CA2466433A1 - Method and apparatus for detecting and imaging the presence of biological materials - Google Patents
Method and apparatus for detecting and imaging the presence of biological materials Download PDFInfo
- Publication number
- CA2466433A1 CA2466433A1 CA002466433A CA2466433A CA2466433A1 CA 2466433 A1 CA2466433 A1 CA 2466433A1 CA 002466433 A CA002466433 A CA 002466433A CA 2466433 A CA2466433 A CA 2466433A CA 2466433 A1 CA2466433 A1 CA 2466433A1
- Authority
- CA
- Canada
- Prior art keywords
- fluorescence
- intrinsic
- biological
- excitation
- biological material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000012620 biological material Substances 0.000 title claims abstract description 58
- 238000000034 method Methods 0.000 title claims abstract description 39
- 238000003384 imaging method Methods 0.000 title claims description 15
- 230000005284 excitation Effects 0.000 claims abstract description 62
- 238000001514 detection method Methods 0.000 claims abstract description 33
- 230000005670 electromagnetic radiation Effects 0.000 claims abstract description 24
- 230000005855 radiation Effects 0.000 claims description 12
- 239000000758 substrate Substances 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 8
- 230000004069 differentiation Effects 0.000 claims description 5
- 241000269627 Amphiuma means Species 0.000 claims 1
- 239000000523 sample Substances 0.000 description 26
- 210000000582 semen Anatomy 0.000 description 9
- 238000004458 analytical method Methods 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 239000002207 metabolite Substances 0.000 description 7
- 210000002700 urine Anatomy 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 238000011109 contamination Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 210000003296 saliva Anatomy 0.000 description 4
- 239000013060 biological fluid Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 231100001261 hazardous Toxicity 0.000 description 3
- 238000005286 illumination Methods 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 230000000813 microbial effect Effects 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 150000003222 pyridines Chemical class 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 102000003983 Flavoproteins Human genes 0.000 description 2
- 108010057573 Flavoproteins Proteins 0.000 description 2
- 238000001444 catalytic combustion detection Methods 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000000295 emission spectrum Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 150000003278 haem Chemical class 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
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- 229920000642 polymer Polymers 0.000 description 2
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- 230000035945 sensitivity Effects 0.000 description 2
- 238000010200 validation analysis Methods 0.000 description 2
- 238000012800 visualization Methods 0.000 description 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 1
- 229910001634 calcium fluoride Inorganic materials 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229910052805 deuterium Inorganic materials 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002795 fluorescence method Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 239000005350 fused silica glass Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229910052594 sapphire Inorganic materials 0.000 description 1
- 239000010980 sapphire Substances 0.000 description 1
- 229930000044 secondary metabolite Natural products 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/274—Calibration, base line adjustment, drift correction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N2021/1734—Sequential different kinds of measurements; Combining two or more methods
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/33—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mathematical Physics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/817,647 US7186990B2 (en) | 2002-01-22 | 2004-04-02 | Method and apparatus for detecting and imaging the presence of biological materials |
| US10/817,647 | 2004-04-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2466433A1 true CA2466433A1 (en) | 2005-10-02 |
Family
ID=34887789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002466433A Abandoned CA2466433A1 (en) | 2004-04-02 | 2004-05-05 | Method and apparatus for detecting and imaging the presence of biological materials |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7186990B2 (enExample) |
| EP (1) | EP1582860A1 (enExample) |
| JP (1) | JP2005292112A (enExample) |
| CN (1) | CN100561200C (enExample) |
| CA (1) | CA2466433A1 (enExample) |
| SG (1) | SG144722A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8535937B2 (en) | 2004-07-29 | 2013-09-17 | Neogen Corporation | Detection of microorganisms with a fluorescence-based device |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6380751B2 (en) | 1992-06-11 | 2002-04-30 | Cascade Microtech, Inc. | Wafer probe station having environment control enclosure |
| US5345170A (en) | 1992-06-11 | 1994-09-06 | Cascade Microtech, Inc. | Wafer probe station having integrated guarding, Kelvin connection and shielding systems |
| US5561377A (en) | 1995-04-14 | 1996-10-01 | Cascade Microtech, Inc. | System for evaluating probing networks |
| US6232789B1 (en) | 1997-05-28 | 2001-05-15 | Cascade Microtech, Inc. | Probe holder for low current measurements |
| US5914613A (en) | 1996-08-08 | 1999-06-22 | Cascade Microtech, Inc. | Membrane probing system with local contact scrub |
| US6002263A (en) | 1997-06-06 | 1999-12-14 | Cascade Microtech, Inc. | Probe station having inner and outer shielding |
| US6256882B1 (en) | 1998-07-14 | 2001-07-10 | Cascade Microtech, Inc. | Membrane probing system |
| US6578264B1 (en) | 1999-06-04 | 2003-06-17 | Cascade Microtech, Inc. | Method for constructing a membrane probe using a depression |
| US6445202B1 (en) | 1999-06-30 | 2002-09-03 | Cascade Microtech, Inc. | Probe station thermal chuck with shielding for capacitive current |
| US6838890B2 (en) | 2000-02-25 | 2005-01-04 | Cascade Microtech, Inc. | Membrane probing system |
| US6914423B2 (en) | 2000-09-05 | 2005-07-05 | Cascade Microtech, Inc. | Probe station |
| US6965226B2 (en) | 2000-09-05 | 2005-11-15 | Cascade Microtech, Inc. | Chuck for holding a device under test |
| DE20114544U1 (de) | 2000-12-04 | 2002-02-21 | Cascade Microtech, Inc., Beaverton, Oreg. | Wafersonde |
| AU2002327490A1 (en) | 2001-08-21 | 2003-06-30 | Cascade Microtech, Inc. | Membrane probing system |
| US6777964B2 (en) | 2002-01-25 | 2004-08-17 | Cascade Microtech, Inc. | Probe station |
| KR100864916B1 (ko) | 2002-05-23 | 2008-10-22 | 캐스케이드 마이크로테크 인코포레이티드 | 피시험 디바이스를 테스트하기 위한 프로브 |
| US6847219B1 (en) | 2002-11-08 | 2005-01-25 | Cascade Microtech, Inc. | Probe station with low noise characteristics |
| US6724205B1 (en) | 2002-11-13 | 2004-04-20 | Cascade Microtech, Inc. | Probe for combined signals |
| US7250779B2 (en) | 2002-11-25 | 2007-07-31 | Cascade Microtech, Inc. | Probe station with low inductance path |
| US6861856B2 (en) | 2002-12-13 | 2005-03-01 | Cascade Microtech, Inc. | Guarded tub enclosure |
| US7221172B2 (en) | 2003-05-06 | 2007-05-22 | Cascade Microtech, Inc. | Switched suspended conductor and connection |
| US7057404B2 (en) | 2003-05-23 | 2006-06-06 | Sharp Laboratories Of America, Inc. | Shielded probe for testing a device under test |
| US7492172B2 (en) | 2003-05-23 | 2009-02-17 | Cascade Microtech, Inc. | Chuck for holding a device under test |
| US7250626B2 (en) | 2003-10-22 | 2007-07-31 | Cascade Microtech, Inc. | Probe testing structure |
| US7187188B2 (en) | 2003-12-24 | 2007-03-06 | Cascade Microtech, Inc. | Chuck with integrated wafer support |
| DE202004021093U1 (de) | 2003-12-24 | 2006-09-28 | Cascade Microtech, Inc., Beaverton | Aktiver Halbleiterscheibenmessfühler |
| EP1754072A2 (en) | 2004-06-07 | 2007-02-21 | CASCADE MICROTECH, INC. (an Oregon corporation) | Thermal optical chuck |
| US7330041B2 (en) | 2004-06-14 | 2008-02-12 | Cascade Microtech, Inc. | Localizing a temperature of a device for testing |
| EP1766426B1 (en) | 2004-07-07 | 2013-09-11 | Cascade Microtech, Inc. | Probe head having a membrane suspended probe |
| EP1789812A2 (en) | 2004-09-13 | 2007-05-30 | Cascade Microtech, Inc. | Double sided probing structures |
| US7545969B2 (en) * | 2004-12-16 | 2009-06-09 | Alliant Techsystems Inc. | Method and system for wide-area ultraviolet detection of forensic evidence |
| US7535247B2 (en) | 2005-01-31 | 2009-05-19 | Cascade Microtech, Inc. | Interface for testing semiconductors |
| US7656172B2 (en) | 2005-01-31 | 2010-02-02 | Cascade Microtech, Inc. | System for testing semiconductors |
| JP2006263044A (ja) * | 2005-03-23 | 2006-10-05 | Fuji Photo Film Co Ltd | 蛍光検出システム |
| US7449899B2 (en) | 2005-06-08 | 2008-11-11 | Cascade Microtech, Inc. | Probe for high frequency signals |
| JP5080459B2 (ja) | 2005-06-13 | 2012-11-21 | カスケード マイクロテック インコーポレイテッド | 広帯域能動／受動差動信号プローブ |
| JP5289675B2 (ja) * | 2005-12-14 | 2013-09-11 | 京セラディスプレイ株式会社 | 汚染物質の除去方法 |
| DE112007001399T5 (de) | 2006-06-09 | 2009-05-07 | Cascade Microtech, Inc., Beaverton | Messfühler für differentielle Signale mit integrierter Symmetrieschaltung |
| US7443186B2 (en) | 2006-06-12 | 2008-10-28 | Cascade Microtech, Inc. | On-wafer test structures for differential signals |
| US7764072B2 (en) | 2006-06-12 | 2010-07-27 | Cascade Microtech, Inc. | Differential signal probing system |
| US7723999B2 (en) | 2006-06-12 | 2010-05-25 | Cascade Microtech, Inc. | Calibration structures for differential signal probing |
| US7403028B2 (en) | 2006-06-12 | 2008-07-22 | Cascade Microtech, Inc. | Test structure and probe for differential signals |
| DE102006000318A1 (de) | 2006-07-03 | 2008-01-10 | Novineon Healthcare Technology Partners Gmbh | Vorrichtung zur Blutungsdetektion |
| US20080012578A1 (en) * | 2006-07-14 | 2008-01-17 | Cascade Microtech, Inc. | System for detecting molecular structure and events |
| US7876114B2 (en) | 2007-08-08 | 2011-01-25 | Cascade Microtech, Inc. | Differential waveguide probe |
| US7615761B2 (en) | 2007-09-10 | 2009-11-10 | Coherent, Inc. | Trace evidence detection using multiple laser light sources |
| WO2009036105A2 (en) * | 2007-09-11 | 2009-03-19 | Baxter International Inc | Infusion therapy sensor system |
| US8512975B2 (en) * | 2008-07-24 | 2013-08-20 | Biomerieux, Inc. | Method for detection and characterization of a microorganism in a sample using time dependent spectroscopic measurements |
| US7888957B2 (en) | 2008-10-06 | 2011-02-15 | Cascade Microtech, Inc. | Probing apparatus with impedance optimized interface |
| US8652800B2 (en) * | 2008-10-31 | 2014-02-18 | Biomerieux, Inc. | Method for separation, characterization and/or identification of microorganisms using spectroscopy |
| CA2741036C (en) * | 2008-10-31 | 2018-01-09 | Biomerieux, Inc. | Methods for separation, characterization, and/or identification of microorganisms using raman spectroscopy |
| WO2010062350A1 (en) * | 2008-10-31 | 2010-06-03 | Biomerieux, Inc. | Methods for detection, characterization and/or identification of microorganisms in a sealed container |
| JP5509213B2 (ja) | 2008-10-31 | 2014-06-04 | ビオメリュー・インコーポレイテッド | 質量分析を使用した微生物の分離、キャラクタリゼーションおよび／または同定方法 |
| US8647835B2 (en) | 2008-10-31 | 2014-02-11 | BIO MéRIEUX, INC. | Methods for separation, characterization and/or identification of microorganisms using spectroscopy |
| JP2012507710A (ja) * | 2008-10-31 | 2012-03-29 | バイオメリュー・インコーポレイテッド | 同定作用物質を使用した微生物の分離、キャラクタリゼーションおよび／または同定方法 |
| EP2364447B1 (en) * | 2008-10-31 | 2019-06-12 | Biomerieux, Inc | Method for the identification of microorganisms |
| US8410806B2 (en) | 2008-11-21 | 2013-04-02 | Cascade Microtech, Inc. | Replaceable coupon for a probing apparatus |
| US8319503B2 (en) | 2008-11-24 | 2012-11-27 | Cascade Microtech, Inc. | Test apparatus for measuring a characteristic of a device under test |
| EP2376914B1 (en) * | 2008-12-16 | 2017-04-19 | Biomerieux, Inc | Methods for the characterization of microorganisms on solid or semi-solid media |
| CA2760982C (en) * | 2009-05-15 | 2019-01-15 | Biomerieux, Inc. | System and methods for rapid identification and/or characterization of a microbial agent in a sample |
| US9150900B2 (en) | 2009-05-15 | 2015-10-06 | Biomerieux, Inc. | Automated transfer mechanism for microbial detection apparatus |
| BR112012031252B1 (pt) * | 2010-06-11 | 2020-06-30 | B. Braun Avitum Ag | aparelho para tratamento extracorpóreo de sangue |
| WO2012035705A1 (ja) * | 2010-09-17 | 2012-03-22 | 国立大学法人東北大学 | 抗体を成分として含む医薬品の有効性の判定方法 |
| RU2013124008A (ru) * | 2010-10-27 | 2014-12-10 | Конинклейке Филипс Электроникс Н.В. | Система обнаружения присутствия и система освещения |
| US20120119110A1 (en) * | 2010-11-16 | 2012-05-17 | Research In Motion Limited | Apparatus, and associated method, for detecting contamination of an object |
| EP2520923A1 (en) * | 2011-05-06 | 2012-11-07 | bioMérieux | Bio-imaging method and system |
| EP2795306B1 (en) | 2011-12-22 | 2022-06-15 | Becton, Dickinson and Company | Methods and apparatus for rapid detection of infectious microorganisms |
| US9605294B2 (en) | 2012-09-04 | 2017-03-28 | Becton, Dickinson And Company | Bacterial pre-concentration and detection technique |
| US20140125809A1 (en) | 2012-11-02 | 2014-05-08 | Syntronics, Llc | Digital ruvis camera |
| WO2015089514A2 (en) * | 2013-12-13 | 2015-06-18 | Colorado State University Research Foundation | Nano-stamp and matched reader for anti-counterfeiting applications |
| US10039934B2 (en) * | 2013-12-30 | 2018-08-07 | PhotonEdge Inc. | Multi-wavelength interleaved optical stimulation |
| US10772553B2 (en) | 2014-08-07 | 2020-09-15 | Teleflex Medical Incorporated | Urine sensing optical fiber probe and system for percutaneous nephrostomy |
| US9880159B2 (en) | 2014-10-01 | 2018-01-30 | Linda S. Powers | Cartridge-based detection system |
| US9867250B1 (en) | 2015-04-20 | 2018-01-09 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | System having a configurable pico-second pulsed LED driver circuit and photomultiplier tube biasing and gating circuits for real-time, time-resolved transient recording of fluorescence |
| CN109863503B (zh) * | 2016-09-02 | 2023-05-23 | 英维特公司 | 用于单分子定量的系统和方法 |
| EP3559721B1 (en) * | 2016-12-23 | 2021-09-15 | Bio-Rad Laboratories, Inc. | Reduction of background signal in blot images |
| JP7007122B2 (ja) | 2017-07-11 | 2022-01-24 | 浜松ホトニクス株式会社 | 試料観察装置及び試料観察方法 |
| JP7014794B2 (ja) * | 2017-07-11 | 2022-02-01 | 浜松ホトニクス株式会社 | 試料観察装置及び試料観察方法 |
| CN110197174A (zh) * | 2018-02-26 | 2019-09-03 | 刘风华 | 文物、字画和原产商品的数字化技术 |
| US11269203B2 (en) | 2020-01-23 | 2022-03-08 | Hong Kong Applied Science And Technology Institute Company Limited | Multifocal system with polarization-independent focusing |
| US11408825B2 (en) | 2020-08-28 | 2022-08-09 | Hong Kong Applied Science and Technology Research Institute Company Limited | Forensic detector and the system thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3580525A (en) * | 1967-11-21 | 1971-05-25 | Telefunken Patent | Arrangement maintaining constant tape tension in magnetic tape recorders |
| US3850525A (en) | 1973-07-09 | 1974-11-26 | Beckman Instruments Inc | Simultaneous multiple measurements in laser photometers |
| US4745285A (en) * | 1986-08-21 | 1988-05-17 | Becton Dickinson And Company | Multi-color fluorescence analysis with single wavelength excitation |
| US4900934A (en) * | 1987-07-15 | 1990-02-13 | University Of Utah | Apparatus for simultaneous visualization and measurement of fluorescence from fluorescent dye-treated cell preparations and solutions |
| US5208651A (en) * | 1991-07-16 | 1993-05-04 | The Regents Of The University Of California | Apparatus and method for measuring fluorescence intensities at a plurality of wavelengths and lifetimes |
| US5294799A (en) * | 1993-02-01 | 1994-03-15 | Aslund Nils R D | Apparatus for quantitative imaging of multiple fluorophores |
| US5418371A (en) * | 1993-02-01 | 1995-05-23 | Aslund; Nils R. D. | Apparatus for quantitative imaging of multiple fluorophores using dual detectors |
| US5424959A (en) * | 1993-07-19 | 1995-06-13 | Texaco Inc. | Interpretation of fluorescence fingerprints of crude oils and other hydrocarbon mixtures using neural networks |
| US5474910A (en) * | 1993-10-15 | 1995-12-12 | Alfano; Robert R. | Method and device for detecting biological molecules and/or microorganisms within a desired area or space |
| US5491343A (en) * | 1994-03-25 | 1996-02-13 | Brooker; Gary | High-speed multiple wavelength illumination source, apparatus containing the same, and applications thereof to methods of irradiating luminescent samples and of quantitative luminescence ratio microscopy |
| US5701012A (en) * | 1996-03-19 | 1997-12-23 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence | Fluorescent biological particle detection system |
| US5760406A (en) * | 1996-06-03 | 1998-06-02 | Powers; Linda | Method and apparatus for sensing the presence of microbes |
| US5866430A (en) * | 1996-06-13 | 1999-02-02 | Grow; Ann E. | Raman optrode processes and devices for detection of chemicals and microorganisms |
| WO1998059233A1 (en) * | 1997-06-23 | 1998-12-30 | Luminex Corporation | Interlaced lasers for multiple fluorescence measurement |
| US6124597A (en) * | 1997-07-07 | 2000-09-26 | Cedars-Sinai Medical Center | Method and devices for laser induced fluorescence attenuation spectroscopy |
| US5968766A (en) * | 1998-03-31 | 1999-10-19 | B.E. Safe | Method and apparatus for sensing the presence of microbes |
| US6750006B2 (en) * | 2002-01-22 | 2004-06-15 | Microbiosystems, Limited Partnership | Method for detecting the presence of microbes and determining their physiological status |
-
2004
- 2004-04-02 US US10/817,647 patent/US7186990B2/en not_active Expired - Fee Related
- 2004-05-05 CA CA002466433A patent/CA2466433A1/en not_active Abandoned
- 2004-05-20 JP JP2004151028A patent/JP2005292112A/ja active Pending
- 2004-05-26 EP EP04012456A patent/EP1582860A1/en not_active Withdrawn
- 2004-05-27 SG SG200402988-0A patent/SG144722A1/en unknown
- 2004-06-10 CN CNB2004100492958A patent/CN100561200C/zh not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8535937B2 (en) | 2004-07-29 | 2013-09-17 | Neogen Corporation | Detection of microorganisms with a fluorescence-based device |
| US9207180B2 (en) | 2004-07-29 | 2015-12-08 | Neogen Corporation | Detection of microorganisms with a fluorescence-based device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1677088A (zh) | 2005-10-05 |
| JP2005292112A (ja) | 2005-10-20 |
| SG144722A1 (en) | 2008-08-28 |
| US20040197771A1 (en) | 2004-10-07 |
| EP1582860A1 (en) | 2005-10-05 |
| US7186990B2 (en) | 2007-03-06 |
| CN100561200C (zh) | 2009-11-18 |
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