CN100500148C - 用于肺部施用的缓冲液体烟碱组合物 - Google Patents

用于肺部施用的缓冲液体烟碱组合物 Download PDF

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Publication number
CN100500148C
CN100500148C CNB038128098A CN03812809A CN100500148C CN 100500148 C CN100500148 C CN 100500148C CN B038128098 A CNB038128098 A CN B038128098A CN 03812809 A CN03812809 A CN 03812809A CN 100500148 C CN100500148 C CN 100500148C
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Prior art keywords
nicotine
liquid pharmaceutical
pharmaceutical formulation
formulation
acid
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Expired - Lifetime
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CNB038128098A
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Chinese (zh)
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CN1658876A (zh
Inventor
马克·P·沃乔尔
福尔克·莫伦
克里斯蒂娜·锡里森
伊丽莎白·斯坦格尔
斯文-博杰·安德森
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Pfizer Health AB
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Otolaryngology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CNB038128098A 2002-06-03 2003-05-30 用于肺部施用的缓冲液体烟碱组合物 Expired - Lifetime CN100500148C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0201669A SE0201669D0 (sv) 2002-06-03 2002-06-03 New formulation and use thereof
SE02016699 2002-06-03

Publications (2)

Publication Number Publication Date
CN1658876A CN1658876A (zh) 2005-08-24
CN100500148C true CN100500148C (zh) 2009-06-17

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Country Link
EP (1) EP1509227B9 (enExample)
JP (2) JP4745658B2 (enExample)
CN (1) CN100500148C (enExample)
AR (1) AR039947A1 (enExample)
AT (1) ATE444753T1 (enExample)
AU (1) AU2003243074B2 (enExample)
BR (1) BR0311451A (enExample)
CA (1) CA2487699C (enExample)
DE (1) DE60329592D1 (enExample)
DK (1) DK1509227T3 (enExample)
ES (1) ES2332405T3 (enExample)
IL (1) IL165195A0 (enExample)
MX (1) MXPA04012041A (enExample)
NZ (1) NZ536863A (enExample)
RU (1) RU2283111C2 (enExample)
SE (1) SE0201669D0 (enExample)
TW (1) TW200407142A (enExample)
WO (1) WO2003101454A1 (enExample)
ZA (1) ZA200409793B (enExample)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN104768406A (zh) * 2012-08-28 2015-07-08 亲切消费者有限公司 烟碱组合物

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
CN104768406A (zh) * 2012-08-28 2015-07-08 亲切消费者有限公司 烟碱组合物
CN104768406B (zh) * 2012-08-28 2018-11-16 亲切消费者有限公司 烟碱组合物

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Publication number Publication date
CA2487699C (en) 2012-04-17
RU2004139067A (ru) 2005-08-10
RU2283111C2 (ru) 2006-09-10
WO2003101454A1 (en) 2003-12-11
BR0311451A (pt) 2005-03-15
DE60329592D1 (de) 2009-11-19
AU2003243074B2 (en) 2008-11-20
JP2010280721A (ja) 2010-12-16
AR039947A1 (es) 2005-03-09
ATE444753T1 (de) 2009-10-15
JP2005533770A (ja) 2005-11-10
ES2332405T3 (es) 2010-02-04
ZA200409793B (en) 2006-08-30
EP1509227A1 (en) 2005-03-02
TW200407142A (en) 2004-05-16
DK1509227T3 (da) 2010-02-01
JP4745658B2 (ja) 2011-08-10
CA2487699A1 (en) 2003-12-11
MXPA04012041A (es) 2005-08-16
JP5430525B2 (ja) 2014-03-05
NZ536863A (en) 2007-05-31
EP1509227B1 (en) 2009-10-07
CN1658876A (zh) 2005-08-24
SE0201669D0 (sv) 2002-06-03
AU2003243074A1 (en) 2003-12-19
EP1509227B9 (en) 2010-05-19
IL165195A0 (en) 2005-12-18

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