CN105770848A - Chilblain ointment containing extract from bitter gourd vines and leaves and preparation method thereof - Google Patents
Chilblain ointment containing extract from bitter gourd vines and leaves and preparation method thereof Download PDFInfo
- Publication number
- CN105770848A CN105770848A CN201610331198.0A CN201610331198A CN105770848A CN 105770848 A CN105770848 A CN 105770848A CN 201610331198 A CN201610331198 A CN 201610331198A CN 105770848 A CN105770848 A CN 105770848A
- Authority
- CN
- China
- Prior art keywords
- momordicae charantiae
- oil phase
- extract
- extractum
- caulis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002674 ointment Substances 0.000 title claims abstract description 46
- 239000000284 extract Substances 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 235000009811 Momordica charantia Nutrition 0.000 title claims abstract description 5
- 208000010445 Chilblains Diseases 0.000 title abstract description 15
- 244000078912 Trichosanthes cucumerina Species 0.000 title abstract 3
- 235000008322 Trichosanthes cucumerina Nutrition 0.000 title abstract 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 43
- 239000012071 phase Substances 0.000 claims abstract description 30
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000003921 oil Substances 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000008346 aqueous phase Substances 0.000 claims abstract description 20
- 239000000341 volatile oil Substances 0.000 claims abstract description 19
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims abstract description 15
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 15
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 15
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000008117 stearic acid Substances 0.000 claims abstract description 15
- 239000003871 white petrolatum Substances 0.000 claims abstract description 15
- 239000000706 filtrate Substances 0.000 claims abstract description 14
- 229940075507 glyceryl monostearate Drugs 0.000 claims abstract description 14
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims abstract description 14
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims abstract description 13
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims abstract description 13
- 239000012153 distilled water Substances 0.000 claims abstract description 12
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 12
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 12
- 238000003756 stirring Methods 0.000 claims abstract description 9
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims abstract description 8
- 238000001914 filtration Methods 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 238000001256 steam distillation Methods 0.000 claims abstract description 8
- 229960004274 stearic acid Drugs 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims abstract description 4
- 239000003814 drug Substances 0.000 claims description 15
- 238000010298 pulverizing process Methods 0.000 claims description 10
- LSPHULWDVZXLIL-UHFFFAOYSA-N (+/-)-Camphoric acid Chemical compound CC1(C)C(C(O)=O)CCC1(C)C(O)=O LSPHULWDVZXLIL-UHFFFAOYSA-N 0.000 claims description 7
- 229940025250 camphora Drugs 0.000 claims description 7
- 239000010238 camphora Substances 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 7
- 239000000155 melt Substances 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 5
- 239000012567 medical material Substances 0.000 claims description 5
- 239000006228 supernatant Substances 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 3
- 244000302512 Momordica charantia Species 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 238000002791 soaking Methods 0.000 claims description 2
- 125000005456 glyceride group Chemical group 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 11
- 239000000203 mixture Substances 0.000 abstract description 4
- 235000006886 Zingiber officinale Nutrition 0.000 abstract description 3
- 235000008397 ginger Nutrition 0.000 abstract description 3
- 244000273928 Zingiber officinale Species 0.000 abstract description 2
- 238000010438 heat treatment Methods 0.000 abstract description 2
- 241000723346 Cinnamomum camphora Species 0.000 abstract 1
- 241000967218 Selaginella tamariscina Species 0.000 abstract 1
- 229960000846 camphor Drugs 0.000 abstract 1
- 229930008380 camphor Natural products 0.000 abstract 1
- 229960002216 methylparaben Drugs 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 description 12
- 239000008280 blood Substances 0.000 description 11
- 238000011282 treatment Methods 0.000 description 11
- 210000004369 blood Anatomy 0.000 description 10
- 230000035617 depilation Effects 0.000 description 10
- 241000283973 Oryctolagus cuniculus Species 0.000 description 7
- 230000017531 blood circulation Effects 0.000 description 6
- 230000036407 pain Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 4
- 206010015150 Erythema Diseases 0.000 description 4
- 208000028990 Skin injury Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 231100000321 erythema Toxicity 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 208000009084 Cold Injury Diseases 0.000 description 3
- 241000219112 Cucumis Species 0.000 description 3
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 3
- 206010037549 Purpura Diseases 0.000 description 3
- 241001672981 Purpura Species 0.000 description 3
- 241000195974 Selaginella Species 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 3
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000002595 cold damage Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 210000002683 foot Anatomy 0.000 description 3
- 208000009146 rhinoscleroma Diseases 0.000 description 3
- 231100000475 skin irritation Toxicity 0.000 description 3
- 230000036556 skin irritation Effects 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 238000010792 warming Methods 0.000 description 3
- 241000004633 Bulbine glauca Species 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 206010072170 Skin wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 241000234299 Zingiberaceae Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000002390 adhesive tape Substances 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000002951 depilatory effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- NLDDIKRKFXEWBK-AWEZNQCLSA-N gingerol Chemical compound CCCCC[C@H](O)CC(=O)CCC1=CC=C(O)C(OC)=C1 NLDDIKRKFXEWBK-AWEZNQCLSA-N 0.000 description 2
- JZLXEKNVCWMYHI-UHFFFAOYSA-N gingerol Natural products CCCCC(O)CC(=O)CCC1=CC=C(O)C(OC)=C1 JZLXEKNVCWMYHI-UHFFFAOYSA-N 0.000 description 2
- 235000002780 gingerol Nutrition 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000003211 malignant effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 210000002268 wool Anatomy 0.000 description 2
- 230000037314 wound repair Effects 0.000 description 2
- QXDWRXCXHXYLNC-UHFFFAOYSA-N 4-phenylheptan-4-ylbenzene Chemical class C=1C=CC=CC=1C(CCC)(CCC)C1=CC=CC=C1 QXDWRXCXHXYLNC-UHFFFAOYSA-N 0.000 description 1
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 241000345998 Calamus manan Species 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 241000905957 Channa melasoma Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 241000218984 Momordica Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- -1 Phenylpropanoid Glycosides Chemical class 0.000 description 1
- 241001448530 Rohdea japonica Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000195975 Selaginellaceae Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 206010043458 Thirst Diseases 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 241000234314 Zingiber Species 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000003836 peripheral circulation Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229930015704 phenylpropanoid Natural products 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 235000012950 rattan cane Nutrition 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 201000003068 rheumatic fever Diseases 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000004218 vascular function Effects 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000001841 zingiber officinale Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses chilblain ointment containing extract from bitter gourd vines and leaves and a preparation method thereof. The preparation method comprises the following steps: extracting volatile oil from dried ginger and selaginella tamariscina by a steam distillation method, filtering, and collecting a filtrate; mixing the filter dregs with ground bitter gourd vines and leaves, extracting and concentrating the filtrate by a decoction method to obtain extract having a relative density of 1.20-1.30 when the temperature is 50 DEG C; respectively heating an oil phase prepared from white vaseline, stearic acid, glyceryl monostearate and azone and an aqueous phase prepared from the prepared extract, glycerinum, tween-80 and distilled water to 75 DEG C, and slowly adding the aqueous phase into the oil phase after the oil phase is molten; and constantly stirring, adding camphor, methylparaben and the prepared volatile oil when the temperature of the mixture is reduced to 50 DEG C, stirring and condensing to obtain the chilblain ointment. The prescription and preparation process of chilblain ointment are simple, raw materials are low in price and easily available, and the curative effect is exact.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, be specifically related to a kind of chilblain containing Caulis Momordicae Charantiae Folium Momordicae Charantiae extract
Cream and preparation method thereof.
Background technology
Chilblain is a kind of peripheral circulation disorders disease, is incident seasonal pathological changes cold season, belongs to
Non-freezing cold injury, is often betiding the best women, child and old people, position many finger,
The back of the hand, heel, foot edge, buccal, ear, nose etc., fall ill annual winter, and spontaneous recovery after it is warm is sick
Journey is delayed, and the most easily recurs the coming year.Pathological study shows, the while that chilblain being because of cold stimulation and there was dampness in the air
Act on body tip position, make vascular function lose, cause microcirculation disturbance, local organization hypoxic-ischemic
Form.Chinese medical theory is thought, cold invasion and attack in winter, causes QI-blood circulation not smooth, and passages through which vital energy circulates intercepts, QI and blood
Sluggish skin forms primary disease, therefore prevention, treatment chilblain are with dispelling cold by warming the meridian, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain for controlling
Treating criterion, and to person of freezing sore surface ulcerated, also need to add expelling pus and promoting granulation medicine, treatment is many to be coated with outside medicine.
Caulis Momordicae Charantiae, Folium Momordicae Charantiae be Cucurbitaceae Momordica plant Fructus Momordicae charantiae (Momordica charantia L.) rattan,
Leaf.Fructus Momordicae charantiae is a kind of traditional medicine food dual purpose plant, all has cultivation in China various places.Compendium of Material Medica is remembered
Carry: Fructus Momordicae charantiae " bitter cold, nontoxic, evil removing is hot, it is tired to solve, the improving eyesight that clears away heart-fire, QI invigorating tonifying YANG "." the southern regions of the Yunnan Province book on Chinese herbal medicine "
Also it is described: Fructus Momordicae charantiae bitter in the mouth, cold in nature, enter the heart, spleen, lung three warp.Evil removing is hot, it is tired to solve, clear away heart-fire improving eyesight.
Rush down the six channels excess-fire, clearing away summer-heat and supplementing QI, only excessive thirst.And have corresponding Therapeutic Method: control all red fire-toxin gas, treat
Malignant boil knot poison, big furuncle.Take leaf, dry as end, often take three money, ashless, wine down, the magical effect.
The concentrated solution of Fructus Momordicae charantiae leaf has broad spectrum antibiotic activity through clinical trial certificate, and its leaf concentrated solution is permissible
Suppression escherichia coli, staphylococcus aureus, Salmonella etc.；The extracting solution of Fructus Momordicae charantiae whole plant also has
Antibacterial activity.In some proved recipes, Caulis Momordicae Charantiae, leaf are used to treat diarrhoea, dysentery, typhoid fever heating, skin ulcer
Carbuncle, eczema, acne, toxic swelling etc..
Rhizoma Zingiberis (Zingiberis Rhizoma) is Zingiberaceae (Zingiberaceae) ginger Rhizoma Zingiberis Recens (Zingiber
Officinale Rosc.) dry rhizome, have another name called Rhizoma Zingiberis, equal Rhizoma Zingiberis Recens.Rhizoma Zingiberis mainly contain volatile oil, gingerol,
The chemical compositions such as Diphenylheptane class.According to Shennong's Herbal record: Rhizoma Zingiberis acrid in the mouth, property heat, return spleen,
Stomach, the heart, lung meridian, have warming spleen and stomach for dispelling cold, the effect such as recuperating depleted YANG is promoted blood circulation, dampness expectorant, is mainly used in clinically
Treatment enteritis, suffer from diarrhoea, vomit, the disease such as coronary heart disease, myocardial infarction, rhagadia manus et pedis.Modern pharmacology and facing
Bed research shows, Rhizoma Zingiberis has that antioxidation, antiinflammatory be antibacterial, emesis is told in town, improves cardiovascular system and anti-swollen
The multiple efficacies such as tumor.The compositions such as volatile oil in Rhizoma Zingiberis, gingerol can promote the blood circulation of local, rises
To protection wound surface, the effect of promotion healing；The water extract of Rhizoma Zingiberis and volatile oil have suppression platelet aggregation,
The effect of antithrombotic.
Herba Selaginellae (Selaginella tarmariscina (Beauv.) Spring) is that fern Herba Selaginellae can
The herb of (Selaginell aceae) Selaginella (Selaginella) plant Herba Selaginellae, have another name called Rohdea japonica Roth,
Graptopelaum Paraguayense etc..Herba Selaginellae is Chinese medicine material, and its property is pungent flat, has the effects such as removing blood stasis dissipating blood stasis, promoting blood circulation and hemostasis,
Cure mainly the diseases such as stomachache, amenorrhea, abdominal mass pouring knot and hematemesis hematochezia hematuria.So far obtain from Rock lily plant
Compound have flavonoid, Phenylpropanoid Glycosides class, alkaloid, organic acid etc., modern pharmacology and clinical research table
Bright Rock lily plant has antiinflammatory, antibacterial, analgesia, blood pressure lowering, blood sugar lowering, antiviral, antitumor, only
The effects such as blood and enhancing immune function of human body, among the people being also used for treats rheumatic arthritis, bones and muscles pain, burning
Wound etc..
With Caulis Momordicae Charantiae, Folium Momordicae Charantiae, Rhizoma Zingiberis, Herba Selaginellae extract as principal agent, with Camphora, glycerol, white vaseline,
The kibe ointment that stearic acid, glyceryl monostearate, Methyl p-hydroxybenzoate, azone etc. are prepared for adjuvant there is not yet literary composition
Offer report.
Summary of the invention
An object of the present invention is according to Chinese medical theory and Caulis Momordicae Charantiae Folium Momordicae Charantiae and Rhizoma Zingiberis, the master of Herba Selaginellae
Want active component and pharmacological action, it is provided that a kind of prescription is with preparation technology is simple, raw material is cheap and easy to get, treatment
Imitate the definite kibe ointment containing Caulis Momordicae Charantiae Folium Momordicae Charantiae extract.
The kibe ointment of the present invention contains: crude drug Caulis Momordicae Charantiae Folium Momordicae Charantiae, Rhizoma Zingiberis, the extract of Herba Selaginellae, and
Adjuvant Camphora, glycerol, white vaseline, stearic acid, glyceryl monostearate, Methyl p-hydroxybenzoate, azone；
Its preparation method is: by Rhizoma Zingiberis and Herba Selaginellae extraction by steam distillation volatile oil, filters, and collects filter
Liquid；Filtering residue is mixed with the Caulis Momordicae Charantiae Folium Momordicae Charantiae after pulverizing, uses decocting method to carry out filtrate extracting, concentrating,
Obtain the extractum that relative density is 1.20～1.30 (50 DEG C)；
Using white vaseline, stearic acid, glyceryl monostearate, azone as oil phase, by prepared extractum and
Glycerol, tween 80 and distilled water, as aqueous phase, are separately heated to 75 DEG C, after oil phase melts, by aqueous phase
Be slowly added in oil phase, and be stirred continuously, camphorate when temperature drops to 50 DEG C, Methyl p-hydroxybenzoate and
The volatile oil extracted, stirs, condenses, obtain kibe ointment.
Concrete, the raw material components proportioning preparing described extractum is: Caulis Momordicae Charantiae Folium Momordicae Charantiae 130-150 weight portion,
Rhizoma Zingiberis 20-30 weight portion, Herba Selaginellae 30-50 weight portion.
Concrete, the component proportion of described oil phase is: white vaseline 0.80～1.20g, stearic acid
1.20～1.50g, glyceryl monostearate 0.50～1.00g, azone 0.20～0.30g；The component of described aqueous phase
Proportioning is: extractum 0.20～0.30g, glycerol 0.70～1.00g, tween 80 are 0.20～0.50g, distilled water
Addition be that to make unguentum gross mass be 10g；The addition of Camphora and Methyl p-hydroxybenzoate be respectively 0.10g and
0.10～0.40g.
The two of the purpose of the present invention are to provide the system of the above-mentioned kibe ointment containing Caulis Momordicae Charantiae Folium Momordicae Charantiae extract
Preparation Method, it comprises the steps:
(1) the dipped medical material of suitable quantity of water 2～3 centimetres are added after Rhizoma Zingiberis and Herba Selaginellae being pulverized, after soaking 30 minutes
Use extraction by steam distillation volatile oil, filter, collect filtrate；By the Caulis Momordicae Charantiae Fructus Momordicae charantiae after filtering residue and pulverizing
Leaf mixes, boiling 3 times, decocts 1h every time, filters off medicinal residues, by decoction liquor and aforementioned Rhizoma Zingiberis, Herba Selaginellae
Filtrate merge, stand after 12h and take supernatant, being evaporated to relative density is 1.20～1.30 (50 DEG C)
Extractum；
(2) using white vaseline, stearic acid, glyceryl monostearate, azone as oil phase, by prepared
Extractum and glycerol, tween 80 and distilled water, as aqueous phase, are separately heated to 75 DEG C, after oil phase melts,
Aqueous phase is slowly added in oil phase, and is stirred continuously, camphorate when temperature drops to 50 DEG C, nipalgin
Formicester and the volatile oil of extraction, stir, condense, obtain kibe ointment.
Concrete, in step (1), the raw material components proportioning preparing described extractum is: Caulis Momordicae Charantiae Folium Momordicae Charantiae
130-150 weight portion, Rhizoma Zingiberis 20-30 weight portion, Herba Selaginellae 30-50 weight portion.
Concrete, in step (2), the component proportion of described oil phase is: white vaseline 0.80～1.20g,
Stearic acid 1.20～1.50g, glyceryl monostearate 0.50～1.00g, azone 0.20～0.30g；Described aqueous phase
Component proportion be: extractum 0.20～0.30g, glycerol 0.70～1.00g, tween 80 be 0.20～0.50g,
The addition of distilled water is that to make unguentum gross mass be 10g；The addition of Camphora and Methyl p-hydroxybenzoate is respectively
0.10g and 0.10～0.40g.
Kibe ointment Skin stimulant experiment in Rabbit of the present invention: take healthy white rabbit, by its spinal column first combing wool
Cut short, be then coated with depilatory, area about 150cm2, clean with warm water after 2～3min, select depilation 24h
Skin zero damage 10 is only tested.Take 5 for skin complete group: depilation district, every left side is coated with kibe ointment 1
G, depilation district, right side is coated with substrate 1g as comparison；Separately take 5 for skin injury group: will lose hair or feathers district with syringe needle
Skin groined type scratches, with ooze out tiny blood pearl for degree, make damaged skin district.A damaged group rabbit every left side
Depilation district, side is coated with kibe ointment 1g, and depilation district, right side is coated with substrate 1g as comparison.Test position covering oilpaper,
With immobilization with adhesive tape after gauze, after 24h, clean with warm water and remove kibe ointment and substrate, in remove kibe ointment and
After substrate, 1h, 12h, 24h, 36h, 48h, 60h, 72h observe, and Continuous Observation was to the 7th day.
Skin wound repair scoring and zest intensity evaluation is carried out by documentation standards.Result of the test shows: either
Skin complete group or skin injury group, after being coated with kibe ointment and substrate thereof, the most there is not water in all rabbit
Swollen, the skin irritation index the most not producing erythema, kibe ointment and substrate thereof is zero.
The main active of the present invention foundation Chinese medical theory and Caulis Momordicae Charantiae Folium Momordicae Charantiae etc. and pharmacological action, choosing
With treating malignant boil knot poison, the Chinese crude drug with effects such as removing blood stasis dissipating blood stasis, promoting blood circulation and hemostasis is raw material, makes treatment
The externally used paste medicine of chilblain.The medicine made is to chilblain determined curative effect, to no skin irritation.The present invention
Pharmaceutical formulation and preparation technology is simple, raw material is cheap and easy to get, curative effect of medication is definite, is worthy of popularization.
Medicine of the present invention is externally used paste.
(1) clinical data
87 example chilblain patients are all from undergraduate course outpatient service, and age 8～35 years old, wherein male 52 example, women 35
Example, all meets the diagnostic criteria of chilblain (erythema nodosa phase and erythema swelling phase).Show as buccal, ear,
The back of the hand, finger, heel, foot edge etc. locality is red or dark violet red speckle or scleroma, without ulcer,
Surface anxiety light, the skin temperature touched is low, can fading of pressure, recovers relatively slow after going pressure, and conscious have gargalesthesia, burning
Bright sense, swelling sense, gargalesthesia aggravates after being heated.
(2) Therapeutic Method
After the chilblain position of non-diabrosis is first cleaned with about 40 DEG C of warm water, dried, with disinfecting cotton swab in chilblain portion
It is appropriate that position and surrounding smear kibe ointment, 2 times/d, to without festering patient, the most repeatedly crumples cold injury before coating
Position half a minute, to improve cold injury position blood circulation, note warming after medication.
(3) therapeutic evaluation
Curing: red and swollen after treatment, purpura and scleroma all disappear, without itching pain, skin recovers normal；
Effective: red and swollen after treatment, purpura reduces, and scleroma diminishes, and pain and gargalesthesia substantially alleviate；
Invalid: red and swollen after treatment, purpura and the unchanged or aggravation that hardens, pain of itching is unchanged or aggravates.
(4) therapeutic outcome
After treatment, therapeutic effect see table.
In above-mentioned 87 example treatments, medicine of the present invention is obvious to treatment of perniosis effect, and wherein cure rate is
93.1%, effective percentage 4.60%, total effective rate is 97.7%.Patient with slight symptoms uses this kibe ointment after one day
Curing, patient with severe symptoms also can cure for about one week.
Detailed description of the invention
By embodiment, the relevant details of the present invention will be further described below, but embodiment does not limit
Protection scope of the present invention processed.
Embodiment 1: a kind of preparation containing Caulis Momordicae Charantiae Folium Momordicae Charantiae extract kibe ointment
Weigh Rhizoma Zingiberis 200g, Herba Selaginellae 300g, add the dipped medical material of suitable quantity of water 2～3 centimetres after pulverizing, soak
Steam distillation is used to collect volatile oil after 30 minutes；Filter, collect filtrate；Hardship after filtering residue and pulverizing
Melon vine Folium Momordicae Charantiae 1300g mixes, and boiling 3 times decocts 1h every time, filters off medicinal residues, by decoction liquor with
Rhizoma Zingiberis, the filtrate of Herba Selaginellae merge, and take supernatant after standing 12h, and being evaporated to relative density is 1.20～1.30
The extractum of (50 DEG C).
Take white vaseline 0.80g, stearic acid 1.20g, glyceryl monostearate 0.50g, azone 0.20g
As oil phase；Take extractum 0.20g, glycerol 0.70g, tween 80 0.20g, distilled water 6.0g as aqueous phase；
It is heated to 75 DEG C, after oil phase melts, aqueous phase is slowly added in oil phase, and is stirred continuously, treat temperature
Drop to camphorate when about 50 DEG C 0.10g, Methyl p-hydroxybenzoate 0.10g and volatile oil 5, stirring, cold
Solidifying, obtain kibe ointment.
Embodiment 2: a kind of preparation containing Caulis Momordicae Charantiae Folium Momordicae Charantiae extract kibe ointment
Weigh Rhizoma Zingiberis 250g, Herba Selaginellae 400g, add the dipped medical material of suitable quantity of water 2～3 centimetres after pulverizing, soak
Steam distillation is used to collect volatile oil after 30 minutes；Filter, collect filtrate；Hardship after filtering residue and pulverizing
Melon vine Folium Momordicae Charantiae 1400g mixes, and boiling 3 times decocts 1h every time, filters off medicinal residues, by decoction liquor with
Rhizoma Zingiberis, the filtrate of Herba Selaginellae merge, and take supernatant after standing 12h, and being evaporated to relative density is 1.20～1.30
The extractum of (50 DEG C).
Take white vaseline 1.00g, stearic acid 1.40g, glyceryl monostearate 0.90g, azone 0.20g
As oil phase；Take extractum 0.30g, glycerol 0.80g, tween 80 0.40g, distilled water 4.6g as aqueous phase；
It is heated to 75 DEG C, after oil phase melts, aqueous phase is slowly added in oil phase, and is stirred continuously, treat temperature
Drop to camphorate when about 50 DEG C 0.10g, Methyl p-hydroxybenzoate 0.30g and volatile oil 5, stirring, cold
Solidifying, obtain kibe ointment.
Embodiment 3: a kind of preparation containing Caulis Momordicae Charantiae Folium Momordicae Charantiae extract kibe ointment
Weigh Rhizoma Zingiberis 300g, Herba Selaginellae 500g, add the dipped medical material of suitable quantity of water 2～3 centimetres after pulverizing, soak
Steam distillation is used to collect volatile oil after 30 minutes；Filter, collect filtrate；Hardship after filtering residue and pulverizing
Melon vine Folium Momordicae Charantiae 1500g mixes, and boiling 3 times decocts 1h every time, filters off medicinal residues, by decoction liquor with
Rhizoma Zingiberis, the filtrate of Herba Selaginellae merge, and take supernatant after standing 12h, and being evaporated to relative density is 1.20～1.30
The extractum of (50 DEG C).
Take white vaseline 1.20g, stearic acid 1.50g, glyceryl monostearate 1.00g, azone 0.30g
As oil phase；Take extractum 0.30g, glycerol 1.00g, tween 80 0.50g, distilled water 3.7g as aqueous phase；
It is heated to 75 DEG C, after oil phase melts, aqueous phase is slowly added in oil phase, and is stirred continuously, treat temperature
Drop to camphorate when 50 DEG C 0.10g, Methyl p-hydroxybenzoate 0.40g and volatile oil 5, stirring, condensation,
Obtain kibe ointment.
Embodiment 4: a kind of irritation test containing Caulis Momordicae Charantiae Folium Momordicae Charantiae extract kibe ointment
It is tested medication with the kibe ointment of embodiment 1 preparation, takes healthy white rabbit 10, by its spinal column
First combing wool is cut short, and is then coated with depilatory, area 150cm2, clean with warm water after 2～3min, depilation
24h skin zero damage.Take 5 for skin complete group: depilation district, every left side is coated with kibe ointment 1g, and right side takes off
Hair-fields is coated with substrate 1g as comparison；Separately take 5 for skin injury group: will depilation district skin well word with syringe needle
Shape is scratched, with ooze out tiny blood pearl for degree, make damaged skin district.Depilation district, damaged group rabbit every left side
Being coated with kibe ointment 1g, depilation district, right side is coated with substrate 1g as comparison.Test position is used after covering oilpaper, gauze
Immobilization with adhesive tape, after 24h, cleans with warm water and removes kibe ointment and substrate, after removing kibe ointment and substrate 1h,
12h, 24h, 36h, 48h, 60h, 72h observe, and Continuous Observation was to the 7th day.By documentation standards
Carry out skin wound repair scoring and zest intensity evaluation.Result of the test shows: either skin complete group
Or skin injury group, after being coated with kibe ointment and substrate thereof, the most there is not edema in all rabbit, do not have yet
Producing erythema, the skin irritation index of kibe ointment and substrate thereof is zero.
Claims (6)
1. the kibe ointment containing Caulis Momordicae Charantiae Folium Momordicae Charantiae extract, it is characterised in that contain: crude drug is bitter
Melon vine Folium Momordicae Charantiae, Rhizoma Zingiberis, the extract of Herba Selaginellae, and adjuvant Camphora, glycerol, white vaseline, stearic acid,
Glyceryl monostearate, Methyl p-hydroxybenzoate, azone；
Its preparation method is: by Rhizoma Zingiberis and Herba Selaginellae extraction by steam distillation volatile oil, filters, and collects filter
Liquid；Filtering residue is mixed with the Caulis Momordicae Charantiae Folium Momordicae Charantiae after pulverizing, uses decocting method to carry out filtrate extracting, concentrating,
Obtain the extractum that relative density is 1.20～1.30 (50 DEG C)；
Using white vaseline, stearic acid, glyceryl monostearate, azone as oil phase, by prepared extractum and
Glycerol, tween 80 and distilled water, as aqueous phase, are separately heated to 75 DEG C, after oil phase melts, by aqueous phase
Be slowly added in oil phase, and be stirred continuously, camphorate when temperature drops to 50 DEG C, Methyl p-hydroxybenzoate and
The volatile oil extracted, stirs, condenses, obtain kibe ointment.
Contain the kibe ointment of Caulis Momordicae Charantiae Folium Momordicae Charantiae extract the most according to claim 1, it is characterised in that:
The raw material components proportioning preparing described extractum is: Caulis Momordicae Charantiae Folium Momordicae Charantiae 130-150 weight portion, Rhizoma Zingiberis 20-30
Weight portion, Herba Selaginellae 30-50 weight portion.
Contain the kibe ointment of Caulis Momordicae Charantiae Folium Momordicae Charantiae extract the most according to claim 1, it is characterised in that:
The component proportion of described oil phase is: white vaseline 0.80～1.20g, stearic acid 1.20～1.50g, monostearate
Glyceride 0.50～1.00g, azone 0.20～0.30g；The component proportion of described aqueous phase is: extractum 0.20～0.30g,
Glycerol 0.70～1.00g, tween 80 are 0.20～0.50g, the addition of distilled water is to make the unguentum gross mass be
10g；The addition of Camphora and Methyl p-hydroxybenzoate is 0.10g and 0.10～0.40g respectively.
4. contain a preparation method for the kibe ointment of Caulis Momordicae Charantiae Folium Momordicae Charantiae extract as claimed in claim 1,
It is characterized in that comprising the steps:
(1) the dipped medical material of suitable quantity of water 2～3 centimetres are added after Rhizoma Zingiberis and Herba Selaginellae being pulverized, after soaking 30 minutes
Use extraction by steam distillation volatile oil, filter, collect filtrate；By the Caulis Momordicae Charantiae Fructus Momordicae charantiae after filtering residue and pulverizing
Leaf mixes, boiling 3 times, decocts 1h every time, filters off medicinal residues, by decoction liquor and aforementioned Rhizoma Zingiberis, Herba Selaginellae
Filtrate merge, stand after 12h and take supernatant, being evaporated to relative density is 1.20～1.30 (50 DEG C)
Extractum；
(2) using white vaseline, stearic acid, glyceryl monostearate, azone as oil phase, by prepared
Extractum and glycerol, tween 80 and distilled water, as aqueous phase, are separately heated to 75 DEG C, after oil phase melts,
Aqueous phase is slowly added in oil phase, and is stirred continuously, camphorate when temperature drops to 50 DEG C, nipalgin
Formicester and the volatile oil of extraction, stir, condense, obtain kibe ointment.
Contain the preparation method of the kibe ointment of Caulis Momordicae Charantiae Folium Momordicae Charantiae extract the most according to claim 4,
It is characterized in that: in step (1), the raw material components proportioning preparing described extractum is: Caulis Momordicae Charantiae Folium Momordicae Charantiae
130-150 weight portion, Rhizoma Zingiberis 20-30 weight portion, Herba Selaginellae 30-50 weight portion.
Contain the preparation method of the kibe ointment of Caulis Momordicae Charantiae Folium Momordicae Charantiae extract the most according to claim 4,
It is characterized in that: in step (2), the component proportion of described oil phase is: white vaseline 0.80～1.20g,
Stearic acid 1.20～1.50g, glyceryl monostearate 0.50～1.00g, azone 0.20～0.30g；Described aqueous phase
Component proportion be: extractum 0.20～0.30g, glycerol 0.70～1.00g, tween 80 be 0.20～0.50g,
The addition of distilled water is that to make unguentum gross mass be 10g；The addition of Camphora and Methyl p-hydroxybenzoate is respectively
0.10g and 0.10～0.40g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610331198.0A CN105770848A (en) | 2016-05-18 | 2016-05-18 | Chilblain ointment containing extract from bitter gourd vines and leaves and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610331198.0A CN105770848A (en) | 2016-05-18 | 2016-05-18 | Chilblain ointment containing extract from bitter gourd vines and leaves and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105770848A true CN105770848A (en) | 2016-07-20 |
Family
ID=56378990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610331198.0A Withdrawn CN105770848A (en) | 2016-05-18 | 2016-05-18 | Chilblain ointment containing extract from bitter gourd vines and leaves and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105770848A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108781770A (en) * | 2018-05-22 | 2018-11-13 | 漯河丝络宝生物科技有限公司 | A method of extracting stoste from luffa vine/cucumber stem/balsampear stem |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102764417A (en) * | 2012-07-03 | 2012-11-07 | 夏义深 | Chinese materia medica frostbite cream |
| CN105434964A (en) * | 2016-01-08 | 2016-03-30 | 夏放军 | Traditional Chinese medicine for treating chilblain and preparation method for traditional Chinese medicine |
-
2016
- 2016-05-18 CN CN201610331198.0A patent/CN105770848A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102764417A (en) * | 2012-07-03 | 2012-11-07 | 夏义深 | Chinese materia medica frostbite cream |
| CN105434964A (en) * | 2016-01-08 | 2016-03-30 | 夏放军 | Traditional Chinese medicine for treating chilblain and preparation method for traditional Chinese medicine |
Non-Patent Citations (1)
| Title |
|---|
| 不详: "佳肴良药—苦瓜", 《世界最新医学信息文摘》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108781770A (en) * | 2018-05-22 | 2018-11-13 | 漯河丝络宝生物科技有限公司 | A method of extracting stoste from luffa vine/cucumber stem/balsampear stem |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102370910A (en) | Wart treating medicament and preparation method thereof | |
| CN101518600B (en) | Chinese medicinal composition for treating bacterial or fungal dermatosis and preparation method thereof | |
| Akwaji et al. | Ethnobotanical survey of commonly used medicinal plants in Northern Cross River State, Nigeria | |
| WO2015018124A1 (en) | Traditional chinese medicine preparation for reducing blood pressure and preparation method thereof | |
| CN105560748A (en) | Toxin drawing-out cream and preparation method thereof | |
| CN102266422A (en) | Chinese medicinal preparation for treating slight and severe chilblains and production method thereof | |
| CN102293931B (en) | Traditional Chinese medicinal composition, clinical preparation and preparation methods thereof | |
| CN103432269B (en) | Chinese medicinal preparation used for treating radiation enteritis | |
| CN102764345B (en) | Basil-bluegum ointment for curing burns and preparation method thereof | |
| CN103845616A (en) | Pharmaceutical composition for eliminating inflammation and disinfecting | |
| CN105770848A (en) | Chilblain ointment containing extract from bitter gourd vines and leaves and preparation method thereof | |
| CN104606337A (en) | Traditional Chinese medicine for treating cholestatic jaundice | |
| Mondal et al. | Ethnobiological and traditional medicine practices in burdwan district, west bengal, india | |
| CN101422577B (en) | External traditional Chinese medicine for treating scald and burn and preparation method thereof | |
| CN105617268A (en) | Medicine for treating scale keratinization type beriberi | |
| CN110384785A (en) | A kind of external application Chinese medicine medical fluid and preparation method thereof for treating virus flu | |
| CN103393940B (en) | External use ointment for treating skin diseases and preparation method thereof | |
| CN105596590A (en) | Traditional Chinese medicine preparation for treating herpes labialis and preparation method thereof | |
| CN102755467B (en) | Rochas winter ointment for treating frostbite and preparation method thereof | |
| CN105412828A (en) | Traditional Chinese medicine ointment for nursing tendinitis and preparation method of traditional Chinese medicine ointment | |
| CN105641226A (en) | Hot-compress salt for treating dysmenorrhea and preparation method | |
| CN105168821A (en) | Cough-relieving traditional Chinese medicine composition and preparation method thereof | |
| CN115381879A (en) | Spray type medicine for treating skin disease and its preparing method | |
| CN103816442B (en) | A kind of Chinese medicine for the treatment of the urinary tract infection caused by diabetes | |
| CN104721728A (en) | Gel for treating acne and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20160720 |