CN100372534C - 托拉塞米冻干制剂及制备方法 - Google Patents
托拉塞米冻干制剂及制备方法 Download PDFInfo
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- CN100372534C CN100372534C CNB2006100396930A CN200610039693A CN100372534C CN 100372534 C CN100372534 C CN 100372534C CN B2006100396930 A CNB2006100396930 A CN B2006100396930A CN 200610039693 A CN200610039693 A CN 200610039693A CN 100372534 C CN100372534 C CN 100372534C
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- torasemide
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Abstract
Description
托拉塞米:碳酸氢钠(重量比) | 3∶1 | 2∶1 | 1∶1 | 1∶2 | 1∶5 | 1∶7 | 1∶9 | 1∶9.5 | 1∶10 |
冻干前冻干后 | 9.099.68 | 9.169.71 | 9.219.23 | 9.089.10 | 9.119.23 | 9.159.31 | 9.169.34 | 9.189.82 | 9.159.65 |
影响因素 | 放置时间(天) | 性状 | 溶液的澄清度与颜色 | 水分(%) | 碱度 | 有关物质(%) | 含量里(%) | |
单个杂质峰 | 杂质峰之和 | |||||||
强光(4500Lx) | 0 | 类白色疏松块状物 | 符合规定 | 5.58 | 9.19 | 均小于0.5% | 0.45 | 99.6 |
510 | 类白色疏松块状物类白色疏松块状物 | 符合规定符合规定 | 5.755.73 | 9.219.19 | 均小于0.5%均小于0.5% | 0.490.50 | 99.699.5 | |
高温60℃ | 051010 | 类白色疏松块状物类白色疏松块状物类白色疏松块状物 | 符合规定符合规定符合规定 | 5.585.655.68 | 9.199.199.26 | 均小于0.5%均小于0.5%均小于0.5% | 0.450.490.56 | 99.699.399.3 |
低温4℃ | 0510 | 类白色疏松块状物类白色疏松块状物类白色疏松块状物 | 符合规定符合规定符合规定 | 5.585.705.72 | 9.199.169.21 | 均小于0.5%均小于0.5%均小于0.5% | 0.450.500.50 | 99.699.599.7 |
Claims (8)
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CNB2006100396930A CN100372534C (zh) | 2006-04-20 | 2006-04-20 | 托拉塞米冻干制剂及制备方法 |
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CNB2006100396930A CN100372534C (zh) | 2006-04-20 | 2006-04-20 | 托拉塞米冻干制剂及制备方法 |
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CN1833642A CN1833642A (zh) | 2006-09-20 |
CN100372534C true CN100372534C (zh) | 2008-03-05 |
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Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102512360B (zh) * | 2011-12-09 | 2014-06-25 | 天津市汉康医药生物技术有限公司 | 稳定安全的供注射用托拉塞米药物组合物 |
CN102579349B (zh) * | 2012-03-02 | 2013-01-23 | 海南美大制药有限公司 | 一种托拉塞米脂质体注射剂 |
CN103242227B (zh) * | 2013-04-24 | 2015-05-13 | 北京康瑞达彤医药科技有限公司 | 一种托拉塞米化合物及其药物组合物 |
CN105997860B (zh) * | 2016-07-09 | 2021-03-09 | 南京臣功制药股份有限公司 | 一种托拉塞米注射液及其制备方法 |
CN109200022B (zh) * | 2017-06-29 | 2021-09-10 | 南京优科生物医药研究有限公司 | 一种注射用托拉塞米及其制备工艺 |
CN111568868B (zh) * | 2020-06-24 | 2022-04-19 | 福州华为医药技术开发有限公司 | 注射用托拉塞米的制备方法 |
CN114376969A (zh) * | 2020-10-19 | 2022-04-22 | 南京济群医药科技股份有限公司 | 一种托拉塞米注射液及其制备方法 |
CN112168776B (zh) * | 2020-10-30 | 2022-05-03 | 康普药业股份有限公司 | 一种低杂质高稳定的托拉塞米注射液和制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3241765A1 (de) * | 1982-11-11 | 1984-05-17 | Henning Berlin Gmbh Chemie- Und Pharmawerk, 1000 Berlin | Stabile zubereitungen fuer injektionszwecke enthaltend hydrochlorothiazid |
US4861786A (en) * | 1986-07-12 | 1989-08-29 | Boehringer Mannheim Gmbh | Composition for a stable vein compatible injectable solution of torasemide process for the preparation and method of use |
CN1477977A (zh) * | 2000-11-10 | 2004-02-25 | ������ҩ�﹤ҵ��˾ | N-(甲基乙基氨基羰基)-4-(3-甲基苯基氨基)-3-吡啶基磺酰胺及环状低聚糖的组合物 |
CN1505512A (zh) * | 2000-02-17 | 2004-06-16 | ������ҩ��ҵ����˾ | 包含托塞米变型ⅱ的稳定药物制剂 |
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2006
- 2006-04-20 CN CNB2006100396930A patent/CN100372534C/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3241765A1 (de) * | 1982-11-11 | 1984-05-17 | Henning Berlin Gmbh Chemie- Und Pharmawerk, 1000 Berlin | Stabile zubereitungen fuer injektionszwecke enthaltend hydrochlorothiazid |
US4861786A (en) * | 1986-07-12 | 1989-08-29 | Boehringer Mannheim Gmbh | Composition for a stable vein compatible injectable solution of torasemide process for the preparation and method of use |
CN1505512A (zh) * | 2000-02-17 | 2004-06-16 | ������ҩ��ҵ����˾ | 包含托塞米变型ⅱ的稳定药物制剂 |
CN1477977A (zh) * | 2000-11-10 | 2004-02-25 | ������ҩ�﹤ҵ��˾ | N-(甲基乙基氨基羰基)-4-(3-甲基苯基氨基)-3-吡啶基磺酰胺及环状低聚糖的组合物 |
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Address after: 210046 Jiangsu city of Nanjing Province Economic and Technological Development Zone HENGFA Road No. 1 Nanjing hicin pharmaceutical Limited by Share Ltd Patentee after: Nanjing hicin pharmaceutical Limited by Share Ltd Address before: 210046 Jiangsu province Nanjing HENGFA economic and Technological Development Zone, Road No. 1 Patentee before: Haichen Pharmaceutical Co., Ltd., Nanjing |