CN100998411A - 一种具有减肥及抗氧化功能的保健食品 - Google Patents
一种具有减肥及抗氧化功能的保健食品 Download PDFInfo
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Abstract
Description
实施例号 | 葡萄籽提取物(kg) | 乌龙茶提取物(kg) | 左旋肉碱(kg) | 小麦胚芽油(kg) | 蜂蜡(kg) |
1 | 5 | 5 | 5 | 20 | 0.5 |
2 | 13 | 8 | 10 | 35 | 0.3 |
3 | 10 | 12 | 16 | 60 | 2 |
4 | 25 | 15 | 19 | 75 | 1 |
5 | 20 | 20 | 20 | 80 | 2 |
组别 | 剂量(g/kg.bw) | 动物数(只) | MDA含量(mmol/L) | F | p |
正常对照组 | - | 10 | 3.58±0.827 | ||
低剂量组 | 0.17 | 10 | 5.36±1.166 | >0.05 | |
中剂量组 | 0.33 | 10 | 5.49±1.246 | >0.05 | |
高剂量组 | 1.00 | 10 | 5.34±1.199 | >0.05 | |
老龄对照组 | - | 10 | 5.80±2.273 | 6.250 |
组别 | 剂量(g/kg.bw) | 动物数(只) | MDA含量(mmol/L) | q值 | p |
正常对照组 | - | 10 | 3.68±0.88** | 5.69 | <0.01 |
低剂量组 | 0.17 | 10 | 4.78±1.60 | ||
中剂量组 | 0.33 | 10 | 4.34±1.21* | 3.96 | <0.05 |
高剂量组 | 1.00 | 10 | 4.26±1.04* | 4.17 | <0.05 |
老龄对照组 | - | 10 | 5.86±1.20 |
组别 | 剂量(g/kg.bw) | 动物数(只) | SOD活力(u/ml) | q值 | p | GSH-Px活力(u/ml) | q值 | p |
正常对照组 | - | 10 | 282.0±27.3** | 4.98 | <0.01 | 174.0±22.0* | 5.32 | <0.01 |
低剂量组 | 0.17 | 10 | 254.0±35.4 | 148.0±30.9 | ||||
中剂量组 | 0.33 | 10 | 260.0±29.2 | 165.0±36.4* | 4.32 | <0.05 | ||
高剂量组 | 1.00 | 10 | 263.0±27.0 | 168.0±24.9* | 4.59 | <0.05 | ||
老龄对照组 | - | 10 | 238.0±21.9 | 128.0±18.0 |
指标 | 对照组 | 试食组 | ||
试食前 | 试食后 | 试食前 | 试食后 | |
红细胞(1012/L) | 4.58±0.61 | 4.38±0.58 | 4.57±0.50 | 4.46±0.49 |
血红蛋白(g/L) | 138.07±14.81 | 134.97±15.00 | 139.93±17.25 | 139.33±16.51 |
白细胞(109/L) | 6.57±1.69 | 6.38±1.70 | 6.61±1.61 | 6.40±1.51 |
尿常规 | 正常 | 正常 | 正常 | 正常 |
大便常规 | 正常 | 正常 | 正常 | 正常 |
指标 | 对照组 | 试食组 | ||
试食前 | 试食后 | 试食前 | 试食后 | |
ALT(U/L) | 23.05±14.14 | 24.01±15.08 | 26.96±18.51 | 23.81±13.67 |
AST(U/L) | 22.43±10.94 | 27.45±7.38 | 24.93±12.08 | 25.85±7.35 |
CHOL(mmol/L) | 4.96±0.77 | 4.67±0.80 | 5.18±0.90 | 4.68±0.81 |
TG(mmol/L) | 1.53±1.02 | 1.54±1.06 | 1.54±1.62 | 1.69±1.40 |
TP(g/L) | 65.97±4.37 | 70.75±3.24 | 65.82±4.55 | 71.32±3.31 |
ALB(g/L) | 42.18±3.01 | 43.70±2.89 | 42.75±3.34 | 44.90±3.01 |
BUN(mmol/L) | 5.67±1.41 | 5.33±1.52 | 5.69±1.46 | 5.19±1.56 |
Cr(μmol/L) | 93.21±19.71 | 94.15±12.78 | 94.90±20.15 | 91.31±14.54 |
GLu(mmol/L) | 5.47±0.82 | 5.13±0.66 | 5.52±0.78 | 5.07±0.88 |
指标 | 对照组 | 试食组 | ||
试食前 | 试食后 | 试食前 | 试食后 | |
MDA(nmol/mL) | 3.68±0.72 | 3.71±0.60 | 3.70±0.71 | 3.67±0.74 |
SOD(NU/ml) | 129.96±12.21 | 131.02±11.20 | 129.99±11.28 | 133.37±12.70 |
GSH-Px(活力单位) | 103.09±20.05 | 105.88±10.15 | 103.11±12.99 | 114.15±13.73* |
指标 | 对照组 | 试食组 | P |
MDA(nmol/mL) | 3.71±0.60 | 3.67±0.74 | >0.05 |
SOD(NU/ml) | 131.02±11.20 | 133.37±12.70 | >0.05 |
GSH-Px(活力单位) | 105.88±10.15 | 114.15±13.73 | <0.05 |
指标 | 对照组 | 试食组 |
MDA降低率(%) | -0.82 | 0.82 |
SOD升高率(%) | 0.82 | 2.60 |
GSH-Px升高率(%) | 2.71 | 10.71 |
组别 | 动物数(只) | 体重 | 增重(g) | 总进食量(g) | 总食物利用率(%) | |
试验前(g) | 试验末(g) | |||||
模型对照组 | 10 | 144.2±4.4 | 366.4±20.7 | 222.3±21.0 | 827.4±7.3 | 26.9±2.4 |
空白对照组 | 10 | 144.8±4.7 | 325.5±18.8## | 180.7±19.2# | 821.8±19.0 | 22.0±2.4# |
低剂量组 | 10 | 144.6±5.0 | 347.9±21.4 | 203.3±22.5 | 825.5±19.3 | 24.5±2.8 |
中剂量组 | 10 | 144.4±4.0 | 346.9±27.7 | 202.5±26.6** | 828.6±17.2 | 24.4±3.2** |
高剂量组 | 10 | 146.0±3.4 | 328.8±24.5** | 182.8±23.9** | 827.0±13.8 | 22.1±2.7** |
A点 | 右三角肌下缘臂外侧正中点 |
B点 | 右肩胛下角 |
C点 | 右脐旁3cm |
F点 | 右骼前上棘 |
人数 | 心率(次/min) | 收缩压(mmHg) | 舒张压(mmHg) | 尿常规 | 尿酮体 | 便常规 | |
正常值范围 | 60~100 | 90~140 | 60~90 | - | - | - | |
试验组(前) | 50 | 77.6±11.7 | 111.1±8.0 | 76.3±5.6 | 未见异常 | - | 未见异常 |
试验组(后) | 50 | 76.6±10.8 | 109.2±8.7 | 76.0±6.6 | 未见异常 | - | 未见异常 |
对照组(前) | 50 | 77.4±12.7 | 112.9±9.3 | 78.0±6.5 | 未见异常 | - | 未见异常 |
对照组(后) | 50 | 79.7±12.2 | 112.1±7.6 | 77.0±7.6 | 未见异常 | - | 未见异常 |
人数 | 红细胞计数(1012/L) | 白细胞计数(109/L) | 血红蛋白含量(g/L) | 血小板计数(109/L) | |
正常值范围 | 3.5~5.5 | 4.0~10.0 | 110~160 | 100~300 | |
试验组(前) | 50 | 4.7±0.3 | 6.6±1.3 | 140.9±12.7 | 228.4±51.3 |
试验组(后) | 50 | 5.0±0.5 | 6.5±1.2 | 141.8±13.9 | 292.0±75.9 |
对照组(前) | 50 | 4.8±0.4 | 6.9±1.4 | 143.0±13.5 | 225.7±54.4 |
对照组(后) | 50 | 5.1±0.5 | 6.7±1.0 | 145.6±13.2 | 284.9±86.7 |
人数 | LYMP% | MONO% | NEUT% | EO% | BASO% | |
正常值范围 | 20~40 | 3~8 | 50~70 | 0.5~5 | 0~1 | |
试验组(前) | 50 | 34.4±9.5 | 7.7±2.0 | 55.4±9.9 | 2.1±1.8 | 0.4±0.2 |
试验组(后) | 50 | 33.6±6.7 | 7.2±1.7 | 56.8±7.4 | 2.1±1.4 | 0.4±0.2 |
对照组(前) | 50 | 33.7±8.6 | 7.7±1.8 | 56.2±8.8 | 2.0±1.8 | 0.4±0.2 |
对照组(后) | 50 | 33.8±7.1 | 7.1±1.7 | 56.7±7.8 | 2.0±1.3 | 0.4±0.2 |
人数 | CRE(mmol/L) | BUN(mmol/L) | URIC(umol/L) | ALT(U/L) | AST(U/L) | |
正常值范围 | 40~120 | 2.5~7.0 | 90~420 | 0~40 | 0~40 | |
试验组(前) | 50 | 72.8±12.5 | 4.5±1.1 | 246.5±60.2 | 19.4±10.6 | 20.6±6.1 |
试验组(后) | 50 | 69.6±10.1 | 4.3±1.3 | 244.9±58.7 | 16.4±7.0 | 22.6±4.9 |
对照组(前) | 50 | 70.1±12.7 | 4.9±1.2 | 246.6±48.2 | 17.3±9.6 | 22.0±5.2 |
对照组(后) | 50 | 72.7±11.7 | 4.4±1.3 | 261.8±71.0 | 18.7±11.3 | 23.7±4.7 |
人数 | TP(g/L) | ALB(g/L) | G(g/L) | A/G | |
正常值范围 | 60~80 | 35~55 | 20~35 | 1.5~2.5 | |
试验组(前) | 50 | 76.7±5.1 | 45.9±3.0 | 30.7±3.2 | 1.5±0.2 |
试验组(后) | 50 | 75.1±3.6 | 48.1±2.4 | 27.1±3.4 | 1.8±0.3 |
对照组(前) | 50 | 76.7±5.1 | 46.2±2.9 | 30.5±3.6 | 1.5±0.2 |
对照组(后) | 50 | 74.9±3.8 | 47.8±3.0 | 27.1±3.7 | 1.8±0.3 |
人数 | 安静心率(次) | 运动稳态心率(次) | 1分钟恢复心率(次) | 负荷量(kg.m/min) | 最大摄氧量(L) | |
试验组(前) | 50 | 77.6±11.7 | 134.2±8.9 | 107.8±7.2 | 366.6±44.3 | 2.3±0.4 |
试验组(后) | 50 | 76.6±10.8 | 136.4±7.2 | 109.9±6.5 | 372.2±40.2 | 2.3±0.3 |
对照组(前) | 50 | 77.4±12.7 | 134.8±9.2 | 106.0±6.6 | 353.2±37.8 | 2.3±0.4 |
对照组(后) | 50 | 79.7±12.2 | 133.8±7.8 | 108.2±7.0 | 368.6±43.2 | 2.4±0.3 |
配对t-检验(t值) | - | 0.454 | 1.320 | 1.597 | 0.632 | 1.004 |
配对t-检验(p值) | - | 0.652 | 0.193 | 0.117 | 0.530 | 0.321 |
成组t-检验(t值) | - | 1.317 | 1.738 | 1.244 | 0.431 | 1.622 |
成组t-检验(p值) | - | 0.191 | 0.085 | 0.217 | 0.667 | 0.108 |
人数 | 体重(kg) | BMI(kg/m2) | 超重度(%) | 体脂总量(kg) | 体脂百分率(%) | |
试验组(前) | 50 | 81.2±6.6 | 30.0±2.7 | 37.8±16.1 | 26.2±2.8 | 32.3±2.6 |
试验组(后) | 50 | 79.2±6.4 | 29.3±2.8 | 34.5±16.8 | 24.4±2.7 | 30.9±2.8 |
前后差值 | 2.0±2.8 | 0.7±1.0 | 3.3±4.7 | 1.8±1.5 | 1.4±1.4 | |
对照组(前) | 50 | 82.2±5.5 | 29.8±2.4 | 35.5±13.6 | 25.9±2.8 | 31.5±2.3 |
对照组(后) | 50 | 82.1±5.4 | 29.8±2.4 | 35.4±13.6 | 25.7±2.4 | 31.3±2.1 |
配对t-检验(t值) | - | 5.105 | 5.029 | 4.958 | 8.276 | 7.356 |
配对t-检验(p值) | - | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
成组t-检验(t值) | - | -2.462 | -1.002 | -0.308 | -2.527 | -0.894 |
成组t-检验(p值) | - | 0.016 | 0.319 | 0.759 | 0.013 | 0.374 |
人数 | 不同部位皮下脂肪厚度(mm) | 不同部位围径(cm) | |||||
肱三角肌 | 肩胛下角 | 脐旁 | 骼前上棘 | 腰围 | 臀围 | ||
试验组(前) | 50 | 13.6±3.2 | 13.7±2.7 | 19.3±4.7 | 16.7±4.9 | 91.9±7.7 | 103.9±9.5 |
试验组(后) | 50 | 13.6±3.2 | 13.7±2.8 | 17.6±4.5 | 15.3±4.5 | 89.1±7.1 | 103.6±9.4 |
前后差值 | 0.0±0.1 | 0.0±0.1 | 1.7±0.7 | 1.4±0.8 | 2.8±1.5 | 0.3±1.2 | |
对照组(前) | 50 | 13.5±2.9 | 13.6±2.6 | 19.0±2.4 | 16.9±3.5 | 91.7±4.9 | 104.2±10.1 |
对照组(后) | 50 | 13.5±2.9 | 13.7±2.6 | 19.1±2.5 | 16.9±3.6 | 91.6±4.3 | 104.0±9.9 |
配对t-检验(t值) | - | 1.827 | 1.294 | 16.819 | 12.171 | 13.970 | 1.818 |
配对t-检验(p值) | - | 0.074 | 0.202 | 0.000 | 0.000 | 0.000 | 0.075 |
成组t-检验(t值) | - | 0.082 | 0.011 | -2.030 | -2.047 | -2.119 | 0.207 |
成组t-检验(p值) | - | 0.935 | 0.991 | 0.046 | 0.043 | 0.037 | 0.836 |
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