CN100391455C - 靛红和羟吲哚衍生物的制药用途 - Google Patents

靛红和羟吲哚衍生物的制药用途 Download PDF

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Publication number
CN100391455C
CN100391455C CNB998037249A CN99803724A CN100391455C CN 100391455 C CN100391455 C CN 100391455C CN B998037249 A CNB998037249 A CN B998037249A CN 99803724 A CN99803724 A CN 99803724A CN 100391455 C CN100391455 C CN 100391455C
Authority
CN
China
Prior art keywords
indole
phenyl
diketone
formula
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB998037249A
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English (en)
Chinese (zh)
Other versions
CN1292694A (zh
Inventor
J·拉马钱德兰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9801370A external-priority patent/SE9801370D0/xx
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1292694A publication Critical patent/CN1292694A/zh
Application granted granted Critical
Publication of CN100391455C publication Critical patent/CN100391455C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB998037249A 1998-03-06 1999-03-04 靛红和羟吲哚衍生物的制药用途 Expired - Fee Related CN100391455C (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
IN464/MAS/1998 1998-03-06
IN464/MAS/98 1998-03-06
IN464MA1998 1998-03-06
SE9801370A SE9801370D0 (sv) 1998-04-20 1998-04-20 New use
SE98013270-9 1998-04-20
SE980132709 1998-04-20
PCT/SE1999/000319 WO1999044608A1 (en) 1998-03-06 1999-03-04 New use

Publications (2)

Publication Number Publication Date
CN1292694A CN1292694A (zh) 2001-04-25
CN100391455C true CN100391455C (zh) 2008-06-04

Family

ID=26324794

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998037249A Expired - Fee Related CN100391455C (zh) 1998-03-06 1999-03-04 靛红和羟吲哚衍生物的制药用途

Country Status (13)

Country Link
US (1) US6906090B1 (enExample)
EP (1) EP1058548B1 (enExample)
JP (1) JP2002505286A (enExample)
KR (1) KR20010041625A (enExample)
CN (1) CN100391455C (enExample)
AT (1) ATE249828T1 (enExample)
AU (1) AU735381B2 (enExample)
BR (1) BR9908510A (enExample)
CA (1) CA2320757A1 (enExample)
DE (1) DE69911380T2 (enExample)
NO (1) NO20004419L (enExample)
NZ (1) NZ506217A (enExample)
WO (1) WO1999044608A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6380235B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Benzimidazolones and analogues
US6444668B1 (en) 1999-05-04 2002-09-03 Wyeth Combination regimens using progesterone receptor modulators
US6498154B1 (en) 1999-05-04 2002-12-24 Wyeth Cyclic regimens using quinazolinone and benzoxazine derivatives
US6306851B1 (en) 1999-05-04 2001-10-23 American Home Products Corporation Cyclocarbamate and cyclic amide derivatives
US6339098B1 (en) 1999-05-04 2002-01-15 American Home Products Corporation 2,1-benzisothiazoline 2,2-dioxides
US6417214B1 (en) 1999-05-04 2002-07-09 Wyeth 3,3-substituted indoline derivatives
US6369056B1 (en) 1999-05-04 2002-04-09 American Home Products Corporation Cyclic urea and cyclic amide derivatives
US6355648B1 (en) 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
US6423699B1 (en) 1999-05-04 2002-07-23 American Home Products Corporation Combination therapies using benzimidazolones
US6329416B1 (en) 1999-05-04 2001-12-11 American Home Products Corporation Combination regimens using 3,3-substituted indoline derivatives
US6358948B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
US6391907B1 (en) * 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
US6358947B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Tetracyclic progesterone receptor modulator compounds and methods
US6462032B1 (en) 1999-05-04 2002-10-08 Wyeth Cyclic regimens utilizing indoline derivatives
US6380178B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Cyclic regimens using cyclocarbamate and cyclic amide derivatives
US6399593B1 (en) 1999-05-04 2002-06-04 Wyeth Cyclic regimens using cyclic urea and cyclic amide derivatives
US6319912B1 (en) 1999-05-04 2001-11-20 American Home Products Corporation Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides
US6509334B1 (en) 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
US6407101B1 (en) 1999-05-04 2002-06-18 American Home Products Corporation Cyanopyrroles
US6372752B1 (en) * 2000-02-07 2002-04-16 Genzyme Corporation Inha inhibitors and methods of use thereof
UA73119C2 (en) 2000-04-19 2005-06-15 American Home Products Corpoir Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
CN101863823B (zh) * 2010-06-03 2012-02-08 山东大学 吲哚二酮类化合物及其扩环衍生物、制备方法及应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1079464A (zh) * 1991-12-18 1993-12-15 阿斯特拉公司 治疗包括胆碱能功能降低的病症有价值的吲哚酮和吲哚二酮的衍生物的制备方法
CN1083061A (zh) * 1992-08-26 1994-03-02 美国辉瑞有限公司 制备芳基哌嗪基-杂环化合物的方法
WO1994029272A1 (en) * 1993-06-16 1994-12-22 Astra Aktiebolag 1-substituted isatin and oxindole derivatives as inhibitors of acetylcholinesterase
CN1097740A (zh) * 1993-01-26 1995-01-25 美国辉瑞有限公司 3-酰基-2-羟吲哚-1-甲酰胺类抗炎前药

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR65270B (en) * 1978-10-10 1980-07-31 Fujisawa Pharmaceutical Co Isatin derivatives and processes for the preparation thereof
IE69677B1 (en) 1989-12-11 1996-10-02 Neurosearch As Isatine derivatives their preparation and use
US5164404A (en) 1991-03-15 1992-11-17 Neurosearch A/S Hydrazone derivatives and their use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1079464A (zh) * 1991-12-18 1993-12-15 阿斯特拉公司 治疗包括胆碱能功能降低的病症有价值的吲哚酮和吲哚二酮的衍生物的制备方法
CN1083061A (zh) * 1992-08-26 1994-03-02 美国辉瑞有限公司 制备芳基哌嗪基-杂环化合物的方法
CN1097740A (zh) * 1993-01-26 1995-01-25 美国辉瑞有限公司 3-酰基-2-羟吲哚-1-甲酰胺类抗炎前药
WO1994029272A1 (en) * 1993-06-16 1994-12-22 Astra Aktiebolag 1-substituted isatin and oxindole derivatives as inhibitors of acetylcholinesterase

Also Published As

Publication number Publication date
NO20004419L (no) 2000-10-20
US6906090B1 (en) 2005-06-14
AU2757399A (en) 1999-09-20
DE69911380T2 (de) 2004-07-01
DE69911380D1 (de) 2003-10-23
CA2320757A1 (en) 1999-09-10
JP2002505286A (ja) 2002-02-19
ATE249828T1 (de) 2003-10-15
AU735381B2 (en) 2001-07-05
NO20004419D0 (no) 2000-09-05
NZ506217A (en) 2002-05-31
EP1058548A1 (en) 2000-12-13
WO1999044608A1 (en) 1999-09-10
EP1058548B1 (en) 2003-09-17
KR20010041625A (ko) 2001-05-25
CN1292694A (zh) 2001-04-25
BR9908510A (pt) 2000-11-21
WO1999044608A8 (en) 2005-01-06
HK1030885A1 (en) 2001-05-25

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20080604

Termination date: 20100304