CN100518732C - 从阿魏(FERULA)属植物中制备ferutinine的方法 - Google Patents

从阿魏(FERULA)属植物中制备ferutinine的方法 Download PDF

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Publication number
CN100518732C
CN100518732C CNB2004800091113A CN200480009111A CN100518732C CN 100518732 C CN100518732 C CN 100518732C CN B2004800091113 A CNB2004800091113 A CN B2004800091113A CN 200480009111 A CN200480009111 A CN 200480009111A CN 100518732 C CN100518732 C CN 100518732C
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CN
China
Prior art keywords
ferutinine
ferula
jaeschkenadiol
extracted
ferulae
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Expired - Fee Related
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CNB2004800091113A
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English (en)
Chinese (zh)
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CN1767841A (zh
Inventor
E·邦巴尔代利
G·丰塔纳
A·克里斯托尼
E·梅尔卡利
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Indena SpA
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Indena SpA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/86—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/30—Azulenes; Hydrogenated azulenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB2004800091113A 2003-04-04 2004-03-23 从阿魏(FERULA)属植物中制备ferutinine的方法 Expired - Fee Related CN100518732C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000661A ITMI20030661A1 (it) 2003-04-04 2003-04-04 Processo per la preparazione della ferutinina da piante del genere ferula
ITMI2003A000661 2003-04-04

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2008101489166A Division CN101371818A (zh) 2003-04-04 2004-03-23 从阿魏(FERULA)属植物中制备ferutinine的方法

Publications (2)

Publication Number Publication Date
CN1767841A CN1767841A (zh) 2006-05-03
CN100518732C true CN100518732C (zh) 2009-07-29

Family

ID=33105046

Family Applications (2)

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CNA2008101489166A Pending CN101371818A (zh) 2003-04-04 2004-03-23 从阿魏(FERULA)属植物中制备ferutinine的方法
CNB2004800091113A Expired - Fee Related CN100518732C (zh) 2003-04-04 2004-03-23 从阿魏(FERULA)属植物中制备ferutinine的方法

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CNA2008101489166A Pending CN101371818A (zh) 2003-04-04 2004-03-23 从阿魏(FERULA)属植物中制备ferutinine的方法

Country Status (19)

Country Link
US (4) US7371886B2 (enExample)
EP (1) EP1615651B1 (enExample)
JP (2) JP4648305B2 (enExample)
KR (2) KR101169893B1 (enExample)
CN (2) CN101371818A (enExample)
AT (1) ATE517631T1 (enExample)
AU (1) AU2004226853B2 (enExample)
BR (1) BRPI0409166B1 (enExample)
CA (2) CA2521100C (enExample)
DK (1) DK1615651T3 (enExample)
ES (1) ES2367361T3 (enExample)
IL (1) IL171230A (enExample)
IT (1) ITMI20030661A1 (enExample)
NO (1) NO333671B1 (enExample)
PL (1) PL1615651T3 (enExample)
PT (1) PT1615651E (enExample)
RU (2) RU2342153C2 (enExample)
SI (1) SI1615651T1 (enExample)
WO (1) WO2004087179A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20032286A1 (it) * 2003-11-24 2005-05-25 Indena Spa Composizioni per il trattamento di dermatiti atopiche di stati allergici cutanei e dell'acne
US8536584B2 (en) 2007-11-14 2013-09-17 Cree, Inc. High voltage wire bond free LEDS
US20100260695A1 (en) * 2009-04-09 2010-10-14 Mary Kay Inc. Combination of plant extracts to improve skin tone
CA2800383C (en) * 2010-05-24 2019-06-25 Indena S.P.A. Tamarind seed polysaccharide for use in the treatment of inflammatory diseases
CA2834828A1 (en) 2011-05-12 2012-11-15 B.R.A.I.N. Biotechnology Research And Information Network Ag Small molecule inhibitors of trpa1
DE202015004868U1 (de) 2014-07-11 2015-12-23 Mary Kay Inc. Topische Hautzusammensetzung und deren Verwendung
CN105820146A (zh) * 2015-01-08 2016-08-03 辽宁医联新药研究所 一种阿魏内酯及其提取纯化的方法
GB2570508A (en) * 2018-01-30 2019-07-31 Saeed Mohammad Sultan Alaryani Humaid Preparation for treatment of wounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1604225A (en) * 1978-05-15 1981-12-02 Skourides A A Extract of ambelferae for pharmacological use
CH672251A5 (enExample) * 1987-05-29 1989-11-15 Inst Khim Rastitelnykh Vesches
JP2001206819A (ja) * 2000-01-24 2001-07-31 Sansho Seiyaku Co Ltd 美白化粧料

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2090198C1 (ru) * 1991-03-12 1997-09-20 Иван Иванович Уваров Способ получения биологически активных веществ, обладающих противогрибковой активностью
DE4444238A1 (de) * 1994-12-13 1996-06-20 Beiersdorf Ag Kosmetische oder dermatologische Wirkstoffkombinationen aus Zimtsäurederivaten und Flavonglycosiden
CA2417552C (en) * 2000-06-27 2014-05-13 Qualilife Pharmaceuticals Inc. Compositions and methods for treating females sexual response
US6623768B1 (en) * 2002-04-16 2003-09-23 Yousry M. A. Naguib Pharmaceutically active composition extracted from Ferula hermonis and process of its extraction

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1604225A (en) * 1978-05-15 1981-12-02 Skourides A A Extract of ambelferae for pharmacological use
CH672251A5 (enExample) * 1987-05-29 1989-11-15 Inst Khim Rastitelnykh Vesches
JP2001206819A (ja) * 2000-01-24 2001-07-31 Sansho Seiyaku Co Ltd 美白化粧料

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Daucane sesquiterpenes from Ferula hermonis". GALAL A M ET AL.JOURNAL OF NATURAL PRODUCTS,Vol.64 No.3. 2001 *
"Sesquiterpenoids from the fruits of Ferula kuhistanicaandantibacterial activity of the constituents of F.Kuhistanica". TAMEMOTO KIMIKO ET AL.PHYTOCHEMISTRY,Vol.58 No.5. 2001 *

Also Published As

Publication number Publication date
KR20060008307A (ko) 2006-01-26
NO333671B1 (no) 2013-08-05
EP1615651A1 (en) 2006-01-18
HK1087618A1 (zh) 2006-10-20
CA2766702C (en) 2015-09-29
US8101215B2 (en) 2012-01-24
ITMI20030661A1 (it) 2004-10-05
US8247005B2 (en) 2012-08-21
US20100255125A1 (en) 2010-10-07
RU2008122295A (ru) 2009-12-10
EP1615651B1 (en) 2011-07-27
NO20054545D0 (no) 2005-10-03
JP5409505B2 (ja) 2014-02-05
CN1767841A (zh) 2006-05-03
PL1615651T3 (pl) 2011-12-30
IL171230A (en) 2014-02-27
WO2004087179A1 (en) 2004-10-14
US20120095094A1 (en) 2012-04-19
NO20054545L (no) 2005-10-06
AU2004226853A1 (en) 2004-10-14
JP2010209099A (ja) 2010-09-24
CA2521100C (en) 2012-05-01
RU2342153C2 (ru) 2008-12-27
KR101132526B1 (ko) 2012-04-03
US20080248139A1 (en) 2008-10-09
ATE517631T1 (de) 2011-08-15
KR101169893B1 (ko) 2012-07-31
KR20110082091A (ko) 2011-07-15
DK1615651T3 (da) 2011-10-24
RU2005130639A (ru) 2006-04-27
RU2469733C2 (ru) 2012-12-20
CA2766702A1 (en) 2004-10-14
US7371886B2 (en) 2008-05-13
BRPI0409166B1 (pt) 2015-09-01
JP4648305B2 (ja) 2011-03-09
CA2521100A1 (en) 2004-10-14
SI1615651T1 (sl) 2011-11-30
BRPI0409166A (pt) 2006-04-11
PT1615651E (pt) 2011-09-02
JP2006522043A (ja) 2006-09-28
US20060275246A1 (en) 2006-12-07
ES2367361T3 (es) 2011-11-02
AU2004226853B2 (en) 2009-06-04
CN101371818A (zh) 2009-02-25

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