CN100460021C - 磷酸钙水泥 - Google Patents
磷酸钙水泥 Download PDFInfo
- Publication number
- CN100460021C CN100460021C CNB2006100737422A CN200610073742A CN100460021C CN 100460021 C CN100460021 C CN 100460021C CN B2006100737422 A CNB2006100737422 A CN B2006100737422A CN 200610073742 A CN200610073742 A CN 200610073742A CN 100460021 C CN100460021 C CN 100460021C
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- China
- Prior art keywords
- calcium phosphate
- compositions
- phosphate
- sodium
- content
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000001506 calcium phosphate Substances 0.000 title claims abstract description 139
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title claims abstract description 121
- 229910000389 calcium phosphate Inorganic materials 0.000 title claims abstract description 117
- 235000011010 calcium phosphates Nutrition 0.000 title claims abstract description 117
- 239000004568 cement Substances 0.000 title abstract description 68
- 239000007788 liquid Substances 0.000 claims abstract description 50
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 49
- 239000011707 mineral Substances 0.000 claims abstract description 49
- 239000011777 magnesium Substances 0.000 claims abstract description 43
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims abstract description 29
- 229910052749 magnesium Inorganic materials 0.000 claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims abstract description 18
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims abstract description 18
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims abstract description 18
- 229940038472 dicalcium phosphate Drugs 0.000 claims abstract description 18
- 239000000203 mixture Substances 0.000 claims description 90
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 claims description 53
- 238000006243 chemical reaction Methods 0.000 claims description 49
- 235000010755 mineral Nutrition 0.000 claims description 48
- 239000002639 bone cement Substances 0.000 claims description 45
- 239000000843 powder Substances 0.000 claims description 42
- 239000011230 binding agent Substances 0.000 claims description 39
- 238000002360 preparation method Methods 0.000 claims description 36
- 239000001488 sodium phosphate Substances 0.000 claims description 29
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 29
- 235000011008 sodium phosphates Nutrition 0.000 claims description 29
- -1 sodium phosphate compound Chemical class 0.000 claims description 27
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 26
- 239000002904 solvent Substances 0.000 claims description 26
- 239000001509 sodium citrate Substances 0.000 claims description 16
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 16
- 235000019263 trisodium citrate Nutrition 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 14
- 229940038773 trisodium citrate Drugs 0.000 claims description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 12
- 239000003381 stabilizer Substances 0.000 claims description 12
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical class [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 12
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 9
- 239000011734 sodium Substances 0.000 claims description 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 7
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 7
- NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 claims description 6
- 239000000654 additive Substances 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 235000011121 sodium hydroxide Nutrition 0.000 claims description 6
- 238000003860 storage Methods 0.000 claims description 6
- 230000000996 additive effect Effects 0.000 claims description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 5
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 4
- 239000011148 porous material Substances 0.000 claims description 4
- FEBUJFMRSBAMES-UHFFFAOYSA-N 2-[(2-{[3,5-dihydroxy-2-(hydroxymethyl)-6-phosphanyloxan-4-yl]oxy}-3,5-dihydroxy-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-4-yl)oxy]-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl phosphinite Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(OC2C(C(OP)C(O)C(CO)O2)O)C(O)C(OC2C(C(CO)OC(P)C2O)O)O1 FEBUJFMRSBAMES-UHFFFAOYSA-N 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 229920002305 Schizophyllan Polymers 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- OOSZCNKVJAVHJI-UHFFFAOYSA-N 1-[(4-fluorophenyl)methyl]piperazine Chemical compound C1=CC(F)=CC=C1CN1CCNCC1 OOSZCNKVJAVHJI-UHFFFAOYSA-N 0.000 claims description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 claims description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 235000015165 citric acid Nutrition 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 239000013078 crystal Substances 0.000 claims description 2
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 2
- KDQPSPMLNJTZAL-UHFFFAOYSA-L disodium hydrogenphosphate dihydrate Chemical compound O.O.[Na+].[Na+].OP([O-])([O-])=O KDQPSPMLNJTZAL-UHFFFAOYSA-L 0.000 claims description 2
- PYLIXCKOHOHGKQ-UHFFFAOYSA-L disodium;hydrogen phosphate;heptahydrate Chemical compound O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O PYLIXCKOHOHGKQ-UHFFFAOYSA-L 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000000945 filler Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 2
- 239000003607 modifier Substances 0.000 claims description 2
- 230000000278 osteoconductive effect Effects 0.000 claims description 2
- 230000002138 osteoinductive effect Effects 0.000 claims description 2
- HWGNBUXHKFFFIH-UHFFFAOYSA-I pentasodium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O HWGNBUXHKFFFIH-UHFFFAOYSA-I 0.000 claims description 2
- 239000001508 potassium citrate Substances 0.000 claims description 2
- 229960002635 potassium citrate Drugs 0.000 claims description 2
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 2
- 235000011082 potassium citrates Nutrition 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 235000010413 sodium alginate Nutrition 0.000 claims description 2
- 239000000661 sodium alginate Substances 0.000 claims description 2
- 229940005550 sodium alginate Drugs 0.000 claims description 2
- 229940074545 sodium dihydrogen phosphate dihydrate Drugs 0.000 claims description 2
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 2
- 235000019983 sodium metaphosphate Nutrition 0.000 claims description 2
- 235000019832 sodium triphosphate Nutrition 0.000 claims description 2
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 2
- 239000001226 triphosphate Substances 0.000 claims description 2
- ASTWEMOBIXQPPV-UHFFFAOYSA-K trisodium;phosphate;dodecahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+].[O-]P([O-])([O-])=O ASTWEMOBIXQPPV-UHFFFAOYSA-K 0.000 claims description 2
- 239000004034 viscosity adjusting agent Substances 0.000 claims description 2
- 239000000230 xanthan gum Substances 0.000 claims description 2
- 235000010493 xanthan gum Nutrition 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 229940082509 xanthan gum Drugs 0.000 claims description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
- 229960004106 citric acid Drugs 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 229960001714 calcium phosphate Drugs 0.000 description 63
- 239000000243 solution Substances 0.000 description 42
- 238000004108 freeze drying Methods 0.000 description 39
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 36
- 239000000523 sample Substances 0.000 description 36
- 238000012360 testing method Methods 0.000 description 36
- 239000002244 precipitate Substances 0.000 description 31
- 239000012065 filter cake Substances 0.000 description 20
- 238000000227 grinding Methods 0.000 description 20
- 230000032683 aging Effects 0.000 description 18
- 229910000019 calcium carbonate Inorganic materials 0.000 description 18
- 238000001035 drying Methods 0.000 description 18
- 238000002156 mixing Methods 0.000 description 15
- 230000035515 penetration Effects 0.000 description 15
- 239000000047 product Substances 0.000 description 15
- 238000000498 ball milling Methods 0.000 description 13
- 239000002245 particle Substances 0.000 description 13
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 12
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical group [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 12
- 235000011007 phosphoric acid Nutrition 0.000 description 12
- 239000002002 slurry Substances 0.000 description 12
- 239000000725 suspension Substances 0.000 description 12
- 238000001556 precipitation Methods 0.000 description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 239000002253 acid Substances 0.000 description 10
- 239000000126 substance Substances 0.000 description 10
- 239000002562 thickening agent Substances 0.000 description 10
- 210000000988 bone and bone Anatomy 0.000 description 9
- 229910019142 PO4 Inorganic materials 0.000 description 8
- 239000010452 phosphate Substances 0.000 description 8
- 239000008367 deionised water Substances 0.000 description 7
- 229910021641 deionized water Inorganic materials 0.000 description 7
- 239000000395 magnesium oxide Substances 0.000 description 7
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 7
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 7
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 7
- 235000021317 phosphate Nutrition 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 238000005245 sintering Methods 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- PLZNPHDJGFDNRM-UHFFFAOYSA-M O.[Na+].[O-][PH2]=O Chemical compound O.[Na+].[O-][PH2]=O PLZNPHDJGFDNRM-UHFFFAOYSA-M 0.000 description 6
- 238000003483 aging Methods 0.000 description 6
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- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 6
- 238000000634 powder X-ray diffraction Methods 0.000 description 6
- 238000012216 screening Methods 0.000 description 6
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 5
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- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 4
- 229940078499 tricalcium phosphate Drugs 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
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- 238000004154 testing of material Methods 0.000 description 3
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- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
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- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
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- 229910052586 apatite Inorganic materials 0.000 description 2
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- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 2
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
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- 229910052585 phosphate mineral Inorganic materials 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- FDFYYWMHPJTGEO-UHFFFAOYSA-K tetracalcium;phosphate Chemical class [Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O FDFYYWMHPJTGEO-UHFFFAOYSA-K 0.000 description 1
- 239000011031 topaz Substances 0.000 description 1
- 229910052853 topaz Inorganic materials 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
- C04B28/34—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
- C04B28/344—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders the phosphate binder being present in the starting composition solely as one or more phosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
- C04B28/34—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
- C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
- C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Ceramic Engineering (AREA)
- Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Materials Engineering (AREA)
- Structural Engineering (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
步骤 | 温度(℃) | 时间(分钟) | 真空(毫乇) |
*R | -15 | 1 | 100 |
**H | -15 | 120 | 100 |
R | -5 | 120 | 200 |
H | -5 | 240 | 200 |
R | 0 | 120 | 1000 |
H | 0 | 600 | 1000 |
R | 10 | 60 | 1000 |
H | 10 | 30 | 1000 |
R | 20 | 60 | 1000 |
H | 20 | 30 | 1000 |
步骤 | 温度(℃) | 时间(分钟) | 真空(毫乇) |
*R | -5 | 1 | 100 |
**H | -5 | 480 | 100 |
R | 0 | 120 | 1000 |
H | 0 | 600 | 1000 |
R | 10 | 60 | 1000 |
H | 10 | 90 | 1000 |
R | 25 | 60 | 1000 |
H | 25 | 90 | 1000 |
步骤 | 温度(℃) | 时间(分钟) | 真空(毫乇) |
*R | -5 | 1 | 200 |
**H | -5 | 60 | 200 |
R | 0 | 60 | 1000 |
H | 0 | 120 | 1000 |
R | 10 | 60 | 1000 |
H | 10 | 30 | 1000 |
R | 20 | 60 | 1000 |
H | 20 | 60 | 1000 |
R | 30 | 60 | 1000 |
H | 30 | 300 | 1000 |
步骤 | 温度(℃) | 时间(分钟) | 真空(毫乇) |
*R | -15 | 1 | 100 |
**H | -15 | 120 | 100 |
R | -5 | 120 | 200 |
H | -5 | 240 | 200 |
R | 0 | 120 | 1000 |
H | 0 | 600 | 1000 |
R | 10 | 60 | 1000 |
H | 10 | 30 | 1000 |
R | 20 | 60 | 1000 |
H | 20 | 30 | 1000 |
步骤 | 温度(℃) | 时间(分钟) | 真空(毫乇) |
*R | -5 | 1 | 100 |
**H | -5 | 480 | 100 |
R | 0 | 120 | 1000 |
H | 0 | 600 | 1000 |
R | 10 | 60 | 1000 |
H | 10 | 90 | 1000 |
R | 25 | 60 | 1000 |
H | 25 | 90 | 1000 |
步骤 | 温度(℃) | 时间(分钟) | 真空(毫乇) |
*R | -5 | 1 | 200 |
**H | -5 | 60 | 200 |
R | 0 | 60 | 1000 |
H | 0 | 120 | 1000 |
R | 10 | 60 | 1000 |
H | 10 | 30 | 1000 |
R | 20 | 60 | 1000 |
H | 20 | 60 | 1000 |
R | 30 | 60 | 1000 |
H | 30 | 300 | 1000 |
原料 | 重量(克) | 百分数(%) |
CaCO<sub>3</sub> | 1394.75±1 | 39.85 |
DCPA | 2105.25±1 | 60.15 |
水 | 3500.00±10 | 100 |
参数 | 设定 |
速度(rpm) | 44±4 |
时间(分钟) | 20 |
Buckner烧瓶容量(%) | 80 |
步骤 | 温度(℃) | 时间(分钟) | 升温速率(℃/分钟) |
升温 | 800 | 100 | 8 |
保温 | 800 | ≥120 | n/a |
升温 | 1550 | 94 | 8 |
保温 | 1550 | 720 | n/a |
冷却 | 800 | ≤10 | 75 |
冷却 | 20 | 15 | 52 |
参数 | 设定 |
筛 | 0.024英寸 |
叶轮速度 | 5000rpm |
参数 | 设定 |
速度(rpm) | 87+/-5 |
时间(分钟) | 360+/-15 |
加入的介质重量(克) | 3000+/-25 |
TTCP重量(克) | 600+/-25 |
化学名称 | 化学式 | Mw | 质量/升 | 摩尔浓度 |
无水磷酸氢二钠 | HNa<sub>2</sub>O<sub>4</sub>P | 141.96克 | 22.8克/升 | 0.1606M |
一水合磷酸二氢钠 | H<sub>2</sub>NaO<sub>4</sub>P·H<sub>2</sub>O | 137.99克 | 45.5克/升 | 0.3297M |
柠檬酸三钠 | C<sub>6</sub>H<sub>5</sub>Na<sub>3</sub>O<sub>7</sub>·2H<sub>2</sub>O | 294.10克 | 147.1克/升 | 0.500M |
样品编号 | 结果 |
1 | 3414psi @ 5分钟7227psi @ 10分钟 |
2 | 3723psi@5分钟6843psi @ 10分钟 |
3 | 2441psi @ 5分钟7444psi @ 10分钟 |
4 | 2615psi @ 5分钟6606psi @ 10分钟 |
5 | 2193psi @ 5分钟6243psi @ 10分钟 |
6 | 2341psi @ 5分钟7153psi @ 10分钟 |
样品平均值 | 2788psi @ 5分钟6919psi @ 10分钟 |
样品编号 | 结果 |
1 | 1947psi @ 5分钟4668psi @ 10分钟 |
2 | 1675psi @ 5分钟3947psi @ 10分钟 |
3 | 1649psi @ 5分钟4567psi @ 10分钟 |
4 | 2371psi @ 5分钟3047psi @ 10分钟 |
5 | 2096psi @ 5分钟5872psi @ 10分钟 |
6 | 2903psi @ 5分钟5483psi @ 10分钟 |
样品平均值 | 2106psi @ 5分钟4930psi @ 10分钟 |
化学名称 | 化学式 | Mw(克) | %重量/粉末组分的总重量 |
含40ppm镁的稳定的DCPD | CaHPO<sub>4</sub>·2H<sub>2</sub>O | 172.05 | 28.6 |
磷酸四钙 | Ca<sub>4</sub>O(PO<sub>4</sub>)<sub>2</sub> | 366.26 | 61 |
柠檬酸三钠 | Na<sub>3</sub>C<sub>6</sub>H<sub>5</sub>O<sub>7</sub>·2H<sub>2</sub>O | 394.11 | 10.4 |
总量 | 100 |
化学名称 | 化学式 | Mw(克) | %重量/总重量(重量(克)) |
无水磷酸氢二钠 | Na<sub>2</sub>HPO<sub>4</sub> | 141.96克 | 2.5 |
一水合磷酸二氢钠 | NaH<sub>2</sub>O<sub>4</sub>P·H<sub>2</sub>O | 137.99克 | 7.1 |
聚乙烯吡咯烷酮 | [-C<sub>6</sub>H<sub>9</sub>NO-]<sub>n</sub> | (111.1)<sub>n</sub> | 7.5 |
水 | H<sub>2</sub>O | 18 | 82.9 |
化学名称 | 化学式 | Mw(克) | %重量/总重量(重量(克)) |
无水磷酸氢二钠 | Na<sub>2</sub>HPO<sub>4</sub> | 141.96克 | 2.7 |
一水合磷酸二氢钠 | NaH<sub>2</sub>O<sub>4</sub>P·H<sub>2</sub>O | 137.99克 | 7.7 |
羧甲基纤维素钠 | [-Na<sub>2</sub>C<sub>16</sub>H<sub>22</sub>O<sub>14</sub>-]<sub>n</sub> | (484.14)<sub>n</sub> | 2.2 |
水 | H<sub>2</sub>O | 18 | 87.4 |
真实时间 | 40℃时加速老化时间 | 50℃时加速老化时间 |
1.5个月 | ~13天 | ~6.5天 |
3个月 | ~26天 | ~13天 |
6个月 | 53天 | 26天 |
1年 | 105天 | 52天 |
2年 | 210天 | 105天 |
样品编号 | 结果 |
1 | 4416psi(30.45MPa)@10分钟 |
2 | 4587psi(31.63MPa)@10分钟 |
3 | 4559psi(31.44MPa)@10分钟 |
4 | 4649psi(32.06MPa)@10分钟 |
5 | 4155psi(28.65MPa)@10分钟 |
6 | 4549psi(31.37MPa)@10分钟 |
样品平均值 | 4486psi(30.93MPa)@10分钟 |
使用者 | 混合时间 | 转移时间结束 |
使用者1 | 35秒 | 1分24秒 |
使用者2 | 54秒 | 1分53秒 |
使用者3 | 53秒 | 2分5秒 |
使用者4 | 42秒 | 1分55秒 |
使用者5 | 45秒 | 1分52秒 |
测试样品 | 在3分钟30秒时注射力(N) |
1 | 73.1 |
2 | 73.3 |
3 | 77.3 |
4 | 111.6 |
5 | 67.2 |
平均 | 80.5 |
测试样品 | 拔出强度(N) |
1 | 156.2 |
2 | 193.4 |
3 | 530 |
4 | 554 |
5 | 500 |
平均 | 386.72 |
测试样品 | HA转化率%(2周) |
1 | 61.3 |
2 | 76.7 |
3 | 62.7 |
平均 | 66.9 |
测试样品 | 体积变化% |
1 | 0.63 |
2 | 0.94 |
3 | 0.54 |
平均 | 0.70 |
Claims (34)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/102,254 | 2005-04-08 | ||
US11/102,254 US7416602B2 (en) | 2005-04-08 | 2005-04-08 | Calcium phosphate cement |
US11/312,094 | 2005-12-20 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008100927981A Division CN101264338B (zh) | 2005-04-08 | 2006-04-07 | 磷酸钙水泥 |
Publications (2)
Publication Number | Publication Date |
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CN1844010A CN1844010A (zh) | 2006-10-11 |
CN100460021C true CN100460021C (zh) | 2009-02-11 |
Family
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Application Number | Title | Priority Date | Filing Date |
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CN2008100927981A Expired - Fee Related CN101264338B (zh) | 2005-04-08 | 2006-04-07 | 磷酸钙水泥 |
CNB2006100737422A Expired - Fee Related CN100460021C (zh) | 2005-04-08 | 2006-04-07 | 磷酸钙水泥 |
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CN2008100927981A Expired - Fee Related CN101264338B (zh) | 2005-04-08 | 2006-04-07 | 磷酸钙水泥 |
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US7416602B2 (en) | 2008-08-26 |
US20060225620A1 (en) | 2006-10-12 |
CN101264338A (zh) | 2008-09-17 |
CN1844010A (zh) | 2006-10-11 |
CN101264338B (zh) | 2012-05-09 |
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