PE20140627A1 - Ensayos interrogatorios basados en celulas y usos de los mismos - Google Patents

Ensayos interrogatorios basados en celulas y usos de los mismos

Info

Publication number
PE20140627A1
PE20140627A1 PE2013002007A PE2013002007A PE20140627A1 PE 20140627 A1 PE20140627 A1 PE 20140627A1 PE 2013002007 A PE2013002007 A PE 2013002007A PE 2013002007 A PE2013002007 A PE 2013002007A PE 20140627 A1 PE20140627 A1 PE 20140627A1
Authority
PE
Peru
Prior art keywords
data
biological system
interrogatory
tests
cell
Prior art date
Application number
PE2013002007A
Other languages
English (en)
Inventor
Niven Rajin Narain
Rangaprasad Sarangarajan
Vivek K Vishnudas
Original Assignee
Berg Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berg Llc filed Critical Berg Llc
Publication of PE20140627A1 publication Critical patent/PE20140627A1/es

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/20—Probabilistic models
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Genetics & Genomics (AREA)
  • Probability & Statistics with Applications (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Mobile Radio Communication Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

SE REFIERE A UN METODO PARA IDENTIFICAR UN MODULAR DE UN SISTEMA BIOLOGICO, QUE COMPRENDE: 1)ESTABLECER EL MODELO PARA EL SISTEMA BIOLOGICO; 2) OBTENER UN PRIMER CONJUNTO DE DATOS QUE COMPRENDE DATOS LIPIDOMICOS, DATOS METABOLOMICOS, DATOS TRANSCRIPTOMICOS, ENTRE OTROS;3)OBTENER UN SEGUNDO CONJUNTO DE DATOS QUE COMPRENDE UN PERFIL BIOENERGETICO, PROLIFERACION CELULAR, APOPTOSIS, ENTRE OTROS; 4)GENERAR UNA RED DE RELACIONES CAUSALES DE CONSENSO ENTRE EL PRIMER CONJUNTO DE DATOS Y EL SEGUNDO CONJUNTO DE DATOS;5) IDENTIFICAR, A PARTIR DE LA RED DE RELACIONES CAUSALES DE CONSENSO, UNA RELACION CAUSAL UNICA EN EL SISTEMA BIOLOGICO. DICHO METODO ES UTIL EN EL TRATAMIENTO DEL CANCER PULMONAR, CANCER DE MAMA, CANCER DE PROSTATA.
PE2013002007A 2011-03-02 2012-03-02 Ensayos interrogatorios basados en celulas y usos de los mismos PE20140627A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161448587P 2011-03-02 2011-03-02
US201261593848P 2012-02-01 2012-02-01

Publications (1)

Publication Number Publication Date
PE20140627A1 true PE20140627A1 (es) 2014-05-30

Family

ID=46758320

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2013002007A PE20140627A1 (es) 2011-03-02 2012-03-02 Ensayos interrogatorios basados en celulas y usos de los mismos
PE2018000152A PE20180776A1 (es) 2011-03-02 2012-03-02 Ensayos interrogatorios basados en celulas y usos de los mismos

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2018000152A PE20180776A1 (es) 2011-03-02 2012-03-02 Ensayos interrogatorios basados en celulas y usos de los mismos

Country Status (20)

Country Link
US (3) US9886545B2 (es)
EP (1) EP2680925B1 (es)
JP (2) JP6105491B2 (es)
KR (1) KR102071081B1 (es)
CN (2) CN103501859B (es)
AU (2) AU2012223136B2 (es)
BR (1) BR112013022208A2 (es)
CA (1) CA2828972C (es)
CL (2) CL2013002526A1 (es)
CO (1) CO6801640A2 (es)
EA (1) EA201391245A1 (es)
ES (1) ES2777894T3 (es)
IL (2) IL228096B (es)
MX (1) MX358408B (es)
MY (2) MY164530A (es)
PE (2) PE20140627A1 (es)
PH (2) PH12017502073A1 (es)
SG (2) SG10201601224WA (es)
WO (1) WO2012119129A1 (es)
ZA (1) ZA201306453B (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2956645A1 (en) 2003-07-12 2005-03-31 David A. Goldberg Sensitive and rapid biodetection
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
US9434937B2 (en) 2011-03-07 2016-09-06 Accelerate Diagnostics, Inc. Rapid cell purification systems
JP2015517801A (ja) * 2012-03-05 2015-06-25 バーグ エルエルシー 広汎性発達障害の診断および治療のための組成物および方法
US9744155B2 (en) 2012-03-28 2017-08-29 Ixcela, Inc. IPA as a therapeutic agent, as a protective agent, and as a biomarker of disease risk
CN108048521B (zh) * 2012-04-02 2022-05-27 博格有限责任公司 基于细胞的探询式分析及其应用
EA201492178A1 (ru) 2012-05-22 2015-12-30 Берг Ллк Основанные на клетках перекрестные анализы для идентификации маркеров индуцированной лекарственными средствами токсичности
US20150302140A1 (en) * 2012-11-02 2015-10-22 H. Lee Moffit Cancer Center And Research Institute, Inc. In silico identification of cancer molecular signaling pathways and drug candidates
US20150302167A1 (en) * 2012-11-09 2015-10-22 Cellworks Group, Inc. System and method for development of therapeutic solutions
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
AU2014274224B2 (en) * 2013-05-28 2016-06-09 Five3 Genomics, Llc Paradigm drug response networks
US20150019189A1 (en) * 2013-07-01 2015-01-15 Counterpoint Health Solutions, Inc. Systems biology approach to therapy
CA2950356A1 (en) * 2014-05-28 2015-12-03 Vito Nv A method for the relative quantification of chemical compounds contained in a mixture of different biological samples
CA2960837A1 (en) * 2014-09-11 2016-03-17 Berg Llc Bayesian causal relationship network models for healthcare diagnosis and treatment based on patient data
SG11201702490PA (en) * 2014-10-10 2017-04-27 Akira Matsumori Method for detecting cardiac failure patient, method for discrimination of cardiac disease, test reagent for cardiac failure, test kit for cardiac failure, device for detecting cardiac failure, and program for detecting cardiac failure
EP3230314B1 (en) 2014-12-08 2023-05-03 Berg LLC Use of markers including filamin a in the diagnosis and treatment of prostate cancer
US10023895B2 (en) 2015-03-30 2018-07-17 Accelerate Diagnostics, Inc. Instrument and system for rapid microogranism identification and antimicrobial agent susceptibility testing
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
CN106250717B (zh) * 2015-06-04 2019-03-12 徐勇 急性髓性白血病的miRNA与转录因子的系统及其构建方法和应用
KR101881398B1 (ko) * 2016-04-07 2018-07-24 한국과학기술원 생물학적 시스템 정보 처리 장치 및 방법
JP7042755B2 (ja) 2016-06-05 2022-03-28 バーグ エルエルシー 患者層別化及び潜在的バイオマーカー同定のためのシステム及び方法
US10282588B2 (en) * 2016-06-09 2019-05-07 Siemens Healthcare Gmbh Image-based tumor phenotyping with machine learning from synthetic data
CA3043709A1 (en) 2016-11-14 2018-05-17 Berg Llc Methods for treating parkinson's disease
WO2018094204A1 (en) * 2016-11-17 2018-05-24 Arivale, Inc. Determining relationships between risks for biological conditions and dynamic analytes
CA3057420C (en) * 2017-05-12 2023-08-01 Laboratory Corporation Of America Holdings Systems and methods for biomarker identificaton
CN109086570B (zh) * 2018-06-29 2020-09-04 迈凯基因科技有限公司 一种多数据库依次交互方法及装置
WO2020006028A1 (en) * 2018-06-29 2020-01-02 The Jackson Laboratory Methods and apparatus for identifying alternative splicing events
US11041847B1 (en) 2019-01-25 2021-06-22 Ixcela, Inc. Detection and modification of gut microbial population
EP3935581A4 (en) 2019-03-04 2022-11-30 Iocurrents, Inc. DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING
US20220246231A1 (en) * 2019-07-09 2022-08-04 Shimadzu Corporation Method for constructing model for predicting differentiation efficiency of ips cell and method for predicting differentiation efficiency of ips cell
EP4029019A4 (en) * 2019-09-11 2023-10-11 Recursion Pharmaceuticals, Inc. SYSTEMS AND METHODS FOR PAIRWISE INFERENCE OF DRUG-GENE INTERACTION NETWORKS
CN112151109B (zh) * 2020-09-09 2023-08-25 中国科学院大连化学物理研究所 用于评价生物分子交联质谱鉴定随机性的半监督学习方法
CN112466403B (zh) * 2020-12-31 2022-06-14 广州基迪奥生物科技有限公司 一种细胞通讯分析方法及系统
KR102556312B1 (ko) 2021-04-12 2023-07-19 서울대학교병원 세뇨관 배양부 및 간질 배양부를 포함하는 신장 모사 장기 칩
WO2023102204A1 (en) * 2021-12-03 2023-06-08 The Trustees Of Indiana University Biomarker for type 1 diabetes
CN116046877B (zh) * 2023-04-03 2024-03-15 深圳先进技术研究院 疾病模型代谢分析方法、包埋模具及喷涂装置

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
EP0247091B1 (en) 1985-11-01 1993-09-29 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5116742A (en) 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US4904582A (en) 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
US4843155A (en) 1987-11-19 1989-06-27 Piotr Chomczynski Product and process for isolating RNA
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
EP1892296A1 (en) 1988-09-02 2008-02-27 Dyax Corporation Generation and selection of recombinant varied binding proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DK0585287T3 (da) 1990-07-10 2000-04-17 Cambridge Antibody Tech Fremgangsmåde til fremstilling af specifikke bindingsparelementer
KR100272077B1 (ko) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
CA2405246A1 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with alterred binding properties
ES2330052T3 (es) 1991-03-01 2009-12-03 Dyax Corporation Proteina quimerica que comprende micro-proteinas que tienen dos o mas puentes disulfuro y relaizaciones de las mismas.
DE69233750D1 (de) 1991-04-10 2009-01-02 Scripps Research Inst Bibliotheken heterodimerer Rezeptoren mittels Phagemiden
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
US5621083A (en) 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
DE69233331T3 (de) 1991-11-22 2007-08-30 Affymetrix, Inc., Santa Clara Kombinatorische Strategien zur Polymersynthese
US6025165A (en) 1991-11-25 2000-02-15 Enzon, Inc. Methods for producing multivalent antigen-binding proteins
EP0552108B1 (en) 1992-01-17 1999-11-10 Lakowicz, Joseph R. Energy transfer phase-modulation fluoro-immunoassay
US5918200A (en) 1992-08-31 1999-06-29 Yamatake-Honeywell Co., Ltd. State estimating apparatus
WO1994016101A2 (en) 1993-01-07 1994-07-21 Koester Hubert Dna sequencing by mass spectrometry
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
WO1994021822A1 (en) 1993-03-19 1994-09-29 Sequenom, Inc. Dna sequencing by mass spectrometry via exonuclease degradation
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
EP0880598A4 (en) 1996-01-23 2005-02-23 Affymetrix Inc RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM
WO1999023254A1 (en) 1997-10-31 1999-05-14 Affymetrix, Inc. Expression profiles in adult and fetal organs
US6020135A (en) 1998-03-27 2000-02-01 Affymetrix, Inc. P53-regulated genes
CA2324995A1 (en) * 1998-04-17 1999-10-28 University Of Vermont And State Agricultural College Methods and products related to metabolic interactions in disease
US6763307B2 (en) 2000-03-06 2004-07-13 Bioseek, Inc. Patient classification
CA2441060A1 (en) * 2001-03-13 2002-09-19 Ashni Naturaceuticals, Inc. Method for association of genomic and proteomic pathways associated with physiological or pathophysiological processes
US8000949B2 (en) 2001-06-18 2011-08-16 Genego, Inc. Methods for identification of novel protein drug targets and biomarkers utilizing functional networks
US7393656B2 (en) 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
US7415359B2 (en) 2001-11-02 2008-08-19 Gene Network Sciences, Inc. Methods and systems for the identification of components of mammalian biochemical networks as targets for therapeutic agents
AU2002304965A1 (en) 2002-05-24 2003-12-12 Zensun (Shanghai) Sci-Tech.Ltd Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy
ATE398808T1 (de) 2002-08-29 2008-07-15 Gene Network Sciences Inc Systeme und verfahren zum schliessen auf biologische netzwerke
CN1714371A (zh) * 2002-11-19 2005-12-28 Gni美国公司 根据时间序列基因表达数据的基因网络的非线性模拟
JP4288345B2 (ja) 2003-06-19 2009-07-01 独立行政法人産業技術総合研究所 新規てんかんモデル動物
EP1512970A1 (en) * 2003-09-05 2005-03-09 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Method for determining the impact of a multicomponent mixture on the biological profile of a disease
US20070134734A1 (en) 2003-10-14 2007-06-14 Cellfree Sciences Co., Ltd. Novel screening method of indicator substance
WO2005107412A2 (en) 2004-04-30 2005-11-17 Rosetta Inpharmatics Llc Systems and methods for reconstruction gene networks in segregating populations
EP1607898A3 (en) 2004-05-18 2006-03-29 Neal E. Solomon A bioinformatics system for functional proteomics modelling
US20100316629A1 (en) 2004-09-01 2010-12-16 Shaughnessy Jr John D Use of gene expression profiling to predict survival in cancer patient
US20070009923A1 (en) 2005-01-24 2007-01-11 Massachusetts Institute Of Technology Use of bayesian networks for modeling cell signaling systems
JP2008537821A (ja) 2005-03-31 2008-09-25 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 生体分子及び疾患の間の関係に関する証拠を収集するシステム及び方法
US20090132171A1 (en) * 2005-05-31 2009-05-21 Jcl Bioassay Corporation Screening Method for Specific Protein in Proteome Comprehensive Analysis
AU2006299079A1 (en) 2005-09-30 2007-04-12 Universiteit Maastricht Tumor angiogenesis associated genes and a method for their identification
WO2007086515A1 (ja) * 2006-01-27 2007-08-02 Takeda Pharmaceutical Company Limited 遺伝子発現解析ツール
US8571803B2 (en) * 2006-11-15 2013-10-29 Gene Network Sciences, Inc. Systems and methods for modeling and analyzing networks
CN101105841B (zh) * 2007-02-12 2011-06-15 浙江大学 由大规模基因芯片表达谱数据构建基因调控亚网络的方法
US8140270B2 (en) * 2007-03-22 2012-03-20 National Center For Genome Resources Methods and systems for medical sequencing analysis
EP2147387A4 (en) * 2007-05-16 2012-05-02 Edsa Micro Corp REAL-TIME FORECASTING SYSTEMS FOR INTELLIGENT ENERGY MONITORING AND MANAGEMENT OF ELECTRICITY NETWORKS
JP2009050171A (ja) 2007-08-23 2009-03-12 Toyobo Co Ltd 表面プラズモン共鳴による基板上におけるリン酸化の検出方法
US7895146B2 (en) * 2007-12-03 2011-02-22 Microsoft Corporation Time modulated generative probabilistic models for automated causal discovery that monitors times of packets
JP5670755B2 (ja) * 2008-03-12 2015-02-18 ザ ロックフェラー ユニバーシティ 翻訳プロファイリング及び分子表現型解析のための方法及び組成物
UA104868C2 (uk) 2008-08-15 2014-03-25 Меррімак Фармасьютікалз, Інк. Спосіб лікування пацієнта, що має неопластичну пухлину, відповідно до спрогнозованої реакції
US20110020312A1 (en) 2009-05-11 2011-01-27 Niven Rajin Narain Methods for treatment of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
EP2600154A4 (en) 2010-03-31 2014-06-11 Univ Kumamoto Nat Univ Corp METHOD FOR PRODUCING DATA SET FOR INTEGRATED PROTEOMIC, INTEGRATED PROTEASE METHOD USING THE DATA SET FOR INTEGRATED PROTEOME, THAT IS PRODUCED BY THE PRODUCTION METHOD, AND METHOD FOR IDENTIFYING, BY ITS USE, THE SUBSTANCE THAT IN THE ORIGIN
CN108048521B (zh) * 2012-04-02 2022-05-27 博格有限责任公司 基于细胞的探询式分析及其应用
US20150019189A1 (en) * 2013-07-01 2015-01-15 Counterpoint Health Solutions, Inc. Systems biology approach to therapy

Also Published As

Publication number Publication date
EP2680925A1 (en) 2014-01-08
CN107273712B (zh) 2021-12-03
US11456054B2 (en) 2022-09-27
BR112013022208A2 (pt) 2022-03-08
JP6105491B2 (ja) 2017-03-29
AU2012223136B2 (en) 2017-05-25
US9886545B2 (en) 2018-02-06
ES2777894T3 (es) 2020-08-06
AU2017202977A1 (en) 2017-05-25
NZ712105A (en) 2017-05-26
CA2828972A1 (en) 2012-09-07
MY164530A (en) 2017-12-29
PH12017502072A1 (en) 2019-01-14
CL2020002805A1 (es) 2021-04-30
EP2680925A4 (en) 2014-12-31
IL257824A (en) 2018-04-30
JP2014512520A (ja) 2014-05-22
IL228096B (en) 2018-03-29
SG193006A1 (en) 2013-10-30
IL228096A0 (en) 2013-09-30
US20240062844A1 (en) 2024-02-22
MY181093A (en) 2020-12-17
SG10201601224WA (en) 2016-03-30
CL2013002526A1 (es) 2014-04-25
CO6801640A2 (es) 2013-11-29
US20120258874A1 (en) 2012-10-11
JP2017148046A (ja) 2017-08-31
AU2012223136A1 (en) 2013-09-19
MX358408B (es) 2018-08-20
NZ614891A (en) 2016-01-29
CN103501859B (zh) 2017-08-25
US20180260515A1 (en) 2018-09-13
KR102071081B1 (ko) 2020-01-29
EP2680925B1 (en) 2019-11-20
MX2013010068A (es) 2013-11-01
ZA201306453B (en) 2021-05-26
KR20140013006A (ko) 2014-02-04
WO2012119129A1 (en) 2012-09-07
CA2828972C (en) 2021-09-07
EA201391245A1 (ru) 2014-05-30
PE20180776A1 (es) 2018-05-07
PH12017502073A1 (en) 2019-01-14
AU2017202977B2 (en) 2019-09-19
CN103501859A (zh) 2014-01-08
CN107273712A (zh) 2017-10-20

Similar Documents

Publication Publication Date Title
PE20140627A1 (es) Ensayos interrogatorios basados en celulas y usos de los mismos
BR112017014333A2 (pt) aparelho e método
BR112015030590A2 (pt) sistema e método para mapear uma topologia de nível de serviço para uma topologia lógica de plano de dados específica quanto ao serviço
AR086370A1 (es) Nodo de red radial y metodos para habilitar en dicho nodo la medicion de temporizacion de id de celda ampliada para el posicionamiento de un equipo de usuario
BR112013002811A8 (pt) meios básicos simplificados para cultura celular pluripotente de humano
BR112015009246A2 (pt) métodos e sistemas para determinar o uso e o conteúdo de pymk com base em um modelo de valores
BR112015010012A2 (pt) método; e sistema
BR112014022829A8 (pt) método de configuração de célula, método de sincronização, equipamento de usuário e estação base
BR112016030212A2 (pt) Célula eletroquímica, campo de fluxo e método de fabrico de campo de fluxo poroso aberto para utilização na mesma
BR112017017886A2 (pt) gerando populações de células endoteliais arteriais
AR093446A1 (es) Anticuerpos de antihemaglutinina y metodos de uso
GB2545361A (en) Protein biomarker panels for detecting colorectal cancer and advanced adenoma
EP3683321A3 (en) Methods relating to circulating tumor cell clusters and the treatment of cancer
BR112017000880A2 (pt) "método para injetar sinais em uma rede de distribuição de serviços públicos e sistema de rede de distribuição de serviços públicos"
BR112017019072A2 (pt) membrana de troca de íons, sistemas eletroquímicos, e métodos
BR112016007251A2 (pt) método de processamento de biomassa que contém celulose
BR112015011878A2 (pt) sistema, método implementado em processador e artigo
BR112015009042A2 (pt) populações de célula renal e usos das mesmas
BR112014031182A2 (pt) método para testar uma formação, sistema para testar a pressão de uma formação e meio de armazenamento legível por computador
AR095134A1 (es) Dispositivo informático, sistema y método relacionado con gráficos y tarjetas de actividad
EA201691682A1 (ru) Способы анализирования редких циркулирующих в крови клеток
PE20190517A1 (es) Preparacion farmaceutica antienvejecimiento
BR112015014190A2 (pt) proporcionando conteúdo organizado
AR093174A1 (es) Gestion de datos inferidos
AR104805A1 (es) Métodos y composiciones para evaluar la capacidad de respuesta de los cánceres a los inhibidores de bet

Legal Events

Date Code Title Description
FG Grant, registration