rangaprasad Sarangarajan
K Vishnudas Vivek
Original Assignee
Berg Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berg Llc filed Critical Berg Llc
Publication of BR112013022208A2 publication Critical patent/BR112013022208A2/pt

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/20—Probabilistic models
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Physiology (AREA)
  • Genetics & Genomics (AREA)
  • Probability & Statistics with Applications (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Mobile Radio Communication Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

ensaios baseados em investigação celular e usos destes. é descrito neste pedido é uma tecnologia de plataforma de descoberta para analisar um sistema ou processo biológico (por exemplo, uma condição de doença, como câncer) através da construção de modelos. em particular, é descrito neste pedido um método para identificar um modulador de um sistema biológico pelo estabelecimento de um modelo para o sistema biológico, obtendo um segundo conjunto de dados do modelo para o sistema biológico, e geração de uma rede de relações causais consenso entre os níveis de expressão da pluralidade de genes e a atividade funcional ou resposta celular baseada somente no primeiro conjunto de dados e no segundo conjunto de dados usando um dispositivo computacional programado.
BR112013022208A 2011-03-02 2012-03-02 Ensaios baseados em investigação celular e usos destes BR112013022208A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161448587P 2011-03-02 2011-03-02
US201261593848P 2012-02-01 2012-02-01
PCT/US2012/027615 WO2012119129A1 (en) 2011-03-02 2012-03-02 Interrogatory cell-based assays and uses thereof

Publications (1)

Publication Number Publication Date
BR112013022208A2 true BR112013022208A2 (pt) 2022-03-08

Family

ID=46758320

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013022208A BR112013022208A2 (pt) 2011-03-02 2012-03-02 Ensaios baseados em investigação celular e usos destes

Country Status (20)

Country Link
US (3) US9886545B2 (pt)
EP (1) EP2680925B1 (pt)
JP (2) JP6105491B2 (pt)
KR (1) KR102071081B1 (pt)
CN (2) CN107273712B (pt)
AU (2) AU2012223136B2 (pt)
BR (1) BR112013022208A2 (pt)
CA (1) CA2828972C (pt)
CL (2) CL2013002526A1 (pt)
CO (1) CO6801640A2 (pt)
EA (1) EA201391245A1 (pt)
ES (1) ES2777894T3 (pt)
IL (2) IL228096B (pt)
MX (1) MX358408B (pt)
MY (2) MY181093A (pt)
PE (2) PE20180776A1 (pt)
PH (2) PH12017502073A1 (pt)
SG (2) SG193006A1 (pt)
WO (1) WO2012119129A1 (pt)
ZA (1) ZA201306453B (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
CA2956645A1 (en) 2003-07-12 2005-03-31 David A. Goldberg Sensitive and rapid biodetection
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
US9434937B2 (en) 2011-03-07 2016-09-06 Accelerate Diagnostics, Inc. Rapid cell purification systems
WO2013134315A1 (en) * 2012-03-05 2013-09-12 Berg Pharma Llc Compositions and methods for diagnosis and treatment of pervasive developmental disorder
US9744155B2 (en) 2012-03-28 2017-08-29 Ixcela, Inc. IPA as a therapeutic agent, as a protective agent, and as a biomarker of disease risk
BR112014024537A2 (pt) 2012-04-02 2017-08-08 Berg Llc métodos para identificar moduladores de um sistema biológico, de um processo de doença, e de angiogênese
SG11201407569PA (en) 2012-05-22 2014-12-30 Berg Llc Interrogatory cell-based assays for identifying drug-induced toxicity markers
WO2014071316A1 (en) * 2012-11-02 2014-05-08 H. Lee Moffitt Cancer Center And Research Institute, Inc. In silico identification of cancer molecular signaling pathways and drug candidates
WO2014072950A1 (en) * 2012-11-09 2014-05-15 Cellworks Research India Private Limited System and method for development of therapeutic solutions
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
JP6216044B2 (ja) * 2013-05-28 2017-10-18 ファイヴ３ ゲノミクス，エルエルシー Ｐａｒａｄｉｇｍ薬剤反応ネットワーク
US20150019189A1 (en) * 2013-07-01 2015-01-15 Counterpoint Health Solutions, Inc. Systems biology approach to therapy
JP6518269B2 (ja) * 2014-05-28 2019-05-22 ヴィート エンフェー 異なる生体試料の混合物中に含まれる化学化合物を相対的に定量する方法
SG10201902151UA (en) * 2014-09-11 2019-04-29 Berg Llc Bayesian causal relationship network models for healthcare diagnosis and treatment based on patient data
WO2016056664A1 (ja) * 2014-10-10 2016-04-14 松森　昭 心不全患者の検出方法、心疾患の識別方法、心不全の検査試薬、心不全の検査キット、心不全を検出するための装置及び心不全を検出するためのプログラム
SG10202012249YA (en) 2014-12-08 2021-01-28 Berg Llc Use of markers including filamin a in the diagnosis and treatment of prostate cancer
WO2016161022A2 (en) 2015-03-30 2016-10-06 Accerlate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
CN106250717B (zh) * 2015-06-04 2019-03-12 徐勇 急性髓性白血病的miRNA与转录因子的系统及其构建方法和应用
KR101881398B1 (ko) * 2016-04-07 2018-07-24 한국과학기술원 생물학적 시스템 정보 처리 장치 및 방법
WO2017214068A1 (en) 2016-06-05 2017-12-14 Berg Llc Systems and methods for patient stratification and identification of potential biomarkers
US10282588B2 (en) * 2016-06-09 2019-05-07 Siemens Healthcare Gmbh Image-based tumor phenotyping with machine learning from synthetic data
EP3538095A4 (en) 2016-11-14 2020-06-17 Berg LLC METHOD FOR TREATING MORBUS PARKINSON
WO2018094204A1 (en) * 2016-11-17 2018-05-24 Arivale, Inc. Determining relationships between risks for biological conditions and dynamic analytes
JP7179766B2 (ja) * 2017-05-12 2022-11-29 ラボラトリー コーポレイション オブ アメリカ ホールディングス バイオマーカー識別のためのシステムおよび方法
EP3814944A4 (en) * 2018-06-29 2022-04-06 The Jackson Laboratory METHOD AND DEVICE FOR IDENTIFICATION OF ALTERNATIVE SPLICING EVENTS
CN109086570B (zh) * 2018-06-29 2020-09-04 迈凯基因科技有限公司 一种多数据库依次交互方法及装置
US11041847B1 (en) 2019-01-25 2021-06-22 Ixcela, Inc. Detection and modification of gut microbial population
WO2020180424A1 (en) 2019-03-04 2020-09-10 Iocurrents, Inc. Data compression and communication using machine learning
JP7185243B2 (ja) * 2019-07-09 2022-12-07 株式会社島津製作所 ｉＰＳ細胞の分化効率予測モデルの構築方法及びｉＰＳ細胞の分化効率予測方法
WO2021050760A1 (en) * 2019-09-11 2021-03-18 Recursion Pharmaceuticals, Inc. Systems and methods for pairwise inference of drug-gene interaction networks
CN112151109B (zh) * 2020-09-09 2023-08-25 中国科学院大连化学物理研究所 用于评价生物分子交联质谱鉴定随机性的半监督学习方法
CN112466403B (zh) * 2020-12-31 2022-06-14 广州基迪奥生物科技有限公司 一种细胞通讯分析方法及系统
KR102556312B1 (ko) 2021-04-12 2023-07-19 서울대학교병원 세뇨관 배양부 및 간질 배양부를 포함하는 신장 모사 장기 칩
WO2023102204A1 (en) * 2021-12-03 2023-06-08 The Trustees Of Indiana University Biomarker for type 1 diabetes
CN116046877B (zh) * 2023-04-03 2024-03-15 深圳先进技术研究院 疾病模型代谢分析方法、包埋模具及喷涂装置

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
WO1987002671A1 (en) 1985-11-01 1987-05-07 International Genetic Engineering, Inc. Modular assembly of antibody genes, antibodies prepared thereby and use
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5116742A (en) 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US4904582A (en) 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
US4843155A (en) 1987-11-19 1989-06-27 Piotr Chomczynski Product and process for isolating RNA
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
DE68927933T2 (de) 1988-09-02 1997-08-14 Dyax Corp Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
JPH06508511A (ja) 1990-07-10 1994-09-29 ケンブリッジ　アンティボディー　テクノロジー　リミティド 特異的な結合ペアーの構成員の製造方法
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
EP0814159B1 (en) 1990-08-29 2005-07-27 GenPharm International, Inc. Transgenic mice capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
DE69129154T2 (de) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
EP0575485A1 (en) 1991-03-01 1993-12-29 Dyax Corp. Process for the development of binding mini-proteins
JP3672306B2 (ja) 1991-04-10 2005-07-20 ザ スクリップス リサーチ インスティテュート ファージミドを使用するヘテロ二量体受容体ライブラリー
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
US5621083A (en) 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
US5677195A (en) 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
US6025165A (en) 1991-11-25 2000-02-15 Enzon, Inc. Methods for producing multivalent antigen-binding proteins
CA2087413A1 (en) 1992-01-17 1993-07-18 Joseph R. Lakowicz Fluorescent energy transfer immunoassay
US5918200A (en) 1992-08-31 1999-06-29 Yamatake-Honeywell Co., Ltd. State estimating apparatus
JPH08509857A (ja) 1993-01-07 1996-10-22 シーケノム・インコーポレーテッド マススペクトロメトリーによるｄｎａ配列決定法
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
EP0689610B1 (en) 1993-03-19 2002-07-03 Sequenom, Inc. Dna sequencing by mass spectrometry via exonuclease degradation
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
EP0880598A4 (en) 1996-01-23 2005-02-23 Affymetrix Inc RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM
DE69829402T2 (de) 1997-10-31 2006-04-13 Affymetrix, Inc. (a Delaware Corp.), Santa Clara Expressionsprofile in adulten und fötalen organen
US6020135A (en) 1998-03-27 2000-02-01 Affymetrix, Inc. P53-regulated genes
JP2002512203A (ja) * 1998-04-17 2002-04-23 ザ ユニバーシティ オブ バーモント アンド ステイト アグリカルチュラル カレッジ 疾患における代謝的相互作用に関連する方法および製品
US6763307B2 (en) 2000-03-06 2004-07-13 Bioseek, Inc. Patient classification
US20030124548A1 (en) * 2001-03-13 2003-07-03 Christos Hatzis Method for association of genomic and proteomic pathways associated with physiological or pathophysiological processes
US8000949B2 (en) 2001-06-18 2011-08-16 Genego, Inc. Methods for identification of novel protein drug targets and biomarkers utilizing functional networks
US7393656B2 (en) 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
US7415359B2 (en) 2001-11-02 2008-08-19 Gene Network Sciences, Inc. Methods and systems for the identification of components of mammalian biochemical networks as targets for therapeutic agents
AU2002304965A1 (en) 2002-05-24 2003-12-12 Zensun (Shanghai) Sci-Tech.Ltd Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy
DK1540505T3 (da) 2002-08-29 2008-10-13 Gene Network Sciences Inc Systemer og fremgangsmåder til dannelse af biologiske net
CN1714371A (zh) * 2002-11-19 2005-12-28 Gni美国公司 根据时间序列基因表达数据的基因网络的非线性模拟
JP4288345B2 (ja) 2003-06-19 2009-07-01 独立行政法人産業技術総合研究所 新規てんかんモデル動物
EP1512970A1 (en) * 2003-09-05 2005-03-09 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Method for determining the impact of a multicomponent mixture on the biological profile of a disease
US20070134734A1 (en) 2003-10-14 2007-06-14 Cellfree Sciences Co., Ltd. Novel screening method of indicator substance
WO2005107412A2 (en) 2004-04-30 2005-11-17 Rosetta Inpharmatics Llc Systems and methods for reconstruction gene networks in segregating populations
EP1607898A3 (en) 2004-05-18 2006-03-29 Neal E. Solomon A bioinformatics system for functional proteomics modelling
US20100316629A1 (en) 2004-09-01 2010-12-16 Shaughnessy Jr John D Use of gene expression profiling to predict survival in cancer patient
CN101194260A (zh) 2005-01-24 2008-06-04 利兰·斯坦福青年大学托管委员会 使用贝叶斯网络建立细胞信号传导系统模型的方法
WO2006103615A1 (en) 2005-03-31 2006-10-05 Koninklijke Philips Electronics N.V. System and method for collecting evidence pertaining to relationships between biomolecules and diseases
EP1887351A4 (en) 2005-05-31 2009-04-08 Jcl Bioassay Corp SCREENING METHOD FOR SPECIFIC PROTEIN IN DETAILED PROTEOME ANALYSIS
EP2982688A3 (en) 2005-09-30 2016-05-25 Universiteit Maastricht Tumor angiogenesis associated genes and a method for their identification
EP1978085A4 (en) * 2006-01-27 2010-12-01 Takeda Pharmaceutical TOOL FOR ANALYZING THE EXPRESSION OF A GENE
US8571803B2 (en) 2006-11-15 2013-10-29 Gene Network Sciences, Inc. Systems and methods for modeling and analyzing networks
CN101105841B (zh) * 2007-02-12 2011-06-15 浙江大学 由大规模基因芯片表达谱数据构建基因调控亚网络的方法
US8140270B2 (en) * 2007-03-22 2012-03-20 National Center For Genome Resources Methods and systems for medical sequencing analysis
EP2147387A4 (en) * 2007-05-16 2012-05-02 Edsa Micro Corp REAL-TIME FORECASTING SYSTEMS FOR INTELLIGENT ENERGY MONITORING AND MANAGEMENT OF ELECTRICITY NETWORKS
JP2009050171A (ja) 2007-08-23 2009-03-12 Toyobo Co Ltd 表面プラズモン共鳴による基板上におけるリン酸化の検出方法
US7895146B2 (en) * 2007-12-03 2011-02-22 Microsoft Corporation Time modulated generative probabilistic models for automated causal discovery that monitors times of packets
US20110071049A1 (en) * 2008-03-12 2011-03-24 Nathaniel Heintz Methods and compositions for translational profiling and molecular phenotyping
BRPI0917871A2 (pt) 2008-08-15 2017-06-20 Merrimack Pharmaceuticals Inc agente terapêutico anti-erbb3 para uso em terapia de um tumor, métodos para predizer responsividade de um tumor de um agente terapêutco anti-erbb3, para selecionar terapia anti-erbb3 para um paciente, para predizer a resposta de células ao tratamento com um agente terapêutico, para identificar um biomarcador, e para evitar administração de uma droga para câncer anti-erbb3, e, kit para predizer a resposta das células ao tratamento com um agente terapêutico
JP2012526828A (ja) 2009-05-11 2012-11-01 バーグ バイオシステムズ，エルエルシー エピメタボリックシフター、多次元細胞内分子、または環境影響因子を使用する代謝性障害の治療方法
EP2600154A4 (en) 2010-03-31 2014-06-11 Univ Kumamoto Nat Univ Corp METHOD FOR PRODUCING DATA SET FOR INTEGRATED PROTEOMIC, INTEGRATED PROTEASE METHOD USING THE DATA SET FOR INTEGRATED PROTEOME, THAT IS PRODUCED BY THE PRODUCTION METHOD, AND METHOD FOR IDENTIFYING, BY ITS USE, THE SUBSTANCE THAT IN THE ORIGIN
BR112014024537A2 (pt) 2012-04-02 2017-08-08 Berg Llc métodos para identificar moduladores de um sistema biológico, de um processo de doença, e de angiogênese
US20150019189A1 (en) * 2013-07-01 2015-01-15 Counterpoint Health Solutions, Inc. Systems biology approach to therapy

Also Published As

Publication number Publication date
NZ712105A (en) 2017-05-26
ZA201306453B (en) 2021-05-26
IL257824A (en) 2018-04-30
ES2777894T3 (es) 2020-08-06
JP2014512520A (ja) 2014-05-22
PE20180776A1 (es) 2018-05-07
KR20140013006A (ko) 2014-02-04
US9886545B2 (en) 2018-02-06
EA201391245A1 (ru) 2014-05-30
AU2017202977A1 (en) 2017-05-25
CN103501859A (zh) 2014-01-08
NZ614891A (en) 2016-01-29
KR102071081B1 (ko) 2020-01-29
EP2680925A4 (en) 2014-12-31
PH12017502073A1 (en) 2019-01-14
SG10201601224WA (en) 2016-03-30
AU2012223136B2 (en) 2017-05-25
AU2017202977B2 (en) 2019-09-19
MY164530A (en) 2017-12-29
CN107273712A (zh) 2017-10-20
CL2020002805A1 (es) 2021-04-30
CA2828972A1 (en) 2012-09-07
SG193006A1 (en) 2013-10-30
AU2012223136A1 (en) 2013-09-19
CA2828972C (en) 2021-09-07
EP2680925A1 (en) 2014-01-08
US20180260515A1 (en) 2018-09-13
US20240062844A1 (en) 2024-02-22
PE20140627A1 (es) 2014-05-30
CN107273712B (zh) 2021-12-03
MX2013010068A (es) 2013-11-01
IL228096A0 (en) 2013-09-30
CL2013002526A1 (es) 2014-04-25
US11456054B2 (en) 2022-09-27
JP2017148046A (ja) 2017-08-31
CO6801640A2 (es) 2013-11-29
JP6105491B2 (ja) 2017-03-29
EP2680925B1 (en) 2019-11-20
WO2012119129A1 (en) 2012-09-07
MY181093A (en) 2020-12-17
US20120258874A1 (en) 2012-10-11
PH12017502072A1 (en) 2019-01-14
MX358408B (es) 2018-08-20
CN103501859B (zh) 2017-08-25
IL228096B (en) 2018-03-29

Similar Documents

Publication Publication Date Title
BR112013022208A2 (pt) Ensaios baseados em investigação celular e usos destes
MX2014011797A (es) Ensayos basados en interrogatorios celulares y uso de los mismos.
BR112016006284A2 (pt) método para conduzir evolução direcionada, produto de programa de computador, e, sistema de computador
BR112012032060A2 (pt) método e sistema para modelos de simulação paralela.
CL2016001867A1 (es) Sistema y dispositivo para la generación de alto rendimiento de gotitas y métodos de uso combinatorios.
BR112015010012A2 (pt) método; e sistema
BR112018009606A2 (pt) construção de alta eficiência de bibliotecas de dna
BR112015018454A2 (pt) métodos de condução de evolução direcionada, método de condução de evolução direcionada de moléculas biológicas e sistema de computador.
BR112013030366A2 (pt) método, aparelho e produto de programa de computador
BRPI0821228A2 (pt) Sistema de modelagem clínica, método para avaliar cenários clínicos hipotéticos, e, processador ou meio legível por computador
CL2012000660A1 (es) Metodo y sistema de analisis y sintesis de datos computarizados para modelos de procesos gaussianos de conjuntos de datos multiples.
AR090903A1 (es) Anticuerpos e inmunoconjugados anti-pmel17
BR112015003472A2 (pt) sistema de apoio para anotação, método de provisão de apoio para anotação, e meio de leitura por computador não temporário que carrega o software que controla um ou mais processadores para realizar o método
BR112014004019A2 (pt) aparelho e método de processamento de informação, e, meio legível por computador.
BR112014017787A8 (pt) Plataforma e interface de múltiplas atividades
BR112017000880A2 (pt) "método para injetar sinais em uma rede de distribuição de serviços públicos e sistema de rede de distribuição de serviços públicos"
BR112015025384A2 (pt) método
BRPI0901425A2 (pt) método para análise de desempenho de um sistema de desenvolvimento de jazida, sistema para análise de desempenho de um sistema de desenvolvimento de jazida, produto de programa de computador para análise de desempenho de um sistema de desenvolvimento de jazida, método de provisão de um sistema para análise de desempenho de um sistema de desenvolvimento de jazida, e método para realização de uma análise de equiparação de curva de tipo de uma resposta de comportamento térmico transiente de um sistema de deselvolvimento de jazida
BR112014027592A2 (pt) método para prover uma interface de rastreamento médico para comunicação entre pelo menos uma ferramenta de rastreamento de intervenção e um aplicativo de intervenção orientada por imagem (igi), interface de rastreamento médico, e produto de programa de computador
BR112018077404A2 (pt) sistema e método de marcação em grupo baseados na aprendizagem
AR103564A1 (es) Método implementado por computadora para crear un modelo de fermentación
Dhama et al. Ross River Virus (RRV) infection in horses and humans: a review.
BR112015013065A8 (pt) método para provisão de dados, primeira base de dados, segunda base de dados, sistema, e, meio legível por computador
BR112017022314A2 (pt) método para fornecer uma plataforma de comunicação on-line para uma comunidade específica de pessoas e sistema para fornecer informações de forma seletiva a uma comunidade específica de pessoas
Lionetto et al. Carbonic anhydrase and chemical pollutants: new applied perspectives

Legal Events

Date Code Title Description
B11Z Dismissal: petition dismissal - article 216, par 2 of industrial property law
B12F Other appeals [chapter 12.6 patent gazette]
B12F Other appeals [chapter 12.6 patent gazette]
B12G Publication of notification of appeal cancelled [chapter 12.7 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 12.6 NA RPI NO 2440 DE 10/10/2017 POR TER SIDO INDEVIDA.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements