CN100418521C - 治疗骨质疏松的骨碎补提取物及其提取方法 - Google Patents
治疗骨质疏松的骨碎补提取物及其提取方法 Download PDFInfo
- Publication number
- CN100418521C CN100418521C CNB008201382A CN00820138A CN100418521C CN 100418521 C CN100418521 C CN 100418521C CN B008201382 A CNB008201382 A CN B008201382A CN 00820138 A CN00820138 A CN 00820138A CN 100418521 C CN100418521 C CN 100418521C
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- Prior art keywords
- extract
- alcohol
- group
- treatment
- resin
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
- A61K36/126—Drynaria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Extraction Or Liquid Replacement (AREA)
Abstract
Description
流速(ml/min) | 效果 | 废液中双氢黄酮 |
2 | 吸附完全 | - |
4 | 吸附完全 | - |
8 | 吸附不完全 | + |
16 | 吸附不完全 | + |
乙醇浓度(组别) | 0% | 50%(1%) | 70%(2) | 95(3) |
0 | 1.668 | 1.888 | 1.587 | |
总黄酮量(g) | 0 | 1.672 | 1.843 | 1.531 |
0 | 1.679 | 1.871 | 1.574 | |
X±SD | 0 | 1.673±0.006 | 1.876±0.023 | 1.564±0.024 |
组别 | 疗前 | 疗后3个月 | 疗后6个月 |
治疗组17 | 0.973±0.124 | 1.038±0.234 | 1.101±0.303 |
对照组17 | 0.958±0.180 | 0.954±0.179 | 0.958±0.145 |
组别 | 疗前 | 疗后3个月 | 疗后6个月 |
治疗组17 | 0.736±0.079 | 0.750±0.079** | 0.828±0.124** |
对照组17 | 0.748±0.095 | 0.744±0.100 | 0.744±0.093 |
组别 | 疗前 | 疗后3个月 | 疗后6个月 |
治疗组17 | 0.585±0.104 | 0.600±0.100* | 0.661±0.159**<sup>#</sup> |
对照组17 | 0.582±0.125 | 0.591±0.124 | 0.581±0.134 |
Claims (8)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2000/000739 WO2002053164A1 (fr) | 2000-12-29 | 2000-12-29 | Extraits de drynaria pour le traitement de l'osteoporose et leur procede d'extraction |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1484529A CN1484529A (zh) | 2004-03-24 |
CN100418521C true CN100418521C (zh) | 2008-09-17 |
Family
ID=4574762
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008201382A Expired - Fee Related CN100418521C (zh) | 2000-12-29 | 2000-12-29 | 治疗骨质疏松的骨碎补提取物及其提取方法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US7122214B2 (zh) |
JP (1) | JP5093965B2 (zh) |
KR (1) | KR100849253B1 (zh) |
CN (1) | CN100418521C (zh) |
HK (1) | HK1055895A1 (zh) |
WO (1) | WO2002053164A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105055462A (zh) * | 2015-08-11 | 2015-11-18 | 张宁 | 一种用于预防和治疗阿尔茨海默病的中药提取物及其应用 |
CN105147744A (zh) * | 2015-10-29 | 2015-12-16 | 北京岐黄制药有限公司 | 骨碎补及其提取物用于预防或治疗肺心病的用途 |
CN105193869A (zh) * | 2015-10-29 | 2015-12-30 | 北京岐黄制药有限公司 | 骨碎补及其提取物用于预防或治疗心衰的用途 |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5508264B2 (ja) | 2007-08-02 | 2014-05-28 | テースリー ファーマシューティカル グループ カンパニー リミテッド | 糖尿病治療のための医薬組成物およびその製造方法 |
CA2825918C (en) | 2011-02-15 | 2018-08-07 | Rotation Medical, Inc. | Methods and apparatus for delivering and positioning sheet-like materials |
CN102229684B (zh) * | 2011-05-11 | 2012-08-01 | 沧州宝恩吸附材料科技有限公司 | 一种分离纯化骨碎补总黄酮专用树脂的合成方法 |
KR101152753B1 (ko) * | 2011-12-30 | 2012-06-18 | 신준식 | 하르파고피툼근 추출물을 유효 성분으로 포함하는 골 대사성 질환의 예방 및 치료용 약학 조성물 |
KR102013457B1 (ko) * | 2012-08-13 | 2019-08-22 | 주식회사 알엔에스 | 에이엠피케이 활성화 효과를 가지는 조성물 |
US9044476B2 (en) | 2013-01-16 | 2015-06-02 | Taipei Medical University | Use of uraria in promoting osteogenesis or providing neuroprotection |
US10258459B2 (en) | 2014-05-09 | 2019-04-16 | Rotation Medical, Inc. | Medical implant delivery system and related methods |
JP2016190814A (ja) * | 2015-03-31 | 2016-11-10 | 株式会社東洋新薬 | カルシウム透過促進剤 |
JP7048025B2 (ja) * | 2017-03-03 | 2022-04-05 | 一正蒲鉾株式会社 | 骨代謝改善用組成物及び骨代謝改善用食品 |
CN108295245A (zh) * | 2018-04-10 | 2018-07-20 | 湖南科技学院 | 增加骨密度药及胶囊剂制备方法 |
CN108854140B (zh) * | 2018-06-01 | 2021-04-02 | 广东展翠食品股份有限公司 | 一种绿色高效萃取佛手黄酮的方法及佛手黄酮 |
CN110646528B (zh) * | 2019-09-16 | 2022-03-01 | 江阴天江药业有限公司 | 一种基于hplc/uplc-qtof-ms检测骨碎补中多成分的方法 |
CN112946111B (zh) * | 2021-01-29 | 2023-01-17 | 广东一方制药有限公司 | 骨碎补生品及其炮制品uplc指纹图谱构建及鉴别方法 |
CN116019847A (zh) * | 2022-12-29 | 2023-04-28 | 西安绿泉科技有限公司 | 一种骨碎补提取物的制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1116938A (zh) * | 1994-08-18 | 1996-02-21 | 龙勉 | 骨碎补有效成分的提取 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1034047C (zh) * | 1992-07-08 | 1997-02-19 | 山东农业大学 | 一种含灭多威的农药组合物 |
JP4082823B2 (ja) * | 1999-05-06 | 2008-04-30 | 日本メナード化粧品株式会社 | 光毒性抑制剤 |
-
2000
- 2000-12-29 KR KR1020037008536A patent/KR100849253B1/ko not_active IP Right Cessation
- 2000-12-29 WO PCT/CN2000/000739 patent/WO2002053164A1/zh active Application Filing
- 2000-12-29 US US10/451,966 patent/US7122214B2/en not_active Expired - Fee Related
- 2000-12-29 JP JP2002554113A patent/JP5093965B2/ja not_active Expired - Fee Related
- 2000-12-29 CN CNB008201382A patent/CN100418521C/zh not_active Expired - Fee Related
-
2003
- 2003-11-06 HK HK03108046.4A patent/HK1055895A1/xx not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1116938A (zh) * | 1994-08-18 | 1996-02-21 | 龙勉 | 骨碎补有效成分的提取 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105055462A (zh) * | 2015-08-11 | 2015-11-18 | 张宁 | 一种用于预防和治疗阿尔茨海默病的中药提取物及其应用 |
CN105147744A (zh) * | 2015-10-29 | 2015-12-16 | 北京岐黄制药有限公司 | 骨碎补及其提取物用于预防或治疗肺心病的用途 |
CN105193869A (zh) * | 2015-10-29 | 2015-12-30 | 北京岐黄制药有限公司 | 骨碎补及其提取物用于预防或治疗心衰的用途 |
Also Published As
Publication number | Publication date |
---|---|
CN1484529A (zh) | 2004-03-24 |
US20040048811A1 (en) | 2004-03-11 |
JP5093965B2 (ja) | 2012-12-12 |
KR20030072577A (ko) | 2003-09-15 |
US7122214B2 (en) | 2006-10-17 |
KR100849253B1 (ko) | 2008-07-29 |
JP2004521883A (ja) | 2004-07-22 |
WO2002053164A1 (fr) | 2002-07-11 |
HK1055895A1 (en) | 2004-01-30 |
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Owner name: BEIJING QIHUANG PHARMACEUTICAL CO., LTD.; APPLICA Free format text: FORMER OWNER: QIHUANG PHARMACEUTICAL INVESTMENT + RESEARCH CO., LTD.; APPLICANT Effective date: 20071221 |
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Effective date of registration: 20071221 Address after: Room 4, Room 408, building 13, Dongli 4, Bai Jia Zhuang, Chaoyang District, Beijing, China. Zip code: 100026 Applicant after: Beijing Qi Huang Pharmaceutical Co., Ltd. Co-applicant after: Xiyuan Hospital of China Academy of Chinese Medical Sciences Address before: Four floor, 13 East Building, Bai Jia Zhuang, Chaoyang District, Beijing, China. Zip code: 100026 Applicant before: Qi Huang pharmaceutical science and Technology Investment Co., Ltd. Co-applicant before: Xiyuan Hospital of China Academy of Chinese Medical Sciences |
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Address after: 101200 No. 17 South Street, Pinggu Town, Pinggu District, Beijing, Pinggu Patentee after: Beijing Qihuang pharmaceutical Limited by Share Ltd Patentee after: Xiyuan Hospital of China Academy of Chinese Medical Sciences Address before: Beijing, China Chaoyang District Bai Jia Zhuang East Lane 13, building 4, Room 408 Patentee before: BEIJING QIHUANG PHARMACEUTICAL MANUFACTURING CO., LTD. Patentee before: Xiyuan Hospital of China Academy of Chinese Medical Sciences |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080917 Termination date: 20181229 |
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CF01 | Termination of patent right due to non-payment of annual fee |