CY1108099T1 - Ενωσεις αμμωνιου κυκλοδεξτρινης μετατραπεισες σε τετρατοταγη δομη - Google Patents

Ενωσεις αμμωνιου κυκλοδεξτρινης μετατραπεισες σε τετρατοταγη δομη

Info

Publication number
CY1108099T1
CY1108099T1 CY20081100523T CY081100523T CY1108099T1 CY 1108099 T1 CY1108099 T1 CY 1108099T1 CY 20081100523 T CY20081100523 T CY 20081100523T CY 081100523 T CY081100523 T CY 081100523T CY 1108099 T1 CY1108099 T1 CY 1108099T1
Authority
CY
Cyprus
Prior art keywords
compound
cyclodextrine
ammonium
square surface
formula
Prior art date
Application number
CY20081100523T
Other languages
English (en)
Inventor
Georg Ludwig Kis
Christian Schoch
Jozsef Szejtli
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1108099T1 publication Critical patent/CY1108099T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Χρήση μιας ένωσης του τύπου (I),όπου το σύμβολο (a) παριστάνει ένα n-σθένους κατάλοιπο το οποίο προέρχεται από μια ένωση κυκλοδεξτρίνης διαμέσου της αφαίρεσης n των υδροξυλο-ομάδων της, το n είναι ένας αριθμός μεγαλύτερος του 0 και παριστάνει τον μέσο αριθμό υποκατάστατων του τύπου (II) ανά μόριο της εν λόγω ένωσης, το h είναι 0 ή 1, το R1 είναι μια δισθενής ομάδα η οποία επιλέγεται από τα αλκυλένιο, υδροξυαλκυλένιο, αλογονοαλκυλένιο, μονοκυκλικό αραλκυλένιο, κυκλοαλκυλένιο και φαινυλένιο, τα R2, R3 και R4 είναι έκαστο ανεξάρτητα από το άλλο μια ομάδα η οποία επιλέγεται από τα αλκύλιο, κυκλοαλκύλιο, αρύλιο, αραλκύλιο και κυκλοετερύλιο, το Xm- είναι ένα m-φορές αρνητικά φορτισμένο ανιόν, το m είναι ένας ακέραιος αριθμός ο οποίος είναι ίσος ή μεγαλύτερος του 1, και το k είναι n/m, στην παρασκευή ενός αντιμολυσματικού φαρμάκου, ως συντηρητικού και ενισχυτή της διαπερατότητας.
CY20081100523T 2002-06-13 2008-05-20 Ενωσεις αμμωνιου κυκλοδεξτρινης μετατραπεισες σε τετρατοταγη δομη CY1108099T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02013074 2002-06-13
EP02028554 2002-12-20
EP03740232A EP1515729B1 (en) 2002-06-13 2003-06-12 Quaternised ammonium cyclodextrin compounds

Publications (1)

Publication Number Publication Date
CY1108099T1 true CY1108099T1 (el) 2014-02-12

Family

ID=29737927

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100523T CY1108099T1 (el) 2002-06-13 2008-05-20 Ενωσεις αμμωνιου κυκλοδεξτρινης μετατραπεισες σε τετρατοταγη δομη

Country Status (15)

Country Link
US (4) US20050222085A1 (el)
EP (1) EP1515729B1 (el)
JP (2) JP4773721B2 (el)
CN (1) CN100589809C (el)
AT (1) ATE386532T1 (el)
AU (1) AU2003276957A1 (el)
BR (1) BR0311722A (el)
CA (1) CA2487332C (el)
CY (1) CY1108099T1 (el)
DE (1) DE60319221T2 (el)
DK (1) DK1515729T3 (el)
ES (1) ES2301807T3 (el)
PT (1) PT1515729E (el)
SI (1) SI1515729T1 (el)
WO (1) WO2003105867A1 (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100678824B1 (ko) * 2005-02-04 2007-02-05 한미약품 주식회사 용해성이 증가된 무정형 타크로리무스 고체분산체 및 이를포함하는 약제학적 조성물
KR20150050595A (ko) 2006-03-28 2015-05-08 자블린 파머슈티칼스 인코포레이티드 저 복용량의 디클로페낙 및 베타-사이클로덱스트린 제형
WO2008120249A1 (en) * 2007-03-30 2008-10-09 Sifi S.P.A. Pharmaceutical formulations based on apolar and polar lipids for ophthalmic use
CN101757621B (zh) * 2008-11-28 2012-07-04 天津金耀集团有限公司 一种眼部抗炎的环糊精包合药物组合物
US9642920B2 (en) * 2009-06-03 2017-05-09 Case Western Reserve University Therapeutic agent delivery system and method
CN102276761A (zh) * 2010-06-11 2011-12-14 南京理工大学 单取代铵基正电型-β-环糊精及其制备方法
GB201114459D0 (en) * 2011-08-22 2011-10-05 Isis Innovation Anti-bacterial compounds
CN103497275B (zh) * 2013-08-09 2015-12-23 华北电力大学（保定） 一种抗菌、抗病毒胍盐星形聚合物及其制备方法和应用
CZ307458B6 (cs) * 2014-11-25 2018-09-12 Spur A.S. Vícevrstvý kryt rány s aktivní vrstvou a způsob jeho výroby
WO2016088124A1 (en) * 2014-12-02 2016-06-09 B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University Modified polysaccharides for use as anti-microbial agents
CN109487588B (zh) * 2018-11-19 2021-04-20 绍兴永通印花有限公司 一种印花用涤纶织物处理液及其使用方法
AU2020221359B2 (en) 2019-02-14 2023-01-05 Cyclopure, Inc. Charge-bearing cyclodextrin polymeric materials and methods of making and using same
CN109836512A (zh) * 2019-03-04 2019-06-04 西南石油大学 一种新型β-CD双子表面活性剂为稠化剂的清洁压裂液
CN112386710A (zh) * 2020-12-09 2021-02-23 星拜(苏州)生物科技有限公司 一种利用包埋技术改善紫檀芪水溶性的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3453257A (en) * 1967-02-13 1969-07-01 Corn Products Co Cyclodextrin with cationic properties
JPS58210901A (ja) * 1982-06-01 1983-12-08 Kao Corp シクロデキストリン誘導体およびその製造方法
IT1229133B (it) * 1989-03-09 1991-07-22 Farmhispania Sali ammonici di policiclodestrine per l'impiego come agenti ipocolesterolemizzanti
JPH0481401A (ja) * 1990-07-24 1992-03-16 Toppan Printing Co Ltd シクロデキストリン誘導体
US5241059A (en) * 1990-05-21 1993-08-31 Toppan Printing Co., Ltd. Cyclodextrin derivatives
JPH0665307A (ja) * 1992-06-17 1994-03-08 Sankyo Co Ltd シクロデキストリン誘導体
AU3609795A (en) * 1994-10-10 1996-05-02 Novartis Ag Ophthalmic and aural compositions containing diclofenac potassium
JP3297969B2 (ja) * 1994-12-26 2002-07-02 ライオン株式会社 点眼剤
US5869079A (en) * 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
TW434023B (en) * 1995-09-18 2001-05-16 Novartis Ag Preserved ophthalmic composition
AU759280C (en) * 1998-02-23 2004-01-22 Cyclops, Ehf High-energy cyclodextrin complexes

Also Published As

Publication number Publication date
BR0311722A (pt) 2005-03-01
US20130137657A1 (en) 2013-05-30
US20050222085A1 (en) 2005-10-06
PT1515729E (pt) 2008-05-30
CA2487332A1 (en) 2003-12-24
US20120004158A1 (en) 2012-01-05
US20090110734A1 (en) 2009-04-30
CN1658888A (zh) 2005-08-24
WO2003105867A1 (en) 2003-12-24
DK1515729T3 (da) 2008-06-16
JP2005529175A (ja) 2005-09-29
JP4773721B2 (ja) 2011-09-14
DE60319221D1 (de) 2008-04-03
JP2011006448A (ja) 2011-01-13
ATE386532T1 (de) 2008-03-15
EP1515729A1 (en) 2005-03-23
EP1515729B1 (en) 2008-02-20
CA2487332C (en) 2012-05-15
AU2003276957A1 (en) 2003-12-31
DE60319221T2 (de) 2009-03-05
SI1515729T1 (sl) 2008-08-31
CN100589809C (zh) 2010-02-17
ES2301807T3 (es) 2008-07-01

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