CA2300134A1 - Compounds possessing neuronal activity - Google Patents
Compounds possessing neuronal activity Download PDFInfo
- Publication number
- CA2300134A1 CA2300134A1 CA002300134A CA2300134A CA2300134A1 CA 2300134 A1 CA2300134 A1 CA 2300134A1 CA 002300134 A CA002300134 A CA 002300134A CA 2300134 A CA2300134 A CA 2300134A CA 2300134 A1 CA2300134 A1 CA 2300134A1
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- Prior art keywords
- straight
- substituted
- alkynyl
- alkyl
- branched alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92083897A | 1997-08-29 | 1997-08-29 | |
| US08/920,838 | 1997-08-29 | ||
| US09/085,441 US6268384B1 (en) | 1997-08-29 | 1998-05-27 | Compounds possessing neuronal activity |
| US09/085,441 | 1998-05-27 | ||
| PCT/US1998/017816 WO1999010340A1 (en) | 1997-08-29 | 1998-08-27 | Compounds possessing neuronal activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2300134A1 true CA2300134A1 (en) | 1999-03-04 |
Family
ID=26772724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002300134A Abandoned CA2300134A1 (en) | 1997-08-29 | 1998-08-27 | Compounds possessing neuronal activity |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7109215B2 (enExample) |
| EP (1) | EP1007521A1 (enExample) |
| JP (1) | JP2001514177A (enExample) |
| CN (1) | CN100436447C (enExample) |
| AU (1) | AU766579B2 (enExample) |
| BR (1) | BR9811923A (enExample) |
| CA (1) | CA2300134A1 (enExample) |
| ID (1) | ID23675A (enExample) |
| IL (1) | IL134536A0 (enExample) |
| IN (1) | IN191127B (enExample) |
| IS (1) | IS5379A (enExample) |
| NO (1) | NO321790B1 (enExample) |
| NZ (1) | NZ502820A (enExample) |
| PL (1) | PL195273B1 (enExample) |
| SG (1) | SG129998A1 (enExample) |
| TW (1) | TW570919B (enExample) |
| WO (1) | WO1999010340A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514686B2 (en) | 1997-04-28 | 2003-02-04 | The University Of British Columbia | Method and composition for modulating amyloidosis |
| US6331537B1 (en) | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
| HUP0102935A3 (en) * | 1998-06-03 | 2002-01-28 | Gpi Nil Holdings Inc Wilmingto | N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres and pharmaceutical compositions containing them |
| US6333340B1 (en) * | 1998-08-14 | 2001-12-25 | Gpi Nil Holdings, Inc. | Small molecule sulfonamides for vision and memory disorders |
| US6339101B1 (en) * | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
| US6300341B1 (en) * | 1998-09-30 | 2001-10-09 | The Procter & Gamble Co. | 2-substituted heterocyclic sulfonamides |
| JP2004510684A (ja) | 1999-07-06 | 2004-04-08 | バーテックス ファーマシューティカルズ インコーポレイテッド | 神経学的疾患の治療のためのアゾアミノ酸誘導体 |
| JP2003503480A (ja) * | 1999-07-06 | 2003-01-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | ニューロン活性を有するｎ−ヘテロ環誘導体 |
| JP2003503478A (ja) * | 1999-07-06 | 2003-01-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | 神経学的疾患の治療のためのβ−アミノ酸誘導体 |
| EP1207882A4 (en) * | 1999-07-30 | 2003-03-19 | Vertex Pharma | DERIVATIVES OF ACYCLIC AND CYCLIC AMINES |
| AU6076000A (en) * | 1999-07-30 | 2001-02-19 | Vertex Pharmaceuticals Incorporated | Cyclic amine derivatives for the treatment of neurological diseases |
| JP2003507376A (ja) * | 1999-08-18 | 2003-02-25 | シエーリング アクチエンゲゼルシャフト | 神経活性を示すピペリジンおよびピロリジン誘導体 |
| US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
| US6818643B1 (en) | 1999-12-08 | 2004-11-16 | Bristol-Myers Squibb Company | Neurotrophic bicyclic diamides |
| WO2001046195A1 (en) | 1999-12-21 | 2001-06-28 | Gpi Nil Holdings, Inc. | Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same |
| JP2002068973A (ja) * | 2000-06-16 | 2002-03-08 | Meiji Milk Prod Co Ltd | 幹細胞分化誘導促進剤 |
| US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| US6376514B1 (en) | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
| RU2005113247A (ru) * | 2002-10-03 | 2006-01-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Производные пиперазина и пиперидина для лечения неврологических заболеваний |
| WO2005033068A1 (en) * | 2003-10-06 | 2005-04-14 | Oy Juvantia Pharma Ltd | Somatostatin receptor 1 and/or 4 selective agonists and antagonists |
| BRPI0506793A (pt) * | 2004-02-20 | 2007-05-22 | Rinat Neuroscience Corp | métodos de tratamento de obesidade ou diabetes com o uso de nt-4/5 |
| JP2009525319A (ja) * | 2006-02-02 | 2009-07-09 | ライナット ニューロサイエンス コーポレイション | ｔｒｋＢアンタゴニストを投与することにより肥満を治療する方法 |
| AU2007210862A1 (en) * | 2006-02-02 | 2007-08-09 | Rinat Neuroscience Corp. | Methods for treating unwanted weight loss or eating disorders by administering a trkB agonist |
| CA2672750A1 (en) * | 2006-12-20 | 2008-07-03 | Rinat Neuroscience Corporation | Trkb agonists for treating autoimmune disorders |
| US9152929B2 (en) | 2013-01-23 | 2015-10-06 | Splunk Inc. | Real time display of statistics and values for selected regular expressions |
| TWI744300B (zh) * | 2016-03-23 | 2021-11-01 | 里爾中央醫學中心 | 改良性熱處理的血小板顆粒裂解液在製備用於治療神經系統疾病的組合物的用途 |
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| US4792555A (en) * | 1987-03-20 | 1988-12-20 | American Home Products Corporation | Phospholipase A2 inhibitors |
| MX9202466A (es) * | 1991-05-24 | 1994-06-30 | Vertex Pharma | Compuestos inmunosupresores novedosos. |
| NZ314207A (en) * | 1992-09-28 | 2000-12-22 | Vertex Pharma | 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers |
| US5686469A (en) * | 1993-02-09 | 1997-11-11 | Miles Inc. | Aminomethylene derivaties as immunosuppressants |
| US5744485A (en) * | 1994-03-25 | 1998-04-28 | Vertex Pharmaceuticals Incorporated | Carbamates and ureas as modifiers of multi-drug resistance |
| US5721256A (en) * | 1997-02-12 | 1998-02-24 | Gpi Nil Holdings, Inc. | Method of using neurotrophic sulfonamide compounds |
-
1998
- 1998-08-27 CA CA002300134A patent/CA2300134A1/en not_active Abandoned
- 1998-08-27 SG SG200201262-3A patent/SG129998A1/en unknown
- 1998-08-27 EP EP98941093A patent/EP1007521A1/en not_active Withdrawn
- 1998-08-27 NZ NZ502820A patent/NZ502820A/xx unknown
- 1998-08-27 CN CNB988093553A patent/CN100436447C/zh not_active Expired - Fee Related
- 1998-08-27 ID IDW20000402A patent/ID23675A/id unknown
- 1998-08-27 PL PL98338791A patent/PL195273B1/pl not_active IP Right Cessation
- 1998-08-27 IL IL13453698A patent/IL134536A0/xx active IP Right Grant
- 1998-08-27 BR BR9811923-0A patent/BR9811923A/pt not_active IP Right Cessation
- 1998-08-27 JP JP2000507669A patent/JP2001514177A/ja not_active Withdrawn
- 1998-08-27 WO PCT/US1998/017816 patent/WO1999010340A1/en not_active Ceased
- 1998-08-27 AU AU89236/98A patent/AU766579B2/en not_active Ceased
- 1998-08-28 TW TW087114310A patent/TW570919B/zh not_active IP Right Cessation
-
2000
- 2000-02-18 IS IS5379A patent/IS5379A/is unknown
- 2000-02-25 NO NO20000953A patent/NO321790B1/no not_active IP Right Cessation
- 2000-06-26 IN IN362CA2000 patent/IN191127B/en unknown
-
2001
- 2001-06-27 US US09/815,193 patent/US7109215B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20020013351A1 (en) | 2002-01-31 |
| US7109215B2 (en) | 2006-09-19 |
| CN1271354A (zh) | 2000-10-25 |
| CN100436447C (zh) | 2008-11-26 |
| BR9811923A (pt) | 2000-08-15 |
| TW570919B (en) | 2004-01-11 |
| NO20000953D0 (no) | 2000-02-25 |
| EP1007521A1 (en) | 2000-06-14 |
| SG129998A1 (en) | 2007-03-20 |
| IN191127B (enExample) | 2003-09-27 |
| ID23675A (id) | 2000-05-11 |
| IL134536A0 (en) | 2001-04-30 |
| AU8923698A (en) | 1999-03-16 |
| NZ502820A (en) | 2002-10-25 |
| NO20000953L (no) | 2000-05-02 |
| JP2001514177A (ja) | 2001-09-11 |
| NO321790B1 (no) | 2006-07-03 |
| IS5379A (is) | 2000-02-18 |
| WO1999010340A1 (en) | 1999-03-04 |
| PL195273B1 (pl) | 2007-08-31 |
| PL338791A1 (en) | 2000-11-20 |
| AU766579B2 (en) | 2003-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |