AU2003243074B2 - A buffered, liquid nicotine composition for pulmonary administration - Google Patents

A buffered, liquid nicotine composition for pulmonary administration Download PDF

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Publication number
AU2003243074B2
AU2003243074B2 AU2003243074A AU2003243074A AU2003243074B2 AU 2003243074 B2 AU2003243074 B2 AU 2003243074B2 AU 2003243074 A AU2003243074 A AU 2003243074A AU 2003243074 A AU2003243074 A AU 2003243074A AU 2003243074 B2 AU2003243074 B2 AU 2003243074B2
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AU
Australia
Prior art keywords
nicotine
pharmaceutical formulation
liquid pharmaceutical
formulation according
tobacco
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU2003243074A
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English (en)
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AU2003243074A1 (en
Inventor
Sven-Borje Andersson
Folke Moren
Elisabeth Sthengel
Kristina Thyresson
Mark P. Warchol
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McNeil AB
Original Assignee
McNeil AB
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Assigned to PFIZER CONSUMER HEALTHCARE HEALTH AB reassignment PFIZER CONSUMER HEALTHCARE HEALTH AB Request for Assignment Assignors: PFIZER HEALTH AB
Assigned to MCNEIL AB reassignment MCNEIL AB Alteration of Name(s) of Applicant(s) under S113 Assignors: PFIZER CONSUMER HEALTHCARE HEALTH AB
Application granted granted Critical
Publication of AU2003243074B2 publication Critical patent/AU2003243074B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Otolaryngology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2003243074A 2002-06-03 2003-05-30 A buffered, liquid nicotine composition for pulmonary administration Expired AU2003243074B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0201669A SE0201669D0 (sv) 2002-06-03 2002-06-03 New formulation and use thereof
SE0201669-9 2002-06-03
PCT/SE2003/000890 WO2003101454A1 (en) 2002-06-03 2003-05-30 A buffered, liquid nicotine composition for pulmonary administration

Publications (2)

Publication Number Publication Date
AU2003243074A1 AU2003243074A1 (en) 2003-12-19
AU2003243074B2 true AU2003243074B2 (en) 2008-11-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003243074A Expired AU2003243074B2 (en) 2002-06-03 2003-05-30 A buffered, liquid nicotine composition for pulmonary administration

Country Status (19)

Country Link
EP (1) EP1509227B9 (enExample)
JP (2) JP4745658B2 (enExample)
CN (1) CN100500148C (enExample)
AR (1) AR039947A1 (enExample)
AT (1) ATE444753T1 (enExample)
AU (1) AU2003243074B2 (enExample)
BR (1) BR0311451A (enExample)
CA (1) CA2487699C (enExample)
DE (1) DE60329592D1 (enExample)
DK (1) DK1509227T3 (enExample)
ES (1) ES2332405T3 (enExample)
IL (1) IL165195A0 (enExample)
MX (1) MXPA04012041A (enExample)
NZ (1) NZ536863A (enExample)
RU (1) RU2283111C2 (enExample)
SE (1) SE0201669D0 (enExample)
TW (1) TW200407142A (enExample)
WO (1) WO2003101454A1 (enExample)
ZA (1) ZA200409793B (enExample)

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Publication number Publication date
CA2487699C (en) 2012-04-17
RU2004139067A (ru) 2005-08-10
RU2283111C2 (ru) 2006-09-10
WO2003101454A1 (en) 2003-12-11
CN100500148C (zh) 2009-06-17
BR0311451A (pt) 2005-03-15
DE60329592D1 (de) 2009-11-19
JP2010280721A (ja) 2010-12-16
AR039947A1 (es) 2005-03-09
ATE444753T1 (de) 2009-10-15
JP2005533770A (ja) 2005-11-10
ES2332405T3 (es) 2010-02-04
ZA200409793B (en) 2006-08-30
EP1509227A1 (en) 2005-03-02
TW200407142A (en) 2004-05-16
DK1509227T3 (da) 2010-02-01
JP4745658B2 (ja) 2011-08-10
CA2487699A1 (en) 2003-12-11
MXPA04012041A (es) 2005-08-16
JP5430525B2 (ja) 2014-03-05
NZ536863A (en) 2007-05-31
EP1509227B1 (en) 2009-10-07
CN1658876A (zh) 2005-08-24
SE0201669D0 (sv) 2002-06-03
AU2003243074A1 (en) 2003-12-19
EP1509227B9 (en) 2010-05-19
IL165195A0 (en) 2005-12-18

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