CN100525745C - Spot-removing cream - Google Patents
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- CN100525745C CN100525745C CNB200710079844XA CN200710079844A CN100525745C CN 100525745 C CN100525745 C CN 100525745C CN B200710079844X A CNB200710079844X A CN B200710079844XA CN 200710079844 A CN200710079844 A CN 200710079844A CN 100525745 C CN100525745 C CN 100525745C
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Abstract
The invention relates to a skin care product, especially de-scar cream whose constitution by weight of is: 3% polyoxyethylene stearate alcohol ether, 2% glycerin monostearate, 8% myristicin acid isopropyl ester, 5% squalane, 0.2% alpha-bisabolo, 8% glycerin, 8% propanediol, 0.2% allantoin llantoin, 10% licorice flavone, Chinese traditional medicine extract dry powder, and additive deionized water to 100%, wherein, Chinese traditional medicine extract dry powder is composed of 2% angelica extract dry powder, 2% dodder extract dry powder, 2% chinaroot greenbrier rhizome extract dry powder, white peony root extract dry powder, and almond extract dry powder. The invention provides a de-scar cream which has a new Chinese traditional medicine as primary de-scar system and assists a gentle external used western medicine alpha-bisabolo, allantoin llantoin and tea poly-phenols in order to get a better treatment effect.
Description
Technical field
The present invention relates to a kind of cosmetics, mainly is the skin skincare product, particularly a kind of balance conditioning QUBAN SHUANG.
Background technology
External Chinese medicine speckle dispelling has the history in thousands of years in China.It comprises: apply, press, be coated with, put on the skin, smoke, wash, smear, net for catching birds or fish, soak, hold, sneeze, blow, drip, suction, plug, subsides etc., its kind is numerous.
License number is that 01122244.1 " face-beautifying and spot-removing cream and preparation method thereof " is to be the cosmetics of main speckle dispelling system with Chinese medicine, and its base material is glycerol, vaseline, lanoline, triethanolamine etc., and its base material is very limited to the contribution of speckle dispelling.
License number is that 01128791.8 " QUBAN SHUANG " also is to be the cosmetics of main speckle dispelling system with Chinese medicine, and its base material is white oil, cetylate isopropyl ester, glycerol, octadecanol, Polyethylene Glycol etc., and its base material is very limited to the contribution of speckle dispelling.
License number is that 02138628.5 " speckle dispelling ointment machin its preparation method " also is to be the cosmetics of main speckle dispelling system with Chinese medicine, its base material is glyceryl monostearate, glycerol, 16-octadecanol, glycerol, lanoline etc., and its base material is very limited to the contribution of speckle dispelling.
The common effect of method of pure use external Chinese medicine speckle dispelling is slower.
Doctor trained in Western medicine is to the Drug therapy of speckle, and except common interior using Ve and the Vc, the overwhelming majority is an external medication.These external used medicines add as effective ingredient often and play a role in the cosmetics.Effective ingredient commonly used has arbutin, Kojic Acid Dipalmitate, ascorbic acid, ellagic acid, Radix Glycyrrhizae liposoluble extract, glucamine etc.The effect of dispelling spots of these external used medicines mainly is to realize by the inhibition to tyrosinase activity.The common effect of doctor trained in Western medicine speckle dispelling composition is obvious, but skin is caused stimulation easily, and thinks safe material composition in the past, find another one situation really today, as say the nineties in century popular fruit acid and whiten, because excessive concentration, may cause skin damage, cause erythema, fester." arbutin " that is extensively adopted by each big cosmetics company once had been considered to safety than higher after Japanese health ministry passes and taken the lead in adopting by Shiseido.But discovering afterwards after this composition is accumulated to certain hour, may cause the melanic increase of cell class on the contrary.In addition, this composition of Kojic Acid Dipalmitate also once was expected, but medical discovery, this composition may cause that cell poisons, chromosome disorder, even causes hepatocarcinoma, also is the composition of comparison danger.
The Chinese medicine of external, the Western medicine of external are evaluation object mostly with the restraint of tyrosinase, and the external used medicine of energy restraint of tyrosinase all has reasonable freckle effect in practice usually.And because the mechanism complexity that the skin speckle occurs, the origin cause of formation is also often indeterminate, and best evaluation method remains clinical speckle dispelling test in conjunction with tyrosinase inhibition rate.
The present invention wishes and can find equilibrium point between external Chinese medicine and external Western medicine.
Summary of the invention
The object of the present invention is to provide a kind of QUBAN SHUANG of new prescription.
Technical scheme of the present invention is:
QUBAN SHUANG, its composition is by weight percentage: polyoxyethylene stearyl alcohol ether 2-4%, glyceryl monostearate 1-3%, isopropyl myristate 6-10%, squalane 4-6%, α-bisabolol 0.1-0.3%, glycerol 6-10%, propylene glycol 6-10%, allantoin 0.1-0.3%, licoflavone 6-14%, the dry powder of Chinese medicine extract, add balance of deionized water to 100%, wherein: the dry powder of Chinese medicine extract is by the dry powder 2% of Radix Angelicae Sinensis extract, the dry powder 2% of Semen Cuscutae extract, the dry powder 2% of Poria extract, the dry powder 2% of Radix Paeoniae Alba extract, the dry powder 2% of Semen Armeniacae Amarum extract is formed.
QUBAN SHUANG, its composition is by weight percentage: the dry powder 10% of polyoxyethylene stearyl alcohol ether 3%, glyceryl monostearate 2%, isopropyl myristate 8%, squalane 5%, α-bisabolol 0.2%, glycerol 8%, propylene glycol 8%, allantoin 0.2%, licoflavone 10%, Chinese medicine extract, add balance of deionized water to 100%, wherein: the dry powder of Chinese medicine extract is made up of the dry powder 2% of Radix Angelicae Sinensis extract, the dry powder 2% of Semen Cuscutae extract, the dry powder 2% of Poria extract, the dry powder 2% of Radix Paeoniae Alba extract, the dry powder 2% of Semen Armeniacae Amarum extract.
QUBAN SHUANG, wherein: the dry powder of Chinese medicine extract also increases the dry powder 6-8% of Daphne odora extract, tea polyphenols 1-3%.
Radix Angelicae Sinensis can be expanded peripheral blood vessel, reduces vascular resistance, increases the blood circulation amount.The aqueous solution of Radix Angelicae Sinensis has the active function of restraint of tyrosinase.
Semen Cuscutae, Cuscuta chinensis Lam, meridian distribution of property and flavor is sweet, temperature.Return the liver,kidney,spleen warp.Function cures mainly nourishing the liver and kidney, and the controlling nocturnal emission with astringent drugs reducing urination is antiabortive, makes eye bright antidiarrheal.Be used for impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Poria, sweet in the mouth, light, property is flat, can dispelling speckles and whitening face.
The Radix Paeoniae Alba, return through, go into liver, spleen channel.
Semen Armeniacae Amarum, the nature and flavor hardship, temperature is returned through going into lung, large intestine channel.Cure mainly expelling phlegm for arresting cough, relieving asthma, intestine moistening.
VC.Aureomariginatn has higher medical value.The medicinal component of VC.Aureomariginatn mainly is " daphnin ".Its flower, but leaf, dermatome people's medicine all.Property is sweet, cold, nontoxic.Eliminating inflammation and expelling toxin is arranged, and the promoting the circulation of blood diuretic goes swollen pain relieving, the effect that the blood that looses is lived and become silted up.Can control innominate toxic swelling, treat skin ulcer, mastitis fester, tooth laryngalgia, gastropathy etc.The source of VC.Aureomariginatn can be with reference to " CN1135914.5 Jinbianruixiang flower perfume and process for super-critical extracting thereof ".Though VC.Aureomariginatn originates in a plurality of places, studying most active is Jiangxi, and the Dayu County in Jiangxi will be planted VC.Aureomariginatn and is decided to be pillar industry, and Nanchang is decided to be city flower with VC.Aureomariginatn, and the present invention is also exploring whether VC.Aureomariginatn can be applied to the speckle dispelling field.
Tea polyphenols can be eliminated the intravital free radical of people, can the restraint of tyrosinase activity.
Other main components are described below:
α-bisabolol is the racemic undersaturated sesquiterpene of making by methodology of organic synthesis, is a kind of antiinflammatory antiallergic activity thing.Be widely used in protection and nursing allergic skin, the antiinflammatory antiallergic.Its chemical name is:
1-Methyl-4(1，5-dimethyl-1-hydroxyhex-4(5)-enyl)cyclohexene。
Allantoin is all mammals necessary a kind of materials of surviving.Allantoin is the same with some water soluble vitamins, has antioxygenic property, and allantoin is similar in conjunction with the ability and the vitamin C of free radical, can effectively improve the oxidation resistance of cell.Allantoin also has and promotes chrotoplast to generate, and wound is healed rapidly, is the good consolidant of skin trauma, again can the horny layer softening element, and make skin keep moisture, moisten and soft.
Isopropyl myristate is one of important interpolation composition of the cosmetics of super quality, skin is had fabulous infiltration, moistens and emollescence, as the emulsifying agent and the wetting agent of cosmetics.
White oil is widely used in the daily use chemicals industry, mainly as the oily matter in the basic cosmetics, on skin, form oil film, except that itself giving smooth sensation, also because the evaporation that barrier effect can block moisture of skin can provide wetting agent to keep the usefulness of moisture of skin.
HANSHENGJIAO has good pseudoplastic behavior, rheological characteristic and compatibility, usually does thickening, stabilizing agent in cosmetics.
The dry powder of the Radix Angelicae Sinensis water extract that the present invention relates to, the dry powder of Semen Cuscutae water extract, the dry powder of Poria water extract, the dry powder of the dry powder of Radix Paeoniae Alba water extract, Semen Armeniacae Amarum water extract, the dry powder of VC.Aureomariginatn water extract are meant the extract concentrated back spray drying that Radix Angelicae Sinensis, Semen Cuscutae, Poria, the Radix Paeoniae Alba, Semen Armeniacae Amarum, VC.Aureomariginatn middle liquid medicine extracting method decocting in water routinely obtains and the dry powder that gets.The acquisition of the dry powder of this apoplexy due to endogenous wind medicine water extract is a routine techniques, and it is not emphasis of the present invention that similar report, the acquisition of the dry powder of Chinese medicine water extract are all arranged in a lot of documents.
Add water after Radix Angelicae Sinensis is pulverized and decoct secondary for 8 times, filter, merge extractive liquid,, concentrate the back spray drying and the dry powder of Radix Angelicae Sinensis water extract.
Add water after Semen Cuscutae is pulverized and decoct secondary for 8 times, filter, merge extractive liquid,, concentrate the back spray drying and the dry powder of Semen Cuscutae water extract.
Add water after Poria is pulverized and decoct secondary for 8 times, filter, merge extractive liquid,, concentrate the back spray drying and the dry powder of Poria water extract.
Add water after the Radix Paeoniae Alba is pulverized and decoct secondary for 8 times, filter, merge extractive liquid,, concentrate the back spray drying and the dry powder of Radix Paeoniae Alba water extract.
Add water after the Semen Armeniacae Amarum root is pulverized and decoct secondary for 8 times, filter, merge extractive liquid,, concentrate the back spray drying and the dry powder of Semen Armeniacae Amarum water extract.
Add water after VC.Aureomariginatn is pulverized and decoct secondary for 8 times, filter, merge extractive liquid,, concentrate the back spray drying and the dry powder of VC.Aureomariginatn water extract.
The invention has the advantages that: the present invention is to be the QUBAN SHUANG of main speckle dispelling system with new prescription Chinese medicine, and suitably be aided with comparatively gentle external Western medicine: α-bisabolol is and allantoin, increase tea polyphenols simultaneously, obtain reasonable therapeutic effect with expectation, but avoid using arbutin etc. potential destructive composition to be arranged as far as possible human body.
The specific embodiment
Embodiment 1
QUBAN SHUANG, its composition is by weight percentage: the dry powder of polyoxyethylene stearyl alcohol ether 2 grams, glyceryl monostearate 1 gram, isopropyl myristate 6 grams, squalane 4 grams, α-bisabolol 0.1 gram, glycerol 6 grams, propylene glycol 6 grams, allantoin 0.1 gram, licoflavone 6 grams, Chinese medicine extract, add balance of deionized water to 100 gram, wherein: the dry powder of Chinese medicine extract is made up of dry powder 2 grams of Radix Angelicae Sinensis extract, dry powder 2 grams of Semen Cuscutae extract, dry powder 2 grams of Poria extract, dry powder 2 grams of Radix Paeoniae Alba extract, dry powder 2 grams of Semen Armeniacae Amarum extract.
Preparation method: the dry powder that in 80 degrees centigrade of hot water of 40 grams, adds Chinese medicine extract, stir, add polyoxyethylene stearyl alcohol ether, glyceryl monostearate, isopropyl myristate, squalane, α-bisabolol, glycerol, propylene glycol, allantoin, licoflavone again, add balance of deionized water to 100 gram, stir, filter, fill obtains QUBAN SHUANG.
Embodiment 2
QUBAN SHUANG, its composition is by weight percentage: the dry powder of polyoxyethylene stearyl alcohol ether 4 grams, glyceryl monostearate 3 grams, isopropyl myristate 10 grams, squalane 6 grams, α-bisabolol 0.3 gram, glycerol 10 grams, propylene glycol 10 grams, allantoin 0.3 gram, licoflavone 14 grams, Chinese medicine extract, add balance of deionized water to 100 gram, wherein: the dry powder of Chinese medicine extract is made up of dry powder 2 grams of Radix Angelicae Sinensis extract, dry powder 2 grams of Semen Cuscutae extract, dry powder 2 grams of Poria extract, dry powder 2 grams of Radix Paeoniae Alba extract, dry powder 2 grams of Semen Armeniacae Amarum extract.Preparation method all the other with embodiment 1.
Embodiment 3
QUBAN SHUANG, its composition is by weight percentage: the dry powder of polyoxyethylene stearyl alcohol ether 3 grams, glyceryl monostearate 2 grams, isopropyl myristate 8 grams, squalane 5 grams, α-bisabolol 0.2 gram, glycerol 8 grams, propylene glycol 8 grams, allantoin 0.2 gram, licoflavone 10 grams, Chinese medicine extract, add balance of deionized water to 100 gram, wherein: the dry powder of Chinese medicine extract is made up of dry powder 2 grams of Radix Angelicae Sinensis extract, dry powder 2 grams of Semen Cuscutae extract, dry powder 2 grams of Poria extract, dry powder 2 grams of Radix Paeoniae Alba extract, dry powder 2 grams of Semen Armeniacae Amarum extract.Preparation method all the other with embodiment 1.
Embodiment 4
QUBAN SHUANG, its composition is by weight percentage: polyoxyethylene stearyl alcohol ether 3 grams, glyceryl monostearate 2 grams, isopropyl myristate 8 grams, squalane 5 grams, α-bisabolol 0.2 gram, glycerol 8 grams, propylene glycol 8 grams, allantoin 0.2 gram, licoflavone 10 grams, the dry powder of Chinese medicine extract, add balance of deionized water to 100 gram, wherein: the dry powder of Chinese medicine extract is by dry powder 2 grams of Radix Angelicae Sinensis extract, dry powder 2 grams of Semen Cuscutae extract, dry powder 2 grams of Poria extract, dry powder 2 grams of Radix Paeoniae Alba extract, dry powder 2 grams of Semen Armeniacae Amarum extract, dry powder 6 grams of Daphne odora extract, tea polyphenols 1 gram is formed.Preparation method all the other with embodiment 1.
Embodiment 5
QUBAN SHUANG, wherein: the dry powder of Chinese medicine extract is made up of dry powder 2 grams, dry powder 2 grams of Semen Cuscutae extract, dry powder 2 grams of Poria extract, dry powder 2 grams of Radix Paeoniae Alba extract, dry powder 2 grams of Semen Armeniacae Amarum extract, dry powder 8 grams of Daphne odora extract, tea polyphenols 3 grams of Radix Angelicae Sinensis extract.Other form and preparation method all the other with embodiment 4.
Embodiment 6
QUBAN SHUANG, wherein: the dry powder of Chinese medicine extract is made up of dry powder 2 grams, dry powder 2 grams of Semen Cuscutae extract, dry powder 2 grams of Poria extract, dry powder 2 grams of Radix Paeoniae Alba extract, dry powder 2 grams of Semen Armeniacae Amarum extract, dry powder 7 grams of Daphne odora extract, tea polyphenols 2 grams of Radix Angelicae Sinensis extract.Other form and preparation method all the other with embodiment 4.
Embodiment 7
QUBAN SHUANG, wherein: the dry powder of Chinese medicine extract is made up of dry powder 2 grams, dry powder 2 grams of Semen Cuscutae extract, dry powder 2 grams of Poria extract, dry powder 2 grams of Radix Paeoniae Alba extract, dry powder 2 grams of Semen Armeniacae Amarum extract, dry powder 2 grams of Daphne odora extract, tea polyphenols 2 grams of Radix Angelicae Sinensis extract.Other form and preparation method all the other with embodiment 4.
Embodiment 8
QUBAN SHUANG, wherein: the dry powder of Chinese medicine extract is made up of dry powder 2 grams, dry powder 2 grams of Semen Cuscutae extract, dry powder 2 grams of Poria extract, dry powder 2 grams of Radix Paeoniae Alba extract, dry powder 2 grams of Semen Armeniacae Amarum extract, dry powder 2 grams of Daphne odora extract, tea polyphenols 6 grams of Radix Angelicae Sinensis extract.Other form and preparation method all the other with embodiment 4.
Test example 1,
Press the method that " Rhizoma Chuanxiong microwave extraction technology is to the influence of tyrosinase activity "/fragrance flavor and cosmetic/2005 the 2nd phase of year April 26-29 page or leaf provides, or by " speckle dispelling Chinese medicine Rhizoma Typhonii Study on extraction "/Chinese Medicine magazine/2002, the method that 33 (11) 538-540 pages or leaves provide detects the performance of QUBAN SHUANG restraint of tyrosinase of the present invention.
Because of the detection method of the relative inhibition of tryrosinase is a classical way, do not launching its concrete step that detects at this.
The QUBAN SHUANG that the embodiment of the invention 3 and embodiment 6, embodiment 7, embodiment 8 provide is respectively 46.2% and 79.2%, 49.8%, 52.5% to the relative inhibition of tryrosinase.
The result shows that related Chinese medicine composition all has the trend of restraint of tyrosinase.If the Daphne odora extract dry powder consumption that increases is on the low side, inhibition trend changes not too obvious; And the Daphne odora extract dry powder consumption that increases arrives appropriate amount, and inhibition trend changes obviously and strengthens.Tea polyphenols changes favourable to inhibition trend.
Test example 2,
Clinical trial relatively, the test of QUBAN SHUANG restraint of tyrosinase is fairly simple, and the QUBAN SHUANG that we select embodiment 6 to provide by the prompting of testing example 1 is carried out following test:
According to the clinical diagnosis of chloasma and criterion of therapeutical effect (revised draft in 2003)/CAIM (Chinese Association Of Integrative Medicine) Dermatology Professional Committee pigment disease group/
One, clinical diagnosis standard
1. facial filbert to dark brown, well-defined patch, symmetry distributes usually, NIP performance and squama.2. do not have obvious subjective symptoms 3. the state of an illness seasonality is arranged, the Chang Xiachong winter, 5. light 4. women's pilosity got rid of the pigmentation that other disease causes.
Two, Clinical typing
Three, curative effect determinate standard
The basic healing: it is basic that 1. naked eyes are looked the mottle area color that disappears〉90 ‰ point systems that 2. disappear calculate treatment back decline index 〉=0.8; 3. the pigmented area skin image measurement ID of efficacy evaluation unit value〉55.
Produce effects: 1. naked eyes are looked the mottle area and are disappeared〉60%, color is obviously thin out; 2. point system is calculated treatment back decline index 〉=0.5; 3. the pigmented area skin image measurement ID of efficacy evaluation unit value〉15.
Take a turn for the better: 1. naked eyes are looked the mottle area and are disappeared〉30%, color is thin out; 2. point system is calculated treatment back decline index 〉=0.3; 3. the pigmented area skin image measurement ID of efficacy evaluation unit value〉5.
Invalid: 1. naked eyes look the mottle area and disappear≤30%, change color is not obvious; 2. point system is calculated treatment back decline index≤0; 3. the pigmented area skin image measurement ID of efficacy evaluation unit value 〉=1.
Explanation
Unconditional at present former 2 is main in the criterion of therapeutical effect, adds when to be had ready conditions with the 3rd.
The computational methods of the pigmented area skin image measurement ID of efficacy evaluation unit value: 1. optical densitometric method (OPT) is calculated: certain some gray scale (color) is A in hypothetical target (skin) image, incident illumination (specific light) is demarcated and is B, the optical density value of this point is: OPT=LnB-LnA, because so B 〉=A is OPT 〉=0; 2. integral optical density (OPTDM) calculates: supposition area (AREA) is M * N.Area branch optical density is the summation of each point optical density in the area; Average optical (OPTDI) is the optical density meansigma methods in the integral optical density.3. ID value representing images is measured efficacy evaluation unit.
Methods of marking and standard:
The scoring of skin lesion area: 0 for harmless; 1 is area＜2cm
22 is area 2-4cm
23 is the skin lesion area〉4cm
2
The scoring of skin lesion color: 0 is the normal colour of skin; 1 is filbert; 2 is brown; 3 is dark brown.
Total mark=area scoring+color scoring
Point system decline index calculation method: total mark before decline index=(total mark before the treatment-treatment back integration)/treatment.
By above-mentioned standard, therapeutic outcome is as follows:
88 examples are organized in the QUBAN SHUANG treatment of adopting embodiments of the invention 6 to provide: cure 50 examples substantially, produce effects 22 examples, 10 examples that take a turn for the better, invalid 6 examples.
Adopt matched group 72 examples that fourth man should the speckle dispelling essence cream: cure 33 examples substantially, produce effects 22 examples, 10 examples that take a turn for the better, invalid 7 examples.
Blank group 25 examples: cure 3 examples substantially, produce effects 8 examples, 2 examples that take a turn for the better, invalid 12 examples.
Claims (2)
1, QUBAN SHUANG, it is characterized in that: its composition is by weight percentage: polyoxyethylene stearyl alcohol ether 2-4%, glyceryl monostearate 1-3%, isopropyl myristate 6-10%, squalane 4-6%, α-bisabolol 0.1-0.3%, glycerol 6-10%, propylene glycol 6-10%, allantoin 0.1-0.3%, licoflavone 6-14%, the dry powder of Chinese medicine extract, add balance of deionized water to 100%, wherein: the dry powder of Chinese medicine extract is by the dry powder 2% of Radix Angelicae Sinensis extract, the dry powder 2% of Semen Cuscutae extract, the dry powder 2% of Poria extract, the dry powder 2% of Radix Paeoniae Alba extract, the dry powder 2% of Semen Armeniacae Amarum extract is formed.
2, QUBAN SHUANG according to claim 1, it is characterized in that: its composition is by weight percentage: polyoxyethylene stearyl alcohol ether 3%, glyceryl monostearate 2%, isopropyl myristate 8%, squalane 5%, α-bisabolol 0.2%, glycerol 8%, propylene glycol 8%, allantoin 0.2%, licoflavone 10%, the dry powder of Chinese medicine extract, add balance of deionized water to 100%, wherein: the dry powder of Chinese medicine extract is by the dry powder 2% of Radix Angelicae Sinensis extract, the dry powder 2% of Semen Cuscutae extract, the dry powder 2% of Poria extract, the dry powder 2% of Radix Paeoniae Alba extract, the dry powder 2% of Semen Armeniacae Amarum extract is formed.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200710079844XA CN100525745C (en) | 2007-02-16 | 2007-02-16 | Spot-removing cream |
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| CNB200710079844XA CN100525745C (en) | 2007-02-16 | 2007-02-16 | Spot-removing cream |
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| CN101053549A CN101053549A (en) | 2007-10-17 |
| CN100525745C true CN100525745C (en) | 2009-08-12 |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008412B (en) * | 2010-11-26 | 2012-08-29 | 新时代健康产业（集团）有限公司 | Skin care composition with whitening efficacy, and preparation method thereof |
| CN103385838A (en) * | 2013-08-05 | 2013-11-13 | 唯美度科技（北京）有限公司 | Anti-freckle whitening emulsion |
| CN104146897B (en) * | 2014-07-21 | 2016-08-24 | 江苏天晟药业有限公司 | A kind of cosmetics with white-skinned face function |
| CN104546712A (en) * | 2014-12-26 | 2015-04-29 | 唯美度科技（北京）有限公司 | Licoflavone alcohol-in-oil preparation and preparation method thereof |
| CN104644503A (en) * | 2015-02-06 | 2015-05-27 | 深圳唯美度生物科技有限公司 | Massage cream capable of deeply retaining water and moisturizing and resisting long-wavelength ultraviolet rays |
| CN105342973A (en) * | 2015-12-11 | 2016-02-24 | 饶雅琴 | Tea polyphenol sun cream and preparation method thereof |
| CN105687026B (en) * | 2016-01-25 | 2018-07-27 | 张馨文 | A kind of spot-eliminating composition and the preparation method and application thereof |
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