SG10201902151UA - Bayesian causal relationship network models for healthcare diagnosis and treatment based on patient data - Google Patents

Bayesian causal relationship network models for healthcare diagnosis and treatment based on patient data

Info

Publication number
SG10201902151UA
SG10201902151UA SG10201902151UA SG10201902151UA SG10201902151UA SG 10201902151U A SG10201902151U A SG 10201902151UA SG 10201902151U A SG10201902151U A SG 10201902151UA SG 10201902151U A SG10201902151U A SG 10201902151UA SG 10201902151U A SG10201902151U A SG 10201902151UA
Authority
SG
Singapore
Prior art keywords
causal relationship
relationship network
data
variables
drug
Prior art date
Application number
SG10201902151UA
Inventor
Niven Narain
Viatcheslav Akmaev
Vijetha Vemulapalli
Original Assignee
Berg Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berg Llc filed Critical Berg Llc
Publication of SG10201902151UA publication Critical patent/SG10201902151UA/en

Links

Classifications

    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N7/00Computing arrangements based on specific mathematical models
    • G06N7/01Probabilistic graphical models, e.g. probabilistic networks
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/70ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

Abstract

BAYESIAN CAUSAL RELATIONSHIP NETWORK MODELS FOR HEALTHCARE DIAGNOSIS AND TREATMENT BASED ON PATIENT DATA Systems, methods, and computer-readable medium are provided for healthcare analysis. Data corresponding to a plurality of patients is received. The data is parsed to generate normalized data for a plurality of variables, with normalized data generated for more than one variable for each patient. A causal relationship network model is generated relating the plurality of variables based on the generated normalized data using a Bayesian network algorithm. The causal relationship network model includes variables related to a plurality of medical conditions or medical drugs. In another aspect, a selection of a medical condition or drug is received. A sub- network is determined from a causal relationship network model. The sub-network includes one or more variables associated with the selected medical condition or drug. One or more predictors for the selected medical condition or drug are identified. [Figure 2]
SG10201902151UA 2014-09-11 2015-09-11 Bayesian causal relationship network models for healthcare diagnosis and treatment based on patient data SG10201902151UA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462049148P 2014-09-11 2014-09-11

Publications (1)

Publication Number Publication Date
SG10201902151UA true SG10201902151UA (en) 2019-04-29

Family

ID=55459589

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201902151UA SG10201902151UA (en) 2014-09-11 2015-09-11 Bayesian causal relationship network models for healthcare diagnosis and treatment based on patient data
SG11201701963UA SG11201701963UA (en) 2014-09-11 2015-09-11 Bayesian causal relationship network models for healthcare diagnosis and treatment based on patient data

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201701963UA SG11201701963UA (en) 2014-09-11 2015-09-11 Bayesian causal relationship network models for healthcare diagnosis and treatment based on patient data

Country Status (12)

Country Link
US (2) US10482385B2 (en)
EP (1) EP3191975A4 (en)
JP (1) JP6916107B2 (en)
CN (2) CN114203296A (en)
AU (2) AU2015314956A1 (en)
CA (1) CA2960837A1 (en)
HK (1) HK1243509A1 (en)
IL (1) IL250966B (en)
NZ (1) NZ730197A (en)
SG (2) SG10201902151UA (en)
WO (1) WO2016040725A1 (en)
ZA (1) ZA201701611B (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6916107B2 (en) 2014-09-11 2021-08-11 バーグ エルエルシー Bayesian Causal Network Model for Health Examination and Treatment Based on Patient Data
US20210280317A1 (en) * 2014-10-07 2021-09-09 AlignCare Services, LLC. System and Method for Improving Health Care Management and Compliance
US11443206B2 (en) 2015-03-23 2022-09-13 Tibco Software Inc. Adaptive filtering and modeling via adaptive experimental designs to identify emerging data patterns from large volume, high dimensional, high velocity streaming data
US10839024B2 (en) * 2016-06-20 2020-11-17 Tibco Software Inc. Detecting important variables and their interactions in big data
US20200185063A1 (en) * 2016-06-05 2020-06-11 Berg Llc Systems and methods for patient stratification and identification of potential biomarkers
US11182229B2 (en) * 2016-12-16 2021-11-23 Sap Se Data processing for predictive analytics
US11315685B2 (en) * 2017-01-25 2022-04-26 UCB Biopharma SRL Method and system for predicting optimal epilepsy treatment regimes
US10699450B2 (en) 2017-09-28 2020-06-30 International Business Machines Corporation Interactive tool for causal graph construction
US11164678B2 (en) * 2018-03-06 2021-11-02 International Business Machines Corporation Finding precise causal multi-drug-drug interactions for adverse drug reaction analysis
CN110555047B (en) * 2018-03-29 2024-03-15 日本电气株式会社 Data processing method and electronic equipment
CN110322019A (en) * 2018-03-29 2019-10-11 日本电气株式会社 For handling the method, system and storage medium of data set
US11694800B2 (en) * 2018-05-09 2023-07-04 International Business Machines Corporation Medical diagnosis system with continuous learning and reasoning
US11276494B2 (en) 2018-05-11 2022-03-15 International Business Machines Corporation Predicting interactions between drugs and diseases
CN110827988B (en) * 2018-08-14 2022-10-21 上海明品医学数据科技有限公司 Control method for medical data research based on mobile terminal
WO2020097122A1 (en) * 2018-11-05 2020-05-14 Children's Hospital Medical Center Computation model of learning networks
CN110147878B (en) * 2018-11-28 2023-01-31 腾讯科技(深圳)有限公司 Data processing method, device and equipment
CN112233736B (en) * 2019-01-15 2022-09-16 合肥工业大学 Knowledge base construction method and system
WO2020154573A1 (en) 2019-01-25 2020-07-30 Children's Hospital Medical Center Bayesian causal inference models for healthcare treatment using real world patient data
CN112352235A (en) * 2019-06-06 2021-02-09 日本电气株式会社 Causal analysis
US11468994B2 (en) * 2019-06-28 2022-10-11 Cerner Innovation, Inc. Pneumonia readmission prevention
US20210012907A1 (en) * 2019-07-11 2021-01-14 International Business Machines Corporation Altering a targeted brain therapeutic based on a brain circuit model
WO2021022365A1 (en) * 2019-08-02 2021-02-11 Intellijoint Surgical Inc. Systems and methods to collaborate, to train an expert system and to provide an expert system
US11107555B2 (en) 2019-10-02 2021-08-31 Kpn Innovations, Llc Methods and systems for identifying a causal link
US11645565B2 (en) 2019-11-12 2023-05-09 Optum Services (Ireland) Limited Predictive data analysis with cross-temporal probabilistic updates
US11552785B2 (en) * 2020-04-02 2023-01-10 Epidaurus Health, Inc. Methods and systems for a synchronized distributed data structure for federated machine learning
US11797776B2 (en) * 2020-09-07 2023-10-24 Accenture Global Solutions Limited Utilizing machine learning models and in-domain and out-of-domain data distribution to predict a causality relationship between events expressed in natural language text
US11335443B1 (en) 2020-09-07 2022-05-17 OpenNano Pte. Ltd. Phenotypic patient data derivation from economic data
CN112185583B (en) * 2020-10-14 2022-05-31 天津之以科技有限公司 Data mining quarantine method based on Bayesian network
US11763325B2 (en) * 2020-11-13 2023-09-19 Adobe Inc. Automated discovery of causal relationships in mixed datasets
CN112614595A (en) * 2020-12-25 2021-04-06 联仁健康医疗大数据科技股份有限公司 Survival analysis model construction method and device, electronic terminal and storage medium
US20220246297A1 (en) * 2021-02-01 2022-08-04 Anthem, Inc. Causal Recommender Engine for Chronic Disease Management
CN113436725B (en) * 2021-06-24 2023-06-23 深圳平安智慧医健科技有限公司 Data processing method, system, computer device and computer readable storage medium
CN113221391B (en) * 2021-07-08 2021-09-07 中国电子科技集团公司第九研究所 Method for guiding material size parameter screening by analyzing circulator performance by BIC criterion
KR20230027810A (en) * 2021-08-20 2023-02-28 가톨릭대학교 산학협력단 Apparatus, method and recording medium for prognostic prediction
CN114176600B (en) * 2021-12-28 2023-10-20 上海交通大学 Electrocardiogram ST segment abnormality discrimination system based on causal analysis
CN115424741B (en) * 2022-11-02 2023-03-24 之江实验室 Adverse drug reaction signal discovery method and system based on cause and effect discovery

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5918200A (en) 1992-08-31 1999-06-29 Yamatake-Honeywell Co., Ltd. State estimating apparatus
EP0879449A2 (en) * 1996-02-09 1998-11-25 Adeza Biomedical Corporation Method for selecting medical and biochemical diagnostic tests using neural network-related applications
US6678669B2 (en) * 1996-02-09 2004-01-13 Adeza Biomedical Corporation Method for selecting medical and biochemical diagnostic tests using neural network-related applications
US6763307B2 (en) 2000-03-06 2004-07-13 Bioseek, Inc. Patient classification
US20030124548A1 (en) 2001-03-13 2003-07-03 Christos Hatzis Method for association of genomic and proteomic pathways associated with physiological or pathophysiological processes
US8000949B2 (en) 2001-06-18 2011-08-16 Genego, Inc. Methods for identification of novel protein drug targets and biomarkers utilizing functional networks
US7393656B2 (en) 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
US7415359B2 (en) 2001-11-02 2008-08-19 Gene Network Sciences, Inc. Methods and systems for the identification of components of mammalian biochemical networks as targets for therapeutic agents
WO2003099320A1 (en) 2002-05-24 2003-12-04 Zensun (Shanghai) Sci-Tech.Ltd Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy
US7512497B2 (en) 2002-08-29 2009-03-31 Gene Network Sciences, Inc. Systems and methods for inferring biological networks
US20040093331A1 (en) * 2002-09-20 2004-05-13 Board Of Regents, University Of Texas System Computer program products, systems and methods for information discovery and relational analyses
CN1714371A (en) 2002-11-19 2005-12-28 Gni美国公司 Nonlinear modeling of gene networks from time series gene expression data
JP4288345B2 (en) 2003-06-19 2009-07-01 独立行政法人産業技術総合研究所 New epilepsy model animal
EP1512970A1 (en) 2003-09-05 2005-03-09 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Method for determining the impact of a multicomponent mixture on the biological profile of a disease
US20070134734A1 (en) 2003-10-14 2007-06-14 Cellfree Sciences Co., Ltd. Novel screening method of indicator substance
WO2005106038A2 (en) 2004-04-15 2005-11-10 University Of Florida Research Foundation, Inc. Neural proteins as biomarkers for nervous system injury and other neural disorders
WO2005107412A2 (en) 2004-04-30 2005-11-17 Rosetta Inpharmatics Llc Systems and methods for reconstruction gene networks in segregating populations
EP1607898A3 (en) 2004-05-18 2006-03-29 Neal E. Solomon A bioinformatics system for functional proteomics modelling
GB0419124D0 (en) 2004-08-27 2004-09-29 Proteome Sciences Plc Methods and compositions relating to Alzheimer's disease
US20100316629A1 (en) 2004-09-01 2010-12-16 Shaughnessy Jr John D Use of gene expression profiling to predict survival in cancer patient
CA2587765A1 (en) 2004-11-17 2006-05-26 Immunivest Corporation Magnetic enrichment of circulating cells, fragments and debris for enabling hts proteomics and genomics in disease detection
CA2593355A1 (en) 2005-01-24 2006-07-27 The Board Of Trustees Of The Leland Stanford Junior University Method for modeling cell signaling systems by means of bayesian networks
WO2006103615A1 (en) 2005-03-31 2006-10-05 Koninklijke Philips Electronics N.V. System and method for collecting evidence pertaining to relationships between biomolecules and diseases
US20090132171A1 (en) 2005-05-31 2009-05-21 Jcl Bioassay Corporation Screening Method for Specific Protein in Proteome Comprehensive Analysis
US7906116B2 (en) 2005-09-01 2011-03-15 Parkash Gill Methods for using and identifying modulators of Delta-like 4
EP2982688A3 (en) 2005-09-30 2016-05-25 Universiteit Maastricht Tumor angiogenesis associated genes and a method for their identification
RU2428104C2 (en) * 2005-11-08 2011-09-10 Конинклейке Филипс Электроникс Н.В. Method of detecting critical trends in multi-parameter control of patient and clinical data with applicxation of clasterisation
EP1840574A1 (en) 2006-03-30 2007-10-03 Institut Pasteur Use of the alpha chain of brain spectrin and fragments thereof, for diagnosing cerebral diseases
US20080046290A1 (en) * 2006-08-21 2008-02-21 Cerner Innovation, Inc. System and method for compiling and displaying discharge instructions for a patient
US8571803B2 (en) 2006-11-15 2013-10-29 Gene Network Sciences, Inc. Systems and methods for modeling and analyzing networks
BRPI0720116B8 (en) * 2006-12-05 2021-07-27 Decode Genetics Ehf method for determining a susceptibility to cardiac arrhythmia or stroke in a human subject, use of an oligonucleotide probe, and apparatus for determining a genetic indicator for cardiac arrhythmia and/or stroke in a human subject
CN101105841B (en) 2007-02-12 2011-06-15 浙江大学 Method for constructing gene controlled subnetwork by large scale gene chip expression profile data
US8140270B2 (en) 2007-03-22 2012-03-20 National Center For Genome Resources Methods and systems for medical sequencing analysis
US20090117562A1 (en) 2007-04-09 2009-05-07 Valerie Wailin Hu Method and kit for diagnosing Autism using gene expression profiling
EP2147387A4 (en) 2007-05-16 2012-05-02 Edsa Micro Corp Real-time predictive systems for intelligent energy monitoring and management of electrical power networks
JP2009050171A (en) 2007-08-23 2009-03-12 Toyobo Co Ltd Method for detecting phosphorylation on substrate by surface plasmon resonance
DE102007044380A1 (en) 2007-09-17 2009-03-19 Siemens Ag Computer-aided studying of probabilistic network from data record of measured, experimentally determined and/or empirical values, comprises studying structure of non-directed graphs having nodes and non-directed edges from the data record
US7895146B2 (en) 2007-12-03 2011-02-22 Microsoft Corporation Time modulated generative probabilistic models for automated causal discovery that monitors times of packets
JP6078211B2 (en) 2008-02-20 2017-02-15 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィアThe Children’S Hospital Of Philadelphia Genetic changes associated with autism and the phenotype of autism and its use for diagnosis and treatment of autism
US8173369B2 (en) 2008-05-15 2012-05-08 The Regents Of The University Of California Peripheral gene expression biomarkers for autism
US8005770B2 (en) * 2008-06-09 2011-08-23 Microsoft Corporation Parallel generation of a bayesian network
WO2010018477A2 (en) 2008-08-15 2010-02-18 Koninklijke Philips Electronics N.V. Model enhanced imaging
BRPI0917871A2 (en) 2008-08-15 2017-06-20 Merrimack Pharmaceuticals Inc anti-erbb3 therapeutic agent for use in tumor therapy, methods for predicting tumor responsiveness of an anti-erbb3 therapeutic agent, for selecting anti-erbb3 therapy for a patient, for predicting cell response to treatment with a therapeutic agent , to identify a biomarker, and to prevent administration of an anti-erbb3 cancer drug, and kit to predict cell response to treatment with a therapeutic agent
WO2010045463A2 (en) * 2008-10-15 2010-04-22 Government Of The United States As Represented By The Secretary Of The Army Clinical decision model
GB2477705B (en) 2008-11-17 2014-04-23 Veracyte Inc Methods and compositions of molecular profiling for disease diagnostics
WO2010056982A2 (en) 2008-11-17 2010-05-20 The George Washington University Compositions and methods for identifying autism spectrum disorders
KR20180018833A (en) 2009-05-11 2018-02-21 베르그 엘엘씨 Methods for treatment of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
US20110202486A1 (en) * 2009-07-21 2011-08-18 Glenn Fung Healthcare Information Technology System for Predicting Development of Cardiovascular Conditions
US20110059861A1 (en) 2009-09-08 2011-03-10 Nodality, Inc. Analysis of cell networks
US20110112380A1 (en) 2009-11-12 2011-05-12 eTenum, LLC Method and System for Optimal Estimation in Medical Diagnosis
WO2011112961A1 (en) 2010-03-12 2011-09-15 Children's Medical Center Corporation Methods and compositions for characterizing autism spectrum disorder based on gene expression patterns
EP2600154A4 (en) 2010-03-31 2014-06-11 Univ Kumamoto Nat Univ Corp Method for generating data set for integrated proteomics, integrated proteomics method using data set for integrated proteomics that is generated by the generation method, and method for identifying causative substance using same
US11195213B2 (en) * 2010-09-01 2021-12-07 Apixio, Inc. Method of optimizing patient-related outcomes
SG10201601224WA (en) * 2011-03-02 2016-03-30 Berg Llc Interrogatory cell-based assays and uses thereof
JP2013537326A (en) * 2011-08-31 2013-09-30 アピシオ,インク. Medical Information Navigation Engine (MINE) system
CN103107315B (en) 2011-11-10 2016-03-30 北京有色金属研究总院 A kind of nano-silicone wire/carbon composite material and preparation method thereof
CN104364393A (en) 2012-03-05 2015-02-18 博格有限责任公司 Compositions and methods for diagnosis and treatment of pervasive developmental disorder
SG11201406201YA (en) 2012-04-02 2014-10-30 Berg Llc Interrogatory cell-based assays and uses thereof
CN104487842B (en) 2012-05-22 2017-09-08 博格有限责任公司 The probing analysis based on cell for differentiating drug-induced toxicity mark
JP6916107B2 (en) 2014-09-11 2021-08-11 バーグ エルエルシー Bayesian Causal Network Model for Health Examination and Treatment Based on Patient Data

Also Published As

Publication number Publication date
US10482385B2 (en) 2019-11-19
ZA201701611B (en) 2019-09-25
AU2020244596A1 (en) 2020-11-05
US20160171383A1 (en) 2016-06-16
AU2015314956A1 (en) 2017-04-06
HK1243509A1 (en) 2018-07-13
IL250966B (en) 2021-07-29
CN114203296A (en) 2022-03-18
CA2960837A1 (en) 2016-03-17
EP3191975A1 (en) 2017-07-19
JP2017537365A (en) 2017-12-14
NZ730197A (en) 2022-07-01
KR20170058391A (en) 2017-05-26
CN107111603A (en) 2017-08-29
US11734593B2 (en) 2023-08-22
EP3191975A4 (en) 2018-04-18
IL250966A0 (en) 2017-04-30
SG11201701963UA (en) 2017-04-27
WO2016040725A1 (en) 2016-03-17
US20200143278A1 (en) 2020-05-07
JP6916107B2 (en) 2021-08-11
AU2020244596B2 (en) 2023-02-23

Similar Documents

Publication Publication Date Title
SG10201902151UA (en) Bayesian causal relationship network models for healthcare diagnosis and treatment based on patient data
WO2019071098A3 (en) Methods for predicting or detecting disease
WO2014210603A3 (en) Systems and method for evaluating and selecting a healthcare professional
WO2016075331A3 (en) Method and system for purely geometric machine learning based fractional flow reserve
IL248870B (en) Systems and methods for reporting blood flow characteristics
WO2015022649A3 (en) Modeling of patient risk factors at discharge
EP2930637A3 (en) Patient-need prediction system
EP3294106A4 (en) Devices, methods, and systems for acquiring medical diagnostic information and provision of telehealth services
NZ733443A (en) System, method, and apparatus for electronic patient care
WO2016100875A3 (en) System and method of conducting in silico clinical trials
MX2016000180A (en) Systems and methods for a tinnitus therapy.
EP2963574A3 (en) Method and system for prediction of post-stenting hemodynamic metrics for treatment planning of arterial stenosis
WO2018096390A8 (en) Methods and systems for managing patient compliance
WO2014152265A3 (en) Geographic utilization of artificial intelligence in real-time for disease identification and alert notification
MX2017004605A (en) Method and system for predicting continous cardiac output (cco) of a patient based on physiological data.
MX2020006034A (en) Computer-implemented method and system for producing orthopedic care.
GB2543724A (en) System and method for providing access to electronic medical records
WO2014165009A3 (en) Method and apparatus for transmitting healthcare messages to an automatically identified set of patients
EP4343707A3 (en) Indication-dependent display of a medical image
MA40535A (en) Hsp90-targeted inflammation and infection imaging and therapy
EP3554353A4 (en) System for characterization, diagnosis, and treatment of a health condition of a patient and methods of using same
WO2015004655A3 (en) Method and apparatus for facial visualization and dental or operational planning
SG10201807959YA (en) Medical data management system
WO2016089741A8 (en) Graphical user interfaces for configuration of medical treatment apparatus
GB2554591A (en) Clinical support system and method