CN100412201C - 永久性羊水细胞系,其制备和用于制备基因转移载体的用途 - Google Patents

永久性羊水细胞系,其制备和用于制备基因转移载体的用途 Download PDF

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CN100412201C
CN100412201C CNB008159017A CN00815901A CN100412201C CN 100412201 C CN100412201 C CN 100412201C CN B008159017 A CNB008159017 A CN B008159017A CN 00815901 A CN00815901 A CN 00815901A CN 100412201 C CN100412201 C CN 100412201C
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adenovirus
cells
gene
vectors
vector
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CN1433476A (zh
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G·希德尔
史蒂芬·科全耐克
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Stefan Kochanek
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CNB008159017A 1999-11-18 2000-11-07 永久性羊水细胞系,其制备和用于制备基因转移载体的用途 Expired - Lifetime CN100412201C (zh)

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DE19955558A DE19955558C2 (de) 1999-11-18 1999-11-18 Permanente Amniozyten-Zelllinie, ihre Herstellung und Verwendung zur Herstellung von Gentransfervektoren
DE19955558.3 1999-11-18

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CN1433476A CN1433476A (zh) 2003-07-30
CN100412201C true CN100412201C (zh) 2008-08-20

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AT (1) ATE257512T1 (enExample)
AU (1) AU784003B2 (enExample)
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Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1528101A1 (en) * 2003-11-03 2005-05-04 ProBioGen AG Immortalized avian cell lines for virus production
ES2329607T3 (es) 2004-02-23 2009-11-27 Crucell Holland B.V. Metodos de purificacion de virus.
DK1869171T4 (en) 2005-04-11 2016-01-18 Crucell Holland Bv Virus cleaning using ultrafiltration
DE102005054628A1 (de) 2005-11-16 2007-05-24 Cevec Pharmaceuticals Gmbh Verfahren zur Herstellung von permanenten humanen Zelllinien
ES2755386T5 (es) 2006-08-28 2023-04-05 Ares Trading Sa Proceso para la purificación de proteínas que contienen fragmentos Fc
CA2742474C (en) 2008-11-03 2016-05-31 Crucell Holland B.V. Method for the production of adenoviral vectors
DE102009003439A1 (de) 2009-02-05 2010-08-26 Cevec Pharmaceuticals Gmbh Neue permanente humane Zelllinie
KR101805938B1 (ko) 2009-10-15 2018-01-10 얀센 백신스 앤드 프리벤션 비.브이. 고밀도 세포 배양액에서 아데노바이러스의 정제 방법
AU2010305765B2 (en) 2009-10-15 2015-07-02 Crucell Holland B.V. Method for the purification of adenovirus particles
JP5250155B2 (ja) 2010-02-15 2013-07-31 クルセル ホランド ベー ヴェー Ad26アデノウイルスベクターの製造方法
MX337687B (es) 2010-08-16 2016-03-15 Cevec Pharmaceuticals Gmbh Linea celular de amniocitos humanos permanente para la produccion de virus de influenza.
KR101427200B1 (ko) * 2011-11-24 2014-08-07 주식회사 바이로메드 아데노바이러스 생산 신규 세포주 및 그의 용도
CA2864956C (en) 2012-03-12 2021-11-09 Crucell Holland B.V. Batches of recombinant adenovirus with altered terminal ends
US8932607B2 (en) 2012-03-12 2015-01-13 Crucell Holland B.V. Batches of recombinant adenovirus with altered terminal ends
AP2014007993A0 (en) 2012-03-22 2014-10-31 Crucell Holland Bv Vaccine against RSV
EP2662451A1 (en) * 2012-05-07 2013-11-13 Stefan Kochanek Nucleic acid construct and use of the same
WO2014060594A1 (en) * 2012-10-19 2014-04-24 Cevec Pharmaceuticals Gmbh Production of a hcmv based vaccine in human amniocyte cell lines
EP2722337A1 (en) 2012-10-19 2014-04-23 CEVEC Pharmaceuticals GmbH Production of a HCMV based vaccine in human amniocyte cell lines
SG11201508567XA (en) 2013-04-25 2015-11-27 Crucell Holland Bv Stabilized soluble prefusion rsv f polypeptides
CN105408348B (zh) 2013-06-17 2021-07-06 扬森疫苗与预防公司 稳定化的可溶性融合前rsv f多肽
DE112014003136A5 (de) 2013-07-01 2016-04-21 Charité - Universitätsmedizin Berlin Immortalisierte humane Chorionzelllinie sowie Verfahren zur Immortalisierung humaner Chorionzellen
WO2016071306A1 (en) 2014-11-04 2016-05-12 Crucell Holland B.V. Therapeutic hpv16 vaccines
EP3042952A1 (en) 2015-01-07 2016-07-13 CEVEC Pharmaceuticals GmbH O-glycan sialylated recombinant glycoproteins and cell lines for producing the same
CN107466324B (zh) 2015-04-14 2022-01-14 扬森疫苗与预防公司 具有双向启动子的表达两种转基因的重组腺病毒
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US10457708B2 (en) 2015-07-07 2019-10-29 Janssen Vaccines & Prevention B.V. Stabilized soluble pre-fusion RSV F polypeptides
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BR112020004143A2 (pt) 2017-09-15 2020-09-01 Janssen Vaccines & Prevention B.V. método para a indução segura de imunidade contra vírus sincicial respiratório (rsv)
AU2018359492B2 (en) 2017-10-31 2023-12-14 Janssen Vaccines & Prevention B.V. Adenovirus and uses thereof
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US11236361B2 (en) 2017-10-31 2022-02-01 Janssen Vaccines & Prevention B.V. Adenovirus and uses thereof
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PH12021550974A1 (en) 2018-11-13 2022-05-02 Janssen Vaccines & Prevention Bv Stablized pre-fusion rsv f proteins
TWI852977B (zh) 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
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AU2020275910A1 (en) 2019-05-15 2021-11-04 Janssen Vaccines & Prevention B.V. Prophylactic treatment of respiratory syncytial virus infection with an adenovirus based vaccine
JP2022532723A (ja) 2019-05-15 2022-07-19 ヤンセン ファッシンズ アンド プリベンション ベーフェー 季節性インフルエンザワクチン及びアデノウイルス系呼吸器合胞体ウイルスワクチンの共投与
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WO2021165226A1 (en) 2020-02-17 2021-08-26 Biotest Ag Subcutaneous administration of factor viii
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EP4175664A2 (en) 2020-07-06 2023-05-10 Janssen Biotech, Inc. Prostate neoantigens and their uses
US20230035403A1 (en) 2020-07-06 2023-02-02 Janssen Biotech, Inc. Method For Determining Responsiveness To Prostate Cancer Treatment
CA3197730A1 (en) 2020-10-15 2022-04-21 F. Hoffman-La Roche Ag Nucleic acid constructs for va rna transcription
AU2021363098A1 (en) 2020-10-15 2023-05-18 F. Hoffmann-La Roche Ag Nucleic acid constructs for simultaneous gene activation
AU2022373653A1 (en) 2021-10-18 2024-05-02 Regeneron Pharmaceuticals, Inc. Eukaryotic cells comprising adenovirus-associated virus polynucleotides
WO2023198685A1 (en) 2022-04-13 2023-10-19 F. Hoffmann-La Roche Ag Method for determining aav genomes
CN119256220A (zh) 2022-05-23 2025-01-03 豪夫迈·罗氏有限公司 用于区分aav颗粒血清型和aav颗粒荷载状态的基于拉曼的方法
EP4532737A1 (en) 2022-06-03 2025-04-09 F. Hoffmann-La Roche AG Method for producing recombinant aav particles
WO2024013239A1 (en) 2022-07-14 2024-01-18 F. Hoffmann-La Roche Ag Method for producing recombinant aav particles
CA3264505A1 (en) 2022-09-12 2024-03-21 Hoffmann La Roche METHOD FOR SEPARING SOLID AND EMPTY VAA PARTICLES
IL322001A (en) 2023-02-07 2025-09-01 Hoffmann La Roche Method for detecting antibodies to anti-AAV particles
AU2024239386A1 (en) 2023-03-21 2025-08-14 F. Hoffmann-La Roche Ag Method for the production of recombinant aav particle preparations
CN117487761A (zh) * 2023-09-25 2024-02-02 南京农业大学 表达Cre基因猪骨髓巨噬细胞系的构建方法及其应用
WO2025158316A1 (en) 2024-01-26 2025-07-31 Janssen Biotech, Inc. Ovarian neoantigens and use thereof
WO2025168663A1 (en) 2024-02-09 2025-08-14 F. Hoffmann-La Roche Ag Method for producing recombinant adeno-associated viral particles

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997000326A1 (en) * 1995-06-15 1997-01-03 Introgene B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997000326A1 (en) * 1995-06-15 1997-01-03 Introgene B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy

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CZ300124B6 (cs) 2009-02-18
JP4456790B2 (ja) 2010-04-28
JP2003514526A (ja) 2003-04-22
PL357495A1 (en) 2004-07-26
CZ20021709A3 (cs) 2002-08-14
EP1230354A2 (de) 2002-08-14
EP1230354B1 (de) 2004-01-07
DE19955558C2 (de) 2003-03-20
CN1433476A (zh) 2003-07-30
WO2001036615A3 (de) 2002-01-10
CA2391591A1 (en) 2001-05-25
DE50004995D1 (de) 2004-02-12
PT1230354E (pt) 2004-04-30
IL149291A0 (en) 2002-11-10
HU227440B1 (en) 2011-06-28
CA2391591C (en) 2008-12-30
DE19955558A1 (de) 2001-06-07
AU1699001A (en) 2001-05-30
ES2211647T3 (es) 2004-07-16
DK1230354T3 (da) 2004-03-22
HUP0203387A3 (en) 2005-07-28
TR200400402T4 (tr) 2004-03-22
HUP0203387A2 (hu) 2002-12-28
PL205966B1 (pl) 2010-06-30
AU784003B2 (en) 2006-01-12
IL149291A (en) 2008-11-26
ATE257512T1 (de) 2004-01-15
WO2001036615A2 (de) 2001-05-25

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