CN100561200C - 用于检测存在的生物物质并使其成像的方法和设备 - Google Patents

用于检测存在的生物物质并使其成像的方法和设备 Download PDF

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Publication number
CN100561200C
CN100561200C CNB2004100492958A CN200410049295A CN100561200C CN 100561200 C CN100561200 C CN 100561200C CN B2004100492958 A CNB2004100492958 A CN B2004100492958A CN 200410049295 A CN200410049295 A CN 200410049295A CN 100561200 C CN100561200 C CN 100561200C
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fluorescence
biological substance
signal
reflection
background
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Expired - Fee Related
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Chinese (zh)
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CN1677088A (zh
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L·S·鲍尔斯
C·R·洛伊德
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MICROBIOSYSTEMS Ltd PARTNERSHI
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N2021/1734—Sequential different kinds of measurements; Combining two or more methods
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/33—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Mathematical Physics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CNB2004100492958A 2004-04-02 2004-06-10 用于检测存在的生物物质并使其成像的方法和设备 Expired - Fee Related CN100561200C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/817,647 2004-04-02
US10/817,647 US7186990B2 (en) 2002-01-22 2004-04-02 Method and apparatus for detecting and imaging the presence of biological materials

Publications (2)

Publication Number Publication Date
CN1677088A CN1677088A (zh) 2005-10-05
CN100561200C true CN100561200C (zh) 2009-11-18

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US (1) US7186990B2 (enExample)
EP (1) EP1582860A1 (enExample)
JP (1) JP2005292112A (enExample)
CN (1) CN100561200C (enExample)
CA (1) CA2466433A1 (enExample)
SG (1) SG144722A1 (enExample)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6380751B2 (en) 1992-06-11 2002-04-30 Cascade Microtech, Inc. Wafer probe station having environment control enclosure
US5345170A (en) 1992-06-11 1994-09-06 Cascade Microtech, Inc. Wafer probe station having integrated guarding, Kelvin connection and shielding systems
US5561377A (en) 1995-04-14 1996-10-01 Cascade Microtech, Inc. System for evaluating probing networks
US6232789B1 (en) 1997-05-28 2001-05-15 Cascade Microtech, Inc. Probe holder for low current measurements
US5914613A (en) 1996-08-08 1999-06-22 Cascade Microtech, Inc. Membrane probing system with local contact scrub
US6002263A (en) 1997-06-06 1999-12-14 Cascade Microtech, Inc. Probe station having inner and outer shielding
US6256882B1 (en) 1998-07-14 2001-07-10 Cascade Microtech, Inc. Membrane probing system
US6578264B1 (en) 1999-06-04 2003-06-17 Cascade Microtech, Inc. Method for constructing a membrane probe using a depression
US6445202B1 (en) 1999-06-30 2002-09-03 Cascade Microtech, Inc. Probe station thermal chuck with shielding for capacitive current
US6838890B2 (en) 2000-02-25 2005-01-04 Cascade Microtech, Inc. Membrane probing system
US6965226B2 (en) 2000-09-05 2005-11-15 Cascade Microtech, Inc. Chuck for holding a device under test
US6914423B2 (en) 2000-09-05 2005-07-05 Cascade Microtech, Inc. Probe station
DE10143173A1 (de) 2000-12-04 2002-06-06 Cascade Microtech Inc Wafersonde
AU2002327490A1 (en) 2001-08-21 2003-06-30 Cascade Microtech, Inc. Membrane probing system
US6777964B2 (en) 2002-01-25 2004-08-17 Cascade Microtech, Inc. Probe station
JP2005527823A (ja) 2002-05-23 2005-09-15 カスケード マイクロテック インコーポレイテッド デバイスのテスト用プローブ
US6847219B1 (en) 2002-11-08 2005-01-25 Cascade Microtech, Inc. Probe station with low noise characteristics
US6724205B1 (en) 2002-11-13 2004-04-20 Cascade Microtech, Inc. Probe for combined signals
US7250779B2 (en) 2002-11-25 2007-07-31 Cascade Microtech, Inc. Probe station with low inductance path
US6861856B2 (en) 2002-12-13 2005-03-01 Cascade Microtech, Inc. Guarded tub enclosure
US7221172B2 (en) 2003-05-06 2007-05-22 Cascade Microtech, Inc. Switched suspended conductor and connection
US7492172B2 (en) 2003-05-23 2009-02-17 Cascade Microtech, Inc. Chuck for holding a device under test
US7057404B2 (en) 2003-05-23 2006-06-06 Sharp Laboratories Of America, Inc. Shielded probe for testing a device under test
US7250626B2 (en) 2003-10-22 2007-07-31 Cascade Microtech, Inc. Probe testing structure
US7187188B2 (en) 2003-12-24 2007-03-06 Cascade Microtech, Inc. Chuck with integrated wafer support
DE202004021093U1 (de) 2003-12-24 2006-09-28 Cascade Microtech, Inc., Beaverton Aktiver Halbleiterscheibenmessfühler
JP2008502167A (ja) 2004-06-07 2008-01-24 カスケード マイクロテック インコーポレイテッド 熱光学チャック
US7330041B2 (en) 2004-06-14 2008-02-12 Cascade Microtech, Inc. Localizing a temperature of a device for testing
JP4980903B2 (ja) 2004-07-07 2012-07-18 カスケード マイクロテック インコーポレイテッド 膜懸垂プローブを具えるプローブヘッド
WO2006022823A1 (en) 2004-07-29 2006-03-02 Centrus International, Inc. Detection of microorganisms with a fluorescence-based device
JP2008512680A (ja) 2004-09-13 2008-04-24 カスケード マイクロテック インコーポレイテッド 両面プロービング構造体
US7545969B2 (en) * 2004-12-16 2009-06-09 Alliant Techsystems Inc. Method and system for wide-area ultraviolet detection of forensic evidence
US7535247B2 (en) 2005-01-31 2009-05-19 Cascade Microtech, Inc. Interface for testing semiconductors
US7656172B2 (en) 2005-01-31 2010-02-02 Cascade Microtech, Inc. System for testing semiconductors
JP2006263044A (ja) * 2005-03-23 2006-10-05 Fuji Photo Film Co Ltd 蛍光検出システム
US7449899B2 (en) 2005-06-08 2008-11-11 Cascade Microtech, Inc. Probe for high frequency signals
EP1932003A2 (en) 2005-06-13 2008-06-18 Cascade Microtech, Inc. Wideband active-passive differential signal probe
JP5289675B2 (ja) * 2005-12-14 2013-09-11 京セラディスプレイ株式会社 汚染物質の除去方法
US7609077B2 (en) 2006-06-09 2009-10-27 Cascade Microtech, Inc. Differential signal probe with integral balun
US7403028B2 (en) 2006-06-12 2008-07-22 Cascade Microtech, Inc. Test structure and probe for differential signals
US7443186B2 (en) 2006-06-12 2008-10-28 Cascade Microtech, Inc. On-wafer test structures for differential signals
US7764072B2 (en) 2006-06-12 2010-07-27 Cascade Microtech, Inc. Differential signal probing system
US7723999B2 (en) 2006-06-12 2010-05-25 Cascade Microtech, Inc. Calibration structures for differential signal probing
DE102006000318A1 (de) 2006-07-03 2008-01-10 Novineon Healthcare Technology Partners Gmbh Vorrichtung zur Blutungsdetektion
US20080012578A1 (en) * 2006-07-14 2008-01-17 Cascade Microtech, Inc. System for detecting molecular structure and events
US7876114B2 (en) 2007-08-08 2011-01-25 Cascade Microtech, Inc. Differential waveguide probe
US7615761B2 (en) * 2007-09-10 2009-11-10 Coherent, Inc. Trace evidence detection using multiple laser light sources
US20090069743A1 (en) * 2007-09-11 2009-03-12 Baxter International Inc. Infusion therapy sensor system
US8512975B2 (en) 2008-07-24 2013-08-20 Biomerieux, Inc. Method for detection and characterization of a microorganism in a sample using time dependent spectroscopic measurements
US7888957B2 (en) 2008-10-06 2011-02-15 Cascade Microtech, Inc. Probing apparatus with impedance optimized interface
BRPI0919896A2 (pt) 2008-10-31 2016-02-16 Bio Merieux Inc metodos para a separacao,caracterizacao e/ou identificacao de micro-organismos por espectroscopia de massa.
EP2352992B1 (en) * 2008-10-31 2020-04-22 bioMerieux, Inc. Methods for identification of microorganisms using spectroscopy
EP2364356B1 (en) * 2008-10-31 2019-06-19 Biomerieux, Inc Methods for detection and identification of microorganisms
CN102272585B (zh) * 2008-10-31 2015-10-07 生物梅里埃公司 采用拉曼光谱法分离、表征和/或鉴定微生物的方法
US8647835B2 (en) 2008-10-31 2014-02-11 BIO MéRIEUX, INC. Methods for separation, characterization and/or identification of microorganisms using spectroscopy
EP2364447B1 (en) * 2008-10-31 2019-06-12 Biomerieux, Inc Method for the identification of microorganisms
RU2533252C2 (ru) * 2008-10-31 2014-11-20 Биомерьё, Инк. Способы разделения и характеристики микроорганизмов с помощью идентификатора
US8410806B2 (en) 2008-11-21 2013-04-02 Cascade Microtech, Inc. Replaceable coupon for a probing apparatus
US8319503B2 (en) 2008-11-24 2012-11-27 Cascade Microtech, Inc. Test apparatus for measuring a characteristic of a device under test
BRPI0922952B8 (pt) 2008-12-16 2021-07-27 Bio Merieux Inc métodos de detectar e identificar um microorganismos em meios sólidos ou semi-sólidos
WO2010132805A2 (en) * 2009-05-15 2010-11-18 Biomerieux, Inc. System and method for automatically venting and sampling a culture specimen container
EP2430461B2 (en) 2009-05-15 2019-08-21 bioMerieux, Inc. Combined detection instrument for culture specimen containers and instrument for identification and/or characterization of a microbial agent in a sample
US20130153474A1 (en) * 2010-06-11 2013-06-20 B. Braun Avitum Ag Apparatus for extracorporeal blood treatment, comprising a measuring device for determining the luminescence of the spent dialysate
JP5682976B2 (ja) * 2010-09-17 2015-03-11 国立大学法人東北大学 抗体を成分として含む医薬品の有効性の判定方法
WO2012056380A1 (en) * 2010-10-27 2012-05-03 Koninklijke Philips Electronics N.V. A presence detection system and a lighting system
US20120119110A1 (en) * 2010-11-16 2012-05-17 Research In Motion Limited Apparatus, and associated method, for detecting contamination of an object
EP2520923A1 (en) * 2011-05-06 2012-11-07 bioMérieux Bio-imaging method and system
ES2919859T3 (es) 2011-12-22 2022-07-28 Becton Dickinson Co Métodos y aparato para la detección rápida de microorganismos infecciosos
EP2893029B1 (en) 2012-09-04 2017-09-27 Becton, Dickinson and Company Bacterial pre-concentration and detection technique
US20140125809A1 (en) 2012-11-02 2014-05-08 Syntronics, Llc Digital ruvis camera
WO2015089514A2 (en) * 2013-12-13 2015-06-18 Colorado State University Research Foundation Nano-stamp and matched reader for anti-counterfeiting applications
US10039934B2 (en) * 2013-12-30 2018-08-07 PhotonEdge Inc. Multi-wavelength interleaved optical stimulation
US10772553B2 (en) 2014-08-07 2020-09-15 Teleflex Medical Incorporated Urine sensing optical fiber probe and system for percutaneous nephrostomy
US9880159B2 (en) 2014-10-01 2018-01-30 Linda S. Powers Cartridge-based detection system
US9867250B1 (en) 2015-04-20 2018-01-09 The Arizona Board Of Regents On Behalf Of The University Of Arizona System having a configurable pico-second pulsed LED driver circuit and photomultiplier tube biasing and gating circuits for real-time, time-resolved transient recording of fluorescence
CN109863503B (zh) * 2016-09-02 2023-05-23 英维特公司 用于单分子定量的系统和方法
WO2018119211A1 (en) * 2016-12-23 2018-06-28 Bio-Rad Laboratories, Inc. Reduction of background signal in blot images
US11353402B2 (en) * 2017-07-11 2022-06-07 Hamamatsu Photonics K.K. Sample observation device and sample observation method
JP7007122B2 (ja) 2017-07-11 2022-01-24 浜松ホトニクス株式会社 試料観察装置及び試料観察方法
CN110197174A (zh) * 2018-02-26 2019-09-03 刘风华 文物、字画和原产商品的数字化技术
US11269203B2 (en) 2020-01-23 2022-03-08 Hong Kong Applied Science And Technology Institute Company Limited Multifocal system with polarization-independent focusing
US11408825B2 (en) 2020-08-28 2022-08-09 Hong Kong Applied Science and Technology Research Institute Company Limited Forensic detector and the system thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968766A (en) * 1998-03-31 1999-10-19 B.E. Safe Method and apparatus for sensing the presence of microbes
US20030138875A1 (en) * 2002-01-22 2003-07-24 Powers Linda S. Method and apparatus for detecting the presence of microbes and determining their physiological status

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3580525A (en) * 1967-11-21 1971-05-25 Telefunken Patent Arrangement maintaining constant tape tension in magnetic tape recorders
US3850525A (en) 1973-07-09 1974-11-26 Beckman Instruments Inc Simultaneous multiple measurements in laser photometers
US4745285A (en) * 1986-08-21 1988-05-17 Becton Dickinson And Company Multi-color fluorescence analysis with single wavelength excitation
US4900934A (en) * 1987-07-15 1990-02-13 University Of Utah Apparatus for simultaneous visualization and measurement of fluorescence from fluorescent dye-treated cell preparations and solutions
US5208651A (en) * 1991-07-16 1993-05-04 The Regents Of The University Of California Apparatus and method for measuring fluorescence intensities at a plurality of wavelengths and lifetimes
US5294799A (en) * 1993-02-01 1994-03-15 Aslund Nils R D Apparatus for quantitative imaging of multiple fluorophores
US5418371A (en) * 1993-02-01 1995-05-23 Aslund; Nils R. D. Apparatus for quantitative imaging of multiple fluorophores using dual detectors
US5424959A (en) * 1993-07-19 1995-06-13 Texaco Inc. Interpretation of fluorescence fingerprints of crude oils and other hydrocarbon mixtures using neural networks
US5474910A (en) * 1993-10-15 1995-12-12 Alfano; Robert R. Method and device for detecting biological molecules and/or microorganisms within a desired area or space
US5491343A (en) * 1994-03-25 1996-02-13 Brooker; Gary High-speed multiple wavelength illumination source, apparatus containing the same, and applications thereof to methods of irradiating luminescent samples and of quantitative luminescence ratio microscopy
US5701012A (en) * 1996-03-19 1997-12-23 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Fluorescent biological particle detection system
US5760406A (en) * 1996-06-03 1998-06-02 Powers; Linda Method and apparatus for sensing the presence of microbes
US5866430A (en) * 1996-06-13 1999-02-02 Grow; Ann E. Raman optrode processes and devices for detection of chemicals and microorganisms
AU8148898A (en) * 1997-06-23 1999-01-04 Luminex Corporation Interlaced lasers for multiple fluorescence measurement
US6124597A (en) * 1997-07-07 2000-09-26 Cedars-Sinai Medical Center Method and devices for laser induced fluorescence attenuation spectroscopy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968766A (en) * 1998-03-31 1999-10-19 B.E. Safe Method and apparatus for sensing the presence of microbes
US20030138875A1 (en) * 2002-01-22 2003-07-24 Powers Linda S. Method and apparatus for detecting the presence of microbes and determining their physiological status

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Publication number Publication date
US7186990B2 (en) 2007-03-06
CA2466433A1 (en) 2005-10-02
SG144722A1 (en) 2008-08-28
CN1677088A (zh) 2005-10-05
JP2005292112A (ja) 2005-10-20
EP1582860A1 (en) 2005-10-05
US20040197771A1 (en) 2004-10-07

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