CN100378079C - 用于制备17-烯丙基氨基格尔德霉素(17-aag)以及其它袢霉素的方法 - Google Patents

用于制备17-烯丙基氨基格尔德霉素(17-aag)以及其它袢霉素的方法 Download PDF

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Publication number
CN100378079C
CN100378079C CNB028187180A CN02818718A CN100378079C CN 100378079 C CN100378079 C CN 100378079C CN B028187180 A CNB028187180 A CN B028187180A CN 02818718 A CN02818718 A CN 02818718A CN 100378079 C CN100378079 C CN 100378079C
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China
Prior art keywords
allylaminogeldanamycin
solvent
ansamycins
volatile
aag
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Expired - Fee Related
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CNB028187180A
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English (en)
Chinese (zh)
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CN1558757A (zh
Inventor
张琳
马库斯·F·贝姆
西埃德·塞加
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Conforma Therapeutics Corp
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Conforma Therapeutics Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CNB028187180A 2001-09-24 2002-09-18 用于制备17-烯丙基氨基格尔德霉素(17-aag)以及其它袢霉素的方法 Expired - Fee Related CN100378079C (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US32663901P 2001-09-24 2001-09-24
US60/326,639 2001-09-24
US33189301P 2001-11-21 2001-11-21
US60/331,893 2001-11-21
PCT/US2002/029715 WO2003026571A2 (en) 2001-09-24 2002-09-18 Process for preparing 17-allyl amino geldanamycin (17-aag) and other ansamycins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2008100062587A Division CN101230040A (zh) 2001-09-24 2002-09-18 用于制备17-烯丙基氨基格尔德霉素(17-aag)以及其它袢霉素的方法

Publications (2)

Publication Number Publication Date
CN1558757A CN1558757A (zh) 2004-12-29
CN100378079C true CN100378079C (zh) 2008-04-02

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ID=26985493

Family Applications (1)

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CNB028187180A Expired - Fee Related CN100378079C (zh) 2001-09-24 2002-09-18 用于制备17-烯丙基氨基格尔德霉素(17-aag)以及其它袢霉素的方法

Country Status (9)

Country Link
US (1) US7579462B2 (cg-RX-API-DMAC7.html)
EP (1) EP1435939B1 (cg-RX-API-DMAC7.html)
JP (1) JP2005504086A (cg-RX-API-DMAC7.html)
KR (1) KR20040054692A (cg-RX-API-DMAC7.html)
CN (1) CN100378079C (cg-RX-API-DMAC7.html)
AT (1) ATE387198T1 (cg-RX-API-DMAC7.html)
CA (1) CA2460498A1 (cg-RX-API-DMAC7.html)
DE (1) DE60225307T2 (cg-RX-API-DMAC7.html)
WO (1) WO2003026571A2 (cg-RX-API-DMAC7.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872715B2 (en) 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
JP2005504086A (ja) 2001-09-24 2005-02-10 コンフォーマ セラピューティクス コーポレーション １７−アリルアミノゲルダナマイシン（１７−ａａｇ）および他のアンサマイシン類を製造する方法
EP2336133A1 (en) 2001-10-30 2011-06-22 Conforma Therapeutics Corporation Purine analogs having HSP90-inhibiting activity
EP1472230B1 (en) 2002-02-08 2009-06-17 Conforma Therapeutic Corporation Ansamycins having improved pharmacological and biological properties
MXPA06002997A (es) 2003-09-18 2007-02-08 Conforma Therapeutics Corp Novedosos compuestos heterociclicos como inhibidores- hsp90.
RU2484086C9 (ru) 2003-12-23 2013-08-20 Инфинити Дискавэри, Инк. Аналоги бензохинонсодержащих ансамицинов (варианты), способ их получения, фармацевтическая композиция (варианты) и способ лечения рака (варианты)
KR101045324B1 (ko) * 2004-08-11 2011-06-30 한국생명공학연구원 젤다나마이신 유도체 및 그 생합성 방법
US7371906B2 (en) * 2004-08-24 2008-05-13 Eastman Kodak Company Process for photo-oxidative stability improvements
CN105688289A (zh) * 2005-02-18 2016-06-22 阿布拉西斯生物科学公司 用于整合入医疗装置的疏水性改善的药物
BRPI0609509A2 (pt) 2005-03-30 2010-04-13 Conforma Therapeutics Corp composto ou um polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto, polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável
CA2603462A1 (en) * 2005-04-07 2006-10-09 Conforma Therapeutics Corporation Phospholipid-based pharmaceutical formulations and methods for producing and using same
US7648976B2 (en) * 2005-11-23 2010-01-19 Bristol-Myers Squibb Company 17-allylamino-17-demethoxygeldanamycin polymorphs and formulations
US20090042847A1 (en) * 2005-11-23 2009-02-12 Kosan Biosciences Incorporated 17-allylamino-17-demethoxygeldanamycin polymorphs and formulations
EP1954265A2 (en) * 2005-12-01 2008-08-13 Conforma Therapeutics Corporation Compositions containing ansamycin
KR100796637B1 (ko) * 2006-09-29 2008-01-22 한국생명공학연구원 젤다나마이신 유도체, 이의 약학적으로 허용가능한 염,이의 제조방법 및 이를 유효성분으로 함유하는 암 예방 및치료제
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
PE20081506A1 (es) * 2006-12-12 2008-12-09 Infinity Discovery Inc Formulaciones de ansamicina
KR100861697B1 (ko) * 2007-01-30 2008-10-07 한국생명공학연구원 Ａｈｂａ 생합성 유전자 변이주를 이용한 안사마이신유도체의 생산 방법 및 신규한 안사마이신 유도체
KR20110090925A (ko) 2008-10-15 2011-08-10 인피니티 파마슈티컬스, 인코포레이티드 안사마이신 하이드로퀴논 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261989A (en) * 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug
WO1995001342A1 (en) * 1993-06-29 1995-01-12 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3595955A (en) * 1969-03-26 1971-07-27 Upjohn Co Geldanamycin and process for producing same
HU9401936D0 (en) 1992-01-06 1994-09-28 Pfizer Process and uses for 4,5-diohydrogeldanamycin and its hydroquinone
US5387584A (en) * 1993-04-07 1995-02-07 Pfizer Inc. Bicyclic ansamycins
US5932566A (en) * 1994-06-16 1999-08-03 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents
US5883236A (en) * 1997-11-19 1999-03-16 Abbott Laboratories Process for N-desmethylating erythromycins and derivatives thereof
JP2002541255A (ja) 1999-04-09 2002-12-03 スローン − ケッタリング インスティチュート フォー キャンサー リサーチ Ｈｅｒ族チロシンキナーゼの分解および／または阻害方法および組成物
JP2005504086A (ja) 2001-09-24 2005-02-10 コンフォーマ セラピューティクス コーポレーション １７−アリルアミノゲルダナマイシン（１７−ａａｇ）および他のアンサマイシン類を製造する方法
EP1923061A1 (en) 2001-09-24 2008-05-21 Conforma Therapeutic Corporation Process for preparing 17-Allyl amino geldanamycin (17-AAG) and other ansamycins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261989A (en) * 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug
WO1995001342A1 (en) * 1993-06-29 1995-01-12 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents

Also Published As

Publication number Publication date
DE60225307T2 (de) 2009-03-19
US20050176695A1 (en) 2005-08-11
US7579462B2 (en) 2009-08-25
KR20040054692A (ko) 2004-06-25
CA2460498A1 (en) 2003-04-03
EP1435939B1 (en) 2008-02-27
ATE387198T1 (de) 2008-03-15
WO2003026571A2 (en) 2003-04-03
JP2005504086A (ja) 2005-02-10
EP1435939A4 (en) 2004-12-29
DE60225307D1 (de) 2008-04-10
EP1435939A2 (en) 2004-07-14
WO2003026571A3 (en) 2003-10-02
CN1558757A (zh) 2004-12-29

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Granted publication date: 20080402

Termination date: 20091019