CN100589809C - 季铵环糊精化合物 - Google Patents

季铵环糊精化合物 Download PDF

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Publication number
CN100589809C
CN100589809C CN03813614A CN03813614A CN100589809C CN 100589809 C CN100589809 C CN 100589809C CN 03813614 A CN03813614 A CN 03813614A CN 03813614 A CN03813614 A CN 03813614A CN 100589809 C CN100589809 C CN 100589809C
Authority
CN
China
Prior art keywords
formula
chemical compound
cyclodextrin
compound
purposes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN03813614A
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English (en)
Chinese (zh)
Other versions
CN1658888A (zh
Inventor
G·L·基斯
C·肖赫
J·塞特利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN1658888A publication Critical patent/CN1658888A/zh
Application granted granted Critical
Publication of CN100589809C publication Critical patent/CN100589809C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CN03813614A 2002-06-13 2003-06-12 季铵环糊精化合物 Expired - Fee Related CN100589809C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP02013074 2002-06-13
EP02013074.6 2002-06-13
EP02028554 2002-12-20
EP02028554.0 2002-12-20

Publications (2)

Publication Number Publication Date
CN1658888A CN1658888A (zh) 2005-08-24
CN100589809C true CN100589809C (zh) 2010-02-17

Family

ID=29737927

Family Applications (1)

Application Number Title Priority Date Filing Date
CN03813614A Expired - Fee Related CN100589809C (zh) 2002-06-13 2003-06-12 季铵环糊精化合物

Country Status (15)

Country Link
US (4) US20050222085A1 (enExample)
EP (1) EP1515729B1 (enExample)
JP (2) JP4773721B2 (enExample)
CN (1) CN100589809C (enExample)
AT (1) ATE386532T1 (enExample)
AU (1) AU2003276957A1 (enExample)
BR (1) BR0311722A (enExample)
CA (1) CA2487332C (enExample)
CY (1) CY1108099T1 (enExample)
DE (1) DE60319221T2 (enExample)
DK (1) DK1515729T3 (enExample)
ES (1) ES2301807T3 (enExample)
PT (1) PT1515729E (enExample)
SI (1) SI1515729T1 (enExample)
WO (1) WO2003105867A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109487588A (zh) * 2018-11-19 2019-03-19 绍兴永通印花有限公司 一种印花用涤纶织物处理液及其使用方法

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100678824B1 (ko) * 2005-02-04 2007-02-05 한미약품 주식회사 용해성이 증가된 무정형 타크로리무스 고체분산체 및 이를포함하는 약제학적 조성물
BRPI0709409A2 (pt) 2006-03-28 2011-07-12 Javelin Pharmaceuticals Inc composição farmacêutica e método para tratar um mamìfero necessitando de analgesia
WO2008120249A1 (en) * 2007-03-30 2008-10-09 Sifi S.P.A. Pharmaceutical formulations based on apolar and polar lipids for ophthalmic use
CN101757621B (zh) * 2008-11-28 2012-07-04 天津金耀集团有限公司 一种眼部抗炎的环糊精包合药物组合物
US9642920B2 (en) * 2009-06-03 2017-05-09 Case Western Reserve University Therapeutic agent delivery system and method
CN102276761A (zh) * 2010-06-11 2011-12-14 南京理工大学 单取代铵基正电型-β-环糊精及其制备方法
GB201114459D0 (en) * 2011-08-22 2011-10-05 Isis Innovation Anti-bacterial compounds
CN103497275B (zh) * 2013-08-09 2015-12-23 华北电力大学（保定） 一种抗菌、抗病毒胍盐星形聚合物及其制备方法和应用
CZ307458B6 (cs) * 2014-11-25 2018-09-12 Spur A.S. Vícevrstvý kryt rány s aktivní vrstvou a způsob jeho výroby
EP3227379B1 (en) * 2014-12-02 2020-07-29 B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University Quaternized starches for use as anti-microbial agents
BR112021014889A2 (pt) * 2019-02-14 2021-10-05 Cyclopure, Inc. Materiais poliméricos de ciclodextrina com carga e métodos de fabricação e uso dos mesmos
CN109836512A (zh) * 2019-03-04 2019-06-04 西南石油大学 一种新型β-CD双子表面活性剂为稠化剂的清洁压裂液
CN112386710A (zh) * 2020-12-09 2021-02-23 星拜(苏州)生物科技有限公司 一种利用包埋技术改善紫檀芪水溶性的方法
CN116987213B (zh) * 2022-04-26 2025-09-09 中国石油化工股份有限公司 一种具有表面活性剂功能的化合物、一种表面活性剂及其制备方法
CN120435346A (zh) 2023-01-12 2025-08-05 赛克洛珀股份有限公司 聚合环糊精吸附剂的再生

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0387681A2 (en) * 1989-03-09 1990-09-19 Farmhispania S.A. Ammonium salts of polycyclodextrins for use as hypocholesteremic agents
US5241059A (en) * 1990-05-21 1993-08-31 Toppan Printing Co., Ltd. Cyclodextrin derivatives
US6107343A (en) * 1994-10-10 2000-08-22 Novartis Ag Ophthalmic and aural compositions containing diclofenac potassium

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3453257A (en) * 1967-02-13 1969-07-01 Corn Products Co Cyclodextrin with cationic properties
JPS58210901A (ja) * 1982-06-01 1983-12-08 Kao Corp シクロデキストリン誘導体およびその製造方法
JPH0481401A (ja) * 1990-07-24 1992-03-16 Toppan Printing Co Ltd シクロデキストリン誘導体
JPH0665307A (ja) * 1992-06-17 1994-03-08 Sankyo Co Ltd シクロデキストリン誘導体
JP3297969B2 (ja) * 1994-12-26 2002-07-02 ライオン株式会社 点眼剤
US5869079A (en) * 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
TW434023B (en) * 1995-09-18 2001-05-16 Novartis Ag Preserved ophthalmic composition
NZ505951A (en) * 1998-02-23 2003-02-28 Cyclops Ehf A method for enhancing the complexation efficiency of a heterocyclic drug with cyclodextrin, by subjecting the heterocycloc drug to chemically reversible ring-opening

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0387681A2 (en) * 1989-03-09 1990-09-19 Farmhispania S.A. Ammonium salts of polycyclodextrins for use as hypocholesteremic agents
US5241059A (en) * 1990-05-21 1993-08-31 Toppan Printing Co., Ltd. Cyclodextrin derivatives
US6107343A (en) * 1994-10-10 2000-08-22 Novartis Ag Ophthalmic and aural compositions containing diclofenac potassium

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109487588A (zh) * 2018-11-19 2019-03-19 绍兴永通印花有限公司 一种印花用涤纶织物处理液及其使用方法
CN109487588B (zh) * 2018-11-19 2021-04-20 绍兴永通印花有限公司 一种印花用涤纶织物处理液及其使用方法

Also Published As

Publication number Publication date
JP2005529175A (ja) 2005-09-29
US20050222085A1 (en) 2005-10-06
SI1515729T1 (sl) 2008-08-31
BR0311722A (pt) 2005-03-01
US20090110734A1 (en) 2009-04-30
ATE386532T1 (de) 2008-03-15
US20130137657A1 (en) 2013-05-30
CY1108099T1 (el) 2014-02-12
PT1515729E (pt) 2008-05-30
DK1515729T3 (da) 2008-06-16
AU2003276957A1 (en) 2003-12-31
WO2003105867A1 (en) 2003-12-24
JP4773721B2 (ja) 2011-09-14
EP1515729B1 (en) 2008-02-20
CA2487332C (en) 2012-05-15
US20120004158A1 (en) 2012-01-05
DE60319221D1 (de) 2008-04-03
JP2011006448A (ja) 2011-01-13
CA2487332A1 (en) 2003-12-24
DE60319221T2 (de) 2009-03-05
ES2301807T3 (es) 2008-07-01
CN1658888A (zh) 2005-08-24
EP1515729A1 (en) 2005-03-23

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C06 Publication
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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
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GR01 Patent grant
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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20100217

Termination date: 20130612