CN100436447C - 具有神经原活性的化合物 - Google Patents

具有神经原活性的化合物 Download PDF

Info

Publication number
CN100436447C
CN100436447C CNB988093553A CN98809355A CN100436447C CN 100436447 C CN100436447 C CN 100436447C CN B988093553 A CNB988093553 A CN B988093553A CN 98809355 A CN98809355 A CN 98809355A CN 100436447 C CN100436447 C CN 100436447C
Authority
CN
China
Prior art keywords
straight
compound
branched alkyl
phenyl
neurotrophic factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB988093553A
Other languages
English (en)
Chinese (zh)
Other versions
CN1271354A (zh
Inventor
P·麦卡夫雷
P·M·诺瓦克
M·穆里堪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/085,441 external-priority patent/US6268384B1/en
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of CN1271354A publication Critical patent/CN1271354A/zh
Application granted granted Critical
Publication of CN100436447C publication Critical patent/CN100436447C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB988093553A 1997-08-29 1998-08-27 具有神经原活性的化合物 Expired - Fee Related CN100436447C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US92083897A 1997-08-29 1997-08-29
US08/920,838 1997-08-29
US09/085,441 1998-05-27
US09/085,441 US6268384B1 (en) 1997-08-29 1998-05-27 Compounds possessing neuronal activity

Publications (2)

Publication Number Publication Date
CN1271354A CN1271354A (zh) 2000-10-25
CN100436447C true CN100436447C (zh) 2008-11-26

Family

ID=26772724

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988093553A Expired - Fee Related CN100436447C (zh) 1997-08-29 1998-08-27 具有神经原活性的化合物

Country Status (17)

Country Link
US (1) US7109215B2 (enExample)
EP (1) EP1007521A1 (enExample)
JP (1) JP2001514177A (enExample)
CN (1) CN100436447C (enExample)
AU (1) AU766579B2 (enExample)
BR (1) BR9811923A (enExample)
CA (1) CA2300134A1 (enExample)
ID (1) ID23675A (enExample)
IL (1) IL134536A0 (enExample)
IN (1) IN191127B (enExample)
IS (1) IS5379A (enExample)
NO (1) NO321790B1 (enExample)
NZ (1) NZ502820A (enExample)
PL (1) PL195273B1 (enExample)
SG (1) SG129998A1 (enExample)
TW (1) TW570919B (enExample)
WO (1) WO1999010340A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514686B2 (en) 1997-04-28 2003-02-04 The University Of British Columbia Method and composition for modulating amyloidosis
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
CA2334002A1 (en) * 1998-06-03 1999-12-09 Mark H. Norman N-linked sulphonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres
US6333340B1 (en) * 1998-08-14 2001-12-25 Gpi Nil Holdings, Inc. Small molecule sulfonamides for vision and memory disorders
US6339101B1 (en) * 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6300341B1 (en) 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
AU5912800A (en) * 1999-07-06 2001-01-22 Vertex Pharmaceuticals Incorporated Beta-amino acid derivatives for the treatment of neurological diseases
JP2003503480A (ja) * 1999-07-06 2003-01-28 バーテックス ファーマシューティカルズ インコーポレイテッド ニューロン活性を有するｎ−ヘテロ環誘導体
JP2004510684A (ja) 1999-07-06 2004-04-08 バーテックス　ファーマシューティカルズ　インコーポレイテッド 神経学的疾患の治療のためのアゾアミノ酸誘導体
WO2001009097A1 (en) * 1999-07-30 2001-02-08 Vertex Pharmaceuticals Incorporated Cyclic amine derivatives for the treatment of neurological diseases
JP2003505508A (ja) * 1999-07-30 2003-02-12 バーテックス ファーマシューティカルズ インコーポレイテッド 非環式又は環式アミド誘導体
EP1204657A1 (en) * 1999-08-18 2002-05-15 Schering Aktiengesellschaft Piperidine and pyrrolidine derivatives displaying neuronal activity
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
US6818643B1 (en) 1999-12-08 2004-11-16 Bristol-Myers Squibb Company Neurotrophic bicyclic diamides
AU1464101A (en) 1999-12-21 2001-07-03 Gpi Nil Holdings, Inc. Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same
JP2002068973A (ja) * 2000-06-16 2002-03-08 Meiji Milk Prod Co Ltd 幹細胞分化誘導促進剤
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US20040180880A1 (en) * 2002-10-03 2004-09-16 Lauffer David J. Piperazine and piperidine derivatives
WO2005033068A1 (en) * 2003-10-06 2005-04-14 Oy Juvantia Pharma Ltd Somatostatin receptor 1 and/or 4 selective agonists and antagonists
WO2005082401A1 (en) * 2004-02-20 2005-09-09 Rinat Neuroscience Corp. Methods of treating obesity or diabetes using nt-4/5
RU2008131939A (ru) * 2006-02-02 2010-02-10 Ринат Ньюросайенс Корп. (Us) Способы лечения нежелательной потери веса или нарушений приема пищи агонистами trkb
US7935342B2 (en) * 2006-02-02 2011-05-03 Rinat Neuroscience Corp. Methods for treating obesity by administering a trkB antagonist
US20100086997A1 (en) * 2006-12-20 2010-04-08 Rinat Enuroscience Corp TrkB Agonists for Treating Autoimmune Disorders
US9152929B2 (en) 2013-01-23 2015-10-06 Splunk Inc. Real time display of statistics and values for selected regular expressions
TWI744300B (zh) * 2016-03-23 2021-11-01 里爾中央醫學中心 改良性熱處理的血小板顆粒裂解液在製備用於治療神經系統疾病的組合物的用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992021313A2 (en) * 1991-05-24 1992-12-10 Vertex Pharmaceuticals Incorporated Novel immunosuppressive compounds
WO1994007858A1 (en) * 1992-09-28 1994-04-14 Vertex Pharmaceuticals Incorporated 1-(2-oxo-acetyl)-piperidine-2-carboxylic acid derivatives as multi-drug-resistent cancer cell sensitizers
WO1995026337A1 (en) * 1994-03-25 1995-10-05 Vertex Pharmaceuticals Incorporated Novel carbamates and ureas as modifiers of multi-drug resistance

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4792555A (en) * 1987-03-20 1988-12-20 American Home Products Corporation Phospholipase A2 inhibitors
US5686469A (en) * 1993-02-09 1997-11-11 Miles Inc. Aminomethylene derivaties as immunosuppressants
US5721256A (en) * 1997-02-12 1998-02-24 Gpi Nil Holdings, Inc. Method of using neurotrophic sulfonamide compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992021313A2 (en) * 1991-05-24 1992-12-10 Vertex Pharmaceuticals Incorporated Novel immunosuppressive compounds
WO1994007858A1 (en) * 1992-09-28 1994-04-14 Vertex Pharmaceuticals Incorporated 1-(2-oxo-acetyl)-piperidine-2-carboxylic acid derivatives as multi-drug-resistent cancer cell sensitizers
WO1995026337A1 (en) * 1994-03-25 1995-10-05 Vertex Pharmaceuticals Incorporated Novel carbamates and ureas as modifiers of multi-drug resistance

Also Published As

Publication number Publication date
CA2300134A1 (en) 1999-03-04
IS5379A (is) 2000-02-18
AU766579B2 (en) 2003-10-16
US20020013351A1 (en) 2002-01-31
JP2001514177A (ja) 2001-09-11
EP1007521A1 (en) 2000-06-14
NO321790B1 (no) 2006-07-03
PL195273B1 (pl) 2007-08-31
NZ502820A (en) 2002-10-25
US7109215B2 (en) 2006-09-19
NO20000953D0 (no) 2000-02-25
NO20000953L (no) 2000-05-02
ID23675A (id) 2000-05-11
CN1271354A (zh) 2000-10-25
BR9811923A (pt) 2000-08-15
TW570919B (en) 2004-01-11
IN191127B (enExample) 2003-09-27
PL338791A1 (en) 2000-11-20
AU8923698A (en) 1999-03-16
WO1999010340A1 (en) 1999-03-04
IL134536A0 (en) 2001-04-30
SG129998A1 (en) 2007-03-20

Similar Documents

Publication Publication Date Title
CN100436447C (zh) 具有神经原活性的化合物
KR100859758B1 (ko) 뉴런 활성을 가진 화합물
JP3476203B2 (ja) カルシトニン擬似体
EA003530B1 (ru) Способы и композиции для стимуляции роста невритов, использующие соединения с афинностью к fkbp12 в комбинации с нейротрофическими факторами
US6716860B2 (en) Azo amino acids derivatives
JP2007308517A (ja) ニューライトの成長を刺激するための方法および組成物
JP2011523647A (ja) カルシウムチャネルブロッカーとしてのｎ−ピペリジニルアセトアミド誘導体
JP2003503482A (ja) 環化アミノ酸誘導体
JP2005075832A (ja) 神経保護、抗うつおよび抗虚血活性を有する新規アダマンタン誘導体、およびその製造法
CN100395236C (zh) 用于治疗神经病的哌嗪和哌啶衍生物
US20040029912A1 (en) Bicyclic derivatives
JP2006504717A5 (enExample)
US6949655B2 (en) Acyclic piperidine derivatives
JP2003505508A (ja) 非環式又は環式アミド誘導体
JP2003506356A (ja) 神経学的疾患の治療のための環状アミン誘導体
JP2003503484A (ja) アミノアルキル誘導体
JP2003503479A (ja) Ｎ置換化グリシン誘導体
RS53456B (sr) Prolekovi [4[4-(5-aminometil-2-fluor-fenil)-piperidin-1-il]-(1h-pirolo-piridin-il)-metanona i njihova sinteza
JP2003503478A (ja) 神経学的疾患の治療のためのβ−アミノ酸誘導体
MXPA00002100A (en) Compounds possessing neuronal activity
AU2005202769A1 (en) Acyclic and Cyclic Amine Derivatives
AU2002344734A1 (en) Acylic piperazine and piperidine derivatives which are useful for treating neuronal damage

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1046947

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20081126

Termination date: 20100827