CN100567279C - 烷基哌嗪-和烷基高哌嗪-羧酸酯衍生物、其制备方法及其作为faah酶抑制剂的用途 - Google Patents

烷基哌嗪-和烷基高哌嗪-羧酸酯衍生物、其制备方法及其作为faah酶抑制剂的用途 Download PDF

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CN100567279C
CN100567279C CNB2005800058872A CN200580005887A CN100567279C CN 100567279 C CN100567279 C CN 100567279C CN B2005800058872 A CNB2005800058872 A CN B2005800058872A CN 200580005887 A CN200580005887 A CN 200580005887A CN 100567279 C CN100567279 C CN 100567279C
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phenyl
alkali
alkyl
compound
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CN1922162A (zh
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A·阿布亚布德拉
A·阿尔马里奥加西亚
C·霍奈尔特
A·T·李
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Sanofi Aventis France
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
CNB2005800058872A 2004-02-26 2005-02-25 烷基哌嗪-和烷基高哌嗪-羧酸酯衍生物、其制备方法及其作为faah酶抑制剂的用途 Expired - Fee Related CN100567279C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0401953A FR2866888B1 (fr) 2004-02-26 2004-02-26 Derives de alkylpiperazine- et alkylhomopiperazine- carboxylates, leur preparation et leur application en therapeutique
FR0401953 2004-02-26

Publications (2)

Publication Number Publication Date
CN1922162A CN1922162A (zh) 2007-02-28
CN100567279C true CN100567279C (zh) 2009-12-09

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CNB2005800058872A Expired - Fee Related CN100567279C (zh) 2004-02-26 2005-02-25 烷基哌嗪-和烷基高哌嗪-羧酸酯衍生物、其制备方法及其作为faah酶抑制剂的用途

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Country Link
US (2) US7482346B2 (enExample)
EP (1) EP1720848B1 (enExample)
JP (1) JP4787234B2 (enExample)
KR (1) KR20060133592A (enExample)
CN (1) CN100567279C (enExample)
AR (1) AR047974A1 (enExample)
AT (1) ATE380184T1 (enExample)
AU (1) AU2005223422B2 (enExample)
BR (1) BRPI0508047A (enExample)
CA (1) CA2554855A1 (enExample)
CY (1) CY1107182T1 (enExample)
DE (1) DE602005003648T2 (enExample)
DK (1) DK1720848T3 (enExample)
ES (1) ES2296162T3 (enExample)
FR (1) FR2866888B1 (enExample)
HR (1) HRP20080024T3 (enExample)
IL (1) IL177422A (enExample)
MA (1) MA28370A1 (enExample)
NO (1) NO20064364L (enExample)
NZ (1) NZ549471A (enExample)
PL (1) PL1720848T3 (enExample)
PT (1) PT1720848E (enExample)
RS (1) RS50542B (enExample)
RU (1) RU2331637C2 (enExample)
SI (1) SI1720848T1 (enExample)
TW (1) TWI350286B (enExample)
WO (1) WO2005090322A1 (enExample)
ZA (1) ZA200607092B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
FR2866884B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique
US7269708B2 (en) * 2004-04-20 2007-09-11 Rambus Inc. Memory controller for non-homogenous memory system
AU2006215080B2 (en) 2005-02-17 2011-03-10 Astellas Pharma Inc. Pyridyl non-aromatic nitrogenated heterocyclic-1-carboxylate ester derivative
US7918848B2 (en) 2005-03-25 2011-04-05 Maquet Cardiovascular, Llc Tissue welding and cutting apparatus and method
US8197472B2 (en) 2005-03-25 2012-06-12 Maquet Cardiovascular, Llc Tissue welding and cutting apparatus and method
US7541359B2 (en) 2005-06-30 2009-06-02 Janssen Pharmaceutica N.V. N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase
EP2065369A4 (en) * 2006-08-23 2011-12-28 Astellas Pharma Inc UREA CONNECTION OR SALT THEREOF
US9968396B2 (en) 2008-05-27 2018-05-15 Maquet Cardiovascular Llc Surgical instrument and method
JP2011521723A (ja) 2008-05-27 2011-07-28 マッケ カーディオバスキュラー，エルエルシー 外科用器具および方法
US9402680B2 (en) 2008-05-27 2016-08-02 Maquet Cardiovasular, Llc Surgical instrument and method
CN101712655B (zh) * 2008-10-08 2012-05-23 秦引林 一种乙酰胺类衍生物及其在制药中的应用
CN101503394B (zh) * 2009-03-11 2010-05-12 深圳市湘雅生物医药研究院 高哌嗪乙酰肼类衍生物及其制备方法和用途
FR2945533B1 (fr) 2009-05-12 2011-05-27 Sanofi Aventis Derives de cyclopenta°c!pyrrolyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
FR2945531A1 (fr) * 2009-05-12 2010-11-19 Sanofi Aventis Derives de 7-aza-spiro°3,5!nonane-7-carboxylates, leur preparation et leur application en therapeutique
AR076687A1 (es) * 2009-05-18 2011-06-29 Infinity Pharmaceuticals Inc Isoxazolinas como inhibidores de la amidahidrolasa de acidos grasos y com-posiciones farmaceuticas que los contienen
TW201044234A (en) * 2009-06-08 2010-12-16 Chunghwa Picture Tubes Ltd Method of scanning touch panel
US9955858B2 (en) 2009-08-21 2018-05-01 Maquet Cardiovascular Llc Surgical instrument and method for use
WO2011085216A2 (en) 2010-01-08 2011-07-14 Ironwood Pharmaceuticals, Inc. Use of faah inhibitors for treating parkinson's disease and restless legs syndrome
WO2011123719A2 (en) 2010-03-31 2011-10-06 Ironwood Pharmaceuticals, Inc. Use of faah inhibitors for treating abdominal, visceral and pelvic pain
WO2012015704A2 (en) * 2010-07-28 2012-02-02 The Regents Of The University Of California Peripherally restricted faah inhibitors
MX354772B (es) 2011-08-19 2018-03-21 Univ California Inhibidores de la amida de acidos grasos (faah) restringidos perifericamente por bifenil metasustituido.
EP3988540A1 (en) 2014-04-07 2022-04-27 The Regents of the University of California Inhibitors of fatty acid amide hydrolase (faah) enzyme with improved oral bioavailability and their use as medicaments
CN104356082B (zh) * 2014-10-31 2016-07-13 厦门大学 一类取代杂环衍生物及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997014689A1 (fr) * 1995-10-18 1997-04-24 Pierre Fabre Medicament Derives d'amines cycliques d'aryl-piperazines, leur preparation et les compositions pharmaceutiques les contenant
DE19816889A1 (de) * 1998-04-16 1999-10-21 Boehringer Ingelheim Pharma Piperazinderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
WO2001072728A2 (en) * 2000-03-31 2001-10-04 Pfizer Products Inc. Novel piperazine derivatives
WO2003097579A1 (en) * 2002-05-22 2003-11-27 Showa Denko K. K. Production process of aminomethyl group-containing benzamide compound
WO2004099176A1 (fr) * 2003-05-07 2004-11-18 Sanofi-Aventis Derives de piperidinyl- et piperazinyl-alkylcarbamates, leurs procedes de preparation et leur application en therapeutique

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0656356A1 (en) * 1992-08-21 1995-06-07 Japan Tobacco Inc. Dioxacycloalkane compound with renin-inhibiting activity
US7049329B2 (en) * 2002-05-16 2006-05-23 Sepracor Inc. Amines that inhibit a mammalian anandamide transporter, and methods of use thereof
FR2843964B1 (fr) * 2002-08-29 2004-10-01 Sanofi Synthelabo Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique
FR2864080B1 (fr) * 2003-12-23 2006-02-03 Sanofi Synthelabo Derives de 1-piperazine-et-1-homopiperazine-carboxylates, leur preparation et leur application en therapeutique
FR2865205B1 (fr) * 2004-01-16 2006-02-24 Sanofi Synthelabo Derives de type aryloxyalkylcarbamates, leur preparation et leur application en therapeutique
FR2866884B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique
FR2866885B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives de piperidinylalkylcarbamates, leur prepation et leur application en therapeutique

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997014689A1 (fr) * 1995-10-18 1997-04-24 Pierre Fabre Medicament Derives d'amines cycliques d'aryl-piperazines, leur preparation et les compositions pharmaceutiques les contenant
DE19816889A1 (de) * 1998-04-16 1999-10-21 Boehringer Ingelheim Pharma Piperazinderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
WO2001072728A2 (en) * 2000-03-31 2001-10-04 Pfizer Products Inc. Novel piperazine derivatives
WO2003097579A1 (en) * 2002-05-22 2003-11-27 Showa Denko K. K. Production process of aminomethyl group-containing benzamide compound
WO2004099176A1 (fr) * 2003-05-07 2004-11-18 Sanofi-Aventis Derives de piperidinyl- et piperazinyl-alkylcarbamates, leurs procedes de preparation et leur application en therapeutique

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WO03097579A! 2003.11.27 *

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US20070027141A1 (en) 2007-02-01
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