CN100439333C - 用于生产旋光异构体纯的氮杂环丁烷-2-羧酸的方法 - Google Patents

用于生产旋光异构体纯的氮杂环丁烷-2-羧酸的方法 Download PDF

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Publication number
CN100439333C
CN100439333C CNB961951133A CN96195113A CN100439333C CN 100439333 C CN100439333 C CN 100439333C CN B961951133 A CNB961951133 A CN B961951133A CN 96195113 A CN96195113 A CN 96195113A CN 100439333 C CN100439333 C CN 100439333C
Authority
CN
China
Prior art keywords
azeoh
tartrate
pure
carboxylic acid
azetidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB961951133A
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English (en)
Chinese (zh)
Other versions
CN1189152A (zh
Inventor
P·巴斯
H·弗里奇
J·-E·尼斯特伦
A·普芬英尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9502381A external-priority patent/SE9502381D0/xx
Priority claimed from SE9600435A external-priority patent/SE9600435D0/xx
Application filed by Astra AB filed Critical Astra AB
Publication of CN1189152A publication Critical patent/CN1189152A/zh
Application granted granted Critical
Publication of CN100439333C publication Critical patent/CN100439333C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CNB961951133A 1995-06-30 1996-06-24 用于生产旋光异构体纯的氮杂环丁烷-2-羧酸的方法 Expired - Fee Related CN100439333C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
SE9502381-8 1995-06-30
SE95023818 1995-06-30
SE9502381A SE9502381D0 (sv) 1995-06-30 1995-06-30 Process for the production of enantiomerically-pure azetidine-2-carboxylic acid
SE96004353 1996-02-06
SE9600435-3 1996-02-06
SE9600435A SE9600435D0 (sv) 1996-02-06 1996-02-06 Process for the production of enantiomerically-pure azetidine-2-carboxylic acid

Publications (2)

Publication Number Publication Date
CN1189152A CN1189152A (zh) 1998-07-29
CN100439333C true CN100439333C (zh) 2008-12-03

Family

ID=26662332

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB961951133A Expired - Fee Related CN100439333C (zh) 1995-06-30 1996-06-24 用于生产旋光异构体纯的氮杂环丁烷-2-羧酸的方法

Country Status (29)

Country Link
US (1) US5942630A (enExample)
EP (1) EP0840724B1 (enExample)
JP (2) JP4167726B2 (enExample)
KR (1) KR100441571B1 (enExample)
CN (1) CN100439333C (enExample)
AR (2) AR002573A1 (enExample)
AT (1) ATE224871T1 (enExample)
AU (1) AU699338B2 (enExample)
BR (1) BR9609451A (enExample)
CA (1) CA2225896C (enExample)
CZ (1) CZ388397A3 (enExample)
DE (1) DE69623966T2 (enExample)
DK (1) DK0840724T3 (enExample)
EE (1) EE03393B1 (enExample)
ES (1) ES2181899T3 (enExample)
HU (1) HUP9901713A3 (enExample)
IL (1) IL122708A (enExample)
IN (1) IN187238B (enExample)
IS (1) IS4636A (enExample)
MY (1) MY132147A (enExample)
NO (1) NO308949B1 (enExample)
NZ (1) NZ311834A (enExample)
PL (1) PL324403A1 (enExample)
PT (1) PT840724E (enExample)
RU (1) RU2163595C2 (enExample)
SK (1) SK179097A3 (enExample)
TR (1) TR199701742T1 (enExample)
TW (1) TW338035B (enExample)
WO (1) WO1997002241A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN187238B (enExample) * 1995-06-30 2002-03-09 Astra Ab
SE9601600D0 (sv) * 1996-04-26 1996-04-26 Astra Ab Improved process
EP1308519B1 (en) * 1997-01-24 2006-04-19 Sumitomo Chemical Company, Limited Process for improving optical purity of azetidine-2-carboxylic acid
JP3757629B2 (ja) * 1998-07-17 2006-03-22 住友化学株式会社 光学活性ｎ−置換アゼチジン−２−カルボン酸化合物の製造方法
SE9802939D0 (sv) 1998-09-01 1998-09-01 Astra Ab New process
SE9901712D0 (sv) * 1999-05-11 1999-05-11 Astra Ab New process
EP1927588A2 (en) 1999-05-14 2008-06-04 Kaneka Corporation Process for producing optically active azetidine-2-carboxylic acids
JP2000344739A (ja) 1999-06-01 2000-12-12 Sumitomo Chem Co Ltd Ｎ−保護−アゼチジン−２−カルボン酸の製造方法
EP1479762B1 (en) * 2002-02-28 2011-09-28 Mitsubishi Chemical Corporation Novel dehydrogenase and gene encoding the same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7513818A (nl) * 1974-12-13 1976-06-15 Merck & Co Inc Werkwijze voor het scheiden van enantiomere 1-tert.butylamino 2.3-dihydroxypropanen.
JPS56104866A (en) * 1980-01-24 1981-08-20 Mitsubishi Chem Ind Ltd Production of (2r,4r)-4-alkyl-2-piperidinecarboxylic acid or its l-tartarate salt
FR2610323B1 (fr) * 1987-02-04 1989-06-23 Delalande Sa Enantiomeres de configuration absolue s de derives amide de l'amino-3 quinuclidine, leur procede de preparation et leur application en therapeutique
GB2206880B (en) * 1987-07-16 1991-04-24 Farmos Oy Optical isomers of an imidazole derivative
IT1231158B (it) * 1989-07-20 1991-11-19 Dompe Farmaceutici Spa Procedimento per la risoluzione ottica della dropropizina.
JPH04108774A (ja) * 1990-08-25 1992-04-09 Mitsubishi Kasei Corp 光学活性なｎ―インダニルニコチン酸アミド誘導体及びこれを有効成分とする農園芸用殺菌剤
US5095014A (en) * 1990-12-07 1992-03-10 A. H. Robins Company, Incorporated 3-(2-chloro-4-(trifluoromethyl)phenoxy)-1-azetidine carboxamides having anticonvulsant activity
JPH05286933A (ja) * 1992-04-10 1993-11-02 Dai Ichi Seiyaku Co Ltd アザスピロオクタン誘導体の塩
FR2690161B1 (fr) * 1992-04-16 1995-06-30 Esteve Labor Dr Derives de pyridone azetidinyl substitues avec activite antimicrobienne.
IN187238B (enExample) * 1995-06-30 2002-03-09 Astra Ab

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
《基础有机化学》. 邢其毅等，263-264，人民教育出版社. 1984
《基础有机化学》. 邢其毅等，263-264，人民教育出版社. 1984 *
The Azetidines Recent Synthetic Developments. Norman H.Cromwell等.Chemical Reviews,Vol.179 No.4. 1979
The Azetidines Recent Synthetic Developments. Norman H.Cromwell等.Chemical Reviews,Vol.179 No.4. 1979 *

Also Published As

Publication number Publication date
JP4167726B2 (ja) 2008-10-22
AU699338B2 (en) 1998-12-03
CN1189152A (zh) 1998-07-29
JP2008247922A (ja) 2008-10-16
NZ311834A (en) 1999-10-28
EE03393B1 (et) 2001-04-16
MY132147A (en) 2007-09-28
IL122708A (en) 2003-12-10
CZ388397A3 (cs) 1998-05-13
AU6323296A (en) 1997-02-05
KR19990028531A (ko) 1999-04-15
NO308949B1 (no) 2000-11-20
ES2181899T3 (es) 2003-03-01
BR9609451A (pt) 1999-03-02
TR199701742T1 (xx) 1998-04-21
HUP9901713A2 (hu) 1999-10-28
US5942630A (en) 1999-08-24
SK179097A3 (en) 1998-08-05
PT840724E (pt) 2003-02-28
DE69623966D1 (de) 2002-10-31
HUP9901713A3 (en) 1999-11-29
CA2225896A1 (en) 1997-01-23
IS4636A (is) 1997-12-19
CA2225896C (en) 2008-06-10
IN187238B (enExample) 2002-03-09
ATE224871T1 (de) 2002-10-15
KR100441571B1 (ko) 2005-01-17
EE9700353A (et) 1998-06-15
DE69623966T2 (de) 2003-08-07
DK0840724T3 (da) 2002-12-09
MX9710269A (es) 1998-03-31
JPH11508589A (ja) 1999-07-27
TW338035B (en) 1998-08-11
NO976056L (no) 1997-12-23
RU2163595C2 (ru) 2001-02-27
AR006711A2 (es) 1999-09-08
WO1997002241A1 (en) 1997-01-23
NO976056D0 (no) 1997-12-23
EP0840724B1 (en) 2002-09-25
PL324403A1 (en) 1998-05-25
AR002573A1 (es) 1998-03-25
IL122708A0 (en) 1998-08-16
EP0840724A1 (en) 1998-05-13

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20081203

Termination date: 20110624