CN100360147C - Medicinal composition, and its pharmaceutical use - Google Patents
Medicinal composition, and its pharmaceutical use Download PDFInfo
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- CN100360147C CN100360147C CNB2005100121581A CN200510012158A CN100360147C CN 100360147 C CN100360147 C CN 100360147C CN B2005100121581 A CNB2005100121581 A CN B2005100121581A CN 200510012158 A CN200510012158 A CN 200510012158A CN 100360147 C CN100360147 C CN 100360147C
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Abstract
The present invention provides medical composition. The present invention is made from the material medicine of 10 to 30 shares of garden balsam stems, 2 to 20 shares of ledebouriella roots, 2 to 20 shares of angelica, 1 to 15 shares of logwood, 2 to 20 shares of radix cyathulae, 2 to 20 shares of cassia twigs, 10 to 30 shares of mulberry twigs, 2 to 20 shares of herba schizonepetae, and 1 to 15 shares of safflowers according to weight shares. The present invention also provides the application of the medical composition in medicine preparation for curing light sensitive dermatosis, hyperlipoidemia, apoplexy hemiplegia or rheumatism.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, relate in particular to a kind of pharmaceutical composition that prevents and/or treats heliosensitivity skin that comprises Chinese medicine.
The invention still further relates to the application of this pharmaceutical composition in preparation treatment light sensitive dermatoses medicine.
The invention still further relates to the application of this pharmaceutical composition in preparation treatment hyperlipemia or its relevant disease medicine.
The invention still further relates to the application of this pharmaceutical composition in preparation treatment apoplectic hemiplegia medicine.
The invention still further relates to the application of this pharmaceutical composition in preparation treatment rheumatism medicine.
Background technology
Human body needs sunlight, because the action of ultraviolet radiation in the daylight behind health, can make child's skeleton solid, in vigorous health; Can improve oxygen content in the cell to the adult, blood sugar lowering and cholesterol amount improve the vigor of life.But human body stands sunlight exposure, shines for a long time, will make skin causalgia, redness occur, even erythema, dermatitis occur, also has diseases such as canceroderm, and particularly the performance of ultraviolet allergy sufferers is even more serious.Along with the minimizing of atmospheric ozone layer and the increase of ultraviolet irradiation, crowd hypersensitive increases gradually to ultraviolet, and the various diseases that is brought out by ultraviolet allergy also increases to some extent.Skin can produce the series of biological variation behind the ultraviolet radiation, quicken as epidermis cell division and basal cell propagation, and acanthosis, degeneration such as corium elastosis change.The long-term serious change that caused by sun exposure of skin claims photoaging.Its Clinical symptoms is that pachyderma wrinkles more, yellow tuberosity and telangiectasis occur, and is different from lax, the dermatoglyph intensification of natural aging-atrophoderma, attenuation of skin.
The various pathological changes that on skin, cause because of daylight or other irradiate light or make it to aggravate be referred to as light dermatoses (photodermatoses), comprise that the light sensitive dermatoses of common indication and some only are the dermatosiss that takes place, inspires or increase the weight of for light in the evolution at it.
Photosensitivity reaction can be divided into phototoxic reaction and photoallergy two classes by its mechanism of action.Even can changing simultaneously, both exist.Acute person such as sunburn, phototoxic contact dermatitis in the phototoxic reaction, chronic person such as porphyria, actinic elastosis; Anaphylactic type such as solar urticaria in the photoallergy, delayed such as polymorphous light eruption, heliosensitivity contact dermatitis etc.No matter be phototoxic reaction or photoallergy, all skin and even the body to the people produces the injury that weight does not wait, and associated diseases is referred to as the light dermatoses.The light dermatoses that summer is more common mainly contains sunburn, photosensitive dermatitis, pleiomorphism daylight rash.
Light sensitive dermatoses is promptly to the irritated caused dermatosis of multiple light.What see at most is that sight ultraviolet B radiation (wavelength 280-320nm) is taken place: reaction, and make epithelial cell biomembrane lipid cross itching, sumptuous function is impaired, DNA damage, gene mutation causes dermatosis.This class disease has: solar dermatitis, polymorphous light eruption, Phytophotodermatitis etc.This type of disease has the advantages that spring and summer is heavy, the autumn and winter alleviate or disappear, and about 15% patient has the photaesthesia family history.The traditional Chinese medical science claims that this type of disease is the Exposure to Sunlight rash, and how because of not anti-, the plain body retention of damp-heat in the interior of natural endowment, the heresy of feeling wind heat again causes the rheumatism heat stagnation and forms in skin.
After solar dermatitis (send out patient in the majority with young and middle-aged women) serve as contact daylight, edematous erythema, pimple etc. appearred in the skin exposure portion, with obvious pruritus, two season of spring and summer serious symptom, autumn and winter season remission or disappear, so annual, show effect repeatedly.Year in year out, skin lesion progressive additive, coarse, cutaneous pigmentation, even can involve the non-exposure portion of skin.
Polymorphous light eruption is a kind of tardy property sensitivity response of skin to sun exposure (mainly being the ultraviolet B radiation of wavelength 290～320nm).Infringement is pleomorphism, shows effect in exposure portion repeatedly.
Computer is very big to skin lethality at the static that open state produces.In addition, radiation injury skin and eyes that computer produces cause eyes dry and astringent, and black eye generate and increase the weight of gradually, and skin is dry, and also might cause light sensitive dermatoses---and little erythema or erythema appear on the skin.
Hyperlipemia (HLP) be dyslipidemia be used to claim, just to suffer from hyperlipemia if meet in following four one or several: total plasma cholesterol too high (〉=220mg%, 5.72mmol/L); Plasma triglyceride too high (〉=150mg%, 1.70mmol/L); Low-density lipoprotein cholesterol too high (〉=140mg%, 3.64mmol/L); HDL-C low excessively (≤35mg%, 0.91mmol/L; ).
Hyperlipemia can be divided into Primary hyperlipemia, and patient's lipid metabolism is obstacle and the environmental factors dyslipidemia that interacts and cause for genetic reasons; The Secondary cases hyperlipemia, because other disease, the dyslipidemia that causes as diseases such as diabetes, thyroid function deficiency, obstructive hepatopathys.
Cardiovascular and cerebrovascular disease mainly comes from atherosclerosis, and the atherosclerosis more than 80% is caused by hyperlipemia.Hyperlipemia have a three-to-four-fold that rate is the cardiovascular and cerebrovascular disease patient that made a definite diagnosis.Hyperlipemia and atherosclerosis may not have uncomfortable symptom in early days in morbidity, and most of patients is just found dyslipidemia after coronary heart disease, apoplexy have taken place, and can show as dizziness, headache, uncomfortable in chest, pained, weak etc.Hyperlipemia is to cause atherosclerotic key factor, too much lipidosis is in endarterium, inner membrance fibrous connective tissue hypertrophy, localized thickening, form atheromatous plaque, speckle increases or increases makes the tube wall sclerosis, and tube chamber dwindles or be inaccessible, cause blood supply position ischemic lesions, each organ dysfunction finally takes place.Hyperlipemia can cause coronary heart disease (comprising angina pectoris, myocardial infarction, arrhythmia, sudden cardiac arrest etc.), cerebral thrombosis (hemiplegia, aphasia, disturbance of consciousness, dysphagia even life danger), renal hypertension, renal failure, visual deterioration, blind etc.Wherein coronary heart disease has become the leader of all kinds of deadly diseases, and its mortality rate surpasses the summation of all disease death rates.Confirm that through long-term scientific experimentation when serum TC is higher than 220mg%, raise with cholesterol concentration, Incidence of CHD linearly rises, and the every decline 1% of serum TC, Incidence of CHD descends 2%.
Rheumatism belongs to the category of the traditional Chinese medical science " numbness disease ".Also claim " numbness ", " arthromyodynia " etc., because human righteousness's deficiency, the damp and hot exopathogen that waits of wind and cold is attacked; Or interior living phlegm-damp, pyretic toxicity, blood stasis cause the passages through which vital energy circulates retardance, occur with limbs joint, myalgia weight person, and numb swelling, joint stuffiness, even joint deformity, or involve the general name that internal organs are a class disease of feature.Rheumatism mainly comprises rheumatic arthritis, rheumatoid arthritis, proliferative arthritis, polyarteritis nodosa, ankylosing spondylitis, systemic lupus erythematosus (sle), Lei Te (Reiter) syndrome, psoriasis arthropathica, gout and chondrocalcinosis, systemic sclerosis, dermatomyositis, dry syndrome, enteritis arthritis, behcets disease, anaphylactoid purpura, mixed connective tissue disease etc.
" apoplexy " is a name of disease of Chinese medicine, also is the general designations of people to acute cerebrovascular disease.The traditional Chinese medical science is thought six big paathogenic factors, i.e. " wind, cold, summer-heat, wet, dry, fire ", also title " six climate exopathogens ".Wherein, the disease due to the endogenous wind, promptly multiclass belongs to apoplexy.Apoplexy is with sudden faint, unconscious, and the facial hemiparalysis that occurs together, dysphonia, hemiplegia etc. are principal character.The cerebral hemorrhage that modern doctor trained in Western medicine refers to, subarachnoid hemorrhage, cerebral infarction, cerebral thrombosis, transient ischemic attack etc. also belong to the apoplexy category.Because of this disease onset rapidly, break with tremendous force, similar to the characteristics of natural " wind ", so be called " apoplexy "." apoplexy " speech sees the medical science monograph Huangdi's Internal Classics of the preceding China of two thousand years the earliest.Unexpected because of its morbidity, also be called apoplexy or cerebrovascular accident.
The morbidity root of apoplexy is hypertension and cerebral arteriosclerosis.When the cerebrovascular wall takes place atherosis, make the narrow or formation dissecting aneurysm of lumen of vessels stenosis, run into that the patient is excited, psychentonia or overexert, under the inducement influence such as hypertension, cause angiorrhexis or obstruction, make cerebral blood circulation form obstacle, cause pathological changes such as part cerebral tissue ischemia, edema, and cause function of nervous system that obstacle takes place, thereby a series of apoplexy condition of illness occurs.The modal symptom of apoplexy shows as patient's appearance language, motion, perceptive function in various degree and obstacle occurs.Wherein, based on dyskinesia, the traditional Chinese medical science is called hemiplegia (hemiplegia), but the hemiplegia that causes because of cerebral cyst, cerebral parasitosis, brain abscess etc. does not then belong to the apoplexy category.
Apoplectic hemiplegia is the commonly encountered diseases and the frequently-occurring disease of middle-aged and elderly people, and its sickness rate and disability rate are very high.The apoplectic hemiplegia patient is many to be caused by cerebrovascular disease, as cerebral thrombosis, cerebral hemorrhage, cerebral trauma, brain atrophy etc., and weight person's death, the lighter oppresses the intracranial nerve, forms paralysis or hemiplegia.Common hemiplegia in clinical, facial hemiparalysis, slurred speech, is afraid of cold at limbs edema, numbness, pain, even is unable to leave the bed, and the aphasia dementia is choked on the drinking-water, dysphagia, symptoms such as gatism.This sick treatment difficulty is big, brings permanent misery and puzzlement for patient, family, society.For many years, many professors expert of medical circle have paid painstaking efforts for the effective way of exploring treatment hemiplegia disease.
The cause of disease of apoplectic hemiplegia can be divided into hemorrhagic and ischemic two classes, the former comprises cerebral hemorrhage, subarachnoid hemorrhage, the latter comprises transient ischemic attack, cerebral thrombosis and cerebral embolism, wherein common with cerebral thrombosis, cause disturbance of blood circulation that substantial connection is arranged and occur grumeleuse in the formation of cerebral thrombosis and the blood.
The Chinese traditional treatment rheumatism has a long history, and has formed complete theoretical system from ancient times to the present gradually, and ancient Chinese medicine doctor has been formulated abundant effectively treatment side's medicine, becomes current rheumatologist's precious resources.The method that often adopts innerwear outer treatment to combine clinically for oral administrationly can play wind-damp dispelling, lively atmosphere blood, sets upright gas, the purpose of conditioning viscera negative and positive, cooperates external treatment reducing swelling and alleviating pain rapidly again, thus treating both the principal and the secondary aspects of a disease at the same time, disease controlling.The Chinese traditional treatment rheumatism can be summarized as following characteristics: can embody the characteristics of individualized treatment according to patient's syndrome, state of an illness characteristics in accordance with the time and the place because of human therapy; Herbal medicine efficacy action temperature and and lasting, toxic and side effects is less, and it is better that the patient accepts the toleration of long-term treatment; Herbal mixture is integrated regulating action by multipath, too many levels, the performance of many target spots, can carry out wholistic therapy at rheumatismal a plurality of pathology links; Can improve patient's general situation, health invigorating delays PD, prevents and improves bone destruction, promotes patient's quality of life.Because the Chinese herbal medicine property of medicine is gentle, side effect is little, is subjected to chronic disease patients' such as rheumatism welcome deeply.
Chinese patent application 95110229.X discloses a kind of health wine for expelling wind, it is characterized in that medicines such as Radix Angelicae Sinensis, Fructus Chaenomelis, Radix Gentianae Macrophyllae, Rhizoma Homalomenae, Herba Cistanches, Semen Cuscutae, Flos Carthami, Ramulus Cinnamomi, Ramulus Mori, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Fructus Lycii, Chinese liquor are screened, clean, dry, pulverize by behind a certain amount of compatibility, sterilization back vanning warehouse-in promptly.The present invention is all effective in cure to diseases such as rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, pain in the low back and legs, numb limbs and tense tendons, sciatica, has functions such as the immunologic function of adjusting, defying age, relaxing muscles and tendons to promote blood circulation, nourishing kidney tonifying YANG, cardiovascular atrophy.
Chinese patent application 94116016. discloses a kind of medical silicon cream and series of products thereof---Radix Arnebiae (Radix Lithospermi) silicon frost and work skin protection silicon frost.Medical silicon cream basic composition is: dimethicone, liquid paraffin, stearic acid, glycerol, ethanol, emulsifying agent is an amount of, water is an amount of; Radix Arnebiae (Radix Lithospermi) silicon frost basic composition is medical silicon cream, Radix Arnebiae (Radix Lithospermi), Flos Carthami; Work skin protection silicon frost basic composition is medical silicon cream, stearyl alcohol, peregal, SG, vitamin E.They have stable in properties, good permeability, and penetration is strong, cold-resistant freezing, anti-ultraviolet, advantages such as bactericidal antiphlogistic.
Chinese patent ZL 98118665.3 relates to a kind of sunscreen of novelty and contains the cosmetics of described sunscreen.Described sunscreen is the Stigma Croci extracting liq, can be used for preparing disposable sun-proof hair conditioner, sun-proof hair styling mousse, sunscreen cream and ultra light sun block lotion thereof.Sunscreen preparation of the present invention is simple, and untoward reaction is few, to the skin safety height, and can play certain sunburn repair.The cosmetics that contain sunscreen of the present invention have also had both the characteristics that sunscreen of the present invention possessed.
Chinese patent application 200310119310.7 discloses a kind of plaster with wind and cold dispelling, toxin removing and clots absorbing function and preparation method thereof, this product is the secret prescription handed down in the family from generation to generation of generations's centuries, it is mainly by Semen Arecae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Radix Clematidis, Flos Carthami, Olibanum, Radix Cynanchi Paniculati, Lignum Sappan, Herba speranskiae tuberculatae, Herba Lycopodii, Radix Achyranthis Bidentatae, Rhizoma Homalomenae, Radix Salviae Miltiorrhizae, Plumbum preparatium, Oleum sesami etc., process and Plumbum preparatium boil the made a kind of externally applied plaster of compatibility, can treat furuncle, vicious, carbuncle, herpes zoster, mastitis, lymphoid tuberculosis, prolapse of lumbar intervertebral disc, various rheumatism, pleurisy hydrops, bony spur, san bronchial asthma, cervical spondylosis etc.
Chinese patent ZL93100059 discloses a kind of prescription: Semen Strychni (processed) powder 100-160 gram, Scorpio 20-30 gram, Radix Angelicae Sinensis 15-25 gram, Fructus Chaenomelis 15-25 gram, Radix Cyathulae 15-25 gram, Radix Saposhnikoviae 15-25 gram, Herba Schizonepetae 15-25 gram, Flos Carthami 15-25 gram.Dosage form: said medicine is made tablet, or capsule, or the watered pill.Function: cure mainly rheumatoid arthritis, rheumatic arthritis, cold rheumatoid joint pain.
Chinese patent ZL98120544.5 discloses a kind of medicine that effects a radical cure apoplexy and organic cardiovascular and cerebrovascular disease, and the component of this medicine is Stigma Croci, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Rhizoma Acori Graminei, Hirudo, Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, Rhizoma Chuanxiong, Calculus Bovis, Caulis Sargentodoxae, Caulis Spatholobi, Radix Notoginseng, Eupolyphaga Seu Steleophaga, Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, roasted SQUAMA MANITIS into puffy with sand, Ramulus Cinnamomi, the Radix Astragali, Lignum Sappan, Radix Saposhnikoviae, Herba Leonuri, Bombyx Batryticatus, Rhizoma valerianae latifoliae, Scorpio, Semen Strychni (processed) powder.This medicine can effect a radical cure apoplexy and cardiovascular and cerebrovascular disease effectively.
Summary of the invention
One object of the present invention is to provide a kind of pharmaceutical composition that prevents and/or treats heliosensitivity skin.
Another object of the present invention is to provide the application of this pharmaceutical composition in preparation treatment light sensitive dermatoses medicine.
A further object of the present invention is to provide the application of this pharmaceutical composition in preparation treatment hyperlipemia or its relevant disease medicine.
An also purpose of the present invention is to provide the application of this pharmaceutical composition in preparation treatment apoplectic hemiplegia medicine.
A present invention also purpose is to provide the application of this pharmaceutical composition in preparation treatment rheumatism medicine.
According to an aspect of the present invention, the invention provides a kind of pharmaceutical composition that prevents and/or treats heliosensitivity skin, it mainly is to be made by the following raw materials in part by weight medicine: 2～20 parts of Radix Angelicae Sinensis, 1～15 part of Lignum Sappan, 2～20 parts of Radix Cyathulaes, 2～20 parts of Ramulus Cinnamomi, 10～30 parts of Ramulus Moris, 2～20 parts of Herba Schizonepetae, 1～15 part on Flos Carthami.Described pharmaceutical composition can be used for treating and/or preventing diseases such as light sensitive dermatoses.
In aforementioned pharmaceutical compositions, when replacing 2～20 portions of Herba Schizonepetae and 1～15 part of Flos Carthami, can be used for preventing and/or treating diseases such as hyperlipemia, rheumatism, apoplectic hemiplegia with 10～30 parts of Herba speranskiae tuberculataes and 2～20 parts of Radix Saposhnikoviaes.
Preferably, described medicine compositions mainly is to be made by the following raw materials in part by weight medicine: 5～15 parts of Radix Angelicae Sinensis, 3～10 parts of Lignum Sappans, 5～15 parts of Radix Cyathulaes, 5～15 parts of Ramulus Cinnamomi, 15～25 parts of Ramulus Moris, 5～15 parts of Herba Schizonepetae, 3～10 parts on Flos Carthami.
Further, described crude drug further comprises: 10～30 parts of Herba speranskiae tuberculataes, 2～20 parts of Radix Saposhnikoviaes.
Further, described pharmaceutical composition is Powdered or paste.
In the preferred embodiment of the invention, pharmaceutical composition provided by the invention is to be made by the following raw materials in part by weight medicine: 15～25 parts of Herba speranskiae tuberculataes, 5～15 parts of Radix Saposhnikoviaes, 5～15 parts of Herba Schizonepetae, 3～10 parts on Flos Carthami, 5～15 parts of Ramulus Cinnamomi, 5～15 parts of Radix Angelicae Sinensis, 3～10 parts of Lignum Sappans, 5～15 parts of Radix Cyathulaes, 15～25 parts of Ramulus Moris.This pharmaceutical composition not only can be treated light sensitive dermatoses, and diseases such as hyperlipemia, rheumatism, apoplectic hemiplegia are had the preferable effect that prevents and/or treats.
The plant origin of the used various Chinese crude drugs of the present invention is described as follows:
Herba speranskiae tuberculatae is the dry herb of cohosh Herba clematidis intricatae Clematis intricata Bge..
Herba Schizonepetae is called false Soviet Union, Herba Schizonepetae, Nepeta lavandulacea, is the dry aerial parts of labiate Herba Schizonepetae Schizonepetatenuifolia Briq..
Radix Saposhnikoviae, another name RADIX SAPOSHINOKOVIAE from Northeast, eastern Radix Saposhnikoviae are the dry root of umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata (Turcz.) Schischk..
Ramulus Cinnamomi is the dry twig of canella cassia tree Cinnamomum cassia Presl..
When the dry root that is classified as umbelliferae angelica Angelica sinensis (Oliv.) Diels.
Lignum Sappan is the dry duramen of Caesalpiniaceae plant Lignum Sappan Caesalpinia sappen Linn..
Radix Cyathulae is the dry root of amaranthaceous plant Radix Cyathulae Cyathula officinalis Kuan.
Flos Carthami is the dried floral of feverfew Flos Carthami Carthamus tinctorius Linn..
Ramulus Mori is the dry twig of moraceae plants Mulberry Morus alba L..
When the treatment light sensitive dermatoses, in order to obtain better therapeutic effect, described pharmaceutical composition also can further comprise glycerol and vinegar, and described glycerol and vinegar are for smearing medicine.
Described glycerol has another name called glycerol, and its concentration can be 30%～70%.When the treatment light sensitive dermatoses, glycerol plays wetting agent.
Described vinegar can be white vinegar or rice vinegar, is preferably 50% nine degree rice vinegars.When the treatment light sensitive dermatoses, vinegar plays the anti-inflammation and sterilization itching-relieving action.
The concentration of above-mentioned glycerol and the number of degrees of vinegar and concentration etc. are the preferred valueses that obtains by test.Smear the mixture of glycerol and vinegar after the bathing in the affected part, can play the effect of auxiliary treatment light sensitive dermatoses.
Described pharmaceutical composition can further comprise carrier or the excipient of pharmaceutically accepting.
Further, the dosage form of described pharmaceutical composition is the externally applied bath medicine.
This dosage form is a better embodiment provided by the invention, those skilled in the art can make various modification and improvement in conjunction with routine techniques to this dosage form based on pharmaceutical composition of the present invention, for example, can with Chinese medicinal powder of the present invention with the water of this area routine carry, alcohol extraction process is prepared into Chinese medical concrete or dry extract; Can also be with mixing such as Chinese medicinal powder of the present invention (or extractum, dry extract), glycerol and vinegar; And then, also can add conventional ointment base etc., be prepared into ointment easy to carry and use, be coated on the affected part, with the treatment light sensitive dermatoses.
According to a further aspect in the invention, the invention provides aforementioned pharmaceutical compositions and prevent and/or treat application in the light sensitive dermatoses medicine in preparation.
Further, described light sensitive dermatoses is solar dermatitis or polymorphous light eruption.
Described light sensitive dermatoses can be to be caused by sun exposure, also can be to be caused by the perspiration wind-engaging.
Further, in described application, also unite and use glycerol and vinegar.
According to a further aspect of the invention, the invention provides aforementioned pharmaceutical compositions and prevent and/or treat application in hyperlipemia or its relevant disease medicine in preparation.
Described hyperlipemia comprises Primary hyperlipemia and Secondary cases hyperlipemia.
The relevant disease of described hyperlipemia comprises coronary heart disease, cerebral thrombosis, renal hypertension, renal failure, visual deterioration, blind etc.
According to also aspect of the present invention, the invention provides aforementioned pharmaceutical compositions and prevent and/or treat application in the apoplectic hemiplegia medicine in preparation.
According to also aspect of the present invention, the invention provides aforementioned pharmaceutical compositions and prevent and/or treat application in the rheumatism medicine in preparation.
Further, described rheumatism is rheumatic arthritis, rheumatoid arthritis, scapulohumeral periarthritis or cold rheumatoid joint pain etc.
Further, described rheumatism is rheumatic arthritis or cold rheumatoid joint pain.
Described cold rheumatoid joint pain is meant that muscle, arthralgia that human feeling's rheumatism cold-evil causes later on are main a kind of disease.It shows more clinically, by Chinese medical discrimination be divided into that wind is heavy, 5 types of weight in wet bases, cold heavy, rheumatism, cold-damp.
The present invention also provides a kind of pharmaceutical composition, and this pharmaceutical composition mainly is to be made by the following raw materials in part by weight medicine: 2～20 parts of Radix Angelicae Sinensis, 1～15 part of Lignum Sappan, 2～20 parts of Radix Cyathulaes, 2～20 parts of Ramulus Cinnamomi, 10～30 parts of Ramulus Moris, 10～30 parts of Herba speranskiae tuberculataes, 2～20 parts of Radix Saposhnikoviaes.Described pharmaceutical composition can be used for preventing and/or treating hyperlipemia, apoplectic hemiplegia, rheumatism.
Preferably, described pharmaceutical composition mainly is to be made by the following raw materials in part by weight medicine: 2～20 parts of Radix Angelicae Sinensis, 1～15 part of Lignum Sappan, 2～20 parts of Radix Cyathulaes, 2～20 parts of Ramulus Cinnamomi, 10～30 parts of Ramulus Moris, 10～30 parts of Herba speranskiae tuberculataes, 2～20 parts of Radix Saposhnikoviaes.
In order to obtain preferable therapeutic effect, described crude drug can further comprise: 2～20 parts of Herba Schizonepetae, 1～15 part on Flos Carthami.Preferably, Herba Schizonepetae is 5～15 parts, 3～10 parts on Flos Carthami.
Described pharmaceutical composition is the bathing medicine.
A kind of application of described pharmaceutical composition is to be used to prepare the medicine that prevents and/or treats hyperlipemia or its relevant disease.
Described hyperlipemia comprises Primary hyperlipemia and Secondary cases hyperlipemia.
The relevant disease of described hyperlipemia comprises coronary heart disease, cerebral thrombosis, renal hypertension, renal failure, visual deterioration, blind etc.
It is to be used to prepare the medicine that prevents and/or treats apoplectic hemiplegia that the another kind of described pharmaceutical composition is used.
Also a kind of application of described pharmaceutical composition is to be used for preparation to prevent and/or treat rheumatismal medicine.
Further, described rheumatism is rheumatic arthritis, rheumatoid arthritis, scapulohumeral periarthritis, cold rheumatoid joint pain or cold rheumatoid joint pain etc.
Further, described rheumatism is rheumatic arthritis or cold rheumatoid joint pain.
The Chinese medicine of respectively distinguishing the flavor of in the pharmaceutical composition of the present invention is clayed into power, is mixed into medicated powder according to recipe quantity, can be sub-packed in then in water, have in the infiltrative pouch standby.
When the treatment light sensitive dermatoses, medicated powder or pouch that medicated powder is housed are put into tub, washing the back water temperature open with 60～80 ℃ hot water is transferred to 35～40 ℃ and can uses, the bathing time: 20～30 minutes, after using 9 degree rice vinegars of 50% glycerol and 50% to mix well then, wipe at the skin place of being treated and get final product.Treat every day 1 time, treatment cycle is 5～7 days.
Pharmaceutical composition of the present invention to the treatment apoplectic hemiplegia, blood fat reducing, wind is removed in thrombus breaking, dispersing cold for relieving pain, relaxing muscles and tendons to promote blood circulation etc. have good adjuvant treatment effect.For treatment of conditions such as apoplectic hemiplegia, hyperlipemia, rheumatisms, still adopt bath method, massage after the bathing and promptly finish treatment, and need not be coated with the mixture of using glycerol and vinegar.But note that heart disease and hypotensive's water temperature are transferred to 30～35 ℃ and are got final product.
When the treatment hyperlipemia, common 7 days is a course of treatment, and when treating 4 courses of treatment, patient's symptom goes down, alleviates; When the treatment rheumatism, common 7 days is a course of treatment, and when treating 2 courses of treatment, patient's symptom is clearly better; When the treatment apoplectic hemiplegia, common 7 days is a course of treatment, treats 3 courses of treatment, patient's remission, and walking is freely.
The present invention is easy to use, is applicable to family's bathing and public place bathing, and ultraviolet allergy is had therapeutical effect, and apoplectic hemiplegia is also had preventive effect, but also blood fat reducing, and wind is removed in thrombus breaking, dispersing cold for relieving pain, relaxing muscles and tendons to promote blood circulation.
The present invention is a several generations pure Chinese material bathe prescription handed down from one's ancestors.This prescription is the treatment apoplectic hemiplegia at first, blood fat reducing, and wind is removed in thrombus breaking, dispersing cold for relieving pain, the bathing medicine of relaxing muscles and tendons to promote blood circulation.Find through inventor's clinical research: after the bathing, be used 50% the glycerol mixed well and 50% 9 degree rice vinegars, treatment skin ultraviolet allergy is had better curative effect.Through clinical trial, during in June, 2003～2004 year December, surplus the treatment ultraviolet case 200 person-time, wherein the severe patient accounts for 20%, the range of age: 35～45 years old; Slight patient accounts for 80%, the range of age: 20～55 years old.Severe patient's sick time was 4～5 years, and treatment time gets final product rehabilitation, effective percentage 100% 5～7 times.
Chinese medicine is ancient traditional therapy of China and medicine, more and more is subjected to common people's concern and trust.The inventor wishes this side is developed, and allows more people be benefited, for Chinese medicine circle of China contributes.
In order to understand essence of the present invention better,, describe in detail but do not limit the present invention below by description to better embodiment of the present invention.Following examples only are exemplary, and the present invention is not limited to this.
The specific embodiment
The used test material of the present invention is commercially available purchase product if no special instructions.The used various Chinese crude drugs of the present invention all can be bought in prepared slices of Chinese crude drugs market.
Preparation of drug combination of the present invention
[embodiment 1]
One, prescription:
Herba speranskiae tuberculatae 15 gram Herba Schizonepetae 5 grams
Radix Saposhnikoviae 5 gram Ramulus Cinnamomi 5 grams
Radix Angelicae Sinensis 5 gram Lignum Sappans 3 grams
Radix Cyathulae 5 gram Flos Carthamis 3 grams
Ramulus Mori 15 grams
Two, preparation method
Said medicine is processed into powder, and mixes.
When being used for the treatment of light sensitive dermatoses, this medicated powder is put into tub, wash the back water temperature open with 60～80 ℃ hot water and be transferred to 35～40 ℃ and promptly can be used for externally applied bath.The bathing time is 20～30 minutes, after mixing well with 9 degree rice vinegars of 50% glycerol and 50% then, wipes at the skin place of need treatment and gets final product.
When being used for the treatment of hyperlipemia, apoplectic hemiplegia, rheumatism, still adopt above-mentioned bath method, massage after the bathing and promptly finish treatment, and need not be coated with the mixture of using glycerol and vinegar.
[embodiment 2]
One, prescription:
Herba Schizonepetae 5 gram Ramulus Cinnamomi 5 grams
Radix Angelicae Sinensis 5 gram Lignum Sappans 3 grams
Radix Cyathulae 5 gram Flos Carthamis 3 grams
Ramulus Mori 15 grams
Two, preparation method
Preparation method and using method are with embodiment 1.Be mainly used in the treatment light sensitive dermatoses.
[embodiment 3]
One, prescription
Herba speranskiae tuberculatae 25 gram Herba Schizonepetae 15 grams
Radix Saposhnikoviae 15 gram Ramulus Cinnamomi 15 grams
Radix Angelicae Sinensis 15 gram Lignum Sappans 10 grams
Radix Cyathulae 15 gram Flos Carthamis 10 grams
Ramulus Mori 25 grams
Two, preparation method
Preparation method and using method are with embodiment 1.
[embodiment 4]
One, prescription
Herba speranskiae tuberculatae 25 gram Radix Saposhnikoviaes 15 grams
Ramulus Cinnamomi 15 gram Radix Angelicae Sinensis 15 grams
Lignum Sappan 10 gram Radix Cyathulaes 15 grams
Ramulus Mori 25 grams
Two, preparation method
Preparation method and using method are with embodiment 1.Be mainly used in diseases such as treatment hyperlipemia, apoplectic hemiplegia, rheumatism.
[embodiment 5]
One, prescription
Herba speranskiae tuberculatae 20 gram Herba Schizonepetae 10 grams
Radix Saposhnikoviae 10 gram Ramulus Cinnamomi 10 grams
Radix Angelicae Sinensis 10 gram Lignum Sappans 7 grams
Radix Cyathulae 10 gram Flos Carthamis 7 grams
Ramulus Mori 20 grams
Two, preparation method
Preparation method and using method are with embodiment 1.
[embodiment 6]
One, prescription
Herba Schizonepetae 12 gram Ramulus Cinnamomi 12 grams
Radix Angelicae Sinensis 12 gram Lignum Sappans 7 grams
Radix Cyathulae 12 gram Flos Carthamis 7 grams
Ramulus Mori 22 grams
Two, preparation method
Preparation method and using method are with embodiment 1.Be mainly used in the treatment light sensitive dermatoses.
[embodiment 7]
One, prescription
Herba speranskiae tuberculatae 17 gram Radix Saposhnikoviaes 7 grams
Radix Angelicae Sinensis 7 gram Lignum Sappans 3 grams
Radix Cyathulae 8 gram Ramulus Cinnamomi 8 grams
Ramulus Mori 18 grams
Two, preparation method
Preparation method and using method are with embodiment 1.Be mainly used in diseases such as treatment hyperlipemia, apoplectic hemiplegia, rheumatism.
Pharmaceutical composition of the present invention is used for the treatment of the clinical trial of light sensitive dermatoses
[embodiment 8]
During in June, 2003～2004 year December, the inventor adopts example surplus the irritated case 200 of pharmaceutical composition of the present invention (prescription and prepared according to embodiment 1 or 2 obtain) treatment ultraviolet, and effective percentage reaches 100%, specifies as follows:
1, clinical diagnosis standard and case are selected
The diagnostic criteria of light sensitive dermatoses: erythema, dermatitis appear in skin behind solar light irradiation, and there is causalgia at weight person's skin lesion place.
Case is selected: the light sensitive dermatoses patient who is treated is the out-patient of the safe and comfortable massage treatment hospital in the Inner Mongol (address is in Cuo Gang town, Xinbaerhu Left Banner, the Inner Mongol), example surplus in the of totally 200.In the light sensitive dermatoses patient who is treated, severe patient accounts for 20%, and the range of age is 35～45 years old; Slight patient accounts for 80%, and the range of age is 20～55 years old.Severe patient's sick time was 4～5 years.
2, Therapeutic Method: treat once every day.Medicated powder of the present invention is put into tub, wash the back water temperature open with 60～80 ℃ hot water and be transferred to 35～40 ℃ and promptly can be used for externally applied bath.The bathing time is 20～30 minutes, after mixing well with 9 degree rice vinegars of 50% glycerol and 50% then, wipes at the skin place of need treatment and gets final product.Treat 5～7 times.
3, treatment time: 5～7 days is a course of treatment.
4, therapeutic effect: general treatment got final product rehabilitation in 5～7 days, and erythema, dermatitis disappear fully, and the skin affected part recovers the normal colour of skin, and effective percentage reaches 100%.
[embodiment 9] concrete case
Yao, the woman, 45 years old, the workman, come to cure in June, 2004, cervical region, arm are subjected to red point occurring behind the solar radiation, the pain of itching, cervical region is than the crowfoot cracks of pipe skin, and the course of disease has 4 years, through medicine of the present invention (prescription and prepared according to embodiment 1 obtain) bathing, smear after arm 3 days cure, cervical region was cured in 7 days, so far the not recurrence of 1 year.
[embodiment 10] concrete case
Bao, man, 38 years old, herdsman, in JIUYUE, 2003 is sought medical advice, and arm red point occurs, the pain of itching after by solar irradiation, medical history 3 years, through medicine of the present invention (prescription and prepared according to embodiment 2 obtain) bathing, smear after arm 3 days cure not recurrence of 2 years so far.
Pharmaceutical composition of the present invention is used for the treatment of the clinical trial of hyperlipemia
[embodiment 11]
The inventor adopts example surplus pharmaceutical composition of the present invention (prescription and prepared according to embodiment 3 or 4 obtain) the treatment hyperlipemia case 50, and effective percentage reaches 80%, specifies as follows:
1, clinical diagnosis standard and case are selected
The diagnostic criteria of hyperlipemia: according to bureau of drug administration of Ministry of Health of the People's Republic of China new drug (Western medicine) clinical research guideline, serum cholesterol (TC) 〉=6.5mmol/L (250mg/dl), or triglyceride (TG) 〉=1.6mmol/L (140mg/dl), or HDL-C (HDL-C) value male≤1.04mmol/L (≤40mg/dl), women≤1.17mmol/L (≤45mg/dl) person is a hyperlipemia.
Case is selected: the hyperlipidemia patient of being treated is the outpatient service and the inpatient of the safe and comfortable massage treatment hospital in the Inner Mongol (address is in Cuo Gang town, Xinbaerhu Left Banner, the Inner Mongol), example surplus in the of totally 50.
2, Therapeutic Method: treat once every day.Medicated powder of the present invention is put into tub, wash the back water temperature open with 60～80 ℃ hot water and be transferred to 35～40 ℃ and promptly can be used for externally applied bath.The bathing time is 20～30 minutes.Massage after the bathing.
3, treatment time: 7 days is a course of treatment.
4, therapeutic effect: effective percentage reaches 80%.Treat 4 courses of treatment, patient's symptom goes down, alleviates.
[embodiment 12] concrete case
Chen, the man, 45 years old, the workman come to cure in January, 2004, the blood fat height, through Chinese medicine of the present invention (prescription and prepared according to embodiment 3 obtain) tub bathing treatment, blood fat is normal after adding Chinese medicine for oral administration and relieving inflammation or internal heat 28 days, does not occur the blood fat height in existing 1 year half.
Pharmaceutical composition of the present invention is used for the treatment of rheumatismal clinical trial
[embodiment 13]
The inventor adopts people surplus pharmaceutical composition of the present invention (prescription and prepared according to embodiment 3 or 4 obtain) the treatment rheumatism case 60, wherein, and rheumatic arthritis 50 examples, cold rheumatoid joint pain 10 examples.Effective percentage reaches 80%, specifies as follows:
1, clinical diagnosis standard and case are selected
Rheumatic arthritis clinical diagnosis standard: limbs joint, myalgia, numb swelling, joint stuffiness, even joint deformity.
Cold rheumatoid joint pain clinical diagnosis standard: perspiring suffers from cold causes muscle, arthralgia.
Case is selected: the rheumatic arthritis of being treated, cold rheumatoid joint pain patient are the outpatient service and the inpatient of the safe and comfortable massage treatment hospital in the Inner Mongol (address is in Cuo Gang town, Xinbaerhu Left Banner, the Inner Mongol), example surplus in the of totally 60.
2, Therapeutic Method: treat once every day.Medicated powder of the present invention is put into tub, wash the back water temperature open with 60～80 ℃ hot water and be transferred to 35～40 ℃ and promptly can be used for externally applied bath.The bathing time is 20～30 minutes.Massage after the bathing.
3, treatment time: 7 days is a course of treatment.
4, therapeutic effect: effective percentage reaches 80%.Treat 2 courses of treatment, patient's symptom is clearly better.
[embodiment 14] concrete case
Bai, the woman, 65 years old, the herdsman came to seek medical advice in 2004 3 years, and treatment rheumatic arthritis through Chinese medicine of the present invention (prescription and prepared according to embodiment 3 obtain) tub bathing treatment, is massaged recovery from illness in 20 days, does not have pain in existing 1 year half.
Pharmaceutical composition of the present invention is used for the treatment of the clinical trial of apoplectic hemiplegia
[embodiment 15]
The hemiplegia that the inventor adopts the radical disease of pharmaceutical composition of the present invention (prescription and prepared according to embodiment 3 or 4 obtain) treatment hypertension to cause, treat 10 surplus the people, effective percentage reaches 80%, specifies as follows:
1, clinical diagnosis standard and case are selected
The clinical diagnosis standard of apoplectic hemiplegia: the radical disease of hypertension is caused hemiplegia (left side paralysis).
Case is selected: the hemiplegic patient who is treated is the outpatient service and the inpatient of the safe and comfortable massage treatment hospital in the Inner Mongol (address is in Cuo Gang town, Xinbaerhu Left Banner, the Inner Mongol), example surplus in the of totally 10.
2, Therapeutic Method: treat once every day.Medicated powder of the present invention is put into tub, wash the back water temperature open with 60～80 ℃ hot water and be transferred to 35～40 ℃ and promptly can be used for externally applied bath.The bathing time is 20～30 minutes.Massage after the bathing.
3, treatment time: 7 days is a course of treatment.
4, therapeutic effect: effective percentage reaches 80%.Treat 3 courses of treatment, patient's remission, walking is freely.
[embodiment 16] concrete case
Chen, the woman, 37 years old, the herdsman, in December, 2003 comes to seek medical advice, and causes the left hand paralysis because of hypertension is radical.Therapeutic Method: Chinese medicine (prescription and prepared according to embodiment 3 obtain) tub bathing, add the Chinese medicine for oral administration blood pressure lowering, massage rehabilitation after 20 days, hypertension does not appear in not recurrence in existing 2 years.
More than the description of better embodiment of the present invention is not limited the present invention, those skilled in the art can make various changes or distortion according to the present invention, only otherwise break away from spirit of the present invention, all should belong to the scope of claims of the present invention.
Claims (8)
1, a kind of pharmaceutical composition that prevents and/or treats heliosensitivity skin, it is characterized in that, described pharmaceutical composition mainly is to be made by the following raw materials in part by weight medicine: 2～20 parts of Radix Angelicae Sinensis, 1～15 part of Lignum Sappan, 2～20 parts of Radix Cyathulaes, 2～20 parts of Ramulus Cinnamomi, 10～30 parts of Ramulus Moris, 2～20 parts of Herba Schizonepetae, 1～15 part on Flos Carthami.
2, the pharmaceutical composition that prevents and/or treats light sensitive dermatoses according to claim 1 is characterized in that, described crude drug further comprises: 10～30 parts of Herba speranskiae tuberculataes, 2～20 parts of Radix Saposhnikoviaes.
3, the pharmaceutical composition that prevents and/or treats light sensitive dermatoses according to claim 1 and 2 is characterized in that, described pharmaceutical composition is Powdered or paste.
4, the pharmaceutical composition that prevents and/or treats light sensitive dermatoses according to claim 1 and 2 is characterized in that, described pharmaceutical composition further comprises glycerol and vinegar.
5, claim 1 or 2 described pharmaceutical compositions prevent and/or treat application in the light sensitive dermatoses medicine in preparation.
6, the described pharmaceutical composition of claim 2 prevents and/or treats application in hyperlipemia or its relevant disease medicine in preparation.
7, the described pharmaceutical composition of claim 2 prevents and/or treats application in the apoplectic hemiplegia medicine in preparation.
8, the described pharmaceutical composition of claim 2 prevents and/or treats application in the rheumatism medicine in preparation.
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| CN101843769B (en) * | 2010-05-25 | 2012-05-09 | 于文广 | Medicament for treating systemic sclerosis and preparation method thereof |
| CN103006996B (en) * | 2012-12-31 | 2014-03-12 | 威海市妇女儿童医院 | Medicine for treating accelerated hypertension |
| CN105147871A (en) * | 2015-09-24 | 2015-12-16 | 王玉梅 | External-use traditional Chinese medicine composition for treating hyperlipidaemia |
| CN106806861A (en) * | 2015-12-01 | 2017-06-09 | 陈建波 | A kind of medicine for treating aged hemiplegic patient |
| CN106474212A (en) * | 2016-12-05 | 2017-03-08 | 张广生 | A kind of ointment for treating shin muscular strain |
| CN108096520B (en) * | 2017-11-27 | 2021-05-14 | 山东中医药大学第二附属医院 | Compound moxa stick |
| CN111569042A (en) * | 2020-06-28 | 2020-08-25 | 马淑珍 | Traditional Chinese medicine preparation for improving human immunity and preparation method thereof |
| CN116832085A (en) * | 2023-04-19 | 2023-10-03 | 上海市第七人民医院(上海中医药大学附属第七人民医院) | Traditional Chinese medicine composition for improving clinical symptoms of chronic renal failure patient |
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| CN1352959A (en) * | 2000-11-02 | 2002-06-12 | 戚嘉和 | Chinese medicine for treating heart disease |
| CN1362256A (en) * | 2001-12-26 | 2002-08-07 | 邹明义 | Osteological Chinese medicine prepn. |
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| CN1352959A (en) * | 2000-11-02 | 2002-06-12 | 戚嘉和 | Chinese medicine for treating heart disease |
| CN1362256A (en) * | 2001-12-26 | 2002-08-07 | 邹明义 | Osteological Chinese medicine prepn. |
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