CN100408556C - 通过阻断花生四烯酰乙醇酰胺的水解调节焦虑 - Google Patents
通过阻断花生四烯酰乙醇酰胺的水解调节焦虑 Download PDFInfo
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- CN100408556C CN100408556C CNB2003801052130A CN200380105213A CN100408556C CN 100408556 C CN100408556 C CN 100408556C CN B2003801052130 A CNB2003801052130 A CN B2003801052130A CN 200380105213 A CN200380105213 A CN 200380105213A CN 100408556 C CN100408556 C CN 100408556C
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
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GB9923738D0 (en) * | 1999-10-07 | 1999-12-08 | Nestle Sa | Nutritional composition |
US20050054730A1 (en) * | 2001-03-27 | 2005-03-10 | The Regents Of The University Of California | Compounds, compositions and treatment of oleoylethanolamide-like modulators of PPARalpha |
US7750030B2 (en) * | 2001-03-29 | 2010-07-06 | Michael Davis | Acute pharmacologic augmentation of psychotherapy with enhancers of learning or conditioning |
AU2003296895A1 (en) * | 2002-08-20 | 2004-05-04 | The Regents Of The University Of California | Combination therapy for controlling appetites |
MXPA05003715A (es) * | 2002-10-07 | 2005-09-30 | Univ California | Modulacion de ansiedad a traves de bloqueo de hidrolisis de anandamida. |
EP1608319A4 (en) * | 2003-04-03 | 2007-02-28 | Univ California | IMPROVED HEMMER FOR SOLUBLE EPOXY HYDROLASE |
EP1677780A4 (en) * | 2003-10-16 | 2007-05-02 | Univ California | DIETETIC COMPOSITIONS AND OTHER COMPOSITIONS, COMPOUNDS AND METHODS FOR ORGANIC LIPID REDUCTION, APPETILE CONTROL, AND METABOLISM MODULATION OF FATTY ACIDS |
FR2865205B1 (fr) * | 2004-01-16 | 2006-02-24 | Sanofi Synthelabo | Derives de type aryloxyalkylcarbamates, leur preparation et leur application en therapeutique |
FR2866886B1 (fr) * | 2004-02-26 | 2007-08-31 | Sanofi Synthelabo | Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique |
EP1765311A4 (en) | 2004-03-16 | 2009-04-29 | Univ California | REDUCTION OF NEPHROPATHY WITH INHIBITORS OF SOLUBLE EPOXY HYDROLASE AND EPOXYEICOSANOIDS |
ATE423093T1 (de) * | 2004-06-23 | 2009-03-15 | Hoffmann La Roche | Neue mao-b-hemmer |
US20060084659A1 (en) * | 2004-10-19 | 2006-04-20 | Michael Davis | Augmentation of psychotherapy with cannabinoid reuptake inhibitors |
AU2005295167B2 (en) * | 2004-10-20 | 2012-05-10 | The Regents Of The University Of California | Improved inhibitors for the soluble epoxide hydrolase |
KR100693528B1 (ko) * | 2004-10-29 | 2007-03-14 | 주식회사 팬택 | 전원 지연 인가 기능을 가지는 무선통신 단말기 |
CA2588607A1 (en) * | 2004-11-23 | 2006-06-01 | Ptc Therapeutics, Inc. | Carbazole, carboline and indole derivatives useful in the inhibition of vegf production |
KR101063663B1 (ko) | 2005-02-17 | 2011-09-07 | 아스텔라스세이야쿠 가부시키가이샤 | 피리딜 비방향족 질소 함유 헤테로환-1-카르복실산에스테르유도체 |
US20090082435A1 (en) * | 2005-04-28 | 2009-03-26 | The Regents Of The University Of California | Methods, Compositions, And Compounds For Modulation Of Monoacylglycerol Lipase, Pain, And Stress-Related Disorders |
EP1954137A4 (en) * | 2005-11-18 | 2008-12-17 | Janssen Pharmaceutica Nv | 2-KETO-OXAZOLE AS MODULATORS OF FATTY ACID AMIDHYDROLASE |
US20070155707A1 (en) * | 2005-12-29 | 2007-07-05 | Kadmus Pharmaceuticals, Inc. | Ionizable inhibitors of fatty acid amide hydrolase |
KR20080091132A (ko) * | 2005-12-29 | 2008-10-09 | 엔.브이.오가논 | 지방산 아미드 가수분해 효소의 억제제 |
WO2007106706A1 (en) * | 2006-03-10 | 2007-09-20 | Boehringer Ingelheim International Gmbh | Cyclic urea compounds as soluble epoxide hydrolase inhibitors effective for the treatment of cardiovascular disorders |
EP2023728A4 (en) * | 2006-05-26 | 2010-11-24 | Janssen Pharmaceutica Nv | OXAZOLYLPIPERIDINES AS MODULATORS OF FATTY ACID AMIDHYDROLASE |
WO2008021625A2 (en) * | 2006-08-18 | 2008-02-21 | N.V. Organon | Combination faah inhibitor and analgesic, anti-inflammatory or anti-pyretic agent |
US7888394B2 (en) * | 2006-08-21 | 2011-02-15 | N.V. Organon | Synthesis, polymorphs, and pharmaceutical formulation of FAAH inhibitors |
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US20080089845A1 (en) * | 2006-09-07 | 2008-04-17 | N.V. Organon | Methods for determining effective doses of fatty acid amide hydrolase inhibitors in vivo |
US20090099240A1 (en) * | 2006-10-02 | 2009-04-16 | N.V. Organon | Methods for treating energy metabolism disorders by inhibiting fatty acid amide hydrolase activity |
WO2008063714A1 (en) * | 2006-11-20 | 2008-05-29 | N.V. Organon | Metabolically-stabilized inhibitors of fatty acid amide hydrolase |
WO2008100977A2 (en) * | 2007-02-14 | 2008-08-21 | N.V. Organon | Carbamates therapeutic release agents as amidase inhibitors |
DE102007022007A1 (de) * | 2007-05-08 | 2008-11-13 | Schebo Biotech Ag | Neuartike Pharmazeutika, Verfahren zu ihrer Herstellung und ihre Verwendung in der Prophylaxe und Therapie von ZNS-Erkrankungen und Diabetes |
WO2008147553A1 (en) * | 2007-05-25 | 2008-12-04 | The Scripps Research Institute | Tetracyclic inhibitors of fatty acid amide hydrolase |
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US8207226B1 (en) | 2008-06-03 | 2012-06-26 | Alcon Research, Ltd. | Use of FAAH antagonists for treating dry eye and ocular pain |
TWI434842B (zh) | 2008-07-14 | 2014-04-21 | Astellas Pharma Inc | Azole compounds |
EP2351749A1 (en) | 2008-11-06 | 2011-08-03 | Astellas Pharma Inc. | Carbamate compound or salt thereof |
FR2938537B1 (fr) * | 2008-11-14 | 2012-10-26 | Sanofi Aventis | Derives de carbamates d'alkyl-heterocycles, leur preparation et leur application en therapeutique. |
CN102333568B (zh) * | 2008-12-24 | 2016-01-20 | 比亚尔-珀特拉和Ca股份公司 | 药物化合物 |
FR2941696B1 (fr) * | 2009-02-05 | 2011-04-15 | Sanofi Aventis | Derives d'azaspiranyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique |
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- 2003-10-07 CN CNB2003801052130A patent/CN100408556C/zh not_active Expired - Fee Related
- 2003-10-07 EA EA200500615A patent/EA010267B1/ru not_active IP Right Cessation
- 2003-10-07 US US10/681,858 patent/US7176201B2/en not_active Expired - Lifetime
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- 2003-10-07 CA CA2501506A patent/CA2501506C/en not_active Expired - Fee Related
- 2003-10-07 AU AU2003279877A patent/AU2003279877B2/en not_active Ceased
- 2003-10-07 UA UAA200504339A patent/UA80841C2/xx unknown
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- 2003-10-07 JP JP2004543510A patent/JP4515911B2/ja not_active Expired - Fee Related
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EP1558591A2 (en) | 2005-08-03 |
JP4515911B2 (ja) | 2010-08-04 |
WO2004033422A2 (en) | 2004-04-22 |
JP2006511484A (ja) | 2006-04-06 |
US20120010283A1 (en) | 2012-01-12 |
EP1558591B1 (en) | 2014-05-07 |
WO2004033422A3 (en) | 2004-07-29 |
AU2003279877A1 (en) | 2004-05-04 |
CN1729171A (zh) | 2006-02-01 |
EA010267B1 (ru) | 2008-06-30 |
US20090048337A1 (en) | 2009-02-19 |
AU2003279877B2 (en) | 2010-05-20 |
EP1558591A4 (en) | 2007-09-12 |
KR20050088992A (ko) | 2005-09-07 |
US20040127518A1 (en) | 2004-07-01 |
CA2501506C (en) | 2014-02-11 |
CA2501506A1 (en) | 2004-04-22 |
EA200500615A1 (ru) | 2005-10-27 |
US8003693B2 (en) | 2011-08-23 |
UA80841C2 (en) | 2007-11-12 |
MXPA05003715A (es) | 2005-09-30 |
US7176201B2 (en) | 2007-02-13 |
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